| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 597,099 | 957,304 | +360,205 | 0.58 | 0.83 | +0.25 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 139,059 | 262,811 | +123,752 | 0.01 | 0.03 | +0.01 | buy |
| Hudson Bay Capital Management LP | 80,000 | 170,000 | +90,000 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 253,140 | 182,865 | +70,275 | 0.06 | 0.04 | 0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 21,138 | 90,873 | +69,735 | 0.04 | 0.16 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 464,450 | 515,453 | +51,003 | 0.02 | 0.03 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 99,412 | 53,246 | +46,166 | 0.05 | 0.07 | 0.00 | sell |
| Parkman Healthcare Partners LLC | 205,109 | 247,664 | +42,555 | 0.67 | 0.67 | -0.01 | buy |
| Granahan Investment Management, LLC | 195,599 | 230,777 | +35,178 | 0.13 | 0.15 | +0.02 | buy |
| BNP Paribas Asset Management Holding S.A. | 516,864 | 539,727 | +22,863 | 0.03 | 0.03 | +0.00 | buy |
| DAFNA Capital Management LLC | 222,717 | 232,717 | +10,000 | 1.24 | 1.07 | -0.18 | buy |
| ALGERT GLOBAL LLC | 72,018 | 81,048 | +9,030 | 0.06 | 0.06 | 0.00 | buy |
| PROFUND ADVISORS LLC | 51,071 | 43,165 | +7,906 | 0.05 | 0.04 | 0.00 | sell |
| Quarry LP | 4,972 | 1,000 | +3,972 | 0.06 | 0.01 | 0.00 | sell |
| Alpha DNA Investment Management LLC | 25,716 | 28,690 | +2,974 | 0.30 | 0.33 | +0.03 | buy |
| Mach-1 Financial Group, LLC | 22,774 | 25,314 | +2,540 | 0.17 | 0.18 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 5,042 | 5,251 | +209 | 0.05 | 0.06 | +0.01 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 518 | 523 | +5 | 0.01 | 0.01 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 20,538 | 20,529 | -9 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 75,968 | 75,187 | -781 | 0.01 | 0.01 | -0.00 | sell |
| E Fund Management Co., Ltd. | 15,038 | 13,501 | -1,537 | 0.02 | 0.02 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 58,126 | 56,346 | -1,780 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 54,951 | 52,471 | -2,480 | 0.01 | 0.01 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 19,826 | 15,418 | -4,408 | 0.11 | 0.08 | -0.03 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 211,784 | 205,428 | -6,356 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 292,708 | 251,404 | -41,304 | 0.03 | 0.02 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 238,532 | 139,170 | -99,362 | 0.07 | 0.04 | -0.03 | sell |
| Octagon Capital Advisors LP | 1,968,000 | 1,868,000 | -100,000 | 6.22 | 5.71 | -0.51 | sell |
| SECTORAL ASSET MANAGEMENT INC | 375,456 | 97,435 | -278,021 | 1.31 | 0.80 | -0.51 | sell |