| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BNP Paribas Asset Management Holding S.A. | 931,048 | 1,521,784 | +590,736 | 0.04 | 0.06 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 1,025,754 | 1,273,789 | +248,035 | 2.00 | 2.53 | +0.52 | buy |
| GSA CAPITAL PARTNERS LLP | 187,415 | 71,550 | +115,865 | 0.24 | 0.09 | 0.00 | sell |
| ALGERT GLOBAL LLC | 112,847 | 180,122 | +67,275 | 0.05 | 0.06 | 0.00 | buy |
| Woodline Partners LP | 3,478,440 | 3,523,937 | +45,497 | 0.45 | 0.35 | -0.09 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,862 | 76,646 | +44,784 | 0.04 | 0.09 | 0.00 | buy |
| PDT Partners, LLC | 87,636 | 125,752 | +38,116 | 0.12 | 0.17 | +0.05 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 14,894 | 30,202 | +15,308 | 0.03 | 0.07 | +0.04 | buy |
| ALPS ADVISORS INC | 68,362 | 73,995 | +5,633 | 0.01 | 0.01 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 213,684 | 218,930 | +5,246 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 10,322 | 14,279 | +3,957 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 68,580 | 72,310 | +3,730 | 0.07 | 0.07 | -0.00 | buy |
| PROFUND ADVISORS LLC | 18,720 | 17,121 | +1,599 | 0.01 | 0.01 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,424 | 4,143 | -1,281 | 0.04 | 0.03 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 80,889 | 78,544 | -2,345 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 256,717 | 254,217 | -2,500 | 0.93 | 0.96 | +0.03 | sell |
| Teza Capital Management LLC | 13,693 | 10,198 | -3,495 | 0.02 | 0.02 | +0.00 | sell |
| Hudson Bay Capital Management LP | 175,000 | 170,000 | -5,000 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 20,347 | 15,183 | -5,164 | 0.06 | 0.06 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 75,522 | 69,552 | -5,970 | 0.68 | 0.69 | +0.01 | sell |
| Rafferty Asset Management, LLC | 84,194 | 77,682 | -6,512 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 126,386 | 119,050 | -7,336 | 0.02 | 0.02 | -0.00 | sell |
| Granahan Investment Management, LLC | 357,838 | 346,093 | -11,745 | 0.22 | 0.22 | -0.00 | sell |
| NEOS Investment Management LLC | 36,938 | 22,233 | -14,705 | 0.02 | 0.01 | -0.01 | sell |
| Decheng Capital LLC | 869,790 | 808,789 | -61,001 | 3.15 | 2.58 | -0.57 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 663,603 | 576,156 | -87,447 | 0.32 | 0.29 | -0.03 | sell |
| Ikarian Capital, LLC | 744,000 | 378,363 | -365,637 | 1.59 | 0.77 | -0.82 | sell |