| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,373,987 | 4,418,197 | +44,210 | 0.06 | 0.07 | +0.01 | buy |
| BlackRock, Inc. | 3,940,456 | 4,181,432 | +240,976 | 0.02 | 0.02 | +0.01 | buy |
| Avoro Capital Advisors LLC | 2,888,888 | 2,888,888 | 0 | 7.35 | 9.64 | +2.29 | hold |
| STATE STREET CORP | 1,314,434 | 1,351,158 | +36,724 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,153,087 | 939,254 | -213,833 | 12.06 | 12.03 | -0.03 | sell |
| Capital World Investors | 824,720 | 777,843 | -46,877 | 0.03 | 0.03 | +0.01 | sell |
| VESTOR CAPITAL, LLC | 200 | 700,914 | +700,714 | 0.00 | 4.91 | +4.90 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 643,975 | 698,993 | +55,018 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 485,074 | 687,400 | +202,326 | 0.01 | 0.03 | +0.01 | buy |
| Hood River Capital Management LLC | 619,586 | 663,375 | +43,789 | 1.60 | 1.79 | +0.18 | buy |
| Redmile Group, LLC | 673,505 | 632,005 | -41,500 | 11.52 | 15.77 | +4.25 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 407,178 | 570,153 | +162,975 | 0.35 | 0.64 | +0.29 | buy |
| Frazier Life Sciences Management, L.P. | 481,307 | 481,307 | 0 | 3.20 | 3.90 | +0.70 | hold |
| DIMENSIONAL FUND ADVISORS LP | 468,990 | 476,038 | +7,048 | 0.03 | 0.03 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 350,521 | 324,900 | -25,621 | 0.06 | 0.07 | +0.01 | sell |
| Invesco Ltd. | 251,373 | 324,755 | +73,382 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 214,949 | 298,841 | +83,892 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 252,463 | 283,784 | +31,321 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 179,265 | 261,917 | +82,652 | 0.01 | 0.02 | +0.01 | buy |
| NORGES BANK | 0 | 259,030 | +259,030 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 260,647 | 256,431 | -4,216 | 0.00 | 0.01 | +0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 254,828 | +254,828 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 241,986 | 254,828 | +12,842 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 209,082 | 235,491 | +26,409 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 162,070 | 169,550 | +7,480 | 0.02 | 0.03 | +0.01 | buy |
| Bank of New York Mellon Corp | 149,307 | 163,610 | +14,303 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 156,064 | 158,675 | +2,611 | 0.01 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 150,616 | 150,616 | 0 | 0.15 | 0.17 | +0.03 | hold |
| UBS Group AG | 143,525 | 148,316 | +4,791 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 143,368 | 146,520 | +3,152 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 182,425 | 128,975 | -53,450 | 1.57 | 1.77 | +0.20 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 108,397 | 124,442 | +16,045 | 0.03 | 0.04 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 112,342 | 111,545 | -797 | 0.49 | 0.61 | +0.12 | sell |
| Pictet Asset Management Holding SA | 110,665 | 107,798 | -2,867 | 0.03 | 0.04 | +0.01 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 92,286 | 105,515 | +13,229 | 0.07 | 0.10 | +0.03 | buy |
| 1832 Asset Management L.P. | 42,600 | 99,300 | +56,700 | 0.01 | 0.05 | +0.03 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 98,707 | +98,707 | 0.00 | 0.12 | +0.12 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 93,031 | 92,234 | -797 | 0.02 | 0.02 | +0.00 | sell |
| Handelsbanken Fonder AB | 91,400 | 90,407 | -993 | 0.08 | 0.10 | +0.02 | sell |
| JPMORGAN CHASE & CO | 99,105 | 87,342 | -11,763 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 69,100 | 83,200 | +14,100 | 0.39 | 0.59 | +0.20 | buy |
| S Squared Technology, LLC | 86,215 | 77,545 | -8,670 | 8.43 | 8.94 | +0.51 | sell |
| Bellevue Group AG | 481,785 | 77,530 | -404,255 | 2.96 | 0.61 | -2.36 | sell |
| Biondo Investment Advisors, LLC | 72,045 | 70,945 | -1,100 | 2.39 | 3.23 | +0.84 | sell |
| SEGALL BRYANT & HAMILL, LLC | 79,497 | 65,211 | -14,286 | 0.21 | 0.29 | +0.08 | sell |
| RHUMBLINE ADVISERS | 68,099 | 61,236 | -6,863 | 0.02 | 0.02 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 9,600 | 59,680 | +50,080 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 59,050 | 58,580 | -470 | 0.00 | 0.00 | +0.00 | sell |
| C WorldWide Group Holding A/S | 67,809 | 57,809 | -10,000 | 0.38 | 0.52 | +0.14 | sell |
| CITIGROUP INC | 31,172 | 56,016 | +24,844 | 0.01 | 0.01 | +0.00 | buy |
