| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 58,266 | 340,849 | +282,583 | 0.01 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 44,223 | 321,944 | +277,721 | 0.06 | 0.44 | +0.38 | buy |
| FRED ALGER MANAGEMENT, LLC | 3,557 | 167,485 | +163,928 | 0.00 | 0.11 | +0.11 | buy |
| Rock Springs Capital Management LP | 34,901 | 90,560 | +55,659 | 0.10 | 0.28 | +0.18 | buy |
| J. Goldman & Co LP | 5,349 | 35,213 | +29,864 | 0.04 | 0.20 | +0.17 | buy |
| Rafferty Asset Management, LLC | 53,183 | 71,806 | +18,623 | 0.04 | 0.05 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 197,039 | 209,487 | +12,448 | 0.03 | 0.03 | +0.00 | buy |
| Hood River Capital Management LLC | 452,456 | 460,489 | +8,033 | 1.58 | 1.71 | +0.13 | buy |
| Integral Health Asset Management, LLC | 62,000 | 70,000 | +8,000 | 0.96 | 1.15 | +0.20 | buy |
| Soleus Capital Management, L.P. | 110,192 | 117,892 | +7,700 | 1.44 | 1.38 | -0.06 | buy |
| TD ASSET MANAGEMENT INC | 15,810 | 22,420 | +6,610 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 15,962 | 10,123 | +5,839 | 0.01 | 0.00 | 0.00 | sell |
| Calamos Advisors LLC | 20,611 | 25,647 | +5,036 | 0.01 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,560,811 | 2,565,555 | +4,744 | 4.08 | 4.64 | +0.56 | buy |
| ExodusPoint Capital Management, LP | 24,101 | 27,750 | +3,649 | 0.03 | 0.04 | 0.00 | buy |
| PROFUND ADVISORS LLC | 9,865 | 12,240 | +2,375 | 0.06 | 0.08 | +0.02 | buy |
| Perigon Wealth Management, LLC | 1,759 | 4,083 | +2,324 | 0.01 | 0.02 | +0.01 | buy |
| Eversept Partners, LP | 106,465 | 108,771 | +2,306 | 1.32 | 1.40 | +0.08 | buy |
| HighVista Strategies LLC | 2,530 | 4,392 | +1,862 | 0.14 | 0.24 | +0.10 | buy |
| CWM, LLC | 33,721 | 32,326 | +1,395 | 0.02 | 0.02 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 49,682 | 50,821 | +1,139 | 0.35 | 0.38 | +0.03 | buy |
| E Fund Management Co., Ltd. | 2,857 | 3,687 | +830 | 0.03 | 0.03 | +0.01 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 5,148 | 4,440 | +708 | 0.01 | 0.01 | 0.00 | sell |
| Empowered Funds, LLC | 24,101 | 24,611 | +510 | 0.10 | 0.09 | -0.01 | buy |
| Confluence Wealth Services, Inc. | 2,420 | 2,920 | +500 | 0.06 | 0.07 | +0.01 | buy |
| ALPS ADVISORS INC | 20,236 | 20,620 | +384 | 0.02 | 0.02 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 339 | 718 | +379 | 0.01 | 0.02 | +0.01 | buy |
| Informed Momentum Co LLC | 15,714 | 16,091 | +377 | 0.34 | 0.36 | +0.02 | buy |
| ProShare Advisors LLC | 4,481 | 4,639 | +158 | 0.00 | 0.00 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 198,593 | 198,683 | +90 | 0.29 | 0.30 | +0.01 | buy |
| West Tower Group, LLC | 36 | 84 | +48 | 0.00 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 7,503 | 7,528 | +25 | 0.01 | 0.01 | +0.00 | buy |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 89 | 99 | +10 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 840 | 766 | -74 | 0.06 | 0.05 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 12,068 | 11,767 | -301 | 0.03 | 0.03 | +0.00 | sell |
| Dynamic Technology Lab Private Ltd | 4,060 | 3,570 | -490 | 0.06 | 0.04 | -0.02 | sell |
| EFG Asset Management (North America) Corp. | 17,784 | 16,234 | -1,550 | 0.45 | 0.45 | -0.00 | sell |
| Legato Capital Management LLC | 12,735 | 10,940 | -1,795 | 0.20 | 0.18 | -0.02 | sell |
| Frazier Life Sciences Management, L.P. | 990,260 | 988,460 | -1,800 | 6.94 | 7.62 | +0.68 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 6,978 | 5,114 | -1,864 | 0.16 | 0.13 | -0.04 | sell |
| ADVISORY RESEARCH INC | 11,653 | 8,989 | -2,664 | 0.18 | 0.14 | -0.03 | sell |
| APIS CAPITAL ADVISORS, LLC | 26,800 | 24,000 | -2,800 | 3.18 | 3.61 | +0.43 | sell |
| Bellevue Group AG | 18,000 | 12,500 | -5,500 | 0.03 | 0.02 | -0.01 | sell |
| Global IMC LLC | 35,170 | 29,517 | -5,653 | 1.21 | 0.93 | -0.29 | sell |
| Nicholas Investment Partners, LP | 374,951 | 355,611 | -19,340 | 3.01 | 3.08 | +0.07 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 285,860 | 244,061 | -41,799 | 0.22 | 0.19 | -0.03 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 118,941 | 71,531 | -47,410 | 4.71 | 3.09 | -1.62 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 324,947 | 256,206 | -68,741 | 0.01 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 241,399 | 77,497 | -163,902 | 0.93 | 0.28 | -0.64 | sell |
| LORD, ABBETT & CO. LLC | 842,648 | 671,311 | -171,337 | 0.34 | 0.29 | -0.05 | sell |
| Redmile Group, LLC | 2,566,661 | 2,003,367 | -563,294 | 11.57 | 11.06 | -0.51 | sell |