| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,688,858 | 5,188,858 | +1,500,000 | 1.28 | 2.53 | +1.25 | buy |
| Candriam S.C.A. | 378,441 | 790,613 | +412,172 | 0.03 | 0.09 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 652,680 | 968,602 | +315,922 | 0.93 | 2.20 | +1.27 | buy |
| Siren, L.L.C. | 2,912,077 | 3,007,077 | +95,000 | 1.55 | 2.14 | +0.59 | buy |
| Aberdeen Group plc | 331,671 | 384,601 | +52,930 | 0.01 | 0.01 | +0.01 | buy |
| Knott David M Jr | 95,200 | 121,241 | +26,041 | 0.54 | 1.34 | +0.80 | buy |
| Rafferty Asset Management, LLC | 69,649 | 92,929 | +23,280 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 17,591 | 39,639 | +22,048 | 0.01 | 0.03 | 0.00 | buy |
| SummitTX Capital, L.P. | 17,554 | 29,143 | +11,589 | 0.01 | 0.02 | +0.01 | buy |
| NEOS Investment Management LLC | 30,293 | 36,665 | +6,372 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 30,293 | 36,125 | +5,832 | 0.03 | 0.07 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 12,169 | 12,356 | +187 | 0.05 | 0.08 | +0.03 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 23,985 | 23,216 | -769 | 0.00 | 0.00 | +0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 27,500 | 26,250 | -1,250 | 0.00 | 0.00 | +0.00 | sell |
| Decheng Capital LLC | 547,609 | 541,559 | -6,050 | 1.30 | 1.74 | +0.44 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 153,783 | 134,217 | -19,566 | 0.14 | 0.74 | +0.60 | sell |
| WINTON GROUP Ltd | 92,229 | 62,251 | -29,978 | 0.05 | 0.05 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 140,021 | 60,614 | -79,407 | 0.07 | 0.07 | -0.01 | sell |
| Sofinnova Investments, Inc. | 1,222,263 | 1,096,705 | -125,558 | 0.91 | 1.13 | +0.22 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,120,062 | 929,981 | -190,081 | 0.06 | 0.09 | +0.03 | sell |
| DAFNA Capital Management LLC | 627,626 | 431,329 | -196,297 | 2.11 | 2.39 | +0.28 | sell |
| Granahan Investment Management, LLC | 455,596 | 169,940 | -285,656 | 0.25 | 0.17 | -0.08 | sell |
| SECTORAL ASSET MANAGEMENT INC | 368,070 | 56,945 | -311,125 | 3.09 | 1.09 | -2.00 | sell |