| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 31,424,760 | 31,424,760 | 0 | 23.86 | 38.69 | +14.83 | hold |
| BlackRock, Inc. | 11,810,866 | 14,997,891 | +3,187,025 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 6,629,453 | 7,962,874 | +1,333,421 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,688,858 | 5,188,858 | +1,500,000 | 1.52 | 3.08 | +1.56 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,266,289 | 5,184,509 | +3,918,220 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 3,394,854 | 4,576,969 | +1,182,115 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 3,769,684 | 3,769,788 | +104 | 0.24 | 0.35 | +0.11 | buy |
| MARSHALL WACE, LLP | 0 | 3,387,794 | +3,387,794 | 0.00 | 0.08 | +0.08 | buy |
| Point72 Asset Management, L.P. | 4,332,479 | 3,280,000 | -1,052,479 | 0.13 | 0.12 | -0.01 | sell |
| Siren, L.L.C. | 2,912,077 | 3,007,077 | +95,000 | 1.55 | 2.14 | +0.59 | buy |
| Fisher Asset Management, LLC | 729,153 | 1,949,788 | +1,220,635 | 0.00 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,598,409 | 1,907,345 | +308,936 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,419,985 | 1,687,374 | +267,389 | 0.05 | 0.05 | -0.00 | buy |
| SAMLYN CAPITAL, LLC | 0 | 1,604,270 | +1,604,270 | 0.00 | 0.61 | +0.61 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,502,463 | 1,524,157 | +21,694 | 0.00 | 0.01 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 1,484,699 | +1,484,699 | 0.00 | 0.06 | +0.06 | buy |
| MORGAN STANLEY | 1,536,088 | 1,210,754 | -325,334 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 950,589 | 1,168,437 | +217,848 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,296,021 | 1,135,178 | -1,160,843 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 177,080 | 1,112,258 | +935,178 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 1,222,263 | 1,096,705 | -125,558 | 1.02 | 1.13 | +0.11 | sell |
| BANK OF AMERICA CORP /DE/ | 1,360,781 | 1,000,818 | -359,963 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 652,680 | 968,602 | +315,922 | 0.97 | 2.20 | +1.22 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 871,150 | 968,241 | +97,091 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,120,062 | 929,981 | -190,081 | 0.06 | 0.09 | +0.03 | sell |
| FRANKLIN RESOURCES INC | 0 | 853,491 | +853,491 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 100,373 | 815,561 | +715,188 | 0.00 | 0.04 | +0.03 | buy |
| NORTHERN TRUST CORP | 707,796 | 794,798 | +87,002 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 378,441 | 790,613 | +412,172 | 0.03 | 0.09 | +0.07 | buy |
| Caption Management, LLC | 0 | 767,698 | +767,698 | 0.00 | 0.81 | +0.81 | buy |
| Soleus Capital Management, L.P. | 0 | 711,983 | +711,983 | 0.00 | 0.72 | +0.72 | buy |
| First Turn Management, LLC | 0 | 565,142 | +565,142 | 0.00 | 1.54 | +1.54 | buy |
| Decheng Capital LLC | 547,609 | 541,559 | -6,050 | 1.30 | 1.74 | +0.44 | sell |
| Bank of New York Mellon Corp | 470,210 | 504,462 | +34,252 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 627,626 | 431,329 | -196,297 | 2.11 | 2.39 | +0.28 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 84,023 | 424,071 | +340,048 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 292,404 | 414,365 | +121,961 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 167,404 | 411,259 | +243,855 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 334,524 | 407,513 | +72,989 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 388,338 | 388,338 | 0 | 0.33 | 0.60 | +0.27 | hold |
| Aberdeen Group plc | 331,671 | 384,601 | +52,930 | 0.01 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 389,141 | 341,865 | -47,276 | 0.01 | 0.01 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.51 | +0.51 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 269,863 | 295,426 | +25,563 | 0.01 | 0.02 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 270,000 | +270,000 | 0.00 | 0.04 | +0.04 | buy |
| Hudson Bay Capital Management LP | 340,000 | 240,000 | -100,000 | 0.03 | 0.03 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 239,966 | 239,966 | 0 | 0.05 | 0.09 | +0.04 | hold |
| RHUMBLINE ADVISERS | 209,636 | 227,146 | +17,510 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 209,857 | 225,913 | +16,056 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 208,639 | +208,639 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 178,397 | 205,203 | +26,806 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 204,338 | +204,338 | 0.00 | 0.35 | +0.35 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 86,058 | 203,268 | +117,210 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 180,000 | +180,000 | 0.00 | 0.22 | +0.22 | buy |
| Patient Square Capital LP | 0 | 170,000 | +170,000 | 0.00 | 0.87 | +0.87 | buy |
| Granahan Investment Management, LLC | 455,596 | 169,940 | -285,656 | 0.25 | 0.17 | -0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 634,944 | 168,876 | -466,068 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 133,496 | 167,996 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 87,771 | 144,093 | +56,322 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 142,518 | +142,518 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 126,838 | 141,600 | +14,762 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 471,522 | 139,631 | -331,891 | 0.01 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 82,229 | 136,121 | +53,892 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 153,783 | 134,217 | -19,566 | 0.14 | 0.74 | +0.60 | sell |
| ALLIANCEBERNSTEIN L.P. | 137,189 | 133,098 | -4,091 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 125,569 | 128,947 | +3,378 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 95,200 | 121,241 | +26,041 | 0.54 | 1.34 | +0.80 | buy |
| CITADEL ADVISORS LLC | 295,054 | 104,701 | -190,353 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 68,316 | 99,318 | +31,002 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 48,894 | 97,283 | +48,389 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 69,649 | 92,929 | +23,280 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 91,431 | 92,431 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,002 | 90,666 | +26,664 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 88,007 | 86,557 | -1,450 | 0.02 | 0.04 | +0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 83,777 | 86,207 | +2,430 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 19,871 | 85,570 | +65,699 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 49,909 | 80,393 | +30,484 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 70,265 | 79,458 | +9,193 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 59,252 | 73,862 | +14,610 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 63,942 | 72,755 | +8,813 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 48,336 | 62,652 | +14,316 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 92,229 | 62,251 | -29,978 | 0.05 | 0.05 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 140,021 | 60,614 | -79,407 | 0.05 | 0.07 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,718 | 58,835 | +28,117 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 49,342 | 58,649 | +9,307 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 368,070 | 56,945 | -311,125 | 3.09 | 1.09 | -2.00 | sell |
| Fort Baker Capital Management LP | 0 | 52,523 | +52,523 | 0.00 | 0.14 | +0.14 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.08 | +0.08 | buy |
| JANE STREET GROUP, LLC | 225,632 | 46,505 | -179,127 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 32,774 | 45,488 | +12,714 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 44,758 | +44,758 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 34,809 | 43,451 | +8,642 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 41,462 | 43,434 | +1,972 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,854 | 43,002 | +21,148 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 31,038 | 42,338 | +11,300 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,030 | 41,993 | +6,963 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,365 | 41,955 | +6,590 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 35,567 | 40,824 | +5,257 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 17,591 | 39,639 | +22,048 | 0.01 | 0.03 | +0.02 | buy |