| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,334,761 | 4,341,447 | +6,686 | 0.03 | 0.04 | +0.01 | buy |
| BlackRock, Inc. | 3,845,155 | 3,834,128 | -11,027 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 2,822,888 | 2,792,208 | -30,680 | 0.01 | 0.01 | +0.00 | sell |
| Avoro Capital Advisors LLC | 2,660,000 | 2,777,777 | +117,777 | 6.40 | 6.34 | -0.06 | buy |
| STATE STREET CORP | 1,355,346 | 1,395,967 | +40,621 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 922,958 | 1,018,831 | +95,873 | 8.76 | 9.61 | +0.85 | buy |
| Capital World Investors | 942,249 | 809,240 | -133,009 | 0.02 | 0.02 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 688,460 | 688,460 | 0 | 3.78 | 3.64 | -0.14 | hold |
| Redmile Group, LLC | 663,471 | 661,388 | -2,083 | 9.71 | 11.36 | +1.65 | sell |
| CITADEL ADVISORS LLC | 34,560 | 636,988 | +602,428 | 0.00 | 0.09 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 619,547 | 611,244 | -8,303 | 0.01 | 0.01 | +0.00 | sell |
| Hood River Capital Management LLC | 533,023 | 606,946 | +73,923 | 1.02 | 1.27 | +0.24 | buy |
| DIMENSIONAL FUND ADVISORS LP | 505,889 | 533,964 | +28,075 | 0.02 | 0.02 | +0.00 | buy |
| BRAIDWELL LP | 727,811 | 520,401 | -207,410 | 3.42 | 2.73 | -0.70 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 261,383 | 467,058 | +205,675 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 530,361 | 348,250 | -182,111 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 222,370 | 248,392 | +26,022 | 0.02 | 0.03 | +0.01 | buy |
| NORTHERN TRUST CORP | 251,408 | 248,165 | -3,243 | 0.00 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 246,180 | 242,863 | -3,317 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 234,421 | 234,578 | +157 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 234,320 | 202,589 | -31,731 | 0.01 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 188,019 | 197,378 | +9,359 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 130,537 | 196,904 | +66,367 | 0.02 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 160,517 | 155,553 | -4,964 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 150,616 | 150,616 | 0 | 0.11 | 0.13 | +0.02 | hold |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 91,099 | 149,302 | +58,203 | 0.03 | 0.07 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 12,562 | 148,713 | +136,151 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 91,153 | 146,354 | +55,201 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 140,883 | 142,843 | +1,960 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 121,812 | 137,995 | +16,183 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 97,240 | 130,173 | +32,933 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 112,382 | 128,960 | +16,578 | 0.02 | 0.03 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 114,204 | 118,514 | +4,310 | 0.23 | 0.30 | +0.07 | buy |
| S Squared Technology, LLC | 109,215 | 109,215 | 0 | 6.33 | 7.33 | +1.00 | hold |
| ORBIMED ADVISORS LLC | 9,200 | 102,745 | +93,545 | 0.03 | 0.43 | +0.40 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 86,688 | 100,431 | +13,743 | 0.05 | 0.07 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 63,993 | 93,908 | +29,915 | 0.01 | 0.02 | +0.01 | buy |
| C WorldWide Group Holding A/S | 85,809 | 85,809 | 0 | 0.16 | 0.23 | +0.07 | hold |
| SEGALL BRYANT & HAMILL, LLC | 148,614 | 85,263 | -63,351 | 0.29 | 0.20 | -0.09 | sell |
| BARCLAYS PLC | 92,871 | 75,896 | -16,975 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 70,753 | 70,552 | -201 | 0.01 | 0.01 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 147,980 | 70,349 | -77,631 | 0.84 | 0.60 | -0.24 | sell |
| Invesco Ltd. | 70,888 | 66,880 | -4,008 | 0.00 | 0.00 | +0.00 | sell |
| Handelsbanken Fonder AB | 66,800 | 66,800 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Legal & General Group Plc | 68,393 | 65,815 | -2,578 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 68,735 | 64,363 | -4,372 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 59,978 | 59,978 | 0 | 0.04 | 0.04 | +0.01 | hold |
| Aberdeen Group plc | 108,518 | 59,372 | -49,146 | 0.03 | 0.02 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 62,835 | 55,792 | -7,043 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 80,123 | 54,816 | -25,307 | 0.01 | 0.01 | -0.00 | sell |
