| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 7,819,863 | 9,440,112 | +1,620,249 | 0.80 | 1.02 | +0.22 | buy |
| GOLDMAN SACHS GROUP INC | 2,125,920 | 3,090,068 | +964,148 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 2,188,354 | 3,028,872 | +840,518 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 759,100 | 1,478,500 | +719,400 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 343,653 | 760,659 | +417,006 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 245,206 | 659,158 | +413,952 | 0.00 | 0.00 | +0.00 | buy |
| Clearline Capital LP | 3,217,894 | 3,618,163 | +400,269 | 0.73 | 0.86 | +0.13 | buy |
| Atle Fund Management AB | 390,000 | 764,901 | +374,901 | 0.39 | 0.89 | +0.50 | buy |
| Paloma Partners Management Co | 0 | 296,659 | +296,659 | 0.00 | 0.18 | +0.18 | buy |
| MILLENNIUM MANAGEMENT LLC | 394,431 | 595,673 | +201,242 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,117 | 201,141 | +197,024 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 174,378 | 361,542 | +187,164 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 274,361 | 455,365 | +181,004 | 0.00 | 0.00 | +0.00 | buy |
| Dauntless Investment Group, LLC | 0 | 134,122 | +134,122 | 0.00 | 1.71 | +1.71 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,350,471 | 1,480,471 | +130,000 | 0.00 | 0.01 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 125,000 | +125,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 29,300 | 144,600 | +115,300 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 34,281 | 139,559 | +105,278 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 144,803 | 247,441 | +102,638 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 104,783 | 197,599 | +92,816 | 0.01 | 0.05 | +0.04 | buy |
| XTX Topco Ltd | 0 | 69,341 | +69,341 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 421,359 | 475,361 | +54,002 | 0.28 | 0.33 | +0.05 | buy |
| Aquatic Capital Management LLC | 0 | 26,930 | +26,930 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 35,816 | 59,200 | +23,384 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 21,099 | +21,099 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 14,600 | +14,600 | 0.00 | 0.03 | +0.03 | buy |
| Avanza Fonder AB | 28,121 | 38,235 | +10,114 | 0.00 | 0.00 | +0.00 | buy |
| Significant Wealth Partners LLC | 13,771 | 22,261 | +8,490 | 0.02 | 0.03 | +0.01 | buy |
| RHUMBLINE ADVISERS | 6,588 | 9,878 | +3,290 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1,484 | 4,544 | +3,060 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 17,931 | 20,668 | +2,737 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 22,687 | 25,399 | +2,712 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 11,000 | 13,000 | +2,000 | 0.01 | 0.01 | -0.00 | buy |
| GAMMA Investing LLC | 8,380 | 9,257 | +877 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 849 | +849 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 470 | +470 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 92,156 | 92,534 | +378 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 187 | +187 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1,500 | 1,637 | +137 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 32 | 75 | +43 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,710,429 | 6,710,429 | 0 | 0.30 | 0.33 | +0.03 | hold |
| MAI Capital Management | 309 | 309 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,698,100 | 4,698,100 | 0 | 0.06 | 0.06 | -0.00 | hold |
| MARSHALL WACE, LLP | 767,744 | 767,744 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knoll Capital Management, LLC | 260,470 | 260,470 | 0 | 0.38 | 0.50 | +0.12 | hold |
| Hudson Bay Capital Management LP | 450,000 | 450,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Clear Harbor Asset Management, LLC | 42,000 | 42,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MANGROVE PARTNERS IM, LLC | 8,636,485 | 8,636,485 | 0 | 2.10 | 2.51 | +0.41 | hold |
| Arax Advisory Partners | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rubric Capital Management LP | 15,307,347 | 15,307,347 | 0 | 0.62 | 0.67 | +0.05 | hold |
| OneDigital Investment Advisors LLC | 18,300 | 18,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Centiva Capital, LP | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GPS Wealth Strategies Group, LLC | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Golden State Equity Partners | 19,900 | 19,900 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Knott David M Jr | 319,337 | 319,337 | 0 | 0.34 | 0.39 | +0.05 | hold |
| New England Capital Financial Advisors LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFG Investments, LLC | 37,433 | 37,433 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Marex Group plc | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Transce3nd, LLC | 127 | 127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIT INVESTMENT ASSOCIATES INC | 970 | 970 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 438,670 | 438,661 | -9 | 0.00 | 0.00 | +0.00 | sell |
| Grove Bank & Trust | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 45,659 | 44,942 | -717 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 44,007 | 33,825 | -10,182 | 0.03 | 0.03 | +0.00 | sell |
| CANTOR FITZGERALD, L. P. | 355,000 | 342,957 | -12,043 | 0.03 | 0.02 | -0.01 | sell |
| HSBC HOLDINGS PLC | 13,577 | 0 | -13,577 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 15,713 | 0 | -15,713 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 416,468 | 395,000 | -21,468 | 0.47 | 0.41 | -0.07 | sell |
| J. Goldman & Co LP | 79,387 | 52,384 | -27,003 | 0.01 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 49,418 | 21,176 | -28,242 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 47,630 | 19,138 | -28,492 | 0.12 | 0.03 | -0.10 | sell |
| AMERIPRISE FINANCIAL INC | 39,030 | 0 | -39,030 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 686,953 | 599,711 | -87,242 | 0.12 | 0.11 | -0.01 | sell |
| Tejara Capital Ltd | 2,521,324 | 2,430,437 | -90,887 | 2.80 | 3.05 | +0.26 | sell |
| BIT Capital GmbH | 101,070 | 0 | -101,070 | 0.03 | 0.00 | -0.03 | sell |
| Persistent Asset Partners Ltd | 113,247 | 0 | -113,247 | 0.22 | 0.00 | -0.22 | sell |
| 683 Capital Management, LLC | 4,635,000 | 4,350,000 | -285,000 | 1.06 | 1.20 | +0.14 | sell |
| DIADEMA PARTNERS LP | 492,215 | 0 | -492,215 | 0.13 | 0.00 | -0.13 | sell |
| NEOS Investment Management LLC | 654,666 | 102,583 | -552,083 | 0.03 | 0.00 | -0.02 | sell |
| TEMA ETFS LLC | 654,666 | 102,583 | -552,083 | 0.44 | 0.07 | -0.37 | sell |
| UBS Group AG | 932,021 | 373,505 | -558,516 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 1,591,056 | 909,640 | -681,416 | 0.02 | 0.02 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 791,815 | 0 | -791,815 | 2.07 | 0.00 | -2.07 | sell |
| Integral Health Asset Management, LLC | 800,000 | 0 | -800,000 | 0.20 | 0.00 | -0.20 | sell |
| PERCEPTIVE ADVISORS LLC | 876,961 | 0 | -876,961 | 0.07 | 0.00 | -0.07 | sell |
| Woodline Partners LP | 947,986 | 0 | -947,986 | 0.01 | 0.00 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 1,275,000 | 0 | -1,275,000 | 1.56 | 0.00 | -1.56 | sell |
| MORGAN STANLEY | 2,179,642 | 785,377 | -1,394,265 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,569,100 | 0 | -1,569,100 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,700,756 | 0 | -1,700,756 | 0.01 | 0.00 | -0.01 | sell |
| Rock Springs Capital Management LP | 6,684,247 | 4,465,292 | -2,218,955 | 0.86 | 0.75 | -0.11 | sell |
| JANUS HENDERSON GROUP PLC | 22,735,121 | 17,688,592 | -5,046,529 | 0.03 | 0.02 | -0.01 | sell |