| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 7,880,882 | 12,345,866 | +4,464,984 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 0 | 2,347,825 | +2,347,825 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,201,705 | 5,394,691 | +2,192,986 | 0.01 | 0.02 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 4,401,371 | 5,097,779 | +696,408 | 0.74 | 0.84 | +0.10 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 677,000 | 1,260,700 | +583,700 | 2.05 | 4.20 | +2.14 | buy |
| Eversept Partners, LP | 496,171 | 777,890 | +281,719 | 0.14 | 0.25 | +0.11 | buy |
| Rock Springs Capital Management LP | 9,283,492 | 9,534,170 | +250,678 | 1.01 | 1.27 | +0.27 | buy |
| JANE STREET GROUP, LLC | 0 | 214,635 | +214,635 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 2,615,458 | 2,829,990 | +214,532 | 3.43 | 5.55 | +2.12 | buy |
| Atle Fund Management AB | 0 | 200,000 | +200,000 | 0.00 | 0.39 | +0.39 | buy |
| Hudson Bay Capital Management LP | 0 | 175,000 | +175,000 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 84,018 | 217,557 | +133,539 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 236,000 | 331,000 | +95,000 | 0.34 | 0.48 | +0.14 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 67,069 | +67,069 | 0.00 | 0.02 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 49,304 | 102,582 | +53,278 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 145,800 | 198,300 | +52,500 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 0 | 47,561 | +47,561 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 348,128 | 384,535 | +36,407 | 0.63 | 0.66 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 32,814 | +32,814 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 227,890 | 254,890 | +27,000 | 0.03 | 0.05 | +0.01 | buy |
| Qube Research & Technologies Ltd | 33,287 | 49,687 | +16,400 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 12,699 | +12,699 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 6,765 | 10,693 | +3,928 | 0.00 | 0.00 | +0.00 | buy |
| GPS Wealth Strategies Group, LLC | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 645 | +645 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 6,958 | 7,273 | +315 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,621 | 14,769 | +148 | 0.00 | 0.00 | +0.00 | buy |
| Cranbrook Wealth Management, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| GeoWealth Management, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,710,429 | 6,710,429 | 0 | 0.40 | 0.41 | +0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 92,156 | 92,156 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,698,100 | 4,698,100 | 0 | 0.09 | 0.11 | +0.02 | hold |
| Knoll Capital Management, LLC | 260,470 | 260,470 | 0 | 0.63 | 0.50 | -0.14 | hold |
| SIGNATUREFD, LLC | 679 | 679 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clear Harbor Asset Management, LLC | 43,500 | 43,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Allworth Financial LP | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rubric Capital Management LP | 15,307,347 | 15,307,347 | 0 | 1.45 | 1.03 | -0.42 | hold |
| OneDigital Investment Advisors LLC | 18,300 | 18,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Centiva Capital, LP | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BFSG, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Artia Global Partners LP | 421,359 | 421,359 | 0 | 0.39 | 0.49 | +0.10 | hold |
| New England Capital Financial Advisors LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFG Investments, LLC | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 38 | 38 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 54,000 | 54,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIT INVESTMENT ASSOCIATES INC | 970 | 970 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 28,577 | 28,577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Plante Moran Financial Advisors, LLC | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 398 | 0 | -398 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 36,231 | 33,800 | -2,431 | 0.06 | 0.07 | +0.00 | sell |
| Ariadne Wealth Management, LP | 3,499 | 0 | -3,499 | 0.20 | 0.00 | -0.20 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,524 | 0 | -4,524 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 27,297 | 20,825 | -6,472 | 0.00 | 0.00 | -0.00 | sell |
| Advisors Preferred, LLC | 24,813 | 18,188 | -6,625 | 0.02 | 0.01 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 41,393 | 33,855 | -7,538 | 0.00 | 0.00 | -0.00 | sell |
| Newbridge Financial Services Group, Inc. | 11,700 | 0 | -11,700 | 0.02 | 0.00 | -0.02 | sell |
| RWA WEALTH PARTNERS, LLC | 12,550 | 0 | -12,550 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 13,926 | 0 | -13,926 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 14,152 | 0 | -14,152 | 0.00 | 0.00 | -0.00 | sell |
| Golden State Equity Partners | 24,800 | 6,500 | -18,300 | 0.02 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 20,535 | 1,403 | -19,132 | 0.00 | 0.00 | -0.00 | sell |
| MANGROVE PARTNERS IM, LLC | 8,752,893 | 8,729,720 | -23,173 | 2.42 | 3.08 | +0.67 | sell |
| ADAR1 Capital Management, LLC | 55,400 | 10,000 | -45,400 | 0.04 | 0.01 | -0.03 | sell |
| Blue Owl Capital Holdings LP | 897,809 | 847,809 | -50,000 | 0.90 | 0.68 | -0.22 | sell |
| TWO SIGMA INVESTMENTS, LP | 201,776 | 134,313 | -67,463 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 73,168 | 0 | -73,168 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 75,000 | 0 | -75,000 | 0.01 | 0.00 | -0.01 | sell |
| Clearline Capital LP | 3,326,718 | 3,244,334 | -82,384 | 1.05 | 1.18 | +0.13 | sell |
| MARSHALL WACE, LLP | 1,144,051 | 1,028,512 | -115,539 | 0.01 | 0.01 | -0.00 | sell |
| Verition Fund Management LLC | 226,494 | 110,004 | -116,490 | 0.01 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 959,467 | 835,194 | -124,273 | 0.14 | 0.10 | -0.04 | sell |
| 683 Capital Management, LLC | 5,000,000 | 4,849,800 | -150,200 | 1.89 | 2.03 | +0.14 | sell |
| CANTOR FITZGERALD, L. P. | 275,000 | 0 | -275,000 | 0.20 | 0.00 | -0.20 | sell |
| CITADEL ADVISORS LLC | 408,989 | 130,258 | -278,731 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 1,246,953 | 846,953 | -400,000 | 0.40 | 0.29 | -0.11 | sell |
| PERCEPTIVE ADVISORS LLC | 1,253,250 | 815,722 | -437,528 | 0.11 | 0.07 | -0.04 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 840,264 | 386,430 | -453,834 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,762,003 | 1,305,371 | -456,632 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,507,513 | 2,008,381 | -499,132 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 1,775,000 | 1,000,000 | -775,000 | 0.64 | 0.48 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,791,310 | 9,715,013 | -2,076,297 | 0.08 | 0.07 | -0.01 | sell |