| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 2,909,528 | 6,049,957 | +3,140,429 | 0.02 | 0.03 | +0.01 | buy |
| Temasek Holdings (Private) Ltd | 6,895,992 | 5,706,345 | +1,189,647 | 0.83 | 0.65 | 0.00 | sell |
| BAKER BROS. ADVISORS LP | 2,607,196 | 3,731,695 | +1,124,499 | 0.64 | 0.96 | +0.32 | buy |
| Woodline Partners LP | 197,584 | 508,565 | +310,981 | 0.05 | 0.10 | +0.05 | buy |
| Aberdeen Group plc | 324,829 | 516,019 | +191,190 | 0.02 | 0.02 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 40,580 | 177,364 | +136,784 | 0.01 | 0.08 | +0.06 | buy |
| PDT Partners, LLC | 32,900 | 158,384 | +125,484 | 0.08 | 0.31 | +0.23 | buy |
| Rafferty Asset Management, LLC | 321,973 | 434,909 | +112,936 | 0.03 | 0.03 | +0.00 | buy |
| WASATCH ADVISORS LP | 312,301 | 402,670 | +90,369 | 0.04 | 0.04 | +0.01 | buy |
| Candriam S.C.A. | 357,878 | 447,878 | +90,000 | 0.05 | 0.06 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,073,704 | 1,122,536 | +48,832 | 0.02 | 0.01 | 0.00 | buy |
| Hudson Bay Capital Management LP | 175,000 | 220,000 | +45,000 | 0.02 | 0.03 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 165,680 | 205,680 | +40,000 | 0.06 | 0.07 | +0.01 | buy |
| Employees Retirement System of Texas | 21,375 | 43,769 | +22,394 | 0.01 | 0.01 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 17,938 | 36,064 | +18,126 | 0.20 | 0.36 | +0.16 | buy |
| PROFUND ADVISORS LLC | 53,675 | 68,474 | +14,799 | 0.05 | 0.06 | 0.00 | buy |
| Clarius Group, LLC | 378,262 | 392,218 | +13,956 | 0.67 | 0.56 | -0.12 | buy |
| China Universal Asset Management Co., Ltd. | 15,981 | 26,721 | +10,740 | 0.07 | 0.07 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 34,464 | 25,033 | +9,431 | 0.05 | 0.04 | 0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 46,558 | 55,612 | +9,054 | 0.00 | 0.00 | 0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 35,013 | 43,827 | +8,814 | 0.02 | 0.02 | -0.00 | buy |
| Dana Investment Advisors, Inc. | 24,057 | 28,756 | +4,699 | 0.02 | 0.02 | -0.01 | buy |
| Northwest & Ethical Investments L.P. | 71,284 | 75,835 | +4,551 | 0.05 | 0.04 | -0.00 | buy |
| E Fund Management Co., Ltd. | 17,290 | 20,552 | +3,262 | 0.02 | 0.03 | +0.00 | buy |
| ProShare Advisors LLC | 28,385 | 31,205 | +2,820 | 0.00 | 0.00 | 0.00 | buy |
| ALPS ADVISORS INC | 97,962 | 98,149 | +187 | 0.02 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,994 | 3,735 | -259 | 0.05 | 0.04 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 12,881 | 12,081 | -800 | 0.12 | 0.10 | -0.02 | sell |
| Pier Capital, LLC | 174,219 | 172,331 | -1,888 | 0.53 | 0.49 | -0.05 | sell |
| AIA Group Ltd | 68,078 | 61,034 | -7,044 | 0.06 | 0.04 | -0.02 | sell |
| Artisan Partners Limited Partnership | 383,942 | 365,832 | -18,110 | 0.01 | 0.01 | -0.00 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 35,040 | 10,200 | -24,840 | 0.19 | 0.05 | -0.14 | sell |
| Knights of Columbus Asset Advisors LLC | 77,352 | 39,441 | -37,911 | 0.11 | 0.06 | -0.05 | sell |
| GILDER GAGNON HOWE & CO LLC | 1,219,392 | 1,172,785 | -46,607 | 0.36 | 0.30 | -0.06 | sell |
| Soleus Capital Management, L.P. | 130,000 | 47,000 | -83,000 | 0.31 | 0.08 | -0.22 | sell |
| BAILLIE GIFFORD & CO | 14,260,724 | 14,041,228 | -219,496 | 0.24 | 0.22 | -0.02 | sell |
| Artal Group S.A. | 802,899 | 502,899 | -300,000 | 0.57 | 0.26 | -0.31 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 348,203 | 43,245 | -304,958 | 0.04 | 0.00 | -0.04 | sell |
| Crestline Management, LP | 5,660,732 | 5,210,732 | -450,000 | 10.35 | 9.45 | -0.90 | sell |
| Flagship Pioneering Inc. | 2,319,968 | 1,364,516 | -955,452 | 3.76 | 1.84 | -1.92 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,574,321 | 1,594,333 | -979,988 | 0.01 | 0.00 | -0.00 | sell |