| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,292,003 | 2,607,196 | +315,193 | 0.27 | 0.64 | +0.36 | buy |
| Rafferty Asset Management, LLC | 229,313 | 321,973 | +92,660 | 0.03 | 0.03 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 99,880 | 165,680 | +65,800 | 0.04 | 0.06 | +0.02 | buy |
| Pier Capital, LLC | 125,080 | 174,219 | +49,139 | 0.42 | 0.53 | +0.12 | buy |
| Knights of Columbus Asset Advisors LLC | 38,128 | 77,352 | +39,224 | 0.07 | 0.11 | +0.03 | buy |
| Capital Research Global Investors | 2,880,323 | 2,909,528 | +29,205 | 0.02 | 0.02 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 20,200 | 46,000 | +25,800 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 58,952 | 34,464 | +24,488 | 0.03 | 0.05 | 0.00 | sell |
| PROFUND ADVISORS LLC | 40,154 | 53,675 | +13,521 | 0.05 | 0.05 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,526 | 15,981 | +12,455 | 0.02 | 0.07 | +0.05 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 14,000 | 24,000 | +10,000 | 0.03 | 0.06 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 52,279 | 60,304 | +8,025 | 0.23 | 0.25 | +0.02 | buy |
| VELA Investment Management, LLC | 19,899 | 26,145 | +6,246 | 0.18 | 0.23 | +0.05 | buy |
| E Fund Management Co., Ltd. | 11,781 | 17,290 | +5,509 | 0.02 | 0.02 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 23,089 | 27,429 | +4,340 | 0.05 | 0.06 | +0.01 | buy |
| ProShare Advisors LLC | 24,332 | 28,385 | +4,053 | 0.00 | 0.00 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,045 | 3,994 | +949 | 0.04 | 0.05 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 46,002 | 46,558 | +556 | 0.00 | 0.00 | 0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,304 | 10,344 | +40 | 0.02 | 0.02 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 18,096 | 17,938 | -158 | 0.23 | 0.20 | -0.03 | sell |
| AIA Group Ltd | 68,447 | 68,078 | -369 | 0.07 | 0.06 | -0.01 | sell |
| Dana Investment Advisors, Inc. | 24,629 | 24,057 | -572 | 0.03 | 0.02 | -0.00 | sell |
| ARTHUR M. COHEN & ASSOCIATES, LLC | 12,941 | 10,564 | -2,377 | 0.07 | 0.05 | -0.02 | sell |
| ALPS ADVISORS INC | 101,400 | 97,962 | -3,438 | 0.02 | 0.02 | -0.00 | sell |
| Northwest & Ethical Investments L.P. | 74,768 | 71,284 | -3,484 | 0.05 | 0.05 | -0.00 | sell |
| WASATCH ADVISORS LP | 321,467 | 312,301 | -9,166 | 0.04 | 0.04 | -0.00 | sell |
| Artisan Partners Limited Partnership | 406,622 | 383,942 | -22,680 | 0.01 | 0.01 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 1,246,199 | 1,219,392 | -26,807 | 0.39 | 0.36 | -0.03 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 40,500 | 10,200 | -30,300 | 0.21 | 0.06 | -0.15 | sell |
| T. Rowe Price Investment Management, Inc. | 647,013 | 498,969 | -148,044 | 0.01 | 0.01 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 254,941 | 12,881 | -242,060 | 1.02 | 0.12 | -0.91 | sell |
| Flagship Pioneering Inc. | 2,619,968 | 2,319,968 | -300,000 | 3.92 | 3.76 | -0.17 | sell |
| Crestline Management, LP | 5,960,732 | 5,660,732 | -300,000 | 14.32 | 10.35 | -3.97 | sell |
| Erste Asset Management GmbH | 334,669 | 26,900 | -307,769 | 0.01 | 0.01 | -0.00 | sell |
| ARCH Venture Management, LLC | 693,749 | 381,249 | -312,500 | 9.30 | 5.00 | -4.29 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,891,950 | 2,574,321 | -317,629 | 0.01 | 0.01 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 14,681,027 | 14,260,724 | -420,303 | 0.28 | 0.24 | -0.03 | sell |
| Polar Capital Holdings Plc | 1,007,086 | 452,669 | -554,417 | 0.15 | 0.06 | -0.09 | sell |
| Woodline Partners LP | 851,489 | 197,584 | -653,905 | 0.21 | 0.05 | -0.16 | sell |