| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 31,424,760 | 31,424,760 | 0 | 19.98 | 23.86 | +3.88 | hold |
| BlackRock, Inc. | 11,457,979 | 11,810,866 | +352,887 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 6,556,243 | 6,629,453 | +73,210 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 5,966,664 | 4,332,479 | -1,634,185 | 0.11 | 0.13 | +0.01 | sell |
| Woodline Partners LP | 4,000,029 | 3,769,684 | -230,345 | 0.17 | 0.24 | +0.07 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,688,858 | 3,688,858 | 0 | 1.13 | 1.52 | +0.39 | hold |
| STATE STREET CORP | 3,630,815 | 3,394,854 | -235,961 | 0.00 | 0.00 | +0.00 | sell |
| Siren, L.L.C. | 1,612,077 | 2,912,077 | +1,300,000 | 0.68 | 1.55 | +0.87 | buy |
| FMR LLC | 2,573,294 | 2,296,021 | -277,273 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,596,329 | 1,598,409 | +2,080 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,469,804 | 1,536,088 | +66,284 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,659,879 | 1,502,463 | -157,416 | 0.00 | 0.00 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,395,726 | 1,419,985 | +24,259 | 0.03 | 0.05 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 497,619 | 1,360,781 | +863,162 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 936,021 | 1,266,289 | +330,268 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 1,216,016 | 1,222,263 | +6,247 | 0.67 | 1.02 | +0.35 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,136,364 | 1,136,364 | 0 | 0.16 | 0.19 | +0.03 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 805,305 | 1,120,062 | +314,757 | 0.03 | 0.06 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 648,074 | 950,589 | +302,515 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 776,742 | 871,150 | +94,408 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 88,163 | 729,153 | +640,990 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 691,247 | 707,796 | +16,549 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 599,610 | 652,680 | +53,070 | 0.56 | 0.97 | +0.41 | buy |
| MILLENNIUM MANAGEMENT LLC | 780,088 | 634,944 | -145,144 | 0.01 | 0.01 | +0.00 | sell |
| DAFNA Capital Management LLC | 627,626 | 627,626 | 0 | 1.41 | 2.11 | +0.70 | hold |
| Decheng Capital LLC | 160,000 | 547,609 | +387,609 | 0.20 | 1.30 | +1.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 408,195 | 471,522 | +63,327 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 484,053 | 470,210 | -13,843 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 490,613 | 455,596 | -35,017 | 0.16 | 0.25 | +0.09 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 348,460 | 389,141 | +40,681 | 0.00 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 389,287 | 388,338 | -949 | 0.18 | 0.33 | +0.15 | sell |
| MACQUARIE GROUP LTD | 379,100 | 379,100 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Candriam S.C.A. | 0 | 378,441 | +378,441 | 0.00 | 0.03 | +0.03 | buy |
| SECTORAL ASSET MANAGEMENT INC | 257,270 | 368,070 | +110,800 | 1.38 | 3.09 | +1.71 | buy |
| Hudson Bay Capital Management LP | 430,000 | 340,000 | -90,000 | 0.02 | 0.03 | +0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 336,225 | 334,524 | -1,701 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 0 | 331,671 | +331,671 | 0.00 | 0.01 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 319,899 | 328,459 | +8,560 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 611,195 | 295,054 | -316,141 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 251,851 | 292,404 | +40,553 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 295,800 | 285,400 | -10,400 | 0.00 | 0.01 | +0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 231,024 | 269,863 | +38,839 | 0.01 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 0.15 | +0.15 | buy |
| Susquehanna Portfolio Strategies, LLC | 247,966 | 239,966 | -8,000 | 0.04 | 0.05 | +0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 239,420 | +239,420 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 482,089 | 225,632 | -256,457 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 368,100 | 219,300 | -148,800 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 155,495 | 209,857 | +54,362 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 210,355 | 209,636 | -719 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 181,359 | 178,397 | -2,962 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 246,670 | 177,080 | -69,590 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 92,801 | 167,404 | +74,603 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 153,783 | 153,783 | 0 | 0.08 | 0.14 | +0.05 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 152,000 | +152,000 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 282,671 | 140,021 | -142,650 | 0.09 | 0.05 | -0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 121,439 | 137,189 | +15,750 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 121,296 | 133,496 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 122,827 | 130,449 | +7,622 | 0.03 | 0.05 | +0.02 | buy |
| Nuveen, LLC | 126,838 | 126,838 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 107,052 | 125,569 | +18,517 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 101,200 | 105,025 | +3,825 | 0.02 | 0.03 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 162,812 | 100,373 | -62,439 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 70,000 | 95,200 | +25,200 | 0.26 | 0.54 | +0.28 | buy |
| WINTON GROUP Ltd | 0 | 92,229 | +92,229 | 0.00 | 0.05 | +0.05 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 91,431 | 91,431 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HRT FINANCIAL LP | 0 | 89,997 | +89,997 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 88,007 | 88,007 | 0 | 0.01 | 0.02 | +0.01 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 173,598 | 87,771 | -85,827 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 86,058 | +86,058 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,590 | 84,023 | +77,433 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 108,299 | 83,777 | -24,522 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 77,656 | 82,950 | +5,294 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 47,966 | 82,229 | +34,263 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 76,919 | 75,486 | -1,433 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 70,010 | 70,265 | +255 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 98,690 | 69,649 | -29,041 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 49,794 | 68,316 | +18,522 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,636 | 64,002 | +16,366 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 60,662 | 63,942 | +3,280 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 59,252 | 59,252 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 57,086 | 52,624 | -4,462 | 0.00 | 0.00 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 49,830 | 49,909 | +79 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 44,369 | 49,342 | +4,973 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 53,928 | 48,894 | -5,034 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 41,573 | 48,336 | +6,763 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 258,937 | 47,593 | -211,344 | 0.02 | 0.01 | -0.02 | sell |
| Verition Fund Management LLC | 73,309 | 44,372 | -28,937 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 11,972 | 42,113 | +30,141 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 41,462 | 41,462 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 71,856 | 41,100 | -30,756 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 229,298 | 36,764 | -192,534 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 35,386 | 35,567 | +181 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,842 | 35,365 | -7,477 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,776 | 35,030 | -1,746 | 0.00 | 0.00 | +0.00 | sell |
| State of Alaska, Department of Revenue | 40,322 | 34,809 | -5,513 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 27,362 | 32,774 | +5,412 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 32,358 | +32,358 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 31,700 | 31,800 | +100 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 31,038 | 31,038 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,718 | 30,718 | 0 | 0.00 | 0.00 | +0.00 | hold |