| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 31,424,760 | 31,424,760 | 0 | 32.05 | 58.76 | +26.71 | hold |
| BlackRock, Inc. | 15,226,475 | 16,416,249 | +1,189,774 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 5,412,901 | 6,029,484 | +616,583 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,089,516 | 5,895,448 | -194,068 | 0.02 | 0.03 | +0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,030,993 | 4,776,423 | -254,570 | 2.95 | 3.09 | +0.15 | sell |
| FMR LLC | 1,165,252 | 4,049,757 | +2,884,505 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,329,935 | 3,135,057 | +1,805,122 | 0.02 | 0.06 | +0.04 | buy |
| Woodline Partners LP | 3,777,798 | 3,007,798 | -770,000 | 0.31 | 0.29 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,252,367 | 2,448,749 | +196,382 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 3,007,077 | 2,420,430 | -586,647 | 1.80 | 1.51 | -0.29 | sell |
| Fisher Asset Management, LLC | 2,190,404 | 2,139,396 | -51,008 | 0.02 | 0.02 | +0.00 | sell |
| MARSHALL WACE, LLP | 3,761,437 | 1,945,088 | -1,816,349 | 0.09 | 0.05 | -0.04 | sell |
| SAMLYN CAPITAL, LLC | 1,908,412 | 1,547,182 | -361,230 | 0.71 | 0.79 | +0.08 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,426,223 | 1,434,320 | +8,097 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,654,754 | 1,419,533 | -235,221 | 0.04 | 0.04 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 999,786 | 1,387,566 | +387,780 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 451,983 | 1,168,738 | +716,755 | 0.40 | 1.24 | +0.85 | buy |
| Sofinnova Investments, Inc. | 923,086 | 945,690 | +22,604 | 1.00 | 1.56 | +0.56 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 941,756 | +941,756 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 903,638 | 941,756 | +38,118 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 840,305 | 932,523 | +92,218 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 1,207,274 | 919,266 | -288,008 | 2.70 | 2.91 | +0.21 | sell |
| Invesco Ltd. | 820,820 | 845,233 | +24,413 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 415,621 | 844,816 | +429,195 | 0.05 | 0.13 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 646,068 | 835,504 | +189,436 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,113,526 | 795,912 | -317,614 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 790,613 | 661,981 | -128,632 | 0.09 | 0.09 | +0.00 | sell |
| Aberdeen Group plc | 769,787 | 650,712 | -119,075 | 0.03 | 0.03 | +0.00 | sell |
| Logos Global Management LP | 1,200,000 | 650,000 | -550,000 | 1.33 | 0.86 | -0.47 | sell |
| TWO SIGMA INVESTMENTS, LP | 312,690 | 635,404 | +322,714 | 0.01 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 589,546 | +589,546 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 511,166 | 543,009 | +31,843 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 430,346 | 512,084 | +81,738 | 0.04 | 0.06 | +0.02 | buy |
| Ikarian Capital, LLC | 0 | 504,559 | +504,559 | 0.00 | 2.55 | +2.55 | buy |
| Decheng Capital LLC | 477,819 | 464,779 | -13,040 | 1.56 | 1.96 | +0.40 | sell |
| DAFNA Capital Management LLC | 443,829 | 441,829 | -2,000 | 2.18 | 2.60 | +0.42 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 413,778 | 423,366 | +9,588 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 80,817 | 418,243 | +337,426 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 288,857 | 369,056 | +80,199 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 195,000 | 355,800 | +160,800 | 0.75 | 1.70 | +0.95 | buy |
| PDT Partners, LLC | 388,338 | 323,567 | -64,771 | 0.50 | 0.52 | +0.03 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 303,316 | 298,156 | -5,160 | 0.02 | 0.02 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 13,098 | 271,434 | +258,336 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 221,710 | 234,052 | +12,342 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 281,681 | 225,008 | -56,673 | 0.01 | 0.01 | -0.00 | sell |
| DIADEMA PARTNERS LP | 238,142 | 223,810 | -14,332 | 2.12 | 2.44 | +0.31 | sell |
| RHUMBLINE ADVISERS | 241,492 | 219,181 | -22,311 | 0.00 | 0.01 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 252,933 | 215,613 | -37,320 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 188,650 | 191,560 | +2,910 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 180,000 | 180,000 | 0 | 0.23 | 0.27 | +0.04 | hold |
