| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Aberdeen Group plc | 384,601 | 769,787 | +385,186 | 0.01 | 0.03 | +0.01 | buy |
| SAMLYN CAPITAL, LLC | 1,604,270 | 1,908,412 | +304,142 | 0.61 | 0.71 | +0.10 | buy |
| Parkman Healthcare Partners LLC | 968,602 | 1,207,274 | +238,672 | 2.20 | 2.70 | +0.51 | buy |
| BAKER BROS. ADVISORS LP | 270,000 | 415,621 | +145,621 | 0.04 | 0.05 | +0.01 | buy |
| Patient Square Capital LP | 170,000 | 195,000 | +25,000 | 0.87 | 0.75 | -0.12 | buy |
| DAFNA Capital Management LLC | 431,329 | 443,829 | +12,500 | 2.39 | 2.18 | -0.21 | buy |
| SummitTX Capital, L.P. | 29,143 | 34,219 | +5,076 | 0.02 | 0.02 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,987 | 14,473 | +3,486 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 56,945 | 45,070 | -11,875 | 1.09 | 0.86 | -0.23 | sell |
| Knott David M Jr | 121,241 | 81,241 | -40,000 | 1.34 | 1.04 | -0.29 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,188,858 | 5,030,993 | -157,865 | 3.08 | 2.95 | -0.14 | sell |
| Sofinnova Investments, Inc. | 1,096,705 | 923,086 | -173,619 | 1.13 | 1.00 | -0.13 | sell |
| Soleus Capital Management, L.P. | 711,983 | 451,983 | -260,000 | 0.72 | 0.40 | -0.32 | sell |