| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 12,053,345 | 12,289,626 | +236,281 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 11,810,735 | 11,992,918 | +182,183 | 0.00 | 0.00 | -0.00 | buy |
| BAILLIE GIFFORD & CO | 11,955,323 | 11,591,585 | -363,738 | 0.12 | 0.12 | -0.00 | sell |
| FMR LLC | 7,538,468 | 6,340,316 | -1,198,152 | 0.01 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 3,246,934 | 5,638,567 | +2,391,633 | 0.03 | 0.05 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 6,262,277 | 5,465,037 | -797,240 | 0.02 | 0.02 | -0.00 | sell |
| STATE STREET CORP | 4,517,994 | 5,464,261 | +946,267 | 0.00 | 0.00 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 5,355,832 | 5,355,832 | 0 | 0.29 | 0.27 | -0.02 | hold |
| Capital Research Global Investors | 4,750,579 | 4,760,858 | +10,279 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,582,295 | 4,568,368 | -2,013,927 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 3,731,695 | 3,731,695 | 0 | 0.51 | 0.39 | -0.11 | hold |
| ALLIANCEBERNSTEIN L.P. | 3,137,140 | 3,520,414 | +383,274 | 0.01 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,172,305 | 3,466,057 | +293,752 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 3,860,732 | 3,410,732 | -450,000 | 86.33 | 85.26 | -1.08 | sell |
| Holocene Advisors, LP | 403,172 | 3,135,712 | +2,732,540 | 0.01 | 0.10 | +0.09 | buy |
| Point72 Asset Management, L.P. | 2,213,947 | 2,519,535 | +305,588 | 0.07 | 0.08 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,412,928 | 2,357,214 | -55,714 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,865,324 | 2,163,705 | +298,381 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 950,764 | 2,012,353 | +1,061,589 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 707,915 | 1,734,659 | +1,026,744 | 3.19 | 5.08 | +1.89 | buy |
| MORGAN STANLEY | 1,312,016 | 1,689,492 | +377,476 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 1,515,991 | 1,631,496 | +115,505 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 900,501 | 1,307,171 | +406,670 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,072,983 | 1,271,190 | +198,207 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,201,709 | 1,234,179 | +32,470 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,056,019 | 1,151,384 | +95,365 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 902,751 | 1,113,586 | +210,835 | 0.02 | 0.03 | +0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 5.61 | +5.61 | buy |
| BANK OF AMERICA CORP /DE/ | 650,222 | 961,138 | +310,916 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 770,527 | 936,230 | +165,703 | 0.04 | 0.05 | +0.01 | buy |
| Casdin Capital, LLC | 890,000 | 890,000 | 0 | 1.13 | 1.08 | -0.06 | hold |
| Candriam S.C.A. | 844,249 | 833,582 | -10,667 | 0.07 | 0.06 | -0.00 | sell |
| Siren, L.L.C. | 821,513 | 821,513 | 0 | 0.59 | 0.47 | -0.13 | hold |
| Bank of New York Mellon Corp | 790,756 | 800,747 | +9,991 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,405,250 | 787,029 | -618,221 | 0.02 | 0.01 | -0.01 | sell |
| MASTERS CAPITAL MANAGEMENT LLC | 600,000 | 750,000 | +150,000 | 1.62 | 1.75 | +0.13 | buy |
| CITADEL ADVISORS LLC | 1,248,953 | 688,224 | -560,729 | 0.02 | 0.01 | -0.01 | sell |
| Cercano Management LLC | 625,000 | 625,000 | 0 | 0.25 | 0.35 | +0.10 | hold |
| Ensign Peak Advisors, Inc | 473,695 | 534,071 | +60,376 | 0.01 | 0.01 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 500,559 | 512,958 | +12,399 | 0.10 | 0.10 | +0.00 | buy |
| Pictet Asset Management Holding SA | 415,112 | 499,162 | +84,050 | 0.01 | 0.01 | +0.00 | buy |
| Yiheng Capital Management, L.P. | 469,981 | 469,981 | 0 | 2.38 | 2.26 | -0.12 | hold |
| BARCLAYS PLC | 425,981 | 437,001 | +11,020 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 109,242 | 430,566 | +321,324 | 0.02 | 0.06 | +0.05 | buy |
| Palo Alto Investors LP | 239,809 | 408,006 | +168,197 | 0.71 | 1.10 | +0.38 | buy |
| TD ASSET MANAGEMENT INC | 496,290 | 394,600 | -101,690 | 0.01 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 390,155 | 372,176 | -17,979 | 0.00 | 0.00 | -0.00 | sell |
| Clarius Group, LLC | 368,995 | 359,745 | -9,250 | 0.30 | 0.31 | +0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 318,193 | 357,341 | +39,148 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 290,000 | 305,000 | +15,000 | 0.03 | 0.03 | +0.00 | buy |
