| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 4,239,577 | 4,904,513 | +664,936 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,680,716 | 4,791,244 | +110,528 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 4,728,782 | 4,779,269 | +50,487 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 1,037,282 | 2,883,657 | +1,846,375 | 0.22 | 0.50 | +0.29 | buy |
| Point72 Asset Management, L.P. | 768,750 | 1,914,932 | +1,146,182 | 0.04 | 0.10 | +0.06 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,594,609 | 1,621,409 | +26,800 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,634,805 | 1,201,021 | -433,784 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,142,169 | 1,171,968 | +29,799 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,185,944 | 1,151,128 | -34,816 | 0.01 | 0.01 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 957,304 | 957,304 | 0 | 0.84 | 0.76 | -0.07 | hold |
| MORGAN STANLEY | 701,395 | 874,882 | +173,487 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 869,790 | 869,790 | 0 | 4.64 | 2.20 | -2.44 | hold |
| BNP Paribas Asset Management Holding S.A. | 539,727 | 685,025 | +145,298 | 0.03 | 0.03 | +0.01 | buy |
| Laurion Capital Management LP | 0 | 547,474 | +547,474 | 0.00 | 0.29 | +0.29 | buy |
| NORTHERN TRUST CORP | 524,689 | 513,498 | -11,191 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 472,182 | 493,276 | +21,094 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 417,754 | 400,169 | -17,585 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 228,996 | 390,299 | +161,303 | 0.02 | 0.04 | +0.01 | buy |
| MACQUARIE GROUP LTD | 379,100 | 379,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 398,666 | 378,063 | -20,603 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 275,924 | 354,921 | +78,997 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 251,404 | 339,667 | +88,263 | 0.02 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 127,231 | 316,127 | +188,896 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,777 | 315,051 | +198,274 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 230,777 | 296,570 | +65,793 | 0.15 | 0.20 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 332,814 | 289,965 | -42,849 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 113,073 | 263,277 | +150,204 | 0.01 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 247,664 | 259,920 | +12,256 | 0.67 | 0.60 | -0.07 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 205,428 | 259,372 | +53,944 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 592,291 | 250,313 | -341,978 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 123,500 | 240,500 | +117,000 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 240,000 | 240,000 | 0 | 0.07 | 0.07 | -0.00 | hold |
| AXA S.A. | 232,009 | 232,072 | +63 | 0.01 | 0.01 | -0.00 | buy |
| DAFNA Capital Management LLC | 232,717 | 231,717 | -1,000 | 1.07 | 1.00 | -0.07 | sell |
| UBS Group AG | 162,484 | 208,729 | +46,245 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 204,398 | 204,398 | 0 | 0.16 | 0.16 | -0.00 | hold |
| Invesco Ltd. | 192,630 | 190,683 | -1,947 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 202,893 | 187,871 | -15,022 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 139,170 | 174,655 | +35,485 | 0.04 | 0.04 | +0.00 | buy |
| RHUMBLINE ADVISERS | 171,338 | 172,673 | +1,335 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 170,000 | 165,000 | -5,000 | 0.03 | 0.03 | -0.00 | sell |
| Legal & General Group Plc | 148,930 | 150,252 | +1,322 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 164,892 | 149,552 | -15,340 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 111,846 | 111,846 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 230,820 | 103,860 | -126,960 | 0.04 | 0.02 | -0.02 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 99,751 | 99,751 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allianz Asset Management GmbH | 23,300 | 98,300 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 14,974 | 97,152 | +82,178 | 0.03 | 0.17 | +0.14 | buy |
| Swiss National Bank | 95,396 | 95,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 97,435 | 93,635 | -3,800 | 0.80 | 0.69 | -0.11 | sell |
| Parallel Advisors, LLC | 85,732 | 85,807 | +75 | 0.05 | 0.04 | -0.00 | buy |
| NORGES BANK | 79,824 | 79,824 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 104,413 | 75,326 | -29,087 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 331,490 | 74,909 | -256,581 | 0.01 | 0.00 | -0.01 | sell |
| GROUP ONE TRADING LLC | 56,370 | 74,840 | +18,470 | 0.03 | 0.05 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 75,187 | 73,498 | -1,689 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 67,542 | +67,542 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 53,246 | 64,122 | +10,876 | 0.03 | 0.03 | +0.00 | buy |
| ALPS ADVISORS INC | 52,471 | 64,090 | +11,619 | 0.01 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 62,255 | 63,305 | +1,050 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 81,048 | 58,258 | -22,790 | 0.06 | 0.04 | -0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 51,759 | 57,898 | +6,139 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 57,265 | +57,265 | 0.00 | 0.08 | +0.08 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56,346 | 56,222 | -124 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 43,165 | 54,430 | +11,265 | 0.04 | 0.04 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 33,600 | 50,800 | +17,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,988 | 49,157 | -2,831 | 0.00 | 0.00 | -0.00 | sell |
| TEXAS PERMANENT SCHOOL FUND CORP | 46,539 | 47,086 | +547 | 0.01 | 0.01 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 48,026 | 46,895 | -1,131 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 46,426 | 46,426 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 79,888 | 40,226 | -39,662 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 47,253 | 39,731 | -7,522 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 43,537 | 38,117 | -5,420 | 0.02 | 0.01 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 62,894 | 37,496 | -25,398 | 0.11 | 0.06 | -0.05 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 110,366 | 35,640 | -74,726 | 0.00 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 35,590 | +35,590 | 0.00 | 0.11 | +0.11 | buy |
| Cresset Asset Management, LLC | 34,214 | 34,848 | +634 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 32,858 | 34,764 | +1,906 | 0.00 | 0.00 | -0.00 | buy |
| State of Alaska, Department of Revenue | 33,158 | 32,931 | -227 | 0.01 | 0.01 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 30,654 | 32,356 | +1,702 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 32,190 | +32,190 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 35,497 | 31,445 | -4,052 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,883 | 30,245 | +11,362 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 29,266 | 29,014 | -252 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 28,217 | 28,303 | +86 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 28,134 | 28,134 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,731 | 27,735 | +1,004 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 27,000 | 26,800 | -200 | 0.01 | 0.01 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 29,886 | 26,335 | -3,551 | 0.00 | 0.00 | -0.00 | sell |
| YOUSIF CAPITAL MANAGEMENT, LLC | 27,094 | 24,639 | -2,455 | 0.01 | 0.01 | -0.00 | sell |
| Pennant Investors, LP | 23,700 | 23,700 | 0 | 0.14 | 0.12 | -0.02 | hold |
| COMERICA BANK | 25,153 | 22,399 | -2,754 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 19,080 | 21,416 | +2,336 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,300 | 20,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 20,529 | 19,825 | -704 | 0.01 | 0.01 | -0.00 | sell |
| Maryland State Retirement & Pension System | 19,758 | 19,758 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 16,438 | 19,369 | +2,931 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 18,286 | 18,256 | -30 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 31,621 | 17,968 | -13,653 | 0.00 | 0.00 | -0.00 | sell |