| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 2,378,157 | 5,519,644 | +3,141,487 | 1.23 | 1.55 | +0.32 | buy |
| SOFTBANK GROUP CORP. | 5,405,406 | 5,405,406 | 0 | 1.39 | 0.78 | -0.61 | hold |
| NEA Management Company, LLC | 5,385,979 | 5,385,979 | 0 | 16.61 | 10.26 | -6.35 | hold |
| Novo Holdings A/S | 4,074,419 | 4,074,419 | 0 | 11.45 | 8.33 | -3.13 | hold |
| Revolution Growth Management Company, Inc. | 3,660,948 | 3,467,565 | -193,383 | 100.00 | 100.00 | 0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 1,217,699 | 3,239,093 | +2,021,394 | 0.05 | 0.07 | +0.03 | buy |
| Nikko Asset Management Americas, Inc. | 1,217,699 | 3,239,093 | +2,021,394 | 0.78 | 1.19 | +0.41 | buy |
| FRANKLIN RESOURCES INC | 811,311 | 2,762,173 | +1,950,862 | 0.01 | 0.03 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,900 | 1,653,896 | +1,651,996 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 15,225 | 1,615,414 | +1,600,189 | 0.00 | 0.04 | +0.04 | buy |
| Alphabet Inc. | 1,551,102 | 1,551,102 | 0 | 4.77 | 3.05 | -1.72 | hold |
| NORGES BANK | 954,849 | 1,027,284 | +72,435 | 0.01 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 673,542 | 945,133 | +271,591 | 0.01 | 0.01 | -0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 280,700 | 943,718 | +663,018 | 0.15 | 0.30 | +0.15 | buy |
| Mariner, LLC | 0 | 923,786 | +923,786 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 12,049 | 798,074 | +786,025 | 0.00 | 0.01 | +0.01 | buy |
| Lingotto Investment Management LLP | 933,859 | 783,859 | -150,000 | 1.52 | 0.71 | -0.81 | sell |
| BlackRock, Inc. | 0 | 445,896 | +445,896 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 438,806 | +438,806 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 400,000 | +400,000 | 0.00 | 0.05 | +0.05 | buy |
| BAMCO INC /NY/ | 225,800 | 390,400 | +164,600 | 0.03 | 0.03 | +0.00 | buy |
| Legal & General Group Plc | 254,968 | 358,432 | +103,464 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 350,300 | +350,300 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 0 | 306,364 | +306,364 | 0.00 | 0.02 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 300,579 | +300,579 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,500,660 | 287,739 | -1,212,921 | 0.07 | 0.01 | -0.06 | sell |
| MORGAN STANLEY | 190,215 | 265,302 | +75,087 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 260,330 | +260,330 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 239,202 | +239,202 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,101 | 216,491 | +190,390 | 0.00 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 150,000 | 175,000 | +25,000 | 0.02 | 0.01 | -0.01 | buy |
| ARES MANAGEMENT LLC | 164,383 | 164,383 | 0 | 0.26 | 0.20 | -0.06 | hold |
| HBK INVESTMENTS L P | 0 | 150,000 | +150,000 | 0.00 | 0.10 | +0.10 | buy |
| FIRST TRUST ADVISORS LP | 181,227 | 142,565 | -38,662 | 0.01 | 0.00 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 133,171 | 132,555 | -616 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 131,800 | +131,800 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 6,048 | 127,929 | +121,881 | 0.01 | 0.08 | +0.07 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 126,500 | 126,500 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Vestmark Advisory Solutions, Inc. | 49,318 | 122,450 | +73,132 | 0.10 | 0.14 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 76,888 | 118,813 | +41,925 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 25,345 | 112,145 | +86,800 | 0.01 | 0.02 | +0.01 | buy |
| ALLEN OPERATIONS LLC | 109,459 | 109,459 | 0 | 1.04 | 0.59 | -0.46 | hold |
| JANE STREET GROUP, LLC | 19,429 | 105,489 | +86,060 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 94,449 | 94,449 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blue Water Life Science Advisors, LP | 0 | 90,000 | +90,000 | 0.00 | 2.69 | +2.69 | buy |
| CWM, LLC | 0 | 85,184 | +85,184 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 61,104 | 84,174 | +23,070 | 0.08 | 0.06 | -0.02 | buy |
| Aberdeen Group plc | 0 | 82,450 | +82,450 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 78,406 | +78,406 | 0.00 | 0.09 | +0.09 | buy |
| Walleye Trading LLC | 614 | 71,665 | +71,051 | 0.00 | 0.05 | +0.05 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 18,900 | 67,200 | +48,300 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 26,687 | 61,026 | +34,339 | 0.00 | 0.00 | +0.00 | buy |
| Dakota Wealth Management | 20,944 | 60,668 | +39,724 | 0.03 | 0.05 | +0.02 | buy |
| CAPTRUST FINANCIAL ADVISORS | 48,170 | 57,182 | +9,012 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 56,743 | +56,743 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 7,596 | 54,012 | +46,416 | 0.01 | 0.05 | +0.04 | buy |
| Covalis Capital LLP | 0 | 50,000 | +50,000 | 0.00 | 0.25 | +0.25 | buy |
| VESTOR CAPITAL, LLC | 2,700 | 48,590 | +45,890 | 0.01 | 0.13 | +0.11 | buy |
| Bank of New York Mellon Corp | 0 | 47,823 | +47,823 | 0.00 | 0.00 | +0.00 | buy |
| Mission Creek Capital Partners, Inc. | 0 | 47,755 | +47,755 | 0.00 | 0.35 | +0.35 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 17,121 | 44,119 | +26,998 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 19,974 | 44,006 | +24,032 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 6,750 | 41,501 | +34,751 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 3,846 | 39,810 | +35,964 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 39,803 | +39,803 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 38,980 | 38,958 | -22 | 0.01 | 0.01 | -0.00 | sell |
| BENJAMIN EDWARDS INC | 12,815 | 35,988 | +23,173 | 0.01 | 0.02 | +0.01 | buy |
| IMC-Chicago, LLC | 14,894 | 35,423 | +20,529 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 926 | 34,957 | +34,031 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 23,369 | 33,638 | +10,269 | 0.04 | 0.04 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 32,315 | +32,315 | 0.00 | 0.10 | +0.10 | buy |
| Green Alpha Advisors, LLC | 0 | 32,283 | +32,283 | 0.00 | 0.87 | +0.87 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 30,648 | +30,648 | 0.00 | 0.00 | +0.00 | buy |
| Bouvel Investment Partners, LLC | 0 | 30,486 | +30,486 | 0.00 | 0.37 | +0.37 | buy |
| Employees Retirement System of Texas | 29,948 | 29,948 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Verition Fund Management LLC | 0 | 27,478 | +27,478 | 0.00 | 0.00 | +0.00 | buy |
| Sculptor Capital LP | 52,955 | 25,000 | -27,955 | 0.06 | 0.01 | -0.05 | sell |
| Renaissance Capital LLC | 11,188 | 24,757 | +13,569 | 0.42 | 0.55 | +0.13 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 4,558 | 24,133 | +19,575 | 0.03 | 0.10 | +0.07 | buy |
| Quadrature Capital Ltd | 0 | 23,291 | +23,291 | 0.00 | 0.02 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 22,952 | +22,952 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 20,171 | +20,171 | 0.00 | 0.02 | +0.02 | buy |
| Crestline Management, LP | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| DnB Asset Management AS | 0 | 18,984 | +18,984 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 18,500 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| Icon Wealth Advisors, LLC | 0 | 16,054 | +16,054 | 0.00 | 0.04 | +0.04 | buy |
| COHEN & STEERS, INC. | 13,000 | 16,000 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| Silverleafe Capital Partners, LLC | 0 | 15,782 | +15,782 | 0.00 | 0.17 | +0.17 | buy |
| StoneX Group Inc. | 0 | 15,615 | +15,615 | 0.00 | 0.03 | +0.03 | buy |
| NORTHWESTERN UNIVERSITY | 14,033 | 14,033 | 0 | 0.93 | 0.76 | -0.17 | hold |
| OXFORD ASSET MANAGEMENT LLP | 0 | 13,526 | +13,526 | 0.00 | 0.21 | +0.21 | buy |
| Nebula Research & Development LLC | 0 | 13,349 | +13,349 | 0.00 | 0.05 | +0.05 | buy |
| Pathstone Holdings, LLC | 0 | 11,886 | +11,886 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 11,878 | +11,878 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 11,032 | +11,032 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 10,297 | +10,297 | 0.00 | 0.00 | +0.00 | buy |
| CW Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 8,934 | +8,934 | 0.00 | 0.00 | +0.00 | buy |
| Freedom Investment Management, Inc. | 0 | 8,771 | +8,771 | 0.00 | 0.02 | +0.02 | buy |
| Rakuten Securities, Inc. | 0 | 8,702 | +8,702 | 0.00 | 0.12 | +0.12 | buy |