| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 2,159,337 | 4,169,770 | +2,010,433 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 562,219 | +562,219 | 0.00 | 0.03 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 972,733 | 1,513,280 | +540,547 | 0.30 | 0.42 | +0.12 | buy |
| CITIGROUP INC | 49,710 | 536,329 | +486,619 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 432,459 | +432,459 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 499,144 | 792,047 | +292,903 | 0.26 | 0.31 | +0.06 | buy |
| Ikarian Capital, LLC | 0 | 291,701 | +291,701 | 0.00 | 1.41 | +1.41 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 275,894 | +275,894 | 0.00 | 0.10 | +0.10 | buy |
| Sio Capital Management, LLC | 0 | 273,720 | +273,720 | 0.00 | 1.69 | +1.69 | buy |
| TWO SIGMA INVESTMENTS, LP | 79,957 | 320,819 | +240,862 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 107,709 | 345,762 | +238,053 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 100,000 | 325,000 | +225,000 | 0.27 | 0.57 | +0.30 | buy |
| ROYAL BANK OF CANADA | 17,306 | 219,785 | +202,479 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 37,298 | 238,747 | +201,449 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 10,414,535 | 10,602,377 | +187,842 | 0.02 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 174,976 | +174,976 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 139,064 | +139,064 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 924,883 | 1,061,750 | +136,867 | 0.19 | 0.17 | -0.02 | buy |
| JANE STREET GROUP, LLC | 124,955 | 244,318 | +119,363 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 2,854,984 | 2,969,534 | +114,550 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 245,459 | 357,072 | +111,613 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 280,847 | 389,495 | +108,648 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 538,850 | 644,789 | +105,939 | 0.01 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 98,388 | +98,388 | 0.00 | 0.08 | +0.08 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 22,178 | 117,128 | +94,950 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 392,399 | 481,762 | +89,363 | 0.80 | 0.76 | -0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 71,640 | 157,281 | +85,641 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 77,563 | +77,563 | 0.00 | 0.04 | +0.04 | buy |
| Laurion Capital Management LP | 452,146 | 525,056 | +72,910 | 0.30 | 0.26 | -0.05 | buy |
| Trexquant Investment LP | 72,285 | 138,072 | +65,787 | 0.03 | 0.05 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 53,216 | +53,216 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,141,547 | 1,191,256 | +49,709 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 46,635 | +46,635 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 0 | 42,324 | +42,324 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 42,300 | +42,300 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 18,342 | 53,622 | +35,280 | 0.01 | 0.04 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,940 | 56,870 | +31,930 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 29,269 | +29,269 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 28,800 | +28,800 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 5,828 | 33,357 | +27,529 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 26,418 | +26,418 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 2,132 | 28,513 | +26,381 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 0 | 25,841 | +25,841 | 0.00 | 0.10 | +0.10 | buy |
| ExodusPoint Capital Management, LP | 33,730 | 55,751 | +22,021 | 0.01 | 0.01 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 21,568 | +21,568 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 0 | 20,729 | +20,729 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 6,402,505 | 6,419,610 | +17,105 | 4.31 | 4.18 | -0.12 | buy |
| D. E. Shaw & Co., Inc. | 95,291 | 111,866 | +16,575 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 16,339 | +16,339 | 0.00 | 0.02 | +0.02 | buy |
| DnB Asset Management AS | 0 | 15,422 | +15,422 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 15,400 | +15,400 | 0.00 | 0.11 | +0.11 | buy |
| Bank of New York Mellon Corp | 182,385 | 196,982 | +14,597 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 0 | 14,500 | +14,500 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 14,500 | +14,500 | 0.00 | 0.02 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,628 | +13,628 | 0.00 | 0.03 | +0.03 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 13,130 | +13,130 | 0.00 | 0.05 | +0.05 | buy |
| ALGERT GLOBAL LLC | 0 | 12,390 | +12,390 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 10,439 | +10,439 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,267 | +10,267 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 10,092 | +10,092 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Trading LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 8,369 | +8,369 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 394,138 | 402,481 | +8,343 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 7,431 | +7,431 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,143 | 94,901 | +5,758 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,346 | 13,868 | +5,522 | 0.03 | 0.03 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 165,567 | 170,471 | +4,904 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 4,900 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 89,750 | 94,056 | +4,306 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 56,778 | 60,619 | +3,841 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,046 | 20,294 | +3,248 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 5,557 | 7,724 | +2,167 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 13,792 | 15,412 | +1,620 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,612 | +1,612 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,500 | +1,500 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 137,049 | 138,458 | +1,409 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 514,504 | 515,842 | +1,338 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 27,573 | 28,407 | +834 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 28,930 | 29,716 | +786 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 44,080 | 44,406 | +326 | 0.05 | 0.05 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 242 | +242 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,233 | 1,343 | +110 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,497 | 22,553 | +56 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 51 | 105 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 14,321 | 14,328 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 7 | +7 | 0.00 | 0.00 | 0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 28,423 | 28,423 | 0 | 0.15 | 0.12 | -0.02 | hold |
| CANADA LIFE ASSURANCE Co | 3,777 | 3,777 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artal Group S.A. | 11,259,438 | 11,259,438 | 0 | 7.22 | 5.15 | -2.06 | hold |
| Ameritas Investment Partners, Inc. | 5,742 | 5,742 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blackstone Inc. | 18,343 | 18,343 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jasper Ridge Partners, L.P. | 23,605 | 23,605 | 0 | 0.02 | 0.01 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 38,000 | 38,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 208 | 208 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 29,324 | 29,324 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |