| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 17,122,563 | 22,735,121 | +5,612,558 | 0.03 | 0.03 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 5,097,779 | 7,819,863 | +2,722,084 | 0.74 | 0.80 | +0.06 | buy |
| Aberdeen Group plc | 0 | 2,188,354 | +2,188,354 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 493,900 | 1,591,056 | +1,097,156 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 0 | 759,100 | +759,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 964,900 | 1,569,100 | +604,200 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 492,215 | +492,215 | 0.00 | 0.13 | +0.13 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 438,670 | +438,670 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 618,784 | 947,986 | +329,202 | 0.01 | 0.01 | -0.00 | buy |
| Tejara Capital Ltd | 2,317,085 | 2,521,324 | +204,239 | 5.32 | 2.80 | -2.52 | buy |
| TWO SIGMA INVESTMENTS, LP | 68,735 | 245,206 | +176,471 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,189,471 | 1,350,471 | +161,000 | 0.01 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 315,000 | 450,000 | +135,000 | 0.01 | 0.01 | -0.00 | buy |
| CANTOR FITZGERALD, L. P. | 225,000 | 355,000 | +130,000 | 0.03 | 0.03 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,150,000 | 1,275,000 | +125,000 | 1.90 | 1.56 | -0.34 | buy |
| Persistent Asset Partners Ltd | 0 | 113,247 | +113,247 | 0.00 | 0.22 | +0.22 | buy |
| Caption Management, LLC | 0 | 104,783 | +104,783 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 101,070 | +101,070 | 0.00 | 0.03 | +0.03 | buy |
| 683 Capital Management, LLC | 4,550,000 | 4,635,000 | +85,000 | 1.57 | 1.06 | -0.51 | buy |
| Virtus Investment Advisers, LLC | 0 | 44,007 | +44,007 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 35,816 | +35,816 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 381,468 | 416,468 | +35,000 | 0.59 | 0.47 | -0.12 | buy |
| GROUP ONE TRADING LLC | 0 | 34,281 | +34,281 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 313,950 | 343,653 | +29,703 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 29,300 | +29,300 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 22,189 | 49,418 | +27,229 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 120,278 | 144,803 | +24,525 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 22,687 | +22,687 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 15,713 | +15,713 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 34,753 | 47,630 | +12,877 | 0.06 | 0.12 | +0.07 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 779,308 | 791,815 | +12,507 | 2.74 | 2.07 | -0.68 | buy |
| Avanza Fonder AB | 19,600 | 28,121 | +8,521 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,119,852 | 2,125,920 | +6,068 | 0.00 | 0.00 | -0.00 | buy |
| Significant Wealth Partners LLC | 10,805 | 13,771 | +2,966 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 273,019 | 274,361 | +1,342 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 320 | 1,484 | +1,164 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 10,700 | 11,000 | +300 | 0.01 | 0.01 | -0.00 | buy |
| Grove Bank & Trust | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,710,429 | 6,710,429 | 0 | 0.45 | 0.30 | -0.15 | hold |
| MAI Capital Management | 309 | 309 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 92,156 | 92,156 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,698,100 | 4,698,100 | 0 | 0.10 | 0.06 | -0.03 | hold |
| PRINCIPAL SECURITIES, INC. | 32 | 32 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Knoll Capital Management, LLC | 260,470 | 260,470 | 0 | 0.59 | 0.38 | -0.21 | hold |
| Atle Fund Management AB | 390,000 | 390,000 | 0 | 0.65 | 0.39 | -0.26 | hold |
| J. Goldman & Co LP | 79,387 | 79,387 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Clear Harbor Asset Management, LLC | 42,000 | 42,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MANGROVE PARTNERS IM, LLC | 8,636,485 | 8,636,485 | 0 | 3.34 | 2.10 | -1.24 | hold |
| Allworth Financial LP | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearline Capital LP | 3,217,894 | 3,217,894 | 0 | 1.49 | 0.73 | -0.76 | hold |
| Rubric Capital Management LP | 15,307,347 | 15,307,347 | 0 | 0.97 | 0.62 | -0.36 | hold |
| OneDigital Investment Advisors LLC | 18,300 | 18,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Centiva Capital, LP | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artia Global Partners LP | 421,359 | 421,359 | 0 | 0.59 | 0.28 | -0.32 | hold |
| ADAR1 Capital Management, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| New England Capital Financial Advisors LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marex Group plc | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Transce3nd, LLC | 127 | 127 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 13 | 13 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIT INVESTMENT ASSOCIATES INC | 970 | 970 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 13,577 | 13,577 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cranbrook Wealth Management, LLC | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| GeoWealth Management, LLC | 158 | 0 | -158 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 9,001 | 8,380 | -621 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 7,237 | 6,588 | -649 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 679 | 0 | -679 | 0.00 | 0.00 | -0.00 | sell |
| BFSG, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 47,085 | 45,659 | -1,426 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 39,433 | 37,433 | -2,000 | 0.01 | 0.01 | -0.00 | sell |
| Golden State Equity Partners | 22,600 | 19,900 | -2,700 | 0.02 | 0.01 | -0.01 | sell |
| Squarepoint Ops LLC | 23,667 | 17,931 | -5,736 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 11,116 | 0 | -11,116 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 331,000 | 319,337 | -11,663 | 0.42 | 0.34 | -0.08 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,435 | 0 | -16,435 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 19,060 | 0 | -19,060 | 0.03 | 0.00 | -0.03 | sell |
| XTX Topco Ltd | 37,974 | 0 | -37,974 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 55,099 | 4,117 | -50,982 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 94,456 | 39,030 | -55,426 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 866,317 | 767,744 | -98,573 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 786,953 | 686,953 | -100,000 | 0.21 | 0.12 | -0.09 | sell |
| Walleye Capital LLC | 129,629 | 0 | -129,629 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 824,603 | 654,666 | -169,937 | 0.07 | 0.03 | -0.04 | sell |
| Polar Asset Management Partners Inc. | 169,977 | 0 | -169,977 | 0.01 | 0.00 | -0.01 | sell |
| Integral Health Asset Management, LLC | 1,000,000 | 800,000 | -200,000 | 0.31 | 0.20 | -0.11 | sell |
| PERCEPTIVE ADVISORS LLC | 1,085,512 | 876,961 | -208,551 | 0.11 | 0.07 | -0.04 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 391,590 | 174,378 | -217,212 | 0.00 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 890,548 | 654,666 | -235,882 | 1.29 | 0.44 | -0.85 | sell |
| Verition Fund Management LLC | 237,777 | 0 | -237,777 | 0.00 | 0.00 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 672,809 | 0 | -672,809 | 0.54 | 0.00 | -0.54 | sell |
| Eversept Partners, LP | 777,890 | 0 | -777,890 | 0.28 | 0.00 | -0.28 | sell |
| MORGAN STANLEY | 3,554,234 | 2,179,642 | -1,374,592 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 2,648,140 | 932,021 | -1,716,119 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 9,599,170 | 6,684,247 | -2,914,923 | 1.28 | 0.86 | -0.42 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,965,432 | 394,431 | -3,571,001 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,715,013 | 1,700,756 | -7,014,257 | 0.05 | 0.01 | -0.05 | sell |