| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 6,877,803 | 7,814,039 | +936,236 | 3.28 | 2.82 | -0.46 | buy |
| Sofinnova Investments, Inc. | 828,005 | 1,211,641 | +383,636 | 1.54 | 1.69 | +0.15 | buy |
| SECTORAL ASSET MANAGEMENT INC | 234,000 | 386,525 | +152,525 | 1.10 | 1.51 | +0.41 | buy |
| First Light Asset Management, LLC | 757,835 | 848,477 | +90,642 | 1.68 | 1.62 | -0.06 | buy |
| TD ASSET MANAGEMENT INC | 102,628 | 180,768 | +78,140 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,684,352 | 2,715,599 | +31,247 | 0.01 | 0.01 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 17,000 | 47,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 30,558 | 40,920 | +10,362 | 0.52 | 0.53 | +0.01 | buy |
| ALPS ADVISORS INC | 43,718 | 52,125 | +8,407 | 0.01 | 0.01 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 152,297 | 156,475 | +4,178 | 0.10 | 0.08 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 779 | 1,809 | +1,030 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,017 | 10,190 | +173 | 0.02 | 0.02 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,415 | 4,012 | -403 | 0.07 | 0.05 | -0.02 | sell |
| E Fund Management Co., Ltd. | 13,492 | 10,307 | -3,185 | 0.03 | 0.02 | -0.01 | sell |
| PROFUND ADVISORS LLC | 45,531 | 34,176 | -11,355 | 0.07 | 0.04 | -0.03 | sell |
| T. Rowe Price Investment Management, Inc. | 1,999,354 | 1,972,484 | -26,870 | 0.04 | 0.03 | -0.01 | sell |
| Rafferty Asset Management, LLC | 250,957 | 200,686 | -50,271 | 0.04 | 0.02 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 1,111,150 | 1,033,750 | -77,400 | 0.03 | 0.02 | -0.01 | sell |
| Woodline Partners LP | 1,094,974 | 1,000,000 | -94,974 | 0.37 | 0.24 | -0.13 | sell |
| Avidity Partners Management LP | 2,334,000 | 2,100,000 | -234,000 | 2.30 | 1.70 | -0.60 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 555,000 | 301,667 | -253,333 | 0.03 | 0.01 | -0.02 | sell |
| Cormorant Asset Management, LP | 1,095,000 | 700,000 | -395,000 | 1.76 | 0.82 | -0.94 | sell |