| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 318,500 | 739,014 | +420,514 | 1.39 | 3.62 | +2.23 | buy |
| Casdin Capital, LLC | 1,840,000 | 2,045,000 | +205,000 | 2.68 | 2.63 | -0.04 | buy |
| Artisan Partners Limited Partnership | 1,099,719 | 1,224,497 | +124,778 | 0.03 | 0.05 | +0.02 | buy |
| Candriam S.C.A. | 1,099,845 | 1,189,886 | +90,041 | 0.11 | 0.14 | +0.03 | buy |
| Capital Research Global Investors | 2,514,588 | 2,565,817 | +51,229 | 0.01 | 0.01 | +0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 207,130 | 229,939 | +22,809 | 0.06 | 0.07 | +0.02 | buy |
| SEGALL BRYANT & HAMILL, LLC | 510,543 | 519,483 | +8,940 | 0.14 | 0.16 | +0.02 | buy |
| Dana Investment Advisors, Inc. | 51,922 | 59,971 | +8,049 | 0.03 | 0.04 | +0.01 | buy |
| Lumbard & Kellner, LLC | 94,782 | 98,282 | +3,500 | 0.63 | 0.77 | +0.14 | buy |
| BAKER BROS. ADVISORS LP | 3,731,695 | 3,734,336 | +2,641 | 0.41 | 0.48 | +0.07 | buy |
| INTRUST BANK NA | 14,339 | 16,477 | +2,138 | 0.02 | 0.03 | +0.01 | buy |
| B. Riley Wealth Advisors, Inc. | 12,213 | 12,813 | +600 | 0.01 | 0.02 | +0.00 | buy |
| Gilbert & Cook, Inc. | 10,871 | 11,179 | +308 | 0.03 | 0.03 | +0.01 | buy |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | 14,451 | 14,674 | +223 | 0.06 | 0.07 | +0.01 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 52,062 | 52,080 | +18 | 0.42 | 0.46 | +0.05 | buy |
| Breakwater Capital Group | 15,586 | 15,601 | +15 | 0.04 | 0.05 | +0.01 | buy |
| 1492 Capital Management LLC | 67,417 | 66,368 | -1,049 | 0.49 | 0.50 | +0.01 | sell |
| China Universal Asset Management Co., Ltd. | 40,643 | 29,819 | -10,824 | 0.06 | 0.05 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 199,000 | 179,000 | -20,000 | 0.47 | 0.43 | -0.04 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 225,680 | 165,080 | -60,600 | 0.06 | 0.06 | -0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 227,110 | 145,045 | -82,065 | 0.04 | 0.03 | -0.01 | sell |
| BAILLIE GIFFORD & CO | 12,066,479 | 11,960,230 | -106,249 | 0.24 | 0.28 | +0.04 | sell |
| Crestline Management, LP | 2,210,732 | 1,910,732 | -300,000 | 91.74 | 9.19 | -82.55 | sell |
| MASTERS CAPITAL MANAGEMENT LLC | 600,000 | 200,000 | -400,000 | 0.38 | 0.13 | -0.25 | sell |
| Alyeska Investment Group, L.P. | 1,941,123 | 219,334 | -1,721,789 | 0.11 | 0.01 | -0.09 | sell |