| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 7,880,882 | 12,345,866 | +4,464,984 | 0.02 | 0.03 | 0.00 | buy |
| Frazier Life Sciences Management, L.P. | 4,401,371 | 5,097,779 | +696,408 | 0.74 | 0.84 | +0.10 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 677,000 | 1,260,700 | +583,700 | 2.05 | 4.20 | +2.14 | buy |
| Eversept Partners, LP | 496,171 | 777,890 | +281,719 | 0.12 | 0.22 | +0.10 | buy |
| Rock Springs Capital Management LP | 9,283,492 | 9,534,170 | +250,678 | 1.01 | 1.27 | +0.27 | buy |
| Tejara Capital Ltd | 2,615,458 | 2,829,990 | +214,532 | 3.43 | 5.55 | +2.12 | buy |
| Knott David M Jr | 236,000 | 331,000 | +95,000 | 0.34 | 0.48 | +0.14 | buy |
| FRED ALGER MANAGEMENT, LLC | 49,304 | 102,582 | +53,278 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 145,800 | 198,300 | +52,500 | 0.01 | 0.02 | +0.01 | buy |
| Monaco Asset Management SAM | 348,128 | 384,535 | +36,407 | 0.63 | 0.66 | +0.03 | buy |
| J. Goldman & Co LP | 227,890 | 254,890 | +27,000 | 0.02 | 0.03 | +0.01 | buy |
| Forefront Analytics, LLC | 36,231 | 33,800 | -2,431 | 0.06 | 0.07 | +0.00 | sell |
| Advisors Preferred, LLC | 24,813 | 18,188 | -6,625 | 0.02 | 0.01 | -0.00 | sell |
| Golden State Equity Partners | 24,800 | 6,500 | -18,300 | 0.02 | 0.01 | -0.00 | sell |
| MANGROVE PARTNERS IM, LLC | 8,752,893 | 8,729,720 | -23,173 | 2.42 | 3.08 | +0.67 | sell |
| ADAR1 Capital Management, LLC | 55,400 | 10,000 | -45,400 | 0.04 | 0.01 | -0.03 | sell |
| Blue Owl Capital Holdings LP | 897,809 | 847,809 | -50,000 | 0.90 | 0.68 | -0.22 | sell |
| Clearline Capital LP | 3,326,718 | 3,244,334 | -82,384 | 0.33 | 0.57 | +0.24 | sell |
| NEOS Investment Management LLC | 959,467 | 835,194 | -124,273 | 0.14 | 0.10 | -0.04 | sell |
| 683 Capital Management, LLC | 5,000,000 | 4,849,800 | -150,200 | 1.36 | 1.52 | +0.16 | sell |
| Soleus Capital Management, L.P. | 1,246,953 | 846,953 | -400,000 | 0.40 | 0.29 | -0.11 | sell |
| PERCEPTIVE ADVISORS LLC | 1,253,250 | 815,722 | -437,528 | 0.11 | 0.07 | -0.04 | sell |
| Integral Health Asset Management, LLC | 1,775,000 | 1,000,000 | -775,000 | 0.64 | 0.48 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,791,310 | 9,715,013 | -2,076,297 | 0.08 | 0.07 | -0.01 | sell |