| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 1,312 | 410,323 | +409,011 | 0.00 | 1.92 | +1.91 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 149,302 | 376,340 | +227,038 | 0.07 | 0.26 | +0.19 | buy |
| Avoro Capital Advisors LLC | 2,777,777 | 2,888,888 | +111,111 | 6.34 | 7.00 | +0.66 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 467,058 | 529,955 | +62,897 | 0.01 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 142,843 | 165,074 | +22,231 | 0.01 | 0.02 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 102,745 | 119,800 | +17,055 | 0.43 | 0.60 | +0.17 | buy |
| Redmile Group, LLC | 661,388 | 677,705 | +16,317 | 11.36 | 12.30 | +0.94 | buy |
| Biondo Investment Advisors, LLC | 51,885 | 68,130 | +16,245 | 1.15 | 2.03 | +0.88 | buy |
| Rhenman & Partners Asset Management AB | 11,750 | 25,000 | +13,250 | 0.23 | 0.58 | +0.35 | buy |
| GW&K Investment Management, LLC | 10,492 | 19,581 | +9,089 | 0.02 | 0.04 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 45,080 | 54,142 | +9,062 | 0.01 | 0.01 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 2,000 | 9,000 | +7,000 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 4,870 | 11,814 | +6,944 | 0.11 | 0.61 | +0.50 | buy |
| Hood River Capital Management LLC | 606,946 | 613,302 | +6,356 | 1.27 | 1.66 | +0.39 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6,757 | 2,171 | +4,586 | 0.00 | 0.00 | 0.00 | sell |
| Evolutionary Tree Capital Management, LLC | 12,461 | 16,811 | +4,350 | 2.40 | 4.81 | +2.41 | buy |
| Fiera Capital Corp | 15,063 | 18,857 | +3,794 | 0.01 | 0.01 | +0.01 | buy |
| State of Alaska, Department of Revenue | 14,274 | 17,902 | +3,628 | 0.03 | 0.05 | 0.00 | buy |
| PROFUND ADVISORS LLC | 8,330 | 9,887 | +1,557 | 0.05 | 0.08 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 18,523 | 20,014 | +1,491 | 0.32 | 0.37 | +0.05 | buy |
| Palisades Investment Partners, LLC | 41,389 | 42,765 | +1,376 | 2.87 | 3.98 | +1.11 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 8,217 | 7,167 | +1,050 | 0.02 | 0.02 | 0.00 | sell |
| DnB Asset Management AS | 2,356 | 3,093 | +737 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 21,398 | 22,087 | +689 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 5,717 | 6,116 | +399 | 0.00 | 0.00 | 0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 3,779 | 4,104 | +325 | 0.01 | 0.02 | +0.01 | buy |
| MINDSET WEALTH MANAGEMENT, LLC | 1,470 | 1,793 | +323 | 0.07 | 0.12 | +0.05 | buy |
| COOKSON PEIRCE & CO INC | 5,654 | 5,954 | +300 | 0.04 | 0.06 | +0.02 | buy |
| Capital World Investors | 809,240 | 809,500 | +260 | 0.02 | 0.03 | +0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 3,820 | 3,970 | +150 | 0.13 | 0.22 | +0.09 | buy |
| Main Management ETF Advisors, LLC | 10,075 | 10,179 | +104 | 0.07 | 0.09 | +0.02 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 11,901 | 11,985 | +84 | 0.29 | 0.42 | +0.14 | buy |
| Regal Investment Advisors LLC | 4,316 | 4,360 | +44 | 0.05 | 0.06 | +0.01 | buy |
| Perigon Wealth Management, LLC | 8,929 | 8,970 | +41 | 0.03 | 0.04 | +0.01 | buy |
| Optimize Financial Inc | 2,815 | 2,855 | +40 | 0.26 | 0.35 | +0.10 | buy |
| Ballentine Partners, LLC | 2,115 | 2,108 | +7 | 0.01 | 0.01 | 0.00 | sell |
| Retirement Wealth Solutions LLC | 2 | 7 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Salomon & Ludwin, LLC | 182 | 183 | +1 | 0.00 | 0.00 | 0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 4,505 | 4,506 | +1 | 0.02 | 0.03 | +0.01 | buy |
| HOHIMER WEALTH MANAGEMENT, LLC | 1,215 | 1,214 | -1 | 0.03 | 0.04 | +0.01 | sell |
| Rakuten Securities, Inc. | 5 | 1 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Quantum Private Wealth, LLC | 7,205 | 7,181 | -24 | 0.37 | 0.52 | +0.15 | sell |
| Argent Trust Co | 1,307 | 1,261 | -46 | 0.01 | 0.01 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 623 | 569 | -54 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 2,072 | 2,013 | -59 | 0.01 | 0.02 | +0.00 | sell |
| City Center Advisors, LLC | 1,702 | 1,628 | -74 | 0.29 | 0.37 | +0.08 | sell |
| TEALWOOD ASSET MANAGEMENT INC | 7,902 | 7,713 | -189 | 0.56 | 0.85 | +0.29 | sell |
| China Universal Asset Management Co., Ltd. | 5,073 | 4,725 | -348 | 0.07 | 0.09 | +0.02 | sell |
| NFJ INVESTMENT GROUP, LLC | 8,612 | 8,249 | -363 | 0.05 | 0.07 | +0.02 | sell |
| Virtus Investment Advisers, LLC | 3,167 | 2,792 | -375 | 0.16 | 0.19 | +0.03 | sell |
| Avanza Fonder AB | 1,418 | 996 | -422 | 0.01 | 0.01 | -0.00 | sell |
| Sound View Wealth Advisors Group, LLC | 2,003 | 1,579 | -424 | 0.02 | 0.03 | +0.00 | sell |
| STRS OHIO | 7,400 | 6,500 | -900 | 0.00 | 0.01 | +0.00 | sell |
| AVIVA PLC | 3,231 | 2,228 | -1,003 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 3,055 | 1,640 | -1,415 | 0.00 | 0.00 | -0.00 | sell |
| Legato Capital Management LLC | 3,757 | 1,913 | -1,844 | 0.07 | 0.04 | -0.03 | sell |
| SEGALL BRYANT & HAMILL, LLC | 85,263 | 83,246 | -2,017 | 9.73 | 0.28 | -9.46 | sell |
| Bridge City Capital, LLC | 14,154 | 12,135 | -2,019 | 0.67 | 0.88 | +0.21 | sell |
| WINTON GROUP Ltd | 8,212 | 5,874 | -2,338 | 0.05 | 0.05 | -0.00 | sell |
| Cynosure Group, LLC | 5,918 | 2,406 | -3,512 | 0.11 | 0.06 | -0.05 | sell |
| Atle Fund Management AB | 42,191 | 33,853 | -8,338 | 2.93 | 2.66 | -0.27 | sell |
| Ikarian Capital, LLC | 24,421 | 14,814 | -9,607 | 0.87 | 0.47 | -0.40 | sell |
| Rafferty Asset Management, LLC | 34,640 | 24,268 | -10,372 | 0.02 | 0.02 | +0.00 | sell |
| Erste Asset Management GmbH | 18,200 | 5,700 | -12,500 | 0.03 | 0.01 | -0.02 | sell |
| S Squared Technology, LLC | 109,215 | 96,215 | -13,000 | 7.33 | 9.19 | +1.86 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 59,978 | 46,732 | -13,246 | 0.04 | 0.05 | +0.00 | sell |
| Decheng Capital LLC | 32,300 | 17,300 | -15,000 | 0.99 | 0.57 | -0.42 | sell |
| PERCEPTIVE ADVISORS LLC | 35,000 | 17,500 | -17,500 | 0.18 | 0.08 | -0.10 | sell |
| Aberdeen Group plc | 59,372 | 39,360 | -20,012 | 0.02 | 0.02 | -0.00 | sell |
| TimesSquare Capital Management, LLC | 118,514 | 97,400 | -21,114 | 100.00 | 0.36 | -99.64 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 39,291 | 4,501 | -34,790 | 0.15 | 0.02 | -0.13 | sell |
| Soleus Capital Management, L.P. | 1,018,831 | 941,059 | -77,772 | 9.61 | 9.84 | +0.23 | sell |
| Frazier Life Sciences Management, L.P. | 688,460 | 488,460 | -200,000 | 3.64 | 3.23 | -0.41 | sell |
| CITADEL ADVISORS LLC | 636,988 | 386,505 | -250,483 | 0.14 | 0.09 | -0.04 | sell |
| BRAIDWELL LP | 520,401 | 202,101 | -318,300 | 2.73 | 1.59 | -1.13 | sell |