| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAILLIE GIFFORD & CO | 14,260,724 | 14,041,228 | -219,496 | 0.24 | 0.22 | -0.02 | sell |
| VANGUARD GROUP INC | 10,834,483 | 10,968,293 | +133,810 | 0.01 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,274,717 | 8,269,949 | +995,232 | 0.03 | 0.03 | +0.00 | buy |
| STATE STREET CORP | 5,485,948 | 6,323,872 | +837,924 | 0.01 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 2,909,528 | 6,049,957 | +3,140,429 | 0.02 | 0.03 | +0.01 | buy |
| Temasek Holdings (Private) Ltd | 6,895,992 | 5,706,345 | -1,189,647 | 0.83 | 0.65 | -0.18 | sell |
| Crestline Management, LP | 5,660,732 | 5,210,732 | -450,000 | 11.25 | 10.12 | -1.13 | sell |
| TAKEDA PHARMACEUTICAL CO LTD | 4,214,559 | 4,214,559 | 0 | 26.55 | 29.92 | +3.37 | hold |
| BAKER BROS. ADVISORS LP | 2,607,196 | 3,731,695 | +1,124,499 | 0.64 | 0.96 | +0.32 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,659,296 | 2,759,633 | +100,337 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,667,397 | 2,146,379 | +478,982 | 0.07 | 0.07 | +0.00 | buy |
| Bank of New York Mellon Corp | 1,870,627 | 1,777,907 | -92,720 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,574,321 | 1,594,333 | -979,988 | 0.01 | 0.00 | -0.00 | sell |
| Camber Capital Management LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 1.08 | +1.08 | buy |
| CITADEL ADVISORS LLC | 68,110 | 1,365,028 | +1,296,918 | 0.00 | 0.03 | +0.03 | buy |
| Flagship Pioneering Inc. | 2,319,968 | 1,364,516 | -955,452 | 3.76 | 1.84 | -1.92 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,119,628 | 1,332,950 | +213,322 | 0.01 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 1,300,000 | 1,300,000 | 0 | 2.75 | 1.99 | -0.77 | hold |
| NORGES BANK | 1,152,646 | 1,235,766 | +83,120 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 641,653 | 1,232,522 | +590,869 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,219,392 | 1,172,785 | -46,607 | 0.36 | 0.30 | -0.06 | sell |
| Yiheng Capital Management, L.P. | 1,150,684 | 1,150,684 | 0 | 3.06 | 3.39 | +0.34 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 1,073,704 | 1,122,536 | +48,832 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,101,679 | 1,088,513 | -13,166 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,006,997 | 1,041,059 | +34,062 | 0.01 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 977,493 | 928,126 | -49,367 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 393,805 | 904,361 | +510,556 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 860,948 | +860,948 | 0.00 | 0.07 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 458,638 | 851,976 | +393,338 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 708,339 | 687,239 | -21,100 | 0.01 | 0.01 | -0.00 | sell |
| Cercano Management LLC | 625,000 | 625,000 | 0 | 0.44 | 0.36 | -0.09 | hold |
| Aberdeen Group plc | 324,829 | 516,019 | +191,190 | 0.02 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 197,584 | 508,565 | +310,981 | 0.05 | 0.10 | +0.05 | buy |
| Artal Group S.A. | 802,899 | 502,899 | -300,000 | 0.59 | 0.27 | -0.32 | sell |
| T. Rowe Price Investment Management, Inc. | 498,969 | 498,969 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Fisher Asset Management, LLC | 0 | 469,169 | +469,169 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 473,494 | 459,536 | -13,958 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 452,669 | 452,669 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Candriam S.C.A. | 357,878 | 447,878 | +90,000 | 0.05 | 0.06 | +0.01 | buy |
| Rafferty Asset Management, LLC | 321,973 | 434,909 | +112,936 | 0.03 | 0.03 | +0.00 | buy |
| WASATCH ADVISORS LP | 312,301 | 402,670 | +90,369 | 0.04 | 0.04 | +0.01 | buy |
| Clarius Group, LLC | 378,262 | 392,218 | +13,956 | 0.67 | 0.56 | -0.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 390,616 | +390,616 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 141,276 | 382,416 | +241,140 | 0.00 | 0.01 | +0.00 | buy |
| ARCH Venture Management, LLC | 381,249 | 381,249 | 0 | 5.00 | 9.75 | +4.74 | hold |
| Artisan Partners Limited Partnership | 383,942 | 365,832 | -18,110 | 0.01 | 0.01 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 260,587 | 363,027 | +102,440 | 0.02 | 0.02 | +0.00 | buy |
