| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 2,883,657 | 4,245,221 | +1,361,564 | 0.50 | 0.62 | +0.12 | buy |
| Parkman Healthcare Partners LLC | 259,920 | 415,535 | +155,615 | 0.60 | 0.85 | +0.25 | buy |
| Granahan Investment Management, LLC | 296,570 | 379,847 | +83,277 | 0.20 | 0.23 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 685,025 | 744,298 | +59,273 | 0.03 | 0.03 | -0.01 | buy |
| PROFUND ADVISORS LLC | 54,430 | 19,737 | +34,693 | 0.04 | 0.01 | 0.00 | sell |
| NEOS Investment Management LLC | 11,477 | 34,606 | +23,129 | 0.01 | 0.02 | +0.01 | buy |
| DAFNA Capital Management LLC | 231,717 | 253,217 | +21,500 | 1.00 | 0.92 | -0.07 | buy |
| ALGERT GLOBAL LLC | 58,258 | 76,257 | +17,999 | 0.04 | 0.04 | 0.00 | buy |
| ALPS ADVISORS INC | 64,090 | 70,948 | +6,858 | 0.01 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56,222 | 58,173 | +1,951 | 0.00 | 0.00 | -0.00 | buy |
| WINTON GROUP Ltd | 57,265 | 59,137 | +1,872 | 0.08 | 0.06 | -0.02 | buy |
| Diversified Trust Co | 12,078 | 13,545 | +1,467 | 0.01 | 0.01 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 64,122 | 65,187 | +1,065 | 0.09 | 0.06 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,911 | 5,325 | +414 | 0.05 | 0.04 | -0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 12,817 | 12,712 | -105 | 0.04 | 0.03 | -0.01 | sell |
| Hudson Bay Capital Management LP | 165,000 | 160,000 | -5,000 | 0.02 | 0.01 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 93,635 | 78,385 | -15,250 | 0.69 | 0.49 | -0.21 | sell |
| PDT Partners, LLC | 97,152 | 73,265 | -23,887 | 0.17 | 0.11 | -0.07 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 259,372 | 223,951 | -35,421 | 0.01 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 174,655 | 138,027 | -36,628 | 0.04 | 0.03 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 204,398 | 153,783 | -50,615 | 0.16 | 0.09 | -0.06 | sell |
| Laurion Capital Management LP | 547,474 | 436,533 | -110,941 | 0.09 | 0.08 | -0.01 | sell |
| Rafferty Asset Management, LLC | 339,667 | 95,792 | -243,875 | 0.02 | 0.01 | -0.02 | sell |