| Swiss National Bank | 171,296 | 176,096 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 158,292 | 154,398 | -3,894 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 154,264 | +154,264 | 0.00 | 0.09 | +0.09 | buy |
| AMERIPRISE FINANCIAL INC | 160,082 | 153,813 | -6,269 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 381,856 | 153,109 | -228,747 | 0.01 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 0 | 152,129 | +152,129 | 0.00 | 0.41 | +0.41 | buy |
| Hudson Bay Capital Management LP | 356,535 | 140,000 | -216,535 | 0.05 | 0.02 | -0.03 | sell |
| Man Group plc | 80,866 | 137,763 | +56,897 | 0.00 | 0.01 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 134,217 | 134,217 | 0 | 0.73 | 1.02 | +0.29 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 133,110 | +133,110 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 124,085 | 126,975 | +2,890 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 193,561 | 122,574 | -70,987 | 0.03 | 0.02 | -0.01 | sell |
| CITIGROUP INC | 26,396 | 112,238 | +85,842 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 45,070 | 110,870 | +65,800 | 0.86 | 2.39 | +1.53 | buy |
| PRUDENTIAL FINANCIAL INC | 87,973 | 110,603 | +22,630 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,776 | 97,410 | -8,366 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 259,400 | 96,417 | -162,983 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 73,847 | 94,710 | +20,863 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 89,625 | 92,431 | +2,806 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 75,816 | 89,202 | +13,386 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 86,557 | 86,557 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Tidal Investments LLC | 86,342 | 85,126 | -1,216 | 0.01 | 0.01 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 86,294 | 83,861 | -2,433 | 0.00 | 0.00 | +0.00 | sell |
| TEMA ETFS LLC | 75,213 | 83,140 | +7,927 | 0.11 | 0.08 | -0.03 | buy |
| WELLS FARGO & COMPANY/MN | 35,725 | 82,913 | +47,188 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 82,458 | +82,458 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 59,197 | 82,399 | +23,202 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 135,800 | 82,036 | -53,764 | 0.04 | 0.02 | -0.02 | sell |
| Russell Investments Group, Ltd. | 80,833 | 81,442 | +609 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 81,241 | 81,241 | 0 | 1.04 | 1.32 | +0.28 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 69,875 | 78,718 | +8,843 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 115,134 | 71,725 | -43,409 | 0.01 | 0.01 | -0.01 | sell |
| CANADA LIFE ASSURANCE Co | 70,518 | 70,518 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caption Management, LLC | 16,033 | 62,000 | +45,967 | 0.02 | 0.07 | +0.05 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 60,494 | +60,494 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 60,000 | +60,000 | 0.00 | 0.06 | +0.06 | buy |
| Corient Private Wealth LLC | 24,143 | 59,127 | +34,984 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 51,024 | 59,021 | +7,997 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 17,295 | 57,255 | +39,960 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 60,203 | 57,048 | -3,155 | 0.50 | 0.55 | +0.05 | sell |
| RAYMOND JAMES FINANCIAL INC | 37,766 | 53,680 | +15,914 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 239,966 | 53,668 | -186,298 | 0.08 | 0.03 | -0.05 | sell |
| WINTON GROUP Ltd | 32,820 | 52,398 | +19,578 | 0.02 | 0.05 | +0.03 | buy |
| MetLife Investment Management, LLC | 44,809 | 52,110 | +7,301 | 0.00 | 0.01 | +0.00 | buy |
| Illinois Municipal Retirement Fund | 36,233 | 51,214 | +14,981 | 0.01 | 0.02 | +0.01 | buy |
| SummitTX Capital, L.P. | 34,219 | 50,463 | +16,244 | 0.02 | 0.04 | +0.02 | buy |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.05 | 0.06 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,511 | 49,526 | +2,015 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,170 | 45,826 | +3,656 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 54,163 | 39,532 | -14,631 | 0.04 | 0.03 | -0.01 | sell |