| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,560,904 | 3,688,858 | +1,127,954 | 0.75 | 0.91 | +0.16 | buy |
| PDT Partners, LLC | 90,298 | 389,287 | +298,989 | 0.05 | 0.18 | +0.13 | buy |
| SECTORAL ASSET MANAGEMENT INC | 26,870 | 257,270 | +230,400 | 0.16 | 1.38 | +1.22 | buy |
| ALGERT GLOBAL LLC | 269,032 | 77,656 | +191,376 | 0.05 | 0.01 | 0.00 | sell |
| Sofinnova Investments, Inc. | 1,037,776 | 1,216,016 | +178,240 | 0.53 | 0.61 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 196,251 | 116,461 | +79,790 | 0.16 | 0.08 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 128,688 | 52,975 | +75,713 | 0.08 | 0.02 | 0.00 | sell |
| Knott David M Jr | 12,000 | 70,000 | +58,000 | 0.04 | 0.26 | +0.21 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 273,123 | 319,899 | +46,776 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 15,251 | 59,662 | +44,411 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 15,251 | 59,662 | +44,411 | 0.04 | 0.13 | +0.09 | buy |
| ALPS ADVISORS INC | 77,107 | 57,086 | +20,021 | 0.00 | 0.00 | 0.00 | sell |
| Granahan Investment Management, LLC | 479,590 | 490,613 | +11,023 | 0.19 | 0.16 | -0.02 | buy |
| DAFNA Capital Management LLC | 625,126 | 627,626 | +2,500 | 1.39 | 1.41 | +0.02 | buy |
| E Fund Management Co., Ltd. | 10,498 | 10,987 | +489 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,572 | 10,057 | +485 | 0.02 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 25,158 | 23,070 | -2,088 | 0.01 | 0.01 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 44,000 | 36,200 | -7,800 | 0.00 | 0.00 | -0.00 | sell |
| Marex Group plc | 29,000 | 17,000 | -12,000 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 112,326 | 98,690 | -13,636 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 137,638 | 88,163 | -49,475 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 76,794 | 22,408 | -54,386 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 110,890 | 28,624 | -82,266 | 0.04 | 0.01 | -0.03 | sell |
| Parkman Healthcare Partners LLC | 1,215,629 | 599,610 | -616,019 | 1.13 | 0.56 | -0.57 | sell |
| Decheng Capital LLC | 808,789 | 160,000 | -648,789 | 1.78 | 0.20 | -1.58 | sell |
| Woodline Partners LP | 5,127,304 | 4,000,029 | -1,127,275 | 0.26 | 0.17 | -0.09 | sell |