| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 488,000 | 7,900,000 | +7,412,000 | 3.59 | 1.90 | -1.69 | buy |
| Vestal Point Capital, LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 2.98 | +2.98 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 17,616 | 1,136,453 | +1,118,837 | 0.01 | 0.61 | +0.60 | buy |
| Man Group plc | 0 | 987,710 | +987,710 | 0.00 | 0.09 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 849,178 | 1,670,187 | +821,009 | 0.02 | 0.03 | +0.01 | buy |
| Commodore Capital LP | 950,000 | 1,745,000 | +795,000 | 3.01 | 4.13 | +1.13 | buy |
| STATE STREET CORP | 2,639,295 | 3,134,140 | +494,845 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 413,385 | 853,437 | +440,052 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,594,869 | 2,018,000 | +423,131 | 0.12 | 0.12 | -0.00 | buy |
| Capital World Investors | 721,957 | 1,128,752 | +406,795 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 471,300 | 877,374 | +406,074 | 0.06 | 0.10 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 166,307 | 566,212 | +399,905 | 1.80 | 5.81 | +4.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 45,700 | 317,400 | +271,700 | 0.00 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 73 | 182,932 | +182,859 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 172,185 | +172,185 | 0.00 | 1.62 | +1.62 | buy |
| TWINBEECH CAPITAL LP | 0 | 159,713 | +159,713 | 0.00 | 0.09 | +0.09 | buy |
| FMR LLC | 13,635,261 | 13,794,490 | +159,229 | 0.04 | 0.03 | -0.01 | buy |
| Ensign Peak Advisors, Inc | 187,974 | 335,946 | +147,972 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 182,695 | 326,385 | +143,690 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 19,505 | 157,079 | +137,574 | 0.17 | 0.97 | +0.80 | buy |
| BlackRock, Inc. | 7,172,370 | 7,307,269 | +134,899 | 0.01 | 0.00 | -0.00 | buy |
| Patient Square Capital LP | 32,000 | 154,000 | +122,000 | 0.52 | 2.05 | +1.53 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,725,622 | 1,844,997 | +119,375 | 0.01 | 0.01 | -0.00 | buy |
| Soleus Capital Management, L.P. | 167,543 | 285,000 | +117,457 | 0.55 | 0.72 | +0.17 | buy |
| Sofinnova Investments, Inc. | 0 | 116,117 | +116,117 | 0.00 | 0.28 | +0.28 | buy |
| VANGUARD GROUP INC | 4,743,482 | 4,845,205 | +101,723 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 84,704 | 177,265 | +92,561 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,770,324 | 1,847,449 | +77,125 | 0.01 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 6,857 | 61,646 | +54,789 | 0.01 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 145,700 | 200,255 | +54,555 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 98,361 | 148,684 | +50,323 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,077 | 57,294 | +49,217 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,338 | 160,774 | +46,436 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 1,898,641 | 1,944,158 | +45,517 | 1.21 | 1.07 | -0.15 | buy |
| Rock Springs Capital Management LP | 716,782 | 761,541 | +44,759 | 1.18 | 1.40 | +0.22 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 8,647 | 52,628 | +43,981 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 135,231 | 169,825 | +34,594 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,984 | 74,891 | +33,907 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 78,077 | 111,671 | +33,594 | 0.01 | 0.02 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 31,230 | +31,230 | 0.00 | 0.39 | +0.39 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 27,617 | +27,617 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 35,301 | 56,784 | +21,483 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 20,485 | +20,485 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 746,527 | 765,280 | +18,753 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 17,624 | +17,624 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 18,816 | 35,617 | +16,801 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 15,942 | +15,942 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 15,702 | +15,702 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,240 | +14,240 | 0.00 | 0.07 | +0.07 | buy |
| XTX Topco Ltd | 0 | 13,127 | +13,127 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 11,795 | +11,795 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 115,400 | 127,000 | +11,600 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 11,550 | +11,550 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 7,254 | 17,840 | +10,586 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,544 | +10,544 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 30,200 | 40,090 | +9,890 | 0.05 | 0.05 | -0.00 | buy |
| Bank of New York Mellon Corp | 207,492 | 216,223 | +8,731 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 8,000 | 16,000 | +8,000 | 0.28 | 0.45 | +0.17 | buy |
| JPMORGAN CHASE & CO | 67,271 | 75,147 | +7,876 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 7,834 | +7,834 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 16,076 | 23,598 | +7,522 | 0.03 | 0.03 | +0.01 | buy |
| RHUMBLINE ADVISERS | 113,261 | 120,752 | +7,491 | 0.00 | 0.00 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 7,112 | +7,112 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 656,967 | 663,927 | +6,960 | 0.02 | 0.01 | -0.00 | buy |
| Exome Asset Management LLC | 77,439 | 84,339 | +6,900 | 2.52 | 2.43 | -0.09 | buy |
| Entropy Technologies, LP | 0 | 6,600 | +6,600 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,215 | 53,046 | +5,831 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,269 | 61,795 | +5,526 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 12,252 | 17,726 | +5,474 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 5,000 | 10,000 | +5,000 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 61,790 | 66,719 | +4,929 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 5,524 | 10,436 | +4,912 | 0.01 | 0.02 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,944 | 28,844 | +4,900 | 0.09 | 0.09 | +0.01 | buy |
| DIADEMA PARTNERS LP | 53,160 | 57,923 | +4,763 | 2.59 | 1.49 | -1.10 | buy |
| AlphaQuest LLC | 917 | 5,417 | +4,500 | 0.01 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 18,900 | 22,924 | +4,024 | 0.01 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,939 | +3,939 | 0.00 | 0.03 | +0.03 | buy |
| E. Ohman J:or Asset Management AB | 53,500 | 57,185 | +3,685 | 0.05 | 0.05 | -0.01 | buy |
| HSBC HOLDINGS PLC | 13,256 | 16,883 | +3,627 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 79,350 | 82,110 | +2,760 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,586 | 25,286 | +2,700 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 16,888 | 19,567 | +2,679 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 212,727 | 215,405 | +2,678 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 21,710 | 24,122 | +2,412 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,659,240 | 2,661,608 | +2,368 | 2.09 | 1.70 | -0.39 | buy |
| FEDERATED HERMES, INC. | 0 | 2,209 | +2,209 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,590 | 40,744 | +2,154 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 16,506 | 18,557 | +2,051 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 17,694 | 19,722 | +2,028 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 1,781 | +1,781 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 17,033 | 18,767 | +1,734 | 0.00 | 0.00 | -0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 990 | +990 | 0.00 | 0.00 | +0.00 | buy |
| SIG BROKERAGE, LP | 6,016 | 6,978 | +962 | 0.12 | 0.07 | -0.06 | buy |
| Corebridge Financial, Inc. | 38,539 | 39,389 | +850 | 0.01 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,410 | 15,210 | +800 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,428 | 17,172 | +744 | 0.01 | 0.01 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 60,743 | 61,379 | +636 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 394 | 996 | +602 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,966 | 2,396 | +430 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 276 | +276 | 0.00 | 0.00 | +0.00 | buy |