| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 576,156 | 2,560,904 | +1,984,748 | 0.32 | 0.81 | +0.50 | buy |
| Woodline Partners LP | 3,523,937 | 5,127,304 | +1,603,367 | 0.36 | 0.26 | -0.09 | buy |
| GILEAD SCIENCES, INC. | 30,061,124 | 31,424,760 | +1,363,636 | 28.86 | 20.88 | -7.97 | buy |
| VANGUARD GROUP INC | 5,389,216 | 6,687,800 | +1,298,584 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 9,694,262 | 10,867,091 | +1,172,829 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,136,364 | +1,136,364 | 0.00 | 0.15 | +0.15 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,082,808 | +1,082,808 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 1,037,776 | +1,037,776 | 0.00 | 0.61 | +0.61 | buy |
| Point72 Asset Management, L.P. | 1,996,279 | 2,867,097 | +870,818 | 0.08 | 0.06 | -0.02 | buy |
| Cutter Capital Management, LP | 0 | 731,818 | +731,818 | 0.00 | 2.50 | +2.50 | buy |
| STATE STREET CORP | 2,993,729 | 3,696,479 | +702,750 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 465,304 | 972,157 | +506,853 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 443,453 | 914,208 | +470,755 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,052,521 | 4,456,846 | +404,325 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 254,217 | 625,126 | +370,909 | 0.96 | 1.39 | +0.43 | buy |
| MILLENNIUM MANAGEMENT LLC | 924,369 | 1,194,622 | +270,253 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 549,914 | 787,080 | +237,166 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 170,000 | 368,550 | +198,550 | 0.02 | 0.02 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 18,500 | 204,000 | +185,500 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,209,613 | 1,389,232 | +179,619 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 165,474 | +165,474 | 0.00 | 0.10 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 146,686 | 298,424 | +151,738 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 137,638 | +137,638 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 579,623 | 714,002 | +134,379 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 346,093 | 479,590 | +133,497 | 0.22 | 0.19 | -0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 71,550 | 196,251 | +124,701 | 0.08 | 0.14 | +0.06 | buy |
| MARSHALL WACE, LLP | 0 | 112,051 | +112,051 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,521,784 | 1,628,019 | +106,235 | 0.06 | 0.03 | -0.02 | buy |
| CITIGROUP INC | 106,695 | 209,922 | +103,227 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 160,145 | 251,571 | +91,426 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 12,578 | 102,658 | +90,080 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 180,122 | 269,032 | +88,910 | 0.06 | 0.05 | -0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 83,997 | +83,997 | 0.00 | 0.07 | +0.07 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 135,030 | 213,372 | +78,342 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 75,711 | +75,711 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 263,517 | 334,981 | +71,464 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 113,038 | 182,731 | +69,693 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 29,953 | 96,724 | +66,771 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 58,800 | 124,100 | +65,300 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 25,700 | 90,954 | +65,254 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 56,041 | +56,041 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 54,582 | +54,582 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 218,930 | 273,123 | +54,193 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 15,337 | 69,469 | +54,132 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 76,646 | 128,688 | +52,042 | 0.03 | 0.02 | -0.00 | buy |
| Invesco Ltd. | 203,987 | 254,024 | +50,037 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 30,202 | 77,209 | +47,007 | 0.07 | 0.03 | -0.04 | buy |
| WINTON GROUP Ltd | 72,310 | 115,595 | +43,285 | 0.07 | 0.06 | -0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 72,510 | 113,260 | +40,750 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 532,099 | 570,042 | +37,943 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 149,207 | 185,559 | +36,352 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 62,014 | 97,423 | +35,409 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 98,296 | 133,596 | +35,300 | 0.00 | 0.00 | -0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 0 | 34,914 | +34,914 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 77,682 | 112,326 | +34,644 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,254 | 108,439 | +34,185 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 15,742 | 48,278 | +32,536 | 0.00 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 31,414 | +31,414 | 0.00 | 0.02 | +0.02 | buy |
| Capula Management Ltd | 0 | 29,053 | +29,053 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 159,264 | 182,909 | +23,645 | 0.00 | 0.00 | -0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 22,420 | +22,420 | 0.00 | 0.08 | +0.08 | buy |
| Bank of New York Mellon Corp | 381,615 | 401,570 | +19,955 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,702,302 | 1,722,083 | +19,781 | 0.01 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 225,167 | 244,308 | +19,141 | 0.05 | 0.03 | -0.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 25,000 | 44,000 | +19,000 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,674 | 42,603 | +17,929 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 17,631 | +17,631 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,985 | +16,985 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 45,718 | 62,340 | +16,622 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 360,594 | 377,098 | +16,504 | 0.00 | 0.00 | -0.00 | buy |
| Marex Group plc | 14,000 | 29,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 14,200 | +14,200 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,155 | 39,310 | +13,155 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 13,025 | +13,025 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 18,038 | 31,038 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 6,887 | 19,756 | +12,869 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 12,065 | +12,065 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 12,000 | +12,000 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 10,899 | +10,899 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 10,498 | +10,498 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 42,968 | 53,466 | +10,498 | 0.01 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 10,452 | +10,452 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 55,305 | 65,735 | +10,430 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 9,572 | +9,572 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 43,351 | 52,719 | +9,368 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 97,764 | 106,170 | +8,406 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 131,064 | 139,347 | +8,283 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 17,121 | 25,158 | +8,037 | 0.01 | 0.01 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 41,733 | 49,429 | +7,696 | 0.00 | 0.00 | -0.00 | buy |
| State of Alaska, Department of Revenue | 30,600 | 37,288 | +6,688 | 0.01 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 11,952 | 18,405 | +6,453 | 0.00 | 0.00 | -0.00 | buy |
| Louisiana State Employees Retirement System | 26,100 | 31,700 | +5,600 | 0.01 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 14,594 | 19,604 | +5,010 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 13,534 | 18,434 | +4,900 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 927 | 5,764 | +4,837 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 18,614 | 23,298 | +4,684 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 11,526 | 16,104 | +4,578 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 9,909 | 13,922 | +4,013 | 0.00 | 0.00 | -0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 20,936 | 24,829 | +3,893 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 78 | 3,721 | +3,643 | 0.00 | 0.00 | +0.00 | buy |