| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 972,733 | 1,513,280 | +540,547 | 0.30 | 0.42 | +0.12 | buy |
| Hood River Capital Management LLC | 499,144 | 792,047 | +292,903 | 0.26 | 0.31 | +0.06 | buy |
| Integral Health Asset Management, LLC | 100,000 | 325,000 | +225,000 | 0.27 | 0.57 | +0.30 | buy |
| Woodline Partners LP | 924,883 | 1,061,750 | +136,867 | 0.19 | 0.17 | -0.02 | buy |
| BIT Capital GmbH | 392,399 | 481,762 | +89,363 | 0.73 | 0.63 | -0.09 | buy |
| Laurion Capital Management LP | 452,146 | 525,056 | +72,910 | 0.07 | 0.08 | +0.01 | buy |
| Redmile Group, LLC | 6,402,505 | 6,419,610 | +17,105 | 4.31 | 4.18 | -0.12 | buy |
| China Universal Asset Management Co., Ltd. | 8,346 | 13,868 | +5,522 | 0.03 | 0.03 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 137,049 | 138,458 | +1,409 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 44,080 | 44,406 | +326 | 0.05 | 0.05 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,988 | 4,671 | -317 | 0.06 | 0.04 | -0.02 | sell |
| Virtue Capital Management, LLC | 35,909 | 34,773 | -1,136 | 0.11 | 0.08 | -0.03 | sell |
| Clarius Group, LLC | 14,966 | 13,037 | -1,929 | 0.02 | 0.02 | -0.01 | sell |
| Bellevue Group AG | 2,168,925 | 2,165,203 | -3,722 | 0.62 | 0.59 | -0.04 | sell |
| Susquehanna Portfolio Strategies, LLC | 34,866 | 30,321 | -4,545 | 0.01 | 0.01 | +0.00 | sell |
| Fisher Asset Management, LLC | 113,164 | 105,833 | -7,331 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 161,884 | 147,201 | -14,683 | 0.02 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 270,000 | 199,415 | -70,585 | 1.57 | 0.99 | -0.57 | sell |
| Cinctive Capital Management LP | 135,000 | 48,335 | -86,665 | 0.18 | 0.04 | -0.13 | sell |
| Deep Track Capital, LP | 1,011,829 | 680,000 | -331,829 | 0.67 | 0.35 | -0.32 | sell |
| ORBIMED ADVISORS LLC | 4,245,000 | 3,574,632 | -670,368 | 1.60 | 1.17 | -0.43 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 525,000 | -775,000 | 0.05 | 0.02 | -0.03 | sell |