| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 2,867,097 | 5,966,664 | +3,099,567 | 0.06 | 0.11 | +0.05 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,560,904 | 3,688,858 | +1,127,954 | 0.81 | 1.13 | +0.32 | buy |
| MORGAN STANLEY | 787,080 | 1,469,804 | +682,724 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 10,867,091 | 11,457,979 | +590,888 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 104,602 | 482,089 | +377,487 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.23 | +0.23 | buy |
| PDT Partners, LLC | 90,298 | 389,287 | +298,989 | 0.05 | 0.18 | +0.13 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 247,966 | +247,966 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 251,571 | 497,619 | +246,048 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108,439 | 348,460 | +240,021 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 377,098 | 611,195 | +234,097 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 26,870 | 257,270 | +230,400 | 0.16 | 1.38 | +1.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,389,232 | 1,596,329 | +207,097 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 77,209 | 282,671 | +205,462 | 0.03 | 0.09 | +0.06 | buy |
| Jain Global LLC | 0 | 199,963 | +199,963 | 0.00 | 0.03 | +0.03 | buy |
| Sofinnova Investments, Inc. | 1,037,776 | 1,216,016 | +178,240 | 0.61 | 0.67 | +0.06 | buy |
| TWO SIGMA ADVISERS, LP | 124,100 | 295,800 | +171,700 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 204,000 | 368,100 | +164,100 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 162,812 | +162,812 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 75,711 | 199,649 | +123,938 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 122,827 | +122,827 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 570,042 | 691,247 | +121,205 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 298,424 | 408,195 | +109,771 | 0.01 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,764 | 101,200 | +95,436 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 84,049 | +84,049 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 401,570 | 484,053 | +82,483 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 97,423 | 173,598 | +76,175 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 71,856 | +71,856 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 54,582 | 126,259 | +71,677 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 182,731 | 246,670 | +63,939 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,002 | 776,742 | +62,740 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 368,550 | 430,000 | +61,450 | 0.02 | 0.02 | +0.00 | buy |
| Knott David M Jr | 12,000 | 70,000 | +58,000 | 0.04 | 0.26 | +0.21 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 49,457 | 99,457 | +50,000 | 0.01 | 0.02 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 273,123 | 319,899 | +46,776 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 15,251 | 59,662 | +44,411 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 15,251 | 59,662 | +44,411 | 0.04 | 0.13 | +0.09 | buy |
| Trexquant Investment LP | 215,366 | 258,937 | +43,571 | 0.02 | 0.02 | +0.00 | buy |
| XTX Topco Ltd | 0 | 35,998 | +35,998 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 0 | 28,858 | +28,858 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 182,909 | 210,355 | +27,446 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 22,067 | +22,067 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 209,922 | 229,298 | +19,376 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 213,372 | 231,024 | +17,652 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 90,954 | 108,299 | +17,345 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 10,251 | 27,362 | +17,111 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 15,603 | +15,603 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 13,285 | +13,285 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 12,796 | +12,796 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 11,972 | +11,972 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 479,590 | 490,613 | +11,023 | 0.19 | 0.16 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 39,191 | 49,794 | +10,603 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 34,071 | 44,369 | +10,298 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 6,396 | 15,766 | +9,370 | 0.01 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 33,011 | 41,462 | +8,451 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 113,260 | 121,439 | +8,179 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 13,900 | 21,900 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 7,991 | +7,991 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 52,719 | 60,662 | +7,943 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 7,597 | +7,597 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 52,150 | 59,252 | +7,102 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,312 | 36,776 | +6,464 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,973 | 8,449 | +5,476 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,572 | 42,842 | +5,270 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,248 | 16,672 | +4,424 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 65,735 | 70,010 | +4,275 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 18,434 | 22,554 | +4,120 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 69,469 | 73,309 | +3,840 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,631 | 5,441 | +3,810 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 42,603 | 45,782 | +3,179 | 0.00 | 0.00 | -0.00 | buy |
| State of Alaska, Department of Revenue | 37,288 | 40,322 | +3,034 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 625,126 | 627,626 | +2,500 | 1.39 | 1.41 | +0.02 | buy |
| ProShare Advisors LLC | 13,046 | 15,365 | +2,319 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,242 | 7,038 | +1,796 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 86,585 | 88,007 | +1,422 | 0.02 | 0.01 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 16,104 | 17,398 | +1,294 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 334,981 | 336,225 | +1,244 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 106,170 | 107,052 | +882 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,840 | 30,718 | +878 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 56 | 618 | +562 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,498 | 10,987 | +489 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,572 | 10,057 | +485 | 0.02 | 0.03 | +0.01 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 417 | +417 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 10,899 | 11,304 | +405 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 49,429 | 49,830 | +401 | 0.00 | 0.00 | +0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 24,829 | 25,203 | +374 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 231,608 | 231,978 | +370 | 0.01 | 0.01 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 736 | 1,038 | +302 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,341 | 47,636 | +295 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 15 | 304 | +289 | 0.00 | 0.00 | +0.00 | buy |
| HANTZ FINANCIAL SERVICES, INC. | 11 | 283 | +272 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 269 | +269 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 242 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 149 | 362 | +213 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 144 | 304 | +160 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 150 | +105 | 0.00 | 0.00 | +0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 15,381 | 15,481 | +100 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 91,331 | 91,431 | +100 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |