| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,292,881 | 4,314,014 | +21,133 | 0.05 | 0.04 | -0.01 | buy |
| BlackRock, Inc. | 3,993,123 | 4,033,872 | +40,749 | 0.02 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 2,849,744 | 2,878,451 | +28,707 | 0.01 | 0.01 | -0.00 | buy |
| Avoro Capital Advisors LLC | 2,622,222 | 2,628,822 | +6,600 | 6.96 | 5.83 | -1.13 | buy |
| STATE STREET CORP | 1,452,811 | 1,278,975 | -173,836 | 0.01 | 0.01 | -0.00 | sell |
| Capital World Investors | 879,083 | 879,203 | +120 | 0.02 | 0.02 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 988,460 | 788,460 | -200,000 | 7.21 | 5.13 | -2.08 | sell |
| Redmile Group, LLC | 810,245 | 753,175 | -57,070 | 8.69 | 8.22 | -0.47 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 591,631 | 591,596 | -35 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 600,261 | 588,599 | -11,662 | 0.03 | 0.02 | -0.00 | sell |
| Hood River Capital Management LLC | 502,104 | 512,726 | +10,622 | 1.48 | 1.19 | -0.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 438,259 | 509,459 | +71,200 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 216,979 | 358,379 | +141,400 | 3.28 | 4.25 | +0.97 | buy |
| JENNISON ASSOCIATES LLC | 410,057 | 303,521 | -106,536 | 0.05 | 0.03 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 301,354 | 277,175 | -24,179 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 365,551 | 275,195 | -90,356 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 238,691 | 262,263 | +23,572 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 275,804 | 256,275 | -19,529 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 240,216 | 243,170 | +2,954 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 179,815 | 221,102 | +41,287 | 0.28 | 0.23 | -0.04 | buy |
| NORGES BANK | 244,097 | 219,528 | -24,569 | 0.01 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 284,159 | 215,628 | -68,531 | 0.16 | 0.11 | -0.06 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 224,945 | 210,202 | -14,743 | 0.01 | 0.01 | -0.00 | sell |
| BRAIDWELL LP | 168,691 | 200,500 | +31,809 | 0.87 | 0.93 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 243,760 | 184,027 | -59,733 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 169,934 | 169,934 | 0 | 0.32 | 0.28 | -0.04 | hold |
| Bank of New York Mellon Corp | 171,653 | 169,346 | -2,307 | 0.01 | 0.00 | -0.00 | sell |
| TimesSquare Capital Management, LLC | 114,222 | 158,868 | +44,646 | 0.31 | 0.36 | +0.05 | buy |
| JPMORGAN CHASE & CO | 127,901 | 151,835 | +23,934 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 157,144 | 149,309 | -7,835 | 0.39 | 0.32 | -0.07 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 119,726 | 123,453 | +3,727 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 163,304 | 121,702 | -41,602 | 0.26 | 0.16 | -0.10 | sell |
| AMERIPRISE FINANCIAL INC | 89,749 | 113,476 | +23,727 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 115,350 | 112,089 | -3,261 | 0.02 | 0.02 | -0.00 | sell |
| C WorldWide Group Holding A/S | 135,809 | 105,809 | -30,000 | 0.26 | 0.20 | -0.05 | sell |
| UBS Group AG | 36,329 | 100,131 | +63,802 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 35,084 | 99,633 | +64,549 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 95,781 | 95,781 | 0 | 0.30 | 0.27 | -0.03 | hold |
| S Squared Technology, LLC | 75,215 | 95,215 | +20,000 | 5.84 | 6.20 | +0.36 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 126,082 | 89,047 | -37,035 | 0.11 | 0.06 | -0.04 | sell |
| Handelsbanken Fonder AB | 94,700 | 85,300 | -9,400 | 0.07 | 0.05 | -0.02 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 98,285 | 81,328 | -16,957 | 0.02 | 0.01 | -0.00 | sell |
| Decheng Capital LLC | 71,772 | 76,772 | +5,000 | 3.09 | 2.58 | -0.51 | buy |
| BANK OF AMERICA CORP /DE/ | 104,654 | 75,799 | -28,855 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 70,578 | 74,701 | +4,123 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 66,255 | 69,425 | +3,170 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 70,309 | 69,136 | -1,173 | 0.01 | 0.01 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 53,656 | 63,010 | +9,354 | 0.05 | 0.04 | -0.01 | buy |
| Aberdeen Group plc | 43,054 | 57,033 | +13,979 | 0.01 | 0.02 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 55,000 | +55,000 | 0.00 | 0.76 | +0.76 | buy |
