| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 8,519,192 | 16,178,963 | +7,659,771 | 0.11 | 0.27 | +0.16 | buy |
| BlackRock, Inc. | 13,034,434 | 14,026,413 | +991,979 | 0.00 | 0.01 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 12,066,479 | 11,960,230 | -106,249 | 0.24 | 0.28 | +0.04 | sell |
| STATE STREET CORP | 6,272,001 | 7,049,304 | +777,303 | 0.00 | 0.01 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 7,012,974 | 7,012,974 | 0 | 0.45 | 0.49 | +0.04 | hold |
| FMR LLC | 4,575,374 | 4,535,836 | -39,538 | 0.00 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 4,407,255 | 4,155,895 | -251,360 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,727,114 | 3,973,342 | +246,228 | 0.00 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 3,195,429 | 3,905,225 | +709,796 | 0.15 | 0.23 | +0.08 | buy |
| BAKER BROS. ADVISORS LP | 3,731,695 | 3,734,336 | +2,641 | 0.41 | 0.48 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,432,314 | 3,161,972 | -1,270,342 | 0.02 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,464,146 | 3,136,149 | +672,003 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 2,571,344 | 3,120,592 | +549,248 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,893,618 | 2,984,807 | +91,189 | 0.02 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,692,175 | 2,860,604 | +168,429 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 0 | 2,824,746 | +2,824,746 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 2,558,865 | 2,791,206 | +232,341 | 0.05 | 0.07 | +0.02 | buy |
| Capital Research Global Investors | 2,514,588 | 2,565,817 | +51,229 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 2,436,895 | 2,414,162 | -22,733 | 0.02 | 0.02 | +0.00 | sell |
| Casdin Capital, LLC | 1,840,000 | 2,045,000 | +205,000 | 2.68 | 2.63 | -0.04 | buy |
| Crestline Management, LP | 2,210,732 | 1,910,732 | -300,000 | 91.74 | 91.90 | +0.16 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,478,486 | 1,420,083 | -58,403 | 0.02 | 0.02 | +0.00 | sell |
| Foresite Capital Management VI LLC | 1,209,971 | 1,396,771 | +186,800 | 5.05 | 5.59 | +0.54 | buy |
| Siren, L.L.C. | 1,396,513 | 1,396,513 | 0 | 0.74 | 0.73 | -0.01 | hold |
| NORTHERN TRUST CORP | 1,310,656 | 1,389,765 | +79,109 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 296,503 | 1,355,514 | +1,059,011 | 0.01 | 0.03 | +0.03 | buy |
| Aberdeen Group plc | 1,854,446 | 1,345,481 | -508,965 | 0.06 | 0.05 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 1,244,955 | +1,244,955 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,207,399 | 1,244,955 | +37,556 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,134,183 | 1,230,957 | +96,774 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 1,099,719 | 1,224,497 | +124,778 | 0.03 | 0.05 | +0.02 | buy |
| Candriam S.C.A. | 1,099,845 | 1,189,886 | +90,041 | 0.11 | 0.14 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,257,950 | 1,125,748 | -132,202 | 0.02 | 0.02 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 1,871,455 | 1,029,080 | -842,375 | 2.16 | 1.24 | -0.92 | sell |
| MORGAN STANLEY | 1,104,757 | 961,050 | -143,707 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 768,039 | 800,283 | +32,244 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 318,500 | 739,014 | +420,514 | 1.39 | 3.62 | +2.23 | buy |
| AMERICAN CENTURY COMPANIES INC | 935,692 | 712,526 | -223,166 | 0.01 | 0.01 | -0.00 | sell |
| Cercano Management LLC | 625,000 | 625,000 | 0 | 0.52 | 2.14 | +1.63 | hold |
| Nuveen, LLC | 295,586 | 608,967 | +313,381 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 515,721 | 582,669 | +66,948 | 0.02 | 0.02 | +0.01 | buy |
| MARSHALL WACE, LLP | 991,268 | 549,830 | -441,438 | 0.02 | 0.01 | -0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 510,543 | 519,483 | +8,940 | 0.10 | 0.16 | +0.06 | buy |
| CITIGROUP INC | 39,278 | 487,278 | +448,000 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 102,579 | 388,469 | +285,890 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 364,082 | 364,082 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Invesco Ltd. | 310,196 | 343,898 | +33,702 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 336,567 | +336,567 | 0.00 | 0.08 | +0.08 | buy |
| Marex Group plc | 287,000 | 295,631 | +8,631 | 0.06 | 0.06 | -0.00 | buy |
| JPMORGAN CHASE & CO | 323,989 | 287,019 | -36,970 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 273,800 | 270,500 | -3,300 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 255,766 | 231,644 | -24,122 | 0.00 | 0.01 | +0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 207,130 | 229,939 | +22,809 | 0.06 | 0.07 | +0.02 | buy |
| Privium Fund Management B.V. | 254,857 | 229,857 | -25,000 | 1.02 | 1.09 | +0.07 | sell |
| XTX Topco Ltd | 78,567 | 226,953 | +148,386 | 0.03 | 0.08 | +0.05 | buy |
| Alyeska Investment Group, L.P. | 1,941,123 | 219,334 | -1,721,789 | 0.11 | 0.01 | -0.09 | sell |
| Susquehanna Portfolio Strategies, LLC | 157,896 | 211,474 | +53,578 | 0.05 | 0.09 | +0.04 | buy |
| MASTERS CAPITAL MANAGEMENT LLC | 600,000 | 200,000 | -400,000 | 1.70 | 0.72 | -0.98 | sell |
| Burkehill Global Management, LP | 200,000 | 200,000 | 0 | 0.19 | 0.19 | -0.00 | hold |
| SCS Capital Management LLC | 197,998 | 197,998 | 0 | 0.04 | 0.05 | +0.01 | hold |
| RHUMBLINE ADVISERS | 184,248 | 194,787 | +10,539 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 107,657 | 189,865 | +82,208 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 99,503 | 179,195 | +79,692 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 199,000 | 179,000 | -20,000 | 0.47 | 0.43 | -0.04 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 128,119 | 171,712 | +43,593 | 0.00 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 166,181 | 166,181 | 0 | 0.02 | 0.03 | +0.00 | hold |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 225,680 | 165,080 | -60,600 | 0.06 | 0.06 | -0.01 | sell |
| ALPS ADVISORS INC | 129,105 | 160,378 | +31,273 | 0.01 | 0.02 | +0.01 | buy |
| E. Ohman J:or Asset Management AB | 0 | 160,000 | +160,000 | 0.00 | 0.10 | +0.10 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 162,576 | 152,086 | -10,490 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 120,368 | 149,804 | +29,436 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 227,110 | 145,045 | -82,065 | 0.04 | 0.03 | -0.01 | sell |
| Man Group plc | 139,045 | 139,065 | +20 | 0.01 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 346,360 | 130,000 | -216,360 | 0.04 | 0.02 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,475 | 123,258 | +72,783 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125,442 | 117,348 | -8,094 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 111,694 | 115,775 | +4,081 | 0.00 | 0.01 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 112,300 | 112,300 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Legal & General Group Plc | 110,250 | 111,953 | +1,703 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 99,554 | 102,241 | +2,687 | 0.02 | 0.01 | -0.00 | buy |
| PFM Health Sciences, LP | 0 | 100,966 | +100,966 | 0.00 | 0.23 | +0.23 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.11 | +0.11 | buy |
| Ghisallo Capital Management LLC | 100,000 | 100,000 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Lumbard & Kellner, LLC | 94,782 | 98,282 | +3,500 | 0.63 | 0.77 | +0.14 | buy |
| Rafferty Asset Management, LLC | 150,687 | 96,342 | -54,345 | 0.01 | 0.01 | -0.01 | sell |
| D.A. DAVIDSON & CO. | 110,235 | 87,741 | -22,494 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 77,558 | 85,621 | +8,063 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 14,058 | 85,567 | +71,509 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 52,084 | 84,892 | +32,808 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 82,357 | 84,652 | +2,295 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 74,069 | 84,644 | +10,575 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 89,534 | 82,650 | -6,884 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 95,193 | 78,937 | -16,256 | 0.00 | 0.00 | -0.00 | sell |
| Phocas Financial Corp. | 0 | 71,197 | +71,197 | 0.00 | 0.25 | +0.25 | buy |
| Knights of Columbus Asset Advisors LLC | 56,329 | 67,591 | +11,262 | 0.06 | 0.09 | +0.03 | buy |
| CITADEL ADVISORS LLC | 181,417 | 66,971 | -114,446 | 0.00 | 0.00 | -0.00 | sell |
| 1492 Capital Management LLC | 67,417 | 66,368 | -1,049 | 0.49 | 0.50 | +0.01 | sell |
| Dana Investment Advisors, Inc. | 51,922 | 59,971 | +8,049 | 0.03 | 0.04 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 59,800 | 59,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 43,800 | 59,600 | +15,800 | 0.00 | 0.00 | +0.00 | buy |