| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 17,122,563 | 22,735,121 | +5,612,558 | 0.03 | 0.03 | 0.00 | buy |
| Frazier Life Sciences Management, L.P. | 5,097,779 | 7,819,863 | +2,722,084 | 0.74 | 0.80 | +0.06 | buy |
| Woodline Partners LP | 618,784 | 947,986 | +329,202 | 0.01 | 0.01 | -0.00 | buy |
| Tejara Capital Ltd | 2,317,085 | 2,521,324 | +204,239 | 5.32 | 2.80 | -2.52 | buy |
| CANTOR FITZGERALD, L. P. | 225,000 | 355,000 | +130,000 | 0.02 | 0.02 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,150,000 | 1,275,000 | +125,000 | 1.90 | 1.52 | -0.38 | buy |
| 683 Capital Management, LLC | 4,550,000 | 4,635,000 | +85,000 | 0.99 | 0.72 | -0.27 | buy |
| Monaco Asset Management SAM | 381,468 | 416,468 | +35,000 | 0.59 | 0.47 | -0.12 | buy |
| Forefront Analytics, LLC | 34,753 | 47,630 | +12,877 | 0.06 | 0.12 | +0.07 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 779,308 | 791,815 | +12,507 | 2.74 | 2.07 | -0.68 | buy |
| Avanza Fonder AB | 19,600 | 28,121 | +8,521 | 0.00 | 0.00 | +0.00 | buy |
| Significant Wealth Partners LLC | 10,805 | 13,771 | +2,966 | 0.02 | 0.02 | -0.00 | buy |
| Golden State Equity Partners | 22,600 | 19,900 | -2,700 | 0.02 | 0.01 | -0.01 | sell |
| Knott David M Jr | 331,000 | 319,337 | -11,663 | 0.42 | 0.34 | -0.08 | sell |
| Soleus Capital Management, L.P. | 786,953 | 686,953 | -100,000 | 0.21 | 0.12 | -0.09 | sell |
| NEOS Investment Management LLC | 824,603 | 654,666 | -169,937 | 0.07 | 0.03 | -0.04 | sell |
| Integral Health Asset Management, LLC | 1,000,000 | 800,000 | -200,000 | 0.31 | 0.20 | -0.11 | sell |
| PERCEPTIVE ADVISORS LLC | 1,085,512 | 876,961 | -208,551 | 0.10 | 0.07 | -0.03 | sell |
| TEMA ETFS LLC | 890,548 | 654,666 | -235,882 | 1.29 | 0.44 | -0.85 | sell |
| Rock Springs Capital Management LP | 9,599,170 | 6,684,247 | -2,914,923 | 1.28 | 0.86 | -0.42 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,715,013 | 1,700,756 | -7,014,257 | 0.05 | 0.01 | -0.05 | sell |