| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 31,424,760 | 31,424,760 | 0 | 38.69 | 32.05 | -6.64 | hold |
| BlackRock, Inc. | 14,997,891 | 15,226,475 | +228,584 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,184,509 | 6,089,516 | +905,007 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 4,576,969 | 5,412,901 | +835,932 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,188,858 | 5,030,993 | -157,865 | 3.08 | 2.95 | -0.14 | sell |
| Woodline Partners LP | 3,769,788 | 3,777,798 | +8,010 | 0.35 | 0.31 | -0.04 | buy |
| MARSHALL WACE, LLP | 3,387,794 | 3,761,437 | +373,643 | 0.08 | 0.09 | +0.01 | buy |
| Siren, L.L.C. | 3,007,077 | 3,007,077 | 0 | 2.14 | 1.80 | -0.34 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,907,345 | 2,252,367 | +345,022 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 1,949,788 | 2,190,404 | +240,616 | 0.02 | 0.02 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 1,604,270 | 1,908,412 | +304,142 | 0.61 | 0.71 | +0.10 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,687,374 | 1,654,754 | -32,620 | 0.05 | 0.04 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,524,157 | 1,426,223 | -97,934 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 104,701 | 1,329,935 | +1,225,234 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 968,602 | 1,207,274 | +238,672 | 2.20 | 2.70 | +0.51 | buy |
| Logos Global Management LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 1.33 | +1.33 | buy |
| FMR LLC | 1,135,178 | 1,165,252 | +30,074 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,210,754 | 1,113,526 | -97,228 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,168,437 | 999,786 | -168,651 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 1,096,705 | 923,086 | -173,619 | 1.13 | 1.00 | -0.13 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 968,241 | 903,638 | -64,603 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 794,798 | 840,305 | +45,507 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 414,365 | 820,820 | +406,455 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 790,613 | 790,613 | 0 | 0.09 | 0.09 | -0.01 | hold |
| Aberdeen Group plc | 384,601 | 769,787 | +385,186 | 0.01 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,000,818 | 646,068 | -354,750 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 504,462 | 511,166 | +6,704 | 0.00 | 0.00 | -0.00 | buy |
| Decheng Capital LLC | 541,559 | 477,819 | -63,740 | 1.74 | 1.56 | -0.18 | sell |
| Soleus Capital Management, L.P. | 711,983 | 451,983 | -260,000 | 0.72 | 0.40 | -0.32 | sell |
| DAFNA Capital Management LLC | 431,329 | 443,829 | +12,500 | 2.39 | 2.18 | -0.21 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 929,981 | 430,346 | -499,635 | 0.09 | 0.04 | -0.05 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 32,700 | 424,700 | +392,000 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 270,000 | 415,621 | +145,621 | 0.04 | 0.05 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 407,513 | 413,778 | +6,265 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 388,338 | 388,338 | 0 | 0.60 | 0.50 | -0.10 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 424,071 | 381,856 | -42,215 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 240,000 | 356,535 | +116,535 | 0.03 | 0.05 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 139,631 | 312,690 | +173,059 | 0.00 | 0.01 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 295,426 | 303,316 | +7,890 | 0.02 | 0.02 | -0.00 | buy |
| UBS Group AG | 411,259 | 288,857 | -122,402 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 203,268 | 281,681 | +78,413 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 85,570 | 259,400 | +173,830 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 252,933 | +252,933 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 227,146 | 241,492 | +14,346 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 239,966 | 239,966 | 0 | 0.09 | 0.08 | -0.01 | hold |
| DIADEMA PARTNERS LP | 0 | 238,142 | +238,142 | 0.00 | 2.12 | +2.12 | buy |
| Nuveen, LLC | 141,600 | 221,710 | +80,110 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 208,639 | 216,311 | +7,672 | 0.03 | 0.03 | -0.00 | buy |
| Patient Square Capital LP | 170,000 | 195,000 | +25,000 | 0.87 | 0.75 | -0.12 | buy |
| Schonfeld Strategic Advisors LLC | 97,283 | 193,561 | +96,278 | 0.01 | 0.03 | +0.02 | buy |
| Legal & General Group Plc | 205,203 | 188,650 | -16,553 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 180,000 | 180,000 | 0 | 0.22 | 0.23 | +0.01 | hold |
| Swiss National Bank | 167,996 | 171,296 | +3,300 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 225,913 | 160,082 | -65,831 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 144,093 | 158,292 | +14,199 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,865 | 143,371 | -198,494 | 0.01 | 0.00 | -0.01 | sell |
| Jump Financial, LLC | 0 | 135,800 | +135,800 | 0.00 | 0.04 | +0.04 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 134,217 | 134,217 | 0 | 0.74 | 0.73 | -0.01 | hold |
| Point72 Asset Management, L.P. | 3,280,000 | 129,273 | -3,150,727 | 0.12 | 0.00 | -0.12 | sell |
| ALLIANCEBERNSTEIN L.P. | 133,098 | 124,085 | -9,013 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 92,929 | 115,134 | +22,205 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 46,505 | 107,979 | +61,474 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 90,666 | 105,776 | +15,110 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 92,431 | 89,625 | -2,806 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 79,458 | 87,973 | +8,515 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 86,557 | 86,557 | 0 | 0.04 | 0.03 | -0.00 | hold |
| Tidal Investments LLC | 0 | 86,342 | +86,342 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 86,207 | 86,294 | +87 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 86,192 | +86,192 | 0.00 | 0.04 | +0.04 | buy |
| Knott David M Jr | 121,241 | 81,241 | -40,000 | 1.34 | 1.04 | -0.29 | sell |
| Man Group plc | 0 | 80,866 | +80,866 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 136,121 | 80,833 | -55,288 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 72,755 | 80,817 | +8,062 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,649 | 75,816 | +17,167 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 36,125 | 75,213 | +39,088 | 0.07 | 0.11 | +0.04 | buy |
| BARCLAYS PLC | 1,112,258 | 74,977 | -1,037,281 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 62,652 | 73,847 | +11,195 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 73,862 | 70,518 | -3,344 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 80,393 | 69,875 | -10,518 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 66,674 | +66,674 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 60,203 | +60,203 | 0.00 | 0.50 | +0.50 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,835 | 59,197 | +362 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 39,639 | 54,163 | +14,524 | 0.03 | 0.04 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,929 | 51,024 | +14,095 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.08 | 0.05 | -0.02 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,955 | 47,511 | +5,556 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 56,945 | 45,070 | -11,875 | 1.09 | 0.86 | -0.23 | sell |
| CANTOR FITZGERALD, L. P. | 0 | 45,000 | +45,000 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 43,434 | 44,809 | +1,375 | 0.01 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 42,338 | 42,338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,993 | 42,170 | +177 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 45,488 | 42,055 | -3,433 | 0.00 | 0.00 | -0.00 | sell |
| State of Alaska, Department of Revenue | 43,451 | 41,865 | -1,586 | 0.01 | 0.01 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 24,817 | 41,066 | +16,249 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 38,556 | +38,556 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 40,824 | 37,766 | -3,058 | 0.00 | 0.00 | -0.00 | sell |
| Louisiana State Employees Retirement System | 39,100 | 37,600 | -1,500 | 0.02 | 0.01 | -0.00 | sell |
| Illinois Municipal Retirement Fund | 0 | 36,233 | +36,233 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 99,318 | 35,725 | -63,593 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 29,143 | 34,219 | +5,076 | 0.02 | 0.02 | +0.00 | buy |