| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 1,516,183 | +1,516,183 | 0.00 | 3.84 | +3.84 | buy |
| T. Rowe Price Investment Management, Inc. | 2,341,783 | 3,319,086 | +977,303 | 0.02 | 0.03 | +0.01 | buy |
| Verition Fund Management LLC | 344,617 | 1,155,236 | +810,619 | 0.05 | 0.17 | +0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,904,065 | 3,489,709 | +585,644 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 400,000 | 944,917 | +544,917 | 0.28 | 0.52 | +0.24 | buy |
| MORGAN STANLEY | 609,483 | 1,037,409 | +427,926 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 10,336,971 | 10,644,024 | +307,053 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 0 | 267,865 | +267,865 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 244,995 | +244,995 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,695 | 246,322 | +215,627 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.69 | +0.69 | buy |
| CITADEL ADVISORS LLC | 3,681,782 | 3,852,429 | +170,647 | 0.06 | 0.06 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 1,023,350 | 1,164,610 | +141,260 | 0.01 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 0 | 131,263 | +131,263 | 0.00 | 0.20 | +0.20 | buy |
| Jump Financial, LLC | 0 | 118,648 | +118,648 | 0.00 | 0.05 | +0.05 | buy |
| HRT FINANCIAL LP | 0 | 113,750 | +113,750 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 145,918 | 257,087 | +111,169 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 101,000 | +101,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 46,009 | 124,287 | +78,278 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 190,168 | 258,818 | +68,650 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,253,737 | 1,302,237 | +48,500 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 11,353 | 59,265 | +47,912 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 43,175 | +43,175 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 292,881 | 332,000 | +39,119 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 38,468 | +38,468 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 37,830 | +37,830 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 35,303 | +35,303 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 1,403,553 | 1,437,026 | +33,473 | 0.23 | 0.21 | -0.02 | buy |
| Invesco Ltd. | 24,950 | 54,366 | +29,416 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 25,612 | +25,612 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 25,307 | +25,307 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 23,106 | +23,106 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 48,068 | 71,066 | +22,998 | 0.44 | 0.66 | +0.22 | buy |
| Corton Capital Inc. | 0 | 19,818 | +19,818 | 0.00 | 0.11 | +0.11 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 19,471 | +19,471 | 0.00 | 0.00 | +0.00 | buy |
| Heritage Wealth Management, Inc. /CA/ | 0 | 15,000 | +15,000 | 0.00 | 0.23 | +0.23 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 116,894 | 131,815 | +14,921 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 11,559,975 | 11,574,821 | +14,846 | 2.86 | 2.86 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 14,291 | +14,291 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 5,989 | 20,201 | +14,212 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 13,604 | +13,604 | 0.00 | 0.02 | +0.02 | buy |
| Carson Advisory Inc. | 0 | 12,770 | +12,770 | 0.00 | 0.14 | +0.14 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 12,582 | +12,582 | 0.00 | 0.03 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 11,978 | +11,978 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 0 | 10,662 | +10,662 | 0.00 | 0.04 | +0.04 | buy |
| XTX Topco Ltd | 0 | 10,611 | +10,611 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,602 | +10,602 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 17,660 | 27,911 | +10,251 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 445,823 | 455,937 | +10,114 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,809 | 15,618 | +7,809 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 54,255 | 60,895 | +6,640 | 0.00 | 0.00 | +0.00 | buy |
| Prospera Financial Services Inc | 18,302 | 24,035 | +5,733 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,188 | 13,634 | +5,446 | 0.02 | 0.03 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 63,176 | 67,472 | +4,296 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 3,392 | +3,392 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 47,907 | 50,054 | +2,147 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 80,800 | 82,762 | +1,962 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,446 | 20,081 | +1,635 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,386 | +1,386 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 14,162 | 15,436 | +1,274 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 55,577 | 56,803 | +1,226 | 0.00 | 0.00 | -0.00 | buy |
| OneAscent Financial Services LLC | 10,324 | 11,427 | +1,103 | 0.02 | 0.02 | +0.00 | buy |
| Creative Planning | 11,000 | 11,590 | +590 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 1,045 | 1,610 | +565 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 14,881 | 15,396 | +515 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 565 | 686 | +121 | 0.00 | 0.00 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 16,915 | 17,013 | +98 | 0.01 | 0.01 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 30 | 47 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 19 | 26 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 7 | +3 | 0.00 | 0.00 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 21,455 | 21,457 | +2 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,018 | 5,018 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,837 | 5,837 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 57,718 | 57,718 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 89,012 | 89,012 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 13,500 | 13,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Matrix Capital Management Company, LP | 13,959,973 | 13,959,973 | 0 | 2.18 | 2.04 | -0.13 | hold |
| Daiwa Securities Group Inc. | 212 | 212 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 30,702 | 30,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 961,486 | 961,486 | 0 | 2.17 | 2.59 | +0.42 | hold |
| Capital International Investors | 2,819,664 | 2,819,664 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Swiss National Bank | 97,400 | 97,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Birchview Capital, LP | 16,000 | 16,000 | 0 | 0.19 | 0.21 | +0.02 | hold |
| Pennant Investors, LP | 32,400 | 32,400 | 0 | 0.15 | 0.14 | -0.01 | hold |
| 5AM Venture Management, LLC | 490,000 | 490,000 | 0 | 1.97 | 1.73 | -0.24 | hold |
| HighMark Wealth Management LLC | 130 | 130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Decheng Capital LLC | 2,099,583 | 2,099,583 | 0 | 8.89 | 4.44 | -4.45 | hold |
| Erste Asset Management GmbH | 9,800 | 9,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 28,786 | 28,786 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,388 | 3,388 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 658 | 650 | -8 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,933 | 21,882 | -51 | 0.00 | 0.00 | -0.00 | sell |
| Arlington Trust Co LLC | 70 | 0 | -70 | 0.00 | 0.00 | -0.00 | sell |