| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAILLIE GIFFORD & CO | 12,094,029 | 9,692,441 | -2,401,588 | 0.57 | 0.58 | +0.01 | sell |
| VANGUARD GROUP INC | 7,734,770 | 9,441,607 | +1,706,837 | 0.01 | 0.01 | +0.00 | buy |
| ARK Investment Management LLC | 7,421,770 | 7,175,767 | -246,003 | 3.46 | 3.45 | -0.01 | sell |
| BlackRock, Inc. | 4,139,428 | 6,737,266 | +2,597,838 | 0.01 | 0.01 | +0.00 | buy |
| SOFTBANK GROUP CORP. | 5,405,406 | 5,405,406 | 0 | 1.38 | 1.68 | +0.30 | hold |
| JPMORGAN CHASE & CO | 4,768,077 | 4,929,361 | +161,284 | 0.02 | 0.03 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 3,869,941 | 3,463,095 | -406,846 | 0.15 | 0.16 | +0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,869,941 | 3,463,095 | -406,846 | 2.45 | 2.71 | +0.26 | sell |
| MORGAN STANLEY | 2,539,455 | 2,416,184 | -123,271 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,131,249 | 2,408,493 | +1,277,244 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 1,330,904 | 2,185,628 | +854,724 | 0.02 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 421,727 | 2,027,484 | +1,605,757 | 0.03 | 0.13 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 649,420 | 1,728,830 | +1,079,410 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 567,907 | 1,607,083 | +1,039,176 | 0.13 | 0.44 | +0.30 | buy |
| Alphabet Inc. | 1,551,102 | 1,551,102 | 0 | 4.62 | 5.20 | +0.58 | hold |
| STATE STREET CORP | 859,872 | 1,472,662 | +612,790 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,450,745 | 1,456,120 | +5,375 | 0.02 | 0.03 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 308,819 | 1,274,549 | +965,730 | 0.02 | 0.08 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,192,139 | 1,234,305 | +42,166 | 0.14 | 0.15 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 850,180 | 904,872 | +54,692 | 0.04 | 0.05 | +0.00 | buy |
| Lingotto Investment Management LLP | 783,859 | 783,859 | 0 | 1.07 | 1.18 | +0.11 | hold |
| GILDER GAGNON HOWE & CO LLC | 413,081 | 778,028 | +364,947 | 0.28 | 0.64 | +0.36 | buy |
| Marex Group plc | 418,947 | 759,733 | +340,786 | 0.51 | 0.76 | +0.25 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,223 | 709,695 | +685,472 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30,415 | 615,714 | +585,299 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 147,742 | 590,137 | +442,395 | 0.01 | 0.04 | +0.03 | buy |
| JANE STREET GROUP, LLC | 213,143 | 503,775 | +290,632 | 0.02 | 0.05 | +0.03 | buy |
| Legal & General Group Plc | 450,645 | 488,242 | +37,597 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 206,207 | 465,036 | +258,829 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 444,300 | +444,300 | 0.00 | 0.05 | +0.05 | buy |
| Mariner, LLC | 409,343 | 414,819 | +5,476 | 0.04 | 0.04 | +0.01 | buy |
| ROYAL BANK OF CANADA | 284,496 | 410,937 | +126,441 | 0.00 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 440,236 | 389,067 | -51,169 | 0.01 | 0.01 | +0.00 | sell |
| Patient Capital Management, LLC | 388,627 | 387,870 | -757 | 1.11 | 1.25 | +0.14 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 469,108 | 383,037 | -86,071 | 0.05 | 0.05 | -0.00 | sell |
| Trexquant Investment LP | 0 | 327,480 | +327,480 | 0.00 | 0.27 | +0.27 | buy |
| Jump Financial, LLC | 0 | 316,696 | +316,696 | 0.00 | 0.39 | +0.39 | buy |
| TWO SIGMA ADVISERS, LP | 380,589 | 312,889 | -67,700 | 0.05 | 0.05 | +0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 308,916 | +308,916 | 0.00 | 0.75 | +0.75 | buy |
| Invesco Ltd. | 211,621 | 305,838 | +94,217 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 232,741 | 299,894 | +67,153 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 299,177 | +299,177 | 0.00 | 0.05 | +0.05 | buy |
| Casdin Capital, LLC | 0 | 294,127 | +294,127 | 0.00 | 1.98 | +1.98 | buy |
| KADENSA CAPITAL Ltd | 302,663 | 288,035 | -14,628 | 3.06 | 2.39 | -0.67 | sell |
| 1832 Asset Management L.P. | 152,400 | 269,800 | +117,400 | 0.02 | 0.04 | +0.02 | buy |
| BAMCO INC /NY/ | 171,243 | 263,250 | +92,007 | 0.03 | 0.06 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 103,720 | 250,434 | +146,714 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 251,430 | 235,264 | -16,166 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 129,950 | 233,328 | +103,378 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 147,256 | 229,329 | +82,073 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 4,256,442 | 225,745 | -4,030,697 | 0.04 | 0.00 | -0.04 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 84,778 | 208,405 | +123,627 | 0.06 | 0.17 | +0.11 | buy |
