| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 3,947,913 | 3,947,913 | 0 | 2.56 | 6.65 | +4.09 | hold |
| BlackRock, Inc. | 1,269,837 | 3,753,525 | +2,483,688 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,956,526 | 3,024,936 | +68,410 | 0.01 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,848,252 | 2,681,900 | -166,352 | 0.01 | 0.02 | +0.01 | sell |
| CITADEL ADVISORS LLC | 1,732,083 | 2,298,403 | +566,320 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,938,145 | 1,609,078 | -329,067 | 0.01 | 0.01 | +0.00 | sell |
| Opaleye Management Inc. | 1,412,656 | 1,412,656 | 0 | 0.44 | 0.62 | +0.19 | hold |
| ORBIMED ADVISORS LLC | 0 | 1,390,576 | +1,390,576 | 0.00 | 0.13 | +0.13 | buy |
| Decheng Capital LLC | 1,323,327 | 1,323,327 | 0 | 0.47 | 0.88 | +0.41 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 621,036 | 1,284,117 | +663,081 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,132,294 | 1,114,650 | -17,644 | 0.00 | 0.00 | +0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 957,420 | 957,420 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFIZER INC | 953,834 | 953,834 | 0 | 0.84 | 2.26 | +1.42 | hold |
| Soleus Capital Management, L.P. | 0 | 950,000 | +950,000 | 0.00 | 0.16 | +0.16 | buy |
| STATE STREET CORP | 249,690 | 887,416 | +637,726 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 792,001 | 758,033 | -33,968 | 0.00 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,289,822 | 664,281 | -625,541 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 144,636 | 652,750 | +508,114 | 0.02 | 0.15 | +0.13 | buy |
| MARSHALL WACE, LLP | 392,643 | 591,473 | +198,830 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 637,116 | 574,806 | -62,310 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,484,098 | 546,566 | -937,532 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 272,034 | 542,852 | +270,818 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 471,250 | +471,250 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 118,186 | 388,299 | +270,113 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 620,407 | 374,260 | -246,147 | 0.09 | 0.11 | +0.02 | sell |
| GOLDMAN SACHS GROUP INC | 462,678 | 372,564 | -90,114 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 283,917 | 310,264 | +26,347 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 297,378 | +297,378 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 322,507 | 289,693 | -32,814 | 0.01 | 0.02 | +0.01 | sell |
| Creative Planning | 285,000 | 285,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 191,551 | 256,079 | +64,528 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 571,257 | 215,113 | -356,144 | 0.00 | 0.00 | -0.00 | sell |
| Peapod Lane Capital LLC | 366,868 | 202,864 | -164,004 | 0.68 | 0.66 | -0.02 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 171,911 | +171,911 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,087 | 171,911 | +120,824 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 125,767 | 161,657 | +35,890 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 269,100 | 161,583 | -107,517 | 0.55 | 0.60 | +0.04 | sell |
| BARCLAYS PLC | 591,217 | 158,856 | -432,361 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 126,863 | +126,863 | 0.00 | 0.05 | +0.05 | buy |
| Quarry LP | 150,000 | 125,114 | -24,886 | 0.07 | 0.10 | +0.03 | sell |
| Bank of New York Mellon Corp | 0 | 122,068 | +122,068 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 112,122 | +112,122 | 0.00 | 0.01 | +0.01 | buy |
| BARR E S & CO | 110,000 | 110,000 | 0 | 0.01 | 0.03 | +0.01 | hold |
| FEDERATED HERMES, INC. | 65,520 | 98,617 | +33,097 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 48,572 | 97,757 | +49,185 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 98,554 | 78,904 | -19,650 | 0.01 | 0.01 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,300 | 77,300 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 74,966 | +74,966 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 78,740 | 68,816 | -9,924 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 0 | 66,674 | +66,674 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 61,412 | 61,412 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 0 | 55,760 | +55,760 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 48,806 | +48,806 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 41,898 | +41,898 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 41,049 | +41,049 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 33,332 | 37,613 | +4,281 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 31,472 | 36,472 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 30,095 | +30,095 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 50,000 | 30,000 | -20,000 | 0.01 | 0.01 | +0.00 | sell |
| Regency Capital Management Inc.\DE | 29,500 | 29,500 | 0 | 0.03 | 0.06 | +0.03 | hold |
| Marquette Asset Management, LLC | 0 | 28,973 | +28,973 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 25,962 | +25,962 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 23,566 | +23,566 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 77,255 | 23,112 | -54,143 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 23,037 | +23,037 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 92,427 | 22,358 | -70,069 | 0.01 | 0.00 | -0.00 | sell |
| Carson Advisory Inc. | 23,270 | 21,170 | -2,100 | 0.03 | 0.05 | +0.02 | sell |
| Sivia Capital Partners, LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| State of Wyoming | 28,466 | 18,756 | -9,710 | 0.01 | 0.01 | +0.00 | sell |
| Jump Financial, LLC | 0 | 17,809 | +17,809 | 0.00 | 0.00 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 16,915 | 17,429 | +514 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 17,100 | +17,100 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 15,500 | +15,500 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 14,755 | +14,755 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 14,289 | +14,289 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 20,400 | 13,843 | -6,557 | 0.00 | 0.00 | +0.00 | sell |
| Scientech Research LLC | 0 | 13,613 | +13,613 | 0.00 | 0.05 | +0.05 | buy |
| Squarepoint Ops LLC | 30,691 | 13,487 | -17,204 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 0 | 12,656 | +12,656 | 0.00 | 0.00 | +0.00 | buy |
| Spark Investment Management LLC | 0 | 12,500 | +12,500 | 0.00 | 0.12 | +0.12 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 471,438 | 12,479 | -458,959 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 0 | 10,958 | +10,958 | 0.00 | 0.08 | +0.08 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,460 | +10,460 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Wealth Management, LLC | 10,186 | 10,186 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 22,447 | 10,096 | -12,351 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 0 | 4,848 | +4,848 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 4,816 | +4,816 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 4,540 | +4,540 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,134 | 3,115 | +1,981 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 1,699 | 1,944 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 1,008 | +1,008 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 689 | +689 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 514 | +514 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 387 | 387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 209 | 209 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 130 | 130 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caitong International Asset Management Co., Ltd | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Inspire Investing, LLC | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |