| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,341,447 | 4,349,628 | +8,181 | 0.04 | 0.05 | +0.01 | buy |
| BlackRock, Inc. | 3,834,128 | 3,937,817 | +103,689 | 0.01 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,777,777 | 2,888,888 | +111,111 | 6.34 | 7.00 | +0.66 | buy |
| VANGUARD GROUP INC | 2,792,208 | 2,778,845 | -13,363 | 0.01 | 0.01 | +0.00 | sell |
| STATE STREET CORP | 1,395,967 | 1,342,303 | -53,664 | 0.01 | 0.01 | +0.00 | sell |
| Soleus Capital Management, L.P. | 1,018,831 | 941,059 | -77,772 | 9.61 | 9.84 | +0.23 | sell |
| Capital World Investors | 809,240 | 809,500 | +260 | 0.02 | 0.03 | +0.01 | buy |
| Redmile Group, LLC | 661,388 | 677,705 | +16,317 | 11.36 | 12.30 | +0.94 | buy |
| Hood River Capital Management LLC | 606,946 | 613,302 | +6,356 | 1.27 | 1.66 | +0.39 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 611,244 | 611,878 | +634 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 467,058 | 529,955 | +62,897 | 0.01 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 533,964 | 492,968 | -40,996 | 0.02 | 0.03 | +0.01 | sell |
| Frazier Life Sciences Management, L.P. | 688,460 | 488,460 | -200,000 | 3.64 | 3.23 | -0.41 | sell |
| Bellevue Group AG | 1,312 | 410,323 | +409,011 | 0.00 | 1.92 | +1.91 | buy |
| CITADEL ADVISORS LLC | 636,988 | 386,505 | -250,483 | 0.09 | 0.06 | -0.03 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 149,302 | 376,340 | +227,038 | 0.07 | 0.26 | +0.19 | buy |
| GOLDMAN SACHS GROUP INC | 348,250 | 293,525 | -54,725 | 0.01 | 0.01 | +0.00 | sell |
| NORGES BANK | 0 | 284,573 | +284,573 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 248,165 | 247,443 | -722 | 0.01 | 0.01 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 248,392 | 245,276 | -3,116 | 0.03 | 0.04 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,863 | 242,774 | -89 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 234,578 | 221,481 | -13,097 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 10,071 | 219,440 | +209,369 | 0.00 | 0.02 | +0.02 | buy |
| BRAIDWELL LP | 520,401 | 202,101 | -318,300 | 2.73 | 1.59 | -1.13 | sell |
| BANK OF AMERICA CORP /DE/ | 137,995 | 190,807 | +52,812 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 197,378 | 189,094 | -8,284 | 0.01 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 128,960 | 183,754 | +54,794 | 0.03 | 0.04 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 142,843 | 165,074 | +22,231 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 130,173 | 159,595 | +29,422 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 196,904 | 156,568 | -40,336 | 0.03 | 0.04 | +0.00 | sell |
| Bank of New York Mellon Corp | 155,553 | 151,313 | -4,240 | 0.00 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 150,616 | 150,616 | 0 | 0.13 | 0.14 | +0.02 | hold |
| JPMORGAN CHASE & CO | 146,354 | 134,624 | -11,730 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 19,850 | 125,675 | +105,825 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 102,745 | 119,800 | +17,055 | 0.43 | 0.60 | +0.17 | buy |
| Handelsbanken Fonder AB | 66,800 | 105,800 | +39,000 | 0.04 | 0.08 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 93,908 | 103,261 | +9,353 | 0.02 | 0.03 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 118,514 | 97,400 | -21,114 | 0.30 | 0.36 | +0.06 | sell |
| S Squared Technology, LLC | 109,215 | 96,215 | -13,000 | 7.33 | 9.19 | +1.86 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 100,431 | 89,362 | -11,069 | 0.07 | 0.07 | +0.01 | sell |
| C WorldWide Group Holding A/S | 85,809 | 85,809 | 0 | 0.23 | 0.37 | +0.14 | hold |
| SEGALL BRYANT & HAMILL, LLC | 85,263 | 83,246 | -2,017 | 0.20 | 0.28 | +0.08 | sell |
| RAYMOND JAMES FINANCIAL INC | 64,363 | 76,538 | +12,175 | 0.00 | 0.01 | +0.00 | buy |
| Biondo Investment Advisors, LLC | 51,885 | 68,130 | +16,245 | 1.15 | 2.03 | +0.88 | buy |
| RHUMBLINE ADVISERS | 70,552 | 66,436 | -4,116 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 65,815 | 63,361 | -2,454 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 75,896 | 60,062 | -15,834 | 0.00 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 66,880 | 60,008 | -6,872 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 45,080 | 54,142 | +9,062 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,179 | 53,911 | +44,732 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 55,792 | 52,345 | -3,447 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 59,978 | 46,732 | -13,246 | 0.04 | 0.05 | +0.00 | sell |
