| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 6,710,429 | +6,710,429 | 0.00 | 0.40 | +0.40 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 4,401,371 | +4,401,371 | 0.00 | 0.74 | +0.74 | buy |
| JANUS HENDERSON GROUP PLC | 5,120,573 | 7,880,882 | +2,760,309 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,328,739 | 11,791,310 | +2,462,571 | 0.06 | 0.08 | +0.02 | buy |
| Rubric Capital Management LP | 13,552,997 | 15,307,347 | +1,754,350 | 1.32 | 1.45 | +0.13 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,253,250 | +1,253,250 | 0.00 | 0.11 | +0.11 | buy |
| MARSHALL WACE, LLP | 0 | 1,144,051 | +1,144,051 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 8,142,109 | 9,283,492 | +1,141,383 | 0.68 | 1.01 | +0.33 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,179,135 | 3,201,705 | +1,022,570 | 0.01 | 0.01 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 897,809 | +897,809 | 0.00 | 0.90 | +0.90 | buy |
| Integral Health Asset Management, LLC | 950,000 | 1,775,000 | +825,000 | 0.31 | 0.64 | +0.33 | buy |
| Eversept Partners, LP | 0 | 496,171 | +496,171 | 0.00 | 0.14 | +0.14 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 4,238,100 | 4,698,100 | +460,000 | 0.08 | 0.09 | +0.01 | buy |
| CITADEL ADVISORS LLC | 43,907 | 408,989 | +365,082 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 623,430 | 959,467 | +336,037 | 0.13 | 0.14 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 397,884 | 677,000 | +279,116 | 0.85 | 2.05 | +1.20 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 275,000 | +275,000 | 0.00 | 0.20 | +0.20 | buy |
| GOLDMAN SACHS GROUP INC | 2,243,814 | 2,507,513 | +263,699 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 30,000 | 236,000 | +206,000 | 0.04 | 0.34 | +0.30 | buy |
| Polar Asset Management Partners Inc. | 0 | 145,800 | +145,800 | 0.00 | 0.01 | +0.01 | buy |
| Tejara Capital Ltd | 2,470,184 | 2,615,458 | +145,274 | 3.02 | 3.43 | +0.41 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,672,309 | 1,762,003 | +89,694 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 55,400 | +55,400 | 0.00 | 0.04 | +0.04 | buy |
| Advisors Preferred, LLC | 8,262 | 24,813 | +16,551 | 0.00 | 0.02 | +0.01 | buy |
| Virtu Financial LLC | 0 | 14,152 | +14,152 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,926 | +13,926 | 0.00 | 0.00 | +0.00 | buy |
| RWA WEALTH PARTNERS, LLC | 0 | 12,550 | +12,550 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 29,242 | 41,393 | +12,151 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 78,718 | 84,018 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 4,524 | +4,524 | 0.00 | 0.00 | +0.00 | buy |
| Golden State Equity Partners | 20,300 | 24,800 | +4,500 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,435 | 20,535 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 4,071 | 6,958 | +2,887 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 5,987 | 6,765 | +778 | 0.00 | 0.00 | -0.00 | buy |
| Knoll Capital Management, LLC | 260,470 | 260,470 | 0 | 0.53 | 0.63 | +0.10 | hold |
| Plante Moran Financial Advisors, LLC | 48 | 48 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANGROVE PARTNERS IM, LLC | 8,752,893 | 8,752,893 | 0 | 2.02 | 2.42 | +0.40 | hold |
| Allworth Financial LP | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearline Capital LP | 3,326,718 | 3,326,718 | 0 | 1.08 | 1.05 | -0.04 | hold |
| Centiva Capital, LP | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Newbridge Financial Services Group, Inc. | 11,700 | 11,700 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Artia Global Partners LP | 421,359 | 421,359 | 0 | 0.34 | 0.39 | +0.05 | hold |
| New England Capital Financial Advisors LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 38 | 38 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 54,000 | 54,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIT INVESTMENT ASSOCIATES INC | 970 | 970 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 28,577 | 28,577 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 820 | 679 | -141 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 18,513 | 18,300 | -213 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 739 | 398 | -341 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 413 | 13 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 1,900 | 0 | -1,900 | 0.00 | 0.00 | -0.00 | sell |
| Clear Harbor Asset Management, LLC | 46,000 | 43,500 | -2,500 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 96,630 | 92,156 | -4,474 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,145 | 0 | -7,145 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 43,817 | 36,231 | -7,586 | 0.07 | 0.06 | -0.01 | sell |
| LEVEL FOUR ADVISORY SERVICES, LLC | 20,000 | 10,000 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Total Clarity Wealth Management, Inc. | 11,860 | 0 | -11,860 | 0.01 | 0.00 | -0.01 | sell |
| PFG Investments, LLC | 31,200 | 17,000 | -14,200 | 0.01 | 0.00 | -0.00 | sell |
| GTS SECURITIES LLC | 15,664 | 0 | -15,664 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 16,221 | 0 | -16,221 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 47,687 | 27,297 | -20,390 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 26,179 | 0 | -26,179 | 0.00 | 0.00 | -0.00 | sell |
| Index Fund Advisors, Inc. | 30,000 | 0 | -30,000 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 38,122 | 0 | -38,122 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 47,030 | 0 | -47,030 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 278,588 | 227,890 | -50,698 | 0.04 | 0.03 | -0.01 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 55,903 | 0 | -55,903 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 405,000 | 348,128 | -56,872 | 0.59 | 0.63 | +0.03 | sell |
| GSA CAPITAL PARTNERS LLP | 75,787 | 0 | -75,787 | 0.02 | 0.00 | -0.02 | sell |
| Qube Research & Technologies Ltd | 109,327 | 33,287 | -76,040 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 86,873 | 0 | -86,873 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 118,978 | 14,621 | -104,357 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 126,500 | 0 | -126,500 | 0.01 | 0.00 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 194,879 | 49,304 | -145,575 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 148,000 | 0 | -148,000 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 351,729 | 201,776 | -149,953 | 0.00 | 0.00 | -0.00 | sell |
| Global IMC LLC | 195,087 | 0 | -195,087 | 0.15 | 0.00 | -0.15 | sell |
| Verition Fund Management LLC | 485,436 | 226,494 | -258,942 | 0.02 | 0.01 | -0.01 | sell |
| Aberdeen Group plc | 817,309 | 73,168 | -744,141 | 0.01 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 5,750,000 | 5,000,000 | -750,000 | 1.94 | 1.89 | -0.05 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,619,627 | 840,264 | -779,363 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 991,971 | 0 | -991,971 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 2,616,953 | 1,246,953 | -1,370,000 | 0.76 | 0.40 | -0.36 | sell |
| MORGAN STANLEY | 1,382,689 | 0 | -1,382,689 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,653,494 | 75,000 | -3,578,494 | 0.51 | 0.01 | -0.50 | sell |