| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 12,715,201 | 13,034,434 | +319,233 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 12,310,889 | 12,066,479 | -244,410 | 0.17 | 0.24 | +0.07 | sell |
| T. Rowe Price Investment Management, Inc. | 7,254,132 | 8,519,192 | +1,265,060 | 0.08 | 0.11 | +0.04 | buy |
| Temasek Holdings (Private) Ltd | 7,012,974 | 7,012,974 | 0 | 0.37 | 0.45 | +0.08 | hold |
| STATE STREET CORP | 6,263,371 | 6,272,001 | +8,630 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,097,211 | 4,575,374 | -1,521,837 | 0.01 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,983,726 | 4,432,314 | -551,412 | 0.02 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 3,835,803 | 4,407,255 | +571,452 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,731,695 | 3,731,695 | 0 | 0.36 | 0.41 | +0.05 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,458,131 | 3,727,114 | +268,983 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 3,152,734 | 3,195,429 | +42,695 | 0.11 | 0.15 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 3,557,935 | 2,893,618 | -664,317 | 0.02 | 0.02 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,374,303 | 2,692,175 | +317,872 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 2,404,704 | 2,571,344 | +166,640 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,329,108 | 2,558,865 | +1,229,757 | 0.02 | 0.05 | +0.03 | buy |
| Capital Research Global Investors | 3,729,244 | 2,514,588 | -1,214,656 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,915,951 | 2,464,146 | -1,451,805 | 0.01 | 0.01 | -0.00 | sell |
| Fisher Asset Management, LLC | 2,589,403 | 2,436,895 | -152,508 | 0.01 | 0.02 | +0.00 | sell |
| Crestline Management, LP | 2,810,732 | 2,210,732 | -600,000 | 87.02 | 91.74 | +4.72 | sell |
| Alyeska Investment Group, L.P. | 859,108 | 1,941,123 | +1,082,015 | 0.04 | 0.11 | +0.07 | buy |
| Lynx1 Capital Management LP | 1,738,750 | 1,880,303 | +141,553 | 5.81 | 5.71 | -0.11 | buy |
| ADAR1 Capital Management, LLC | 52,116 | 1,871,455 | +1,819,339 | 0.06 | 2.16 | +2.10 | buy |
| Aberdeen Group plc | 2,032,967 | 1,854,446 | -178,521 | 0.05 | 0.06 | +0.01 | sell |
| Casdin Capital, LLC | 1,840,000 | 1,840,000 | 0 | 1.89 | 2.68 | +0.79 | hold |
| Vestal Point Capital, LP | 465,000 | 1,773,326 | +1,308,326 | 0.28 | 0.95 | +0.67 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,524,123 | 1,478,486 | -45,637 | 0.01 | 0.02 | +0.00 | sell |
| Siren, L.L.C. | 1,396,513 | 1,396,513 | 0 | 0.69 | 0.74 | +0.06 | hold |
| NORTHERN TRUST CORP | 1,199,744 | 1,310,656 | +110,912 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 369,767 | 1,257,950 | +888,183 | 0.00 | 0.02 | +0.01 | buy |
| Foresite Capital Management VI LLC | 1,000,000 | 1,209,971 | +209,971 | 4.99 | 5.05 | +0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,200,475 | 1,207,399 | +6,924 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 932,144 | 1,134,183 | +202,039 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,219,854 | 1,104,757 | -115,097 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 1,166,379 | 1,099,845 | -66,534 | 0.10 | 0.11 | +0.01 | sell |
| Artisan Partners Limited Partnership | 0 | 1,099,719 | +1,099,719 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 763,892 | 991,268 | +227,376 | 0.01 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 379,051 | 935,692 | +556,641 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 762,087 | 768,039 | +5,952 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 737,990 | +737,990 | 0.00 | 0.13 | +0.13 | buy |
| Cercano Management LLC | 625,000 | 625,000 | 0 | 0.39 | 0.52 | +0.13 | hold |
| MASTERS CAPITAL MANAGEMENT LLC | 1,000,000 | 600,000 | -400,000 | 2.28 | 1.70 | -0.58 | sell |
| Ensign Peak Advisors, Inc | 515,721 | 515,721 | 0 | 0.02 | 0.02 | +0.00 | hold |
| SEGALL BRYANT & HAMILL, LLC | 537,000 | 510,543 | -26,457 | 0.12 | 0.10 | -0.02 | sell |
| STEMPOINT CAPITAL LP | 419,058 | 426,561 | +7,503 | 1.19 | 1.57 | +0.39 | buy |
| Woodline Partners LP | 114,082 | 364,082 | +250,000 | 0.01 | 0.03 | +0.02 | buy |
| Hudson Bay Capital Management LP | 450,000 | 346,360 | -103,640 | 0.04 | 0.04 | -0.00 | sell |
| JPMORGAN CHASE & CO | 171,948 | 323,989 | +152,041 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 318,500 | 318,500 | 0 | 1.22 | 1.39 | +0.17 | hold |