| Bridgewater Associates, LP | 46,367 | 54,489 | +8,122 | 0.05 | 0.08 | +0.03 | buy |
| SEI INVESTMENTS CO | 46,570 | 54,040 | +7,470 | 0.01 | 0.02 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 2,475 | 52,407 | +49,932 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 26,210 | 52,161 | +25,951 | 0.01 | 0.02 | +0.01 | buy |
| Neuberger Berman Group LLC | 33,084 | 51,876 | +18,792 | 0.01 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 49,837 | 48,790 | -1,047 | 0.00 | 0.00 | +0.00 | sell |
| Palisades Investment Partners, LLC | 45,405 | 47,801 | +2,396 | 4.60 | 5.05 | +0.45 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 40,715 | 44,935 | +4,220 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 35,495 | 43,848 | +8,353 | 0.01 | 0.02 | +0.01 | buy |
| Swiss National Bank | 43,000 | 41,360 | -1,640 | 0.01 | 0.01 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 40,128 | 40,296 | +168 | 0.12 | 0.15 | +0.03 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 40,134 | +40,134 | 0.00 | 0.09 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 36,937 | 38,697 | +1,760 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,227 | 36,936 | +26,709 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,988 | 34,502 | +19,514 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,929 | 34,039 | +2,110 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,342 | 34,033 | +2,691 | 0.01 | 0.02 | +0.00 | buy |
| Granite Investment Partners, LLC | 24,284 | 32,837 | +8,553 | 0.39 | 0.63 | +0.24 | buy |
| PRUDENTIAL FINANCIAL INC | 29,638 | 32,662 | +3,024 | 0.01 | 0.01 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 35,859 | 31,998 | -3,861 | 0.11 | 0.12 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 24,831 | 31,836 | +7,005 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 3,523 | 30,558 | +27,035 | 0.00 | 0.02 | +0.01 | buy |
| Fisher Asset Management, LLC | 27,784 | 27,676 | -108 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,069 | 25,867 | -10,202 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 30,155 | 25,141 | -5,014 | 0.01 | 0.01 | +0.00 | sell |
| Atle Fund Management AB | 37,579 | 24,019 | -13,560 | 2.19 | 2.40 | +0.21 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,186 | 23,692 | -2,494 | 0.01 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 43,318 | 22,712 | -20,606 | 0.01 | 0.01 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 21,413 | 21,711 | +298 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 15,937 | 20,318 | +4,381 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 20,285 | 20,285 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TFG Asset Management GP Ltd | 19,668 | 19,668 | 0 | 1.00 | 1.19 | +0.19 | hold |
| Lisanti Capital Growth, LLC | 18,515 | 19,050 | +535 | 1.21 | 1.56 | +0.35 | buy |
| GW&K Investment Management, LLC | 19,245 | 18,295 | -950 | 0.04 | 0.05 | +0.01 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 17,226 | 17,229 | +3 | 0.01 | 0.01 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 17,071 | +17,071 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,637 | 16,801 | +1,164 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,014 | 16,420 | -3,594 | 0.31 | 0.29 | -0.02 | sell |
| Cinctive Capital Management LP | 2,874 | 16,367 | +13,493 | 0.05 | 0.24 | +0.19 | buy |
| Rhenman & Partners Asset Management AB | 16,675 | 16,325 | -350 | 0.53 | 0.57 | +0.04 | sell |
| Informed Momentum Co LLC | 16,483 | 16,227 | -256 | 0.49 | 0.54 | +0.05 | sell |
| CASTLEARK MANAGEMENT LLC | 31,630 | 16,150 | -15,480 | 0.27 | 0.16 | -0.11 | sell |
| SG Americas Securities, LLC | 5,899 | 16,147 | +10,248 | 0.00 | 0.00 | +0.00 | buy |
| Mediolanum International Funds Ltd | 0 | 15,940 | +15,940 | 0.00 | 0.05 | +0.05 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 15,753 | +15,753 | 0.00 | 0.01 | +0.01 | buy |
| CIM, LLC | 14,990 | 15,703 | +713 | 0.56 | 0.75 | +0.19 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,121 | 15,297 | +176 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,542 | 15,196 | +1,654 | 0.02 | 0.03 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,756 | 14,483 | -1,273 | 0.01 | 0.01 | +0.00 | sell |
| Fiera Capital Corp | 24,146 | 14,251 | -9,895 | 0.02 | 0.02 | -0.00 | sell |