| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 17,616 | 1,136,453 | +1,118,837 | 0.01 | 0.61 | +0.60 | buy |
| Commodore Capital LP | 950,000 | 1,745,000 | +795,000 | 3.01 | 4.13 | +1.13 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,594,869 | 2,018,000 | +423,131 | 0.12 | 0.12 | -0.00 | buy |
| Capital World Investors | 721,957 | 1,128,752 | +406,795 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 471,300 | 877,374 | +406,074 | 0.06 | 0