| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 11,259,438 | 11,259,438 | 0 | 7.22 | 5.15 | -2.06 | hold |
| FMR LLC | 10,414,535 | 10,602,377 | +187,842 | 0.02 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,321,471 | 8,208,113 | -113,358 | 0.02 | 0.02 | -0.00 | sell |
| Samsara BioCapital, LLC | 6,788,609 | 6,788,609 | 0 | 19.85 | 18.65 | -1.20 | hold |
| Redmile Group, LLC | 6,402,505 | 6,419,610 | +17,105 | 4.31 | 4.18 | -0.12 | buy |
| STATE STREET CORP | 2,159,337 | 4,169,770 | +2,010,433 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,245,000 | 3,574,632 | -670,368 | 1.60 | 1.17 | -0.43 | sell |
| VANGUARD GROUP INC | 2,854,984 | 2,969,534 | +114,550 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 2,940,672 | 2,940,672 | 0 | 0.34 | 0.27 | -0.07 | hold |
| Bellevue Group AG | 2,168,925 | 2,165,203 | -3,722 | 0.62 | 0.59 | -0.04 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 972,733 | 1,513,280 | +540,547 | 0.30 | 0.42 | +0.12 | buy |
| GOLDMAN SACHS GROUP INC | 1,430,764 | 1,232,146 | -198,618 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,141,547 | 1,191,256 | +49,709 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 924,883 | 1,061,750 | +136,867 | 0.19 | 0.17 | -0.02 | buy |
| Hood River Capital Management LLC | 499,144 | 792,047 | +292,903 | 0.26 | 0.31 | +0.06 | buy |
| Deep Track Capital, LP | 1,011,829 | 680,000 | -331,829 | 0.67 | 0.35 | -0.32 | sell |
| CITADEL ADVISORS LLC | 538,850 | 644,789 | +105,939 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 562,219 | +562,219 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 49,710 | 536,329 | +486,619 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 452,146 | 525,056 | +72,910 | 0.30 | 0.26 | -0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 525,000 | -775,000 | 0.05 | 0.02 | -0.03 | sell |
| NORTHERN TRUST CORP | 514,504 | 515,842 | +1,338 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 392,399 | 481,762 | +89,363 | 0.80 | 0.76 | -0.04 | buy |
| UBS Group AG | 0 | 432,459 | +432,459 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 394,138 | 402,481 | +8,343 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 280,847 | 389,495 | +108,648 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 527,008 | 372,043 | -154,965 | 0.03 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 245,459 | 357,072 | +111,613 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 107,709 | 345,762 | +238,053 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 100,000 | 325,000 | +225,000 | 0.27 | 0.57 | +0.30 | buy |
| TWO SIGMA INVESTMENTS, LP | 79,957 | 320,819 | +240,862 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 339,894 | 309,646 | -30,248 | 0.01 | 0.01 | -0.00 | sell |
| Ikarian Capital, LLC | 0 | 291,701 | +291,701 | 0.00 | 1.41 | +1.41 | buy |
| DIMENSIONAL FUND ADVISORS LP | 330,336 | 289,235 | -41,101 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 275,894 | +275,894 | 0.00 | 0.10 | +0.10 | buy |
| Sio Capital Management, LLC | 0 | 273,720 | +273,720 | 0.00 | 1.69 | +1.69 | buy |
| MORGAN STANLEY | 584,163 | 257,455 | -326,708 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 124,955 | 244,318 | +119,363 | 0.00 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,131,668 | 242,156 | -889,512 | 0.06 | 0.01 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 37,298 | 238,747 | +201,449 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 17,306 | 219,785 | +202,479 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 270,000 | 199,415 | -70,585 | 1.57 | 0.99 | -0.57 | sell |
| Bank of New York Mellon Corp | 182,385 | 196,982 | +14,597 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 174,976 | +174,976 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 165,567 | 170,471 | +4,904 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 168,997 | 168,997 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 71,640 | 157,281 | +85,641 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 161,884 | 147,201 | -14,683 | 0.02 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 139,064 | +139,064 | 0.00 | 0.02 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 137,049 | 138,458 | +1,409 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 72,285 | 138,072 | +65,787 | 0.03 | 0.05 | +0.02 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 22,178 | 117,128 | +94,950 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 95,291 | 111,866 | +16,575 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 113,164 | 105,833 | -7,331 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 98,388 | +98,388 | 0.00 | 0.08 | +0.08 | buy |
| Invesco Ltd. | 307,037 | 96,538 | -210,499 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,143 | 94,901 | +5,758 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 89,750 | 94,056 | +4,306 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 136,049 | 80,101 | -55,948 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 98,100 | 78,300 | -19,800 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 77,563 | +77,563 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 56,778 | 60,619 | +3,841 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,940 | 56,870 | +31,930 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 33,730 | 55,751 | +22,021 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 18,342 | 53,622 | +35,280 | 0.01 | 0.04 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 53,216 | +53,216 | 0.00 | 0.04 | +0.04 | buy |
| Cinctive Capital Management LP | 135,000 | 48,335 | -86,665 | 0.18 | 0.04 | -0.13 | sell |
| Jump Financial, LLC | 0 | 46,635 | +46,635 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 47,002 | 45,112 | -1,890 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 44,080 | 44,406 | +326 | 0.05 | 0.05 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 42,324 | +42,324 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 42,300 | +42,300 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,055 | 41,471 | -11,584 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 85,129 | 41,378 | -43,751 | 0.05 | 0.02 | -0.03 | sell |
| Ensign Peak Advisors, Inc | 40,940 | 38,974 | -1,966 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 38,000 | 38,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 50,515 | 37,914 | -12,601 | 0.00 | 0.00 | -0.00 | sell |
| Virtue Capital Management, LLC | 35,909 | 34,773 | -1,136 | 0.11 | 0.08 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 48,372 | 34,284 | -14,088 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 5,828 | 33,357 | +27,529 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 34,866 | 30,321 | -4,545 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 28,930 | 29,716 | +786 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 29,324 | 29,324 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 0 | 29,269 | +29,269 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,680 | 28,870 | -11,810 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 28,800 | +28,800 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,132 | 28,513 | +26,381 | 0.00 | 0.01 | +0.01 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 28,423 | 28,423 | 0 | 0.15 | 0.12 | -0.02 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 27,573 | 28,407 | +834 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 26,418 | +26,418 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 0 | 25,841 | +25,841 | 0.00 | 0.10 | +0.10 | buy |
| Jasper Ridge Partners, L.P. | 23,605 | 23,605 | 0 | 0.02 | 0.01 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,497 | 22,553 | +56 | 0.00 | 0.00 | -0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 21,568 | +21,568 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 25,292 | 20,866 | -4,426 | 0.01 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 0 | 20,729 | +20,729 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,046 | 20,294 | +3,248 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 37,842 | 19,421 | -18,421 | 0.06 | 0.03 | -0.03 | sell |
| SEI INVESTMENTS CO | 32,214 | 18,539 | -13,675 | 0.00 | 0.00 | -0.00 | sell |