| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 11,992,918 | 13,057,890 | +1,064,972 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 12,289,626 | 12,715,201 | +425,575 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 11,591,585 | 12,310,889 | +719,304 | 0.12 | 0.17 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 5,638,567 | 7,254,132 | +1,615,565 | 0.05 | 0.08 | +0.03 | buy |
| Temasek Holdings (Private) Ltd | 5,355,832 | 7,012,974 | +1,657,142 | 0.27 | 0.37 | +0.10 | buy |
| STATE STREET CORP | 5,464,261 | 6,263,371 | +799,110 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,340,316 | 6,097,211 | -243,105 | 0.00 | 0.01 | +0.00 | sell |
| NORGES BANK | 0 | 5,119,622 | +5,119,622 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 5,465,037 | 4,983,726 | -481,311 | 0.02 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,568,368 | 3,915,951 | -652,417 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,163,705 | 3,835,803 | +1,672,098 | 0.00 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,731,695 | 3,731,695 | 0 | 0.39 | 0.36 | -0.03 | hold |
| Capital Research Global Investors | 4,760,858 | 3,729,244 | -1,031,614 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 3,520,414 | 3,557,935 | +37,521 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,466,057 | 3,458,131 | -7,926 | 0.00 | 0.00 | +0.00 | sell |
| Holocene Advisors, LP | 3,135,712 | 3,152,734 | +17,022 | 0.10 | 0.11 | +0.01 | buy |
| Crestline Management, LP | 3,410,732 | 2,810,732 | -600,000 | 85.26 | 87.02 | +1.77 | sell |
| Fisher Asset Management, LLC | 1,631,496 | 2,589,403 | +957,907 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 2,012,353 | 2,404,704 | +392,351 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,357,214 | 2,374,303 | +17,089 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 1,113,586 | 2,032,967 | +919,381 | 0.03 | 0.05 | +0.03 | buy |
| Casdin Capital, LLC | 890,000 | 1,840,000 | +950,000 | 1.08 | 1.89 | +0.81 | buy |
| Lynx1 Capital Management LP | 261,687 | 1,738,750 | +1,477,063 | 0.77 | 5.81 | +5.04 | buy |
| Point72 Asset Management, L.P. | 2,519,535 | 1,700,000 | -819,535 | 0.08 | 0.04 | -0.04 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,271,190 | 1,524,123 | +252,933 | 0.01 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 821,513 | 1,396,513 | +575,000 | 0.47 | 0.69 | +0.22 | buy |
| Pictet Asset Management Holding SA | 499,162 | 1,329,108 | +829,946 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 1,689,492 | 1,219,854 | -469,638 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,151,384 | 1,200,475 | +49,091 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,234,179 | 1,199,744 | -34,435 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 833,582 | 1,166,379 | +332,797 | 0.06 | 0.10 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 0 | 1,023,253 | +1,023,253 | 0.00 | 0.19 | +0.19 | buy |
| MASTERS CAPITAL MANAGEMENT LLC | 750,000 | 1,000,000 | +250,000 | 1.75 | 2.28 | +0.53 | buy |
| Foresite Capital Management VI LLC | 1,000,000 | 1,000,000 | 0 | 5.61 | 4.99 | -0.62 | hold |
| BANK OF AMERICA CORP /DE/ | 961,138 | 932,144 | -28,994 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 859,108 | +859,108 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 688,224 | 779,148 | +90,924 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 787,029 | 763,892 | -23,137 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 800,747 | 762,087 | -38,660 | 0.00 | 0.00 | +0.00 | sell |
| Palo Alto Investors LP | 408,006 | 641,239 | +233,233 | 1.10 | 1.47 | +0.38 | buy |
| Cercano Management LLC | 625,000 | 625,000 | 0 | 0.35 | 0.39 | +0.04 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 936,230 | 591,461 | -344,769 | 0.05 | 0.03 | -0.01 | sell |
| Qube Research & Technologies Ltd | 227,990 | 590,314 | +362,324 | 0.00 | 0.01 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 512,958 | 537,000 | +24,042 | 0.10 | 0.12 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 534,071 | 515,721 | -18,350 | 0.01 | 0.02 | +0.00 | sell |
| Vestal Point Capital, LP | 0 | 465,000 | +465,000 | 0.00 | 0.28 | +0.28 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 209,595 | 450,985 | +241,390 | 0.00 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 305,000 | 450,000 | +145,000 | 0.03 | 0.04 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 266,292 | 430,177 | +163,885 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 1,734,659 | 419,058 | -1,315,601 | 5.08 | 1.19 | -3.89 | sell |
| BARCLAYS PLC | 437,001 | 407,359 | -29,642 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 357,341 | 379,051 | +21,710 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,307,171 | 369,767 | -937,404 | 0.01 | 0.00 | -0.01 | sell |
| Clarius Group, LLC | 359,745 | 368,995 | +9,250 | 0.31 | 0.35 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 394,600 | 339,410 | -55,190 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 168,500 | 318,500 | +150,000 | 0.60 | 1.22 | +0.62 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,271 | 298,792 | +297,521 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 249,467 | 291,936 | +42,469 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 291,000 | 287,001 | -3,999 | 0.05 | 0.05 | -0.00 | sell |
| Nuveen, LLC | 284,777 | 275,508 | -9,269 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 267,500 | 273,800 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 205,680 | 225,680 | +20,000 | 0.05 | 0.05 | +0.01 | buy |
| Trexquant Investment LP | 430,566 | 209,609 | -220,957 | 0.06 | 0.03 | -0.03 | sell |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.22 | +0.22 | buy |
| SCS Capital Management LLC | 197,998 | 197,998 | 0 | 0.03 | 0.03 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 104,179 | 193,681 | +89,502 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 182,886 | 191,567 | +8,681 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 205,845 | 184,238 | -21,607 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 201,565 | 183,000 | -18,565 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 99,561 | 180,221 | +80,660 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 175,021 | 171,948 | -3,073 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 167,713 | +167,713 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 90,000 | 154,800 | +64,800 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 171,553 | 153,781 | -17,772 | 0.02 | 0.02 | +0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 135,758 | 151,591 | +15,833 | 0.03 | 0.04 | +0.01 | buy |
| SG Americas Securities, LLC | 38,201 | 149,592 | +111,391 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 143,952 | 131,223 | -12,729 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,526 | 129,409 | -117 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 129,887 | 128,800 | -1,087 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 101,260 | 127,030 | +25,770 | 0.02 | 0.03 | +0.01 | buy |
| ALPS ADVISORS INC | 70,230 | 120,718 | +50,488 | 0.01 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 113,517 | 114,082 | +565 | 0.01 | 0.01 | -0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 112,300 | +112,300 | 0.00 | 0.02 | +0.02 | buy |
| D.A. DAVIDSON & CO. | 0 | 106,933 | +106,933 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 207,594 | 105,086 | -102,508 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 100,000 | 100,000 | 0 | 0.16 | 0.15 | -0.01 | hold |
| Ghisallo Capital Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.07 | +0.07 | buy |
| Integrated Wealth Concepts LLC | 91,074 | 94,582 | +3,508 | 0.01 | 0.02 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 93,587 | +93,587 | 0.00 | 0.03 | +0.03 | buy |
| Monashee Investment Management LLC | 0 | 91,620 | +91,620 | 0.00 | 0.85 | +0.85 | buy |
| HRT FINANCIAL LP | 0 | 78,352 | +78,352 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 79,075 | 75,164 | -3,911 | 0.01 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 80,126 | 73,581 | -6,545 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 40,156 | 71,634 | +31,478 | 0.02 | 0.04 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 26,223 | 70,830 | +44,607 | 0.00 | 0.00 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 67,440 | 68,200 | +760 | 0.18 | 0.25 | +0.07 | buy |
| 1492 Capital Management LLC | 0 | 67,487 | +67,487 | 0.00 | 0.43 | +0.43 | buy |
| Capricorn Fund Managers Ltd | 0 | 62,197 | +62,197 | 0.00 | 0.25 | +0.25 | buy |
| Creative Planning | 54,834 | 60,766 | +5,932 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 64,634 | 60,270 | -4,364 | 0.00 | 0.00 | +0.00 | sell |