| RTW INVESTMENTS, LP | 400,000 | 200,000 | -200,000 | 0.36 | 0.20 | -0.16 | sell |
| CWM, LLC | 183,729 | 192,194 | +8,465 | 0.04 | 0.05 | +0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 114,373 | 190,828 | +76,455 | 0.65 | 1.04 | +0.40 | buy |
| Swiss National Bank | 144,400 | 179,200 | +34,800 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 590,717 | 164,850 | -425,867 | 0.35 | 0.12 | -0.23 | sell |
| ARES MANAGEMENT LLC | 164,383 | 164,383 | 0 | 0.53 | 0.61 | +0.07 | hold |
| Vestmark Advisory Solutions, Inc. | 338,241 | 160,562 | -177,679 | 0.31 | 0.25 | -0.06 | sell |
| Aberdeen Group plc | 213,294 | 160,126 | -53,168 | 0.02 | 0.02 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 170,906 | 159,960 | -10,946 | 0.00 | 0.00 | +0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 113,791 | 136,372 | +22,581 | 0.57 | 0.70 | +0.13 | buy |
| CAPTRUST FINANCIAL ADVISORS | 108,213 | 135,066 | +26,853 | 0.02 | 0.02 | +0.01 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 131,598 | 132,098 | +500 | 0.07 | 0.08 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 132,418 | 131,707 | -711 | 0.21 | 0.26 | +0.05 | sell |
| Kohlberg Kravis Roberts & Co. L.P. | 0 | 117,652 | +117,652 | 0.00 | 0.16 | +0.16 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,066 | 113,386 | +91,320 | 0.00 | 0.01 | +0.01 | buy |
| Voleon Capital Management LP | 0 | 109,318 | +109,318 | 0.00 | 0.22 | +0.22 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,493 | 101,276 | +94,783 | 0.00 | 0.03 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 100,939 | +100,939 | 0.00 | 0.13 | +0.13 | buy |
| Diversify Advisory Services, LLC | 91,780 | 98,106 | +6,326 | 0.23 | 0.29 | +0.06 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 91,661 | +91,661 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 82,670 | 88,563 | +5,893 | 0.07 | 0.07 | +0.00 | buy |
| RHUMBLINE ADVISERS | 89,783 | 87,948 | -1,835 | 0.00 | 0.01 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,474 | 86,722 | +14,248 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 34,530 | 85,789 | +51,259 | 0.03 | 0.08 | +0.05 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 85,000 | +85,000 | 0.00 | 0.20 | +0.20 | buy |
| Summit Financial, LLC | 0 | 84,356 | +84,356 | 0.00 | 0.10 | +0.10 | buy |
| Renaissance Capital LLC | 66,300 | 84,166 | +17,866 | 2.94 | 3.81 | +0.87 | buy |
| Sculptor Capital LP | 186,700 | 84,000 | -102,700 | 0.19 | 0.09 | -0.10 | sell |
| FWL INVESTMENT MANAGEMENT, LLC | 68,458 | 82,599 | +14,141 | 1.33 | 1.74 | +0.41 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 53,900 | 80,000 | +26,100 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 30,990 | 76,776 | +45,786 | 0.00 | 0.01 | +0.01 | buy |
| ALLEN OPERATIONS LLC | 76,621 | 76,621 | 0 | 0.67 | 0.74 | +0.07 | hold |
| Blue Water Life Science Advisors, LP | 0 | 72,412 | +72,412 | 0.00 | 5.33 | +5.33 | buy |
| Westwind Capital | 73,283 | 72,402 | -881 | 0.95 | 1.22 | +0.27 | sell |
| BLAIR WILLIAM & CO/IL | 67,637 | 70,941 | +3,304 | 0.01 | 0.02 | +0.00 | buy |
| MITCHELL CAPITAL MANAGEMENT CO | 0 | 70,338 | +70,338 | 0.00 | 0.97 | +0.97 | buy |
| Cetera Investment Advisers | 32,417 | 70,269 | +37,852 | 0.00 | 0.01 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 69,594 | +69,594 | 0.00 | 0.45 | +0.45 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 69,363 | 68,342 | -1,021 | 0.01 | 0.01 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 71,345 | 66,760 | -4,585 | 0.00 | 0.01 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 64,545 | +64,545 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,485 | 61,963 | +11,478 | 0.01 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 36,447 | 61,651 | +25,204 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 10,600 | 61,089 | +50,489 | 0.00 | 0.01 | +0.00 | buy |
| DIVERSIFY WEALTH MANAGEMENT, LLC | 56,288 | 57,952 | +1,664 | 0.23 | 0.30 | +0.07 | buy |
| Venture Visionary Partners LLC | 13,157 | 57,368 | +44,211 | 0.03 | 0.16 | +0.13 | buy |
| Walleye Capital LLC | 0 | 57,092 | +57,092 | 0.00 | 0.04 | +0.04 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 62,005 | 56,306 | -5,699 | 0.00 | 0.00 | +0.00 | sell |