| Invesco Ltd. | 291,936 | 310,196 | +18,260 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 298,792 | 296,503 | -2,289 | 0.01 | 0.01 | +0.00 | sell |
| BRAIDWELL LP | 0 | 296,324 | +296,324 | 0.00 | 0.19 | +0.19 | buy |
| Nuveen, LLC | 275,508 | 295,586 | +20,078 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 287,001 | 287,000 | -1 | 0.05 | 0.06 | +0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 450,985 | 285,820 | -165,165 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 273,800 | 273,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 339,410 | 255,766 | -83,644 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 0 | 254,857 | +254,857 | 0.00 | 1.02 | +1.02 | buy |
| Palo Alto Investors LP | 641,239 | 234,582 | -406,657 | 1.47 | 0.69 | -0.78 | sell |
| GREAT LAKES ADVISORS, LLC | 0 | 227,110 | +227,110 | 0.00 | 0.04 | +0.04 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 225,680 | 225,680 | 0 | 0.05 | 0.06 | +0.01 | hold |
| GROUPAMA ASSET MANAGMENT | 151,591 | 207,130 | +55,539 | 0.04 | 0.06 | +0.02 | buy |
| Burkehill Global Management, LP | 200,000 | 200,000 | 0 | 0.22 | 0.19 | -0.03 | hold |
| Rhenman & Partners Asset Management AB | 100,000 | 199,000 | +99,000 | 0.15 | 0.47 | +0.32 | buy |
| SCS Capital Management LLC | 197,998 | 197,998 | 0 | 0.03 | 0.04 | +0.01 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 195,108 | +195,108 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 183,000 | 184,248 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 779,148 | 181,417 | -597,731 | 0.01 | 0.00 | -0.01 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 153,781 | 166,181 | +12,400 | 0.02 | 0.02 | +0.01 | buy |
| SECTOR GAMMA AS | 0 | 162,710 | +162,710 | 0.00 | 0.74 | +0.74 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,409 | 162,576 | +33,167 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 167,713 | 157,896 | -9,817 | 0.04 | 0.05 | +0.00 | sell |
| Rafferty Asset Management, LLC | 191,567 | 150,687 | -40,880 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 48,994 | 139,045 | +90,051 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 120,718 | 129,105 | +8,387 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,478 | 128,119 | +89,641 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 184,238 | 125,442 | -58,796 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 105,086 | 120,368 | +15,282 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 112,300 | 112,300 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,459 | 111,694 | +64,235 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 131,223 | 110,250 | -20,973 | 0.00 | 0.00 | +0.00 | sell |
| D.A. DAVIDSON & CO. | 106,933 | 110,235 | +3,302 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 193,681 | 107,657 | -86,024 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 38,438 | 102,579 | +64,141 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 100,000 | 100,000 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Integrated Wealth Concepts LLC | 94,582 | 99,554 | +4,972 | 0.02 | 0.02 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,830 | 99,503 | +28,673 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 128,800 | 95,193 | -33,607 | 0.00 | 0.00 | -0.00 | sell |
| Lumbard & Kellner, LLC | 0 | 94,782 | +94,782 | 0.00 | 0.63 | +0.63 | buy |
| AMERIPRISE FINANCIAL INC | 180,221 | 89,534 | -90,687 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 73,581 | 82,357 | +8,776 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 78,567 | +78,567 | 0.00 | 0.03 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 93,587 | 78,007 | -15,580 | 0.03 | 0.03 | -0.01 | sell |
| MetLife Investment Management, LLC | 75,164 | 77,558 | +2,394 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 60,766 | 74,069 | +13,303 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 12,700 | 71,179 | +58,479 | 0.01 | 0.05 | +0.04 | buy |
| PROFUND ADVISORS LLC | 71,634 | 68,227 | -3,407 | 0.04 | 0.05 | +0.01 | sell |
| 1492 Capital Management LLC | 67,487 | 67,417 | -70 | 0.43 | 0.49 | +0.07 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 26,900 | 65,301 | +38,401 | 0.00 | 0.01 | +0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 68,200 | 64,800 | -3,400 | 0.25 | 0.32 | +0.07 | sell |
| JANUS HENDERSON GROUP PLC | 60,028 | 60,028 | 0 | 0.00 | 0.00 | +0.00 | hold |