| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 13,959,973 | 13,959,973 | 0 | 0.43 | 2.45 | +2.02 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 8,547,896 | 8,547,896 | 0 | 0.60 | 0.54 | -0.06 | hold |
| FMR LLC | 8,676,723 | 5,075,837 | -3,600,886 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 5,654,757 | 4,612,707 | -1,042,050 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 3,070,442 | 3,108,095 | +37,653 | 3.85 | 2.71 | -1.14 | buy |
| CITADEL ADVISORS LLC | 4,502,913 | 2,717,521 | -1,785,392 | 0.02 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 1,950,722 | 1,611,567 | -339,155 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 552,820 | 1,504,320 | +951,500 | 0.02 | 0.04 | +0.02 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 1,232,340 | 1,498,030 | +265,690 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,450,000 | 1,465,801 | +15,801 | 0.92 | 0.81 | -0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,334,459 | 1,292,100 | -42,359 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 3,052,392 | 1,246,613 | -1,805,779 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 796,900 | 1,149,400 | +352,500 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 240,341 | 1,128,577 | +888,236 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 1,517,077 | 1,055,282 | -461,795 | 0.06 | 0.03 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 923,901 | 1,036,911 | +113,010 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 0 | 967,000 | +967,000 | 0.00 | 0.59 | +0.59 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 961,486 | 961,486 | 0 | 0.80 | 0.99 | +0.19 | hold |
| Almitas Capital LLC | 0 | 960,928 | +960,928 | 0.00 | 1.25 | +1.25 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,052,398 | 908,601 | -143,797 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 392,608 | 886,086 | +493,478 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 508,233 | 775,536 | +267,303 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 619,253 | 634,064 | +14,811 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 255,201 | 608,585 | +353,384 | 0.07 | 0.17 | +0.10 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 661,682 | 556,944 | -104,738 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 626,663 | 505,644 | -121,019 | 0.00 | 0.00 | -0.00 | sell |
| 5AM Venture Management, LLC | 490,000 | 490,000 | 0 | 0.45 | 0.37 | -0.08 | hold |
| JPMORGAN CHASE & CO | 495,810 | 489,199 | -6,611 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 482,481 | 483,338 | +857 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 495,266 | 474,225 | -21,041 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 468,413 | 406,210 | -62,203 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 263,216 | +263,216 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 101,270 | 229,138 | +127,868 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 195,482 | +195,482 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 178,465 | 194,062 | +15,597 | 0.06 | 0.05 | -0.01 | buy |
| Bank of New York Mellon Corp | 333,719 | 173,310 | -160,409 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 172,989 | 161,193 | -11,796 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 129,129 | 128,124 | -1,005 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,077 | 121,095 | +77,018 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 148,755 | 115,105 | -33,650 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 110,738 | 109,538 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 40,291 | 107,159 | +66,868 | 0.02 | 0.03 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 102,880 | 106,080 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 89,012 | 89,012 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 94,213 | 86,713 | -7,500 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 78,927 | +78,927 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 63,647 | 75,395 | +11,748 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 74,925 | 74,529 | -396 | 0.18 | 0.15 | -0.03 | sell |
| ALGERT GLOBAL LLC | 19,119 | 73,100 | +53,981 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 40,211 | 68,662 | +28,451 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 47,045 | 67,893 | +20,848 | 0.00 | 0.00 | +0.00 | buy |
| Anfield Capital Management, LLC | 9,767 | 64,659 | +54,892 | 0.02 | 0.09 | +0.07 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 60,695 | 63,945 | +3,250 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 83,717 | 59,805 | -23,912 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 55,414 | 56,216 | +802 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 54,459 | +54,459 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 53,809 | 51,462 | -2,347 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 19,243 | 49,959 | +30,716 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 15,408 | 45,506 | +30,098 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 43,926 | 43,686 | -240 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 11,465 | 42,186 | +30,721 | 0.00 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 35,709 | +35,709 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 34,090 | 34,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 0 | 33,557 | +33,557 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 23,747 | 31,931 | +8,184 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 41,339 | 31,448 | -9,891 | 0.03 | 0.03 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,595 | 31,262 | -4,333 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 30,744 | 30,555 | -189 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 12,184 | 29,998 | +17,814 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 29,800 | +29,800 | 0.00 | 0.00 | +0.00 | buy |
| Regency Capital Management Inc.\DE | 29,500 | 29,500 | 0 | 0.08 | 0.06 | -0.02 | hold |
| AMERICAN CENTURY COMPANIES INC | 23,312 | 29,475 | +6,163 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 29,191 | +29,191 | 0.00 | 0.01 | +0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 27,605 | 27,605 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 28,076 | 27,304 | -772 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 14,152 | 26,149 | +11,997 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 25,706 | +25,706 | 0.00 | 0.01 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 24,712 | +24,712 | 0.00 | 0.00 | +0.00 | buy |
| Carson Advisory Inc. | 15,770 | 24,570 | +8,800 | 0.05 | 0.06 | +0.01 | buy |
| 49 WEALTH MANAGEMENT, LLC | 12,413 | 22,558 | +10,145 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 22,295 | +22,295 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,891 | 21,891 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 21,500 | 21,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 20,407 | +20,407 | 0.00 | 0.00 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 16,915 | 16,915 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,619 | 16,619 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Birchview Capital, LP | 16,000 | 16,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| State of Wyoming | 0 | 15,454 | +15,454 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 21,239 | 15,448 | -5,791 | 0.01 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 15,210 | +15,210 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 8,343 | 13,676 | +5,333 | 0.00 | 0.01 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 13,066 | +13,066 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 103,916 | 12,303 | -91,613 | 0.02 | 0.00 | -0.02 | sell |
| Creative Planning | 13,399 | 11,300 | -2,099 | 0.00 | 0.00 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 11,054 | +11,054 | 0.00 | 0.01 | +0.01 | buy |
| Paloma Partners Management Co | 0 | 10,024 | +10,024 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 9,800 | 9,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 9,509 | 9,683 | +174 | 0.02 | 0.02 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 37,485 | 7,949 | -29,536 | 0.00 | 0.00 | -0.00 | sell |