| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAILLIE GIFFORD & CO | 14,041,228 | 13,763,596 | -277,632 | 0.22 | 0.25 | +0.02 | sell |
| VANGUARD GROUP INC | 10,968,293 | 11,312,439 | +344,146 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,269,949 | 9,823,767 | +1,553,818 | 0.03 | 0.04 | +0.01 | buy |
| Capital Research Global Investors | 6,049,957 | 7,126,533 | +1,076,576 | 0.03 | 0.04 | +0.01 | buy |
| Temasek Holdings (Private) Ltd | 5,706,345 | 5,706,345 | 0 | 0.65 | 0.62 | -0.03 | hold |
| Crestline Management, LP | 5,210,732 | 4,760,732 | -450,000 | 10.12 | 8.67 | -1.45 | sell |
| STATE STREET CORP | 6,323,872 | 4,434,790 | -1,889,082 | 0.01 | 0.00 | -0.00 | sell |
| TAKEDA PHARMACEUTICAL CO LTD | 4,214,559 | 4,214,559 | 0 | 29.92 | 42.13 | +12.20 | hold |
| BAKER BROS. ADVISORS LP | 3,731,695 | 3,731,695 | 0 | 0.96 | 1.11 | +0.15 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,759,633 | 2,982,538 | +222,905 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,146,379 | 2,418,833 | +272,454 | 0.07 | 0.08 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 687,239 | 2,297,716 | +1,610,477 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,594,333 | 2,255,470 | +661,137 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 137,620 | 2,018,534 | +1,880,914 | 0.00 | 0.02 | +0.02 | buy |
| Camber Capital Management LP | 1,500,000 | 2,000,000 | +500,000 | 1.08 | 1.79 | +0.72 | buy |
| Bank of New York Mellon Corp | 1,777,907 | 1,540,271 | -237,636 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,332,950 | 1,417,472 | +84,522 | 0.01 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 1,300,000 | 1,300,000 | 0 | 1.99 | 2.30 | +0.32 | hold |
| MORGAN STANLEY | 928,126 | 1,223,878 | +295,752 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 904,361 | 1,218,925 | +314,564 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,365,028 | 1,218,698 | -146,330 | 0.03 | 0.03 | +0.00 | sell |
| Yiheng Capital Management, L.P. | 1,150,684 | 1,150,684 | 0 | 3.39 | 3.77 | +0.38 | hold |
| Artisan Partners Limited Partnership | 365,832 | 1,141,517 | +775,685 | 0.01 | 0.04 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,122,536 | 1,088,537 | -33,999 | 0.01 | 0.02 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,088,513 | 1,082,959 | -5,554 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,041,059 | 1,059,304 | +18,245 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,053,150 | +1,053,150 | 0.00 | 0.08 | +0.08 | buy |
| NORGES BANK | 1,235,766 | 823,941 | -411,825 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 851,976 | 742,048 | -109,928 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 447,878 | 726,499 | +278,621 | 0.06 | 0.10 | +0.04 | buy |
| Cercano Management LLC | 625,000 | 625,000 | 0 | 0.36 | 0.39 | +0.03 | hold |
| MILLENNIUM MANAGEMENT LLC | 390,616 | 619,929 | +229,313 | 0.01 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 516,019 | 573,035 | +57,016 | 0.02 | 0.03 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 459,536 | 522,594 | +63,058 | 0.01 | 0.01 | +0.00 | buy |
| Artal Group S.A. | 502,899 | 502,899 | 0 | 0.27 | 0.30 | +0.03 | hold |
| Vestal Point Capital, LP | 0 | 500,000 | +500,000 | 0.00 | 0.87 | +0.87 | buy |
| Fisher Asset Management, LLC | 469,169 | 478,108 | +8,939 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 392,218 | 409,995 | +17,777 | 0.56 | 0.67 | +0.12 | buy |
| WASATCH ADVISORS LP | 402,670 | 402,409 | -261 | 0.04 | 0.05 | +0.01 | sell |
| Ensign Peak Advisors, Inc | 346,304 | 346,304 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 345,373 | +345,373 | 0.00 | 0.01 | +0.01 | buy |
| AXA S.A. | 360,808 | 344,785 | -16,023 | 0.02 | 0.02 | +0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 325,000 | +325,000 | 0.00 | 0.75 | +0.75 | buy |
| STEMPOINT CAPITAL LP | 0 | 251,010 | +251,010 | 0.00 | 1.71 | +1.71 | buy |
| FMR LLC | 1,232,522 | 234,870 | -997,652 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 218,200 | 232,800 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 48,716 | 231,364 | +182,648 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 230,431 | 223,400 | -7,031 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 211,017 | 222,917 | +11,900 | 0.20 | 0.12 | -0.08 | buy |
| JPMORGAN CHASE & CO | 138,940 | 221,062 | +82,122 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 207,124 | 207,124 | 0 | 0.04 | 0.04 | +0.01 | hold |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 205,680 | 205,680 | 0 | 0.07 | 0.08 | +0.01 | hold |
| RHUMBLINE ADVISERS | 171,959 | 194,859 | +22,900 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 171,386 | 179,152 | +7,766 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 220,000 | 175,000 | -45,000 | 0.04 | 0.03 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 149,116 | 172,281 | +23,165 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 172,331 | 165,486 | -6,845 | 0.49 | 0.57 | +0.09 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 125,775 | 163,945 | +38,170 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 163,074 | +163,074 | 0.00 | 0.03 | +0.03 | buy |
| PDT Partners, LLC | 158,384 | 158,384 | 0 | 0.31 | 0.35 | +0.04 | hold |
| Rafferty Asset Management, LLC | 434,909 | 151,482 | -283,427 | 0.03 | 0.01 | -0.02 | sell |
| UBS Group AG | 343,879 | 136,223 | -207,656 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 64,775 | 130,504 | +65,729 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 107,450 | 129,346 | +21,896 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 151,560 | 127,060 | -24,500 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 64,874 | 123,680 | +58,806 | 0.01 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 363,027 | 120,612 | -242,415 | 0.02 | 0.01 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 80,429 | 116,743 | +36,314 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 114,402 | 116,232 | +1,830 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 111,436 | 115,954 | +4,518 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 112,323 | +112,323 | 0.00 | 0.14 | +0.14 | buy |
| ALPS ADVISORS INC | 98,149 | 111,239 | +13,090 | 0.01 | 0.02 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 165,075 | 103,096 | -61,979 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 191,505 | 94,867 | -96,638 | 0.01 | 0.01 | -0.00 | sell |
| BIT Capital GmbH | 82,000 | 86,177 | +4,177 | 0.15 | 0.18 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 50,595 | 77,140 | +26,545 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 80,393 | 76,931 | -3,462 | 0.00 | 0.00 | +0.00 | sell |
| Northwest & Ethical Investments L.P. | 75,835 | 75,835 | 0 | 0.04 | 0.05 | +0.01 | hold |
| WELLS FARGO & COMPANY/MN | 64,783 | 74,321 | +9,538 | 0.00 | 0.00 | +0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 43,827 | 72,388 | +28,561 | 0.02 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 62,264 | 71,810 | +9,546 | 0.01 | 0.01 | +0.00 | buy |
| AIA Group Ltd | 61,034 | 69,344 | +8,310 | 0.04 | 0.05 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 66,129 | 66,322 | +193 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 104,640 | 60,398 | -44,242 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 64,210 | 59,800 | -4,410 | 0.00 | 0.00 | +0.00 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 29,770 | 59,170 | +29,400 | 0.15 | 0.31 | +0.16 | buy |
| Holocene Advisors, LP | 860,948 | 59,042 | -801,906 | 0.07 | 0.01 | -0.06 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 220,638 | 58,780 | -161,858 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 71,651 | 58,523 | -13,128 | 0.02 | 0.02 | -0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 39,441 | 57,995 | +18,554 | 0.06 | 0.09 | +0.03 | buy |
| Woodline Partners LP | 508,565 | 56,554 | -452,011 | 0.10 | 0.01 | -0.08 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 127,270 | 54,056 | -73,214 | 0.01 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 55,612 | 52,863 | -2,749 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 52,718 | 52,128 | -590 | 0.00 | 0.00 | +0.00 | sell |
| Bayesian Capital Management, LP | 21,800 | 50,500 | +28,700 | 0.04 | 0.13 | +0.09 | buy |
| CITIGROUP INC | 382,416 | 44,551 | -337,865 | 0.01 | 0.00 | -0.01 | sell |
| Employees Retirement System of Texas | 43,769 | 43,769 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 43,245 | 43,245 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 39,575 | 43,033 | +3,458 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 23,900 | 39,500 | +15,600 | 0.00 | 0.00 | +0.00 | buy |