| Swiss National Bank | 42,000 | 42,900 | +900 | 0.00 | 0.01 | +0.00 | buy |
| Palisades Investment Partners, LLC | 41,389 | 42,765 | +1,376 | 2.87 | 3.98 | +1.11 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,455 | 40,629 | +6,174 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 59,372 | 39,360 | -20,012 | 0.02 | 0.02 | -0.00 | sell |
| Corient Private Wealth LLC | 39,130 | 38,346 | -784 | 0.01 | 0.01 | +0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 37,934 | 37,269 | -665 | 0.07 | 0.10 | +0.03 | sell |
| FEDERATED HERMES, INC. | 23,981 | 34,541 | +10,560 | 0.01 | 0.01 | +0.01 | buy |
| Atle Fund Management AB | 42,191 | 33,853 | -8,338 | 2.93 | 2.66 | -0.27 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,589 | 33,617 | -168,972 | 0.01 | 0.00 | -0.01 | sell |
| SEI INVESTMENTS CO | 23,393 | 32,310 | +8,917 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,653 | 31,572 | +11,919 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,920 | 31,529 | +1,609 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,994 | 31,342 | +4,348 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 9,650 | 29,943 | +20,293 | 0.00 | 0.01 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 29,260 | +29,260 | 0.00 | 0.21 | +0.21 | buy |
| Russell Investments Group, Ltd. | 26,549 | 28,954 | +2,405 | 0.01 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 25,496 | 27,015 | +1,519 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 54,816 | 26,461 | -28,355 | 0.01 | 0.00 | -0.00 | sell |
| Granite Investment Partners, LLC | 0 | 25,760 | +25,760 | 0.00 | 0.38 | +0.38 | buy |
| Rhenman & Partners Asset Management AB | 11,750 | 25,000 | +13,250 | 0.23 | 0.58 | +0.35 | buy |
| Informed Momentum Co LLC | 0 | 24,667 | +24,667 | 0.00 | 0.68 | +0.68 | buy |
| Rafferty Asset Management, LLC | 34,640 | 24,268 | -10,372 | 0.02 | 0.02 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 21,379 | 22,450 | +1,071 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 21,398 | 22,087 | +689 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,882 | 20,583 | -299 | 0.00 | 0.01 | +0.00 | sell |
| BESSEMER GROUP INC | 149 | 20,260 | +20,111 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 18,523 | 20,014 | +1,491 | 0.32 | 0.37 | +0.05 | buy |
| GW&K Investment Management, LLC | 10,492 | 19,581 | +9,089 | 0.02 | 0.04 | +0.03 | buy |
| SG Americas Securities, LLC | 3,318 | 18,909 | +15,591 | 0.00 | 0.01 | +0.00 | buy |
| Fiera Capital Corp | 15,063 | 18,857 | +3,794 | 0.01 | 0.01 | +0.01 | buy |
| State of Alaska, Department of Revenue | 14,274 | 17,902 | +3,628 | 0.03 | 0.05 | +0.02 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 18,584 | 17,734 | -850 | 0.01 | 0.01 | +0.00 | sell |
| 1832 Asset Management L.P. | 0 | 17,600 | +17,600 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 35,000 | 17,500 | -17,500 | 0.18 | 0.08 | -0.10 | sell |
| Decheng Capital LLC | 32,300 | 17,300 | -15,000 | 0.99 | 0.57 | -0.42 | sell |
| Verition Fund Management LLC | 31,333 | 16,969 | -14,364 | 0.03 | 0.02 | -0.01 | sell |
| Evolutionary Tree Capital Management, LLC | 12,461 | 16,811 | +4,350 | 2.40 | 4.81 | +2.41 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 5,785 | 15,756 | +9,971 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,550 | 15,650 | +100 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 15,503 | 15,503 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 24,421 | 14,814 | -9,607 | 0.87 | 0.47 | -0.40 | sell |
| MILLENNIUM MANAGEMENT LLC | 148,713 | 14,658 | -134,055 | 0.02 | 0.00 | -0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,340 | 14,466 | -14,874 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 20,133 | 14,157 | -5,976 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 11,609 | 13,881 | +2,272 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,430 | 13,844 | -586 | 0.01 | 0.02 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,290 | 12,954 | -336 | 0.00 | 0.00 | +0.00 | sell |
| Illinois Municipal Retirement Fund | 14,245 | 12,699 | -1,546 | 0.03 | 0.04 | +0.01 | sell |