| Janney Montgomery Scott LLC | 37,047 | 52,592 | +15,545 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 56,540 | 52,429 | -4,111 | 0.00 | 0.00 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 46,800 | 46,800 | 0 | 0.44 | 0.35 | -0.09 | hold |
| TD ASSET MANAGEMENT INC | 33,480 | 43,480 | +10,000 | 0.01 | 0.01 | +0.00 | buy |
| Corient Private Wealth LLC | 47,687 | 43,009 | -4,678 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 39,100 | 42,400 | +3,300 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 37,939 | 41,193 | +3,254 | 0.01 | 0.01 | -0.00 | buy |
| Palisades Investment Partners, LLC | 37,043 | 40,479 | +3,436 | 2.94 | 2.68 | -0.26 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,554 | 38,468 | +28,914 | 0.00 | 0.01 | +0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 36,566 | 36,518 | -48 | 0.07 | 0.06 | -0.01 | sell |
| JANE STREET GROUP, LLC | 18,181 | 35,855 | +17,674 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,225 | 35,206 | +3,981 | 0.00 | 0.00 | -0.00 | buy |
| GW&K Investment Management, LLC | 36,029 | 34,930 | -1,099 | 0.06 | 0.05 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 29,720 | 31,120 | +1,400 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 111,705 | 29,777 | -81,928 | 0.03 | 0.01 | -0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 5,194 | 27,711 | +22,517 | 0.02 | 0.10 | +0.08 | buy |
| Rafferty Asset Management, LLC | 45,840 | 27,201 | -18,639 | 0.03 | 0.02 | -0.01 | sell |
| CANADA LIFE ASSURANCE Co | 26,776 | 26,754 | -22 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 15,611 | 25,361 | +9,750 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 16,000 | 24,902 | +8,902 | 0.02 | 0.02 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,068 | 24,502 | +1,434 | 0.01 | 0.01 | -0.00 | buy |
| Edgestream Partners, L.P. | 32,257 | 23,810 | -8,447 | 0.26 | 0.16 | -0.10 | sell |
| Rhenman & Partners Asset Management AB | 17,000 | 23,750 | +6,750 | 0.25 | 0.38 | +0.13 | buy |
| ORBIMED ADVISORS LLC | 23,500 | 23,500 | 0 | 0.08 | 0.08 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 25,863 | 23,382 | -2,481 | 0.01 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 39,411 | 23,169 | -16,242 | 0.01 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 22,339 | +22,339 | 0.00 | 0.14 | +0.14 | buy |
| HRT FINANCIAL LP | 0 | 22,007 | +22,007 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 34,249 | 21,164 | -13,085 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,261 | 20,388 | +1,127 | 0.00 | 0.00 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 19,854 | 19,563 | -291 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 47,623 | 18,956 | -28,667 | 0.01 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 18,200 | 18,200 | 0 | 0.04 | 0.04 | -0.00 | hold |
| EFG Asset Management (North America) Corp. | 13,529 | 17,714 | +4,185 | 0.41 | 0.38 | -0.03 | buy |
| WELLS FARGO & COMPANY/MN | 13,956 | 16,928 | +2,972 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,879 | 15,879 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Fiera Capital Corp | 16,200 | 15,673 | -527 | 0.01 | 0.01 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 15,503 | 15,503 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,386 | 15,205 | -181 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 14,317 | 14,997 | +680 | 0.01 | 0.01 | -0.00 | buy |
| State of Alaska, Department of Revenue | 14,428 | 14,423 | -5 | 0.03 | 0.03 | -0.00 | sell |
| Illinois Municipal Retirement Fund | 12,641 | 14,146 | +1,505 | 0.03 | 0.03 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 13,910 | 13,678 | -232 | 0.12 | 0.10 | -0.02 | sell |
| Corebridge Financial, Inc. | 14,257 | 13,225 | -1,032 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 12,819 | 13,048 | +229 | 0.01 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 12,607 | 12,607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Louisiana State Employees Retirement System | 12,200 | 12,200 | 0 | 0.04 | 0.04 | -0.00 | hold |
| State of New Jersey Common Pension Fund D | 9,893 | 11,803 | +1,910 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 12,680 | 11,704 | -976 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 11,509 | 11,630 | +121 | 0.00 | 0.00 | -0.00 | buy |