| Biondo Investment Advisors, LLC | 21,240 | 51,885 | +30,645 | 0.38 | 1.15 | +0.76 | buy |
| TD ASSET MANAGEMENT INC | 20,080 | 45,080 | +25,000 | 0.00 | 0.01 | +0.00 | buy |
| Atle Fund Management AB | 20,158 | 42,191 | +22,033 | 1.19 | 2.93 | +1.75 | buy |
| Swiss National Bank | 41,400 | 42,000 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Palisades Investment Partners, LLC | 40,203 | 41,389 | +1,186 | 2.42 | 2.87 | +0.45 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 38,146 | 39,291 | +1,145 | 0.13 | 0.15 | +0.03 | buy |
| Corient Private Wealth LLC | 40,538 | 39,130 | -1,408 | 0.01 | 0.01 | +0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 38,357 | 37,934 | -423 | 0.06 | 0.07 | +0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 0 | 35,000 | +35,000 | 0.00 | 0.18 | +0.18 | buy |
| Rafferty Asset Management, LLC | 34,665 | 34,640 | -25 | 0.02 | 0.02 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,680 | 34,455 | +9,775 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 66,000 | 32,300 | -33,700 | 2.29 | 0.99 | -1.30 | sell |
| Verition Fund Management LLC | 26,514 | 31,333 | +4,819 | 0.02 | 0.03 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,120 | 29,920 | -1,200 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,089 | 29,340 | -6,749 | 0.01 | 0.01 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 22,878 | 27,095 | +4,217 | 0.44 | 0.62 | +0.17 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,382 | 26,994 | +3,612 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 10,358 | 26,549 | +16,191 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 26,151 | 25,496 | -655 | 0.01 | 0.01 | -0.00 | sell |
| Ikarian Capital, LLC | 0 | 24,421 | +24,421 | 0.00 | 0.87 | +0.87 | buy |
| FEDERATED HERMES, INC. | 42,743 | 23,981 | -18,762 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 19,300 | 23,393 | +4,093 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 20,847 | 21,398 | +551 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,135 | 21,379 | +2,244 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,126 | 20,882 | +756 | 0.00 | 0.00 | +0.00 | buy |
| SYNOVUS FINANCIAL CORP | 20,643 | 20,516 | -127 | 0.03 | 0.04 | +0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,968 | 20,133 | +8,165 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 18,425 | 19,850 | +1,425 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,547 | 19,653 | +3,106 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 18,700 | 18,584 | -116 | 0.01 | 0.01 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 18,523 | +18,523 | 0.00 | 0.32 | +0.32 | buy |
| Erste Asset Management GmbH | 18,200 | 18,200 | 0 | 0.02 | 0.03 | +0.01 | hold |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,650 | 15,550 | -100 | 0.00 | 0.01 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 15,503 | 15,503 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fiera Capital Corp | 15,511 | 15,063 | -448 | 0.01 | 0.01 | +0.00 | sell |
| Fieldview Capital Management, LLC | 14,546 | 14,705 | +159 | 0.30 | 0.42 | +0.12 | buy |
| State of New Jersey Common Pension Fund D | 15,033 | 14,599 | -434 | 0.01 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 14,746 | 14,430 | -316 | 0.01 | 0.01 | +0.00 | sell |
| State of Alaska, Department of Revenue | 15,130 | 14,274 | -856 | 0.02 | 0.03 | +0.00 | sell |
| Illinois Municipal Retirement Fund | 12,311 | 14,245 | +1,934 | 0.02 | 0.03 | +0.01 | buy |
| Bridge City Capital, LLC | 0 | 14,154 | +14,154 | 0.00 | 0.67 | +0.67 | buy |
| ALPS ADVISORS INC | 17,462 | 13,367 | -4,095 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,283 | 13,290 | -1,993 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 15,116 | 13,108 | -2,008 | 0.00 | 0.00 | +0.00 | sell |
| Evolutionary Tree Capital Management, LLC | 12,296 | 12,461 | +165 | 1.79 | 2.40 | +0.60 | buy |
| Privium Fund Management B.V. | 9,320 | 12,170 | +2,850 | 0.28 | 0.39 | +0.11 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 11,574 | 11,901 | +327 | 0.23 | 0.29 | +0.05 | buy |
| Louisiana State Employees Retirement System | 11,900 | 11,800 | -100 | 0.03 | 0.03 | +0.01 | sell |
| Rhenman & Partners Asset Management AB | 12,750 | 11,750 | -1,000 | 0.22 | 0.23 | +0.01 | sell |
| Creative Planning | 8,356 | 11,609 | +3,253 | 0.00 | 0.00 | +0.00 | buy |