| AXA S.A. | 360,595 | 360,808 | +213 | 0.02 | 0.02 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 348,497 | 346,304 | -2,193 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 290,985 | 343,879 | +52,894 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 115,352 | 230,431 | +115,079 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 284,104 | 220,638 | -63,466 | 0.01 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 175,000 | 220,000 | +45,000 | 0.03 | 0.04 | +0.01 | buy |
| Swiss National Bank | 216,700 | 218,200 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 211,017 | +211,017 | 0.00 | 0.20 | +0.20 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 208,644 | 207,124 | -1,520 | 0.04 | 0.04 | -0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 165,680 | 205,680 | +40,000 | 0.06 | 0.07 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,376 | 191,505 | +163,129 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 40,580 | 177,364 | +136,784 | 0.01 | 0.08 | +0.06 | buy |
| Pier Capital, LLC | 174,219 | 172,331 | -1,888 | 0.53 | 0.49 | -0.05 | sell |
| RHUMBLINE ADVISERS | 166,763 | 171,959 | +5,196 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 91,044 | 171,386 | +80,342 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 136,600 | 165,075 | +28,475 | 0.01 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 32,900 | 158,384 | +125,484 | 0.08 | 0.31 | +0.23 | buy |
| BARCLAYS PLC | 324,019 | 151,560 | -172,459 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101,223 | 149,116 | +47,893 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 183,316 | 138,940 | -44,376 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 139,960 | 137,620 | -2,340 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 127,270 | +127,270 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 123,974 | 125,775 | +1,801 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 116,265 | +116,265 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 79,139 | 114,402 | +35,263 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 112,118 | +112,118 | 0.00 | 0.11 | +0.11 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 117,351 | 111,436 | -5,915 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 106,713 | 107,450 | +737 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,914 | 104,640 | +43,726 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 97,962 | 98,149 | +187 | 0.02 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 111,473 | 85,628 | -25,845 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 82,000 | +82,000 | 0.00 | 0.07 | +0.07 | buy |
| BIT Capital GmbH | 0 | 82,000 | +82,000 | 0.00 | 0.15 | +0.15 | buy |
| PRUDENTIAL FINANCIAL INC | 81,244 | 80,429 | -815 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 91,521 | 80,393 | -11,128 | 0.01 | 0.00 | -0.00 | sell |
| Northwest & Ethical Investments L.P. | 71,284 | 75,835 | +4,551 | 0.05 | 0.04 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 191,643 | 72,105 | -119,538 | 0.01 | 0.00 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 71,651 | +71,651 | 0.00 | 0.02 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 73,585 | 71,142 | -2,443 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 165,327 | 69,314 | -96,013 | 0.06 | 0.03 | -0.03 | sell |
| PROFUND ADVISORS LLC | 53,675 | 68,474 | +14,799 | 0.05 | 0.05 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 66,059 | 66,129 | +70 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 14,319 | 64,874 | +50,555 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 66,365 | 64,783 | -1,582 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 29,682 | 64,775 | +35,093 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 64,210 | 64,210 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 62,264 | 62,264 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AIA Group Ltd | 68,078 | 61,034 | -7,044 | 0.06 | 0.04 | -0.02 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 58,725 | 58,847 | +122 | 0.01 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 46,558 | 55,612 | +9,054 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 52,692 | 52,718 | +26 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 53,201 | 50,595 | -2,606 | 0.00 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 50,500 | 50,500 | 0 | 0.00 | 0.00 | -0.00 | hold |