| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 13,959,973 | 13,959,973 | 0 | 2.45 | 1.97 | -0.49 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 8,547,896 | 4,475,054 | -4,072,842 | 0.54 | 0.25 | -0.30 | sell |
| BlackRock, Inc. | 4,761,173 | 4,238,089 | -523,084 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 4,612,707 | 3,271,240 | -1,341,467 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 2,717,521 | 3,216,727 | +499,206 | 0.01 | 0.01 | -0.00 | buy |
| Decheng Capital LLC | 3,108,095 | 2,338,095 | -770,000 | 2.71 | 1.52 | -1.19 | sell |
| Opaleye Management Inc. | 967,000 | 1,767,500 | +800,500 | 0.59 | 0.94 | +0.34 | buy |
| MORGAN STANLEY | 1,611,567 | 1,713,188 | +101,621 | 0.00 | 0.00 | -0.00 | buy |
| Almitas Capital LLC | 960,928 | 1,626,896 | +665,968 | 1.25 | 1.08 | -0.17 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 1,498,030 | 1,520,630 | +22,600 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,292,100 | 1,312,964 | +20,864 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,246,613 | 1,288,985 | +42,372 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,128,577 | 1,239,459 | +110,882 | 0.01 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 1,504,320 | 1,217,094 | -287,226 | 0.04 | 0.02 | -0.02 | sell |
| MPM BioImpact LLC | 1,465,801 | 1,106,851 | -358,950 | 0.81 | 0.48 | -0.33 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 263,216 | 1,067,233 | +804,017 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 1,050,000 | +1,050,000 | 0.00 | 0.28 | +0.28 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,036,911 | 979,855 | -57,056 | 0.00 | 0.00 | -0.00 | sell |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 961,486 | 961,486 | 0 | 0.99 | 0.73 | -0.26 | hold |
| MILLENNIUM MANAGEMENT LLC | 886,086 | 957,563 | +71,477 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 634,064 | 918,107 | +284,043 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,149,400 | 889,700 | -259,700 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 489,199 | 859,710 | +370,511 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 908,601 | 616,800 | -291,801 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 556,944 | 539,345 | -17,599 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 1,055,282 | 530,582 | -524,700 | 0.03 | 0.01 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 505,644 | 505,006 | -638 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 406,210 | 497,362 | +91,152 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 483,338 | 493,982 | +10,644 | 0.00 | 0.00 | -0.00 | buy |
| 5AM Venture Management, LLC | 490,000 | 490,000 | 0 | 0.37 | 0.35 | -0.02 | hold |
| NORTHERN TRUST CORP | 474,225 | 484,738 | +10,513 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 229,138 | 345,039 | +115,901 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 161,193 | 323,514 | +162,321 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 232,058 | +232,058 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 195,482 | 223,097 | +27,615 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 775,536 | 215,999 | -559,537 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 67,893 | 200,113 | +132,220 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 193,709 | +193,709 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 183,678 | +183,678 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,075,837 | 182,309 | -4,893,528 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 180,224 | +180,224 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 176,292 | +176,292 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 175,000 | +175,000 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 173,310 | 162,935 | -10,375 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 146,673 | +146,673 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 608,585 | 144,170 | -464,415 | 0.17 | 0.03 | -0.14 | sell |
| HRT FINANCIAL LP | 78,927 | 140,394 | +61,467 | 0.00 | 0.00 | +0.00 | buy |
| Anfield Capital Management, LLC | 64,659 | 129,318 | +64,659 | 0.09 | 0.14 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,124 | 128,208 | +84 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 194,062 | 122,988 | -71,074 | 0.05 | 0.03 | -0.02 | sell |
| BARCLAYS PLC | 75,395 | 117,395 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 109,538 | 109,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 0 | 106,748 | +106,748 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 106,080 | 106,080 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 86,713 | 92,214 | +5,501 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 89,012 | 89,012 | 0 | 0.00 | 0.00 | -0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 27,605 | 70,641 | +43,036 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 63,945 | 63,945 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 22,295 | 60,021 | +37,726 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 59,805 | 59,805 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 42,186 | 57,946 | +15,760 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 68,662 | 57,592 | -11,070 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 56,216 | 57,587 | +1,371 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 49,959 | 57,017 | +7,058 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 26,149 | 56,389 | +30,240 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 15,000 | 53,500 | +38,500 | 0.02 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 73,100 | 51,100 | -22,000 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 51,462 | 50,872 | -590 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 115,105 | 50,756 | -64,349 | 0.00 | 0.00 | -0.00 | sell |
| Harvest Investment Services, LLC | 0 | 48,680 | +48,680 | 0.00 | 0.04 | +0.04 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 45,506 | 45,506 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 43,686 | 45,501 | +1,815 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 31,931 | 42,804 | +10,873 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,300 | 40,103 | +28,803 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 74,529 | 36,032 | -38,497 | 0.15 | 0.06 | -0.09 | sell |
| SEI INVESTMENTS CO | 0 | 35,320 | +35,320 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 35,709 | 35,169 | -540 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 15,454 | 34,716 | +19,262 | 0.01 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 27,304 | 34,609 | +7,305 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 29,800 | 34,067 | +4,267 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,262 | 32,714 | +1,452 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,475 | 32,084 | +2,609 | 0.00 | 0.00 | -0.00 | buy |
| Regency Capital Management Inc.\DE | 29,500 | 29,500 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Corebridge Financial, Inc. | 30,555 | 28,411 | -2,144 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 20,407 | 28,038 | +7,631 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 26,911 | +26,911 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 22,558 | 26,639 | +4,081 | 0.01 | 0.01 | -0.00 | buy |
| Brevan Howard Capital Management LP | 15,448 | 26,351 | +10,903 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 24,973 | +24,973 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 24,712 | 24,712 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Carson Advisory Inc. | 24,570 | 24,670 | +100 | 0.06 | 0.05 | -0.00 | buy |
| Savant Capital, LLC | 0 | 23,893 | +23,893 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 34,090 | 22,971 | -11,119 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,683 | 22,713 | +13,030 | 0.02 | 0.03 | +0.01 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 22,340 | +22,340 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,891 | 21,891 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,210 | 19,510 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 17,949 | +17,949 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 17,490 | +17,490 | 0.00 | 0.01 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 17,134 | +17,134 | 0.00 | 0.02 | +0.02 | buy |