| Pier Capital, LLC | 314,796 | 301,171 | -13,625 | 0.67 | 0.68 | +0.01 | sell |
| Marex Group plc | 262,000 | 291,000 | +29,000 | 0.07 | 0.05 | -0.02 | buy |
| Nuveen, LLC | 595,217 | 284,777 | -310,440 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 250,900 | 267,500 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,300 | 266,292 | +246,992 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 19,082 | 264,061 | +244,979 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 261,687 | +261,687 | 0.00 | 0.77 | +0.77 | buy |
| Boxer Capital Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 1.16 | +1.16 | buy |
| Invesco Ltd. | 219,795 | 249,467 | +29,672 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 396,586 | 230,968 | -165,618 | 0.06 | 0.05 | -0.01 | sell |
| Qube Research & Technologies Ltd | 0 | 227,990 | +227,990 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 226,203 | +226,203 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 85,332 | 224,903 | +139,571 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 142,708 | 216,774 | +74,066 | 0.13 | 0.24 | +0.11 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 386,539 | 209,595 | -176,944 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 135,969 | 207,594 | +71,625 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 315,102 | 205,845 | -109,257 | 0.00 | 0.00 | -0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 205,680 | 205,680 | 0 | 0.05 | 0.05 | +0.00 | hold |
| RHUMBLINE ADVISERS | 212,503 | 201,565 | -10,938 | 0.00 | 0.00 | -0.00 | sell |
| SCS Capital Management LLC | 197,998 | 197,998 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Rafferty Asset Management, LLC | 122,262 | 182,886 | +60,624 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 191,613 | 175,021 | -16,592 | 0.00 | 0.00 | -0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 171,553 | 171,553 | 0 | 0.02 | 0.02 | -0.00 | hold |
| DAFNA Capital Management LLC | 168,500 | 168,500 | 0 | 0.65 | 0.60 | -0.05 | hold |
| Jump Financial, LLC | 0 | 166,399 | +166,399 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 131,755 | 143,952 | +12,197 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 137,880 | 139,663 | +1,783 | 0.01 | 0.01 | -0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 175,531 | 135,758 | -39,773 | 0.04 | 0.03 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 134,703 | 129,887 | -4,816 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 119,327 | 129,526 | +10,199 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 342,923 | 123,819 | -219,104 | 0.13 | 0.05 | -0.08 | sell |
| Woodline Partners LP | 113,517 | 113,517 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 89,639 | 104,179 | +14,540 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 85,840 | 101,260 | +15,420 | 0.03 | 0.02 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 100,000 | 100,000 | 0 | 0.18 | 0.16 | -0.02 | hold |
| AMERIPRISE FINANCIAL INC | 102,033 | 99,561 | -2,472 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 96,046 | 91,074 | -4,972 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 27,600 | 90,000 | +62,400 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 80,518 | +80,518 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 79,627 | 80,126 | +499 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 79,075 | 79,075 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Savvy Advisors, Inc. | 97,793 | 77,093 | -20,700 | 0.09 | 0.05 | -0.04 | sell |
| AlphaQuest LLC | 22,964 | 74,422 | +51,458 | 0.03 | 0.07 | +0.04 | buy |
| ALPS ADVISORS INC | 78,356 | 70,230 | -8,126 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 116,101 | 69,216 | -46,885 | 0.02 | 0.01 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 57,150 | 67,440 | +10,290 | 0.15 | 0.18 | +0.03 | buy |
| XTX Topco Ltd | 0 | 65,345 | +65,345 | 0.00 | 0.05 | +0.05 | buy |
| TT International Asset Management LTD | 65,000 | 65,000 | 0 | 0.17 | 0.18 | +0.01 | hold |
| FRANKLIN RESOURCES INC | 64,525 | 64,634 | +109 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 60,028 | 60,028 | 0 | 0.00 | 0.00 | -0.00 | hold |