| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 216,979 | 358,379 | +141,400 | 3.28 | 4.25 | +0.97 | buy |
| Allspring Global Investments Holdings, LLC | 111,705 | 29,777 | +81,928 | 0.03 | 0.01 | 0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 438,259 | 509,459 | +71,200 | 0.01 | 0.01 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 114,222 | 158,868 | +44,646 | 0.31 | 100.00 | +99.69 | buy |
| Woodline Partners LP | 179,815 | 221,102 | +41,287 | 0.28 | 0.23 | -0.04 | buy |
| BRAIDWELL LP | 168,691 | 200,500 | +31,809 | 0.87 | 0.93 | +0.06 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 5,194 | 27,711 | +22,517 | 0.02 | 0.10 | +0.08 | buy |
| S Squared Technology, LLC | 75,215 | 95,215 | +20,000 | 5.84 | 6.20 | +0.36 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 98,285 | 81,328 | +16,957 | 0.02 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 43,054 | 57,033 | +13,979 | 0.01 | 0.02 | +0.00 | buy |
| Hood River Capital Management LLC | 502,104 | 512,726 | +10,622 | 1.48 | 1.19 | -0.29 | buy |
| TD ASSET MANAGEMENT INC | 33,480 | 43,480 | +10,000 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 17,000 | 23,750 | +6,750 | 0.25 | 0.38 | +0.13 | buy |
| Avoro Capital Advisors LLC | 2,622,222 | 2,628,822 | +6,600 | 6.96 | 5.83 | -1.13 | buy |
| CWM, LLC | 13,846 | 8,053 | +5,793 | 0.01 | 0.01 | -0.01 | sell |
| Decheng Capital LLC | 71,772 | 76,772 | +5,000 | 3.09 | 2.58 | -0.51 | buy |
| EFG Asset Management (North America) Corp. | 13,529 | 17,714 | +4,185 | 0.41 | 0.38 | -0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 119,726 | 123,453 | +3,727 | 0.01 | 0.01 | 0.00 | buy |
| PROFUND ADVISORS LLC | 9,985 | 6,321 | +3,664 | 0.07 | 0.04 | 0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 7,270 | 10,839 | +3,569 | 0.02 | 0.02 | +0.00 | buy |
| Palisades Investment Partners, LLC | 37,043 | 40,479 | +3,436 | 2.94 | 2.68 | -0.26 | buy |
| PRUDENTIAL FINANCIAL INC | 37,939 | 41,193 | +3,254 | 0.01 | 0.01 | 0.00 | buy |
| Privium Fund Management B.V. | 6,350 | 9,250 | +2,900 | 0.29 | 0.33 | +0.04 | buy |
| STRS OHIO | 5,000 | 7,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 6,881 | 8,848 | +1,967 | 0.00 | 0.00 | 0.00 | buy |
| AlphaQuest LLC | 1,398 | 3,020 | +1,622 | 0.02 | 0.07 | 0.00 | buy |
| Evolutionary Tree Capital Management, LLC | 9,112 | 10,700 | +1,588 | 1.66 | 1.71 | +0.04 | buy |
| WINTON GROUP Ltd | 5,291 | 6,565 | +1,274 | 0.07 | 0.07 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,526 | 6,098 | +572 | 0.11 | 0.09 | -0.02 | buy |
| Bellevue Group AG | 4,779 | 5,047 | +268 | 0.01 | 0.02 | +0.00 | buy |
| Sound View Wealth Advisors Group, LLC | 1,200 | 1,420 | +220 | 0.02 | 0.02 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 3,530 | 3,750 | +220 | 0.14 | 0.12 | -0.03 | buy |
| VIRTUS ADVISERS, LLC | 1,802 | 2,016 | +214 | 0.15 | 0.13 | -0.02 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 9,949 | 9,777 | +172 | 0.02 | 0.02 | 0.00 | sell |
| Perigon Wealth Management, LLC | 8,166 | 8,289 | +123 | 0.04 | 0.03 | -0.01 | buy |
| Capital World Investors | 879,083 | 879,203 | +120 | 0.02 | 0.02 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,513 | 2,595 | +82 | 0.02 | 0.01 | -0.00 | buy |
| Ballentine Partners, LLC | 2,089 | 2,145 | +56 | 0.01 | 0.01 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 26,776 | 26,754 | +22 | 0.01 | 0.01 | -0.00 | sell |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 5,980 | 5,975 | +5 | 0.02 | 0.02 | 0.00 | sell |
| State of Alaska, Department of Revenue | 14,428 | 14,423 | +5 | 0.03 | 0.03 | 0.00 | sell |
| Rakuten Securities, Inc. | 16 | 20 | +4 | 0.00 | 0.00 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 5,135 | 5,136 | +1 | 0.02 | 0.02 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 2,379 | 2,353 | -26 | 0.10 | 0.12 | +0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 13,910 | 13,678 | -232 | 0.12 | 0.10 | -0.02 | sell |
| Jackson Creek Investment Advisors LLC | 8,296 | 8,052 | -244 | 0.45 | 0.38 | -0.07 | sell |
| Main Management ETF Advisors, LLC | 3,880 | 3,560 | -320 | 0.03 | 0.03 | -0.01 | sell |
| Cynosure Group, LLC | 3,989 | 3,630 | -359 | 0.11 | 0.08 | -0.02 | sell |
| ZACKS INVESTMENT MANAGEMENT | 9,447 | 9,078 | -369 | 0.01 | 0.01 | -0.00 | sell |
| Fiera Capital Corp | 16,200 | 15,673 | -527 | 0.01 | 0.01 | -0.00 | sell |
| Brevan Howard Capital Management LP | 2,094 | 1,396 | -698 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 2,296 | 1,537 | -759 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 2,941 | 1,934 | -1,007 | 0.03 | 0.02 | -0.01 | sell |
| GW&K Investment Management, LLC | 36,029 | 34,930 | -1,099 | 0.06 | 0.05 | -0.01 | sell |
| Nebula Research & Development LLC | 4,705 | 2,670 | -2,035 | 0.10 | 0.05 | -0.05 | sell |
| SEGALL BRYANT & HAMILL, LLC | 157,144 | 149,309 | -7,835 | 0.39 | 0.32 | -0.07 | sell |
| Edgestream Partners, L.P. | 32,257 | 23,810 | -8,447 | 0.26 | 0.16 | -0.10 | sell |
| Nicholas Investment Partners, LP | 18,807 | 5,086 | -13,721 | 0.31 | 0.07 | -0.24 | sell |
| Rafferty Asset Management, LLC | 45,840 | 27,201 | -18,639 | 0.03 | 0.02 | -0.01 | sell |
| C WorldWide Group Holding A/S | 135,809 | 105,809 | -30,000 | 0.26 | 0.20 | -0.05 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 126,082 | 89,047 | -37,035 | 100.00 | 100.00 | 0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 163,304 | 121,702 | -41,602 | 0.26 | 0.16 | -0.10 | sell |
| Redmile Group, LLC | 810,245 | 753,175 | -57,070 | 8.69 | 8.22 | -0.47 | sell |
| LORD, ABBETT & CO. LLC | 284,159 | 215,628 | -68,531 | 0.16 | 0.11 | -0.06 | sell |
| JENNISON ASSOCIATES LLC | 410,057 | 303,521 | -106,536 | 0.05 | 0.03 | -0.02 | sell |
| Frazier Life Sciences Management, L.P. | 988,460 | 788,460 | -200,000 | 7.21 | 5.13 | -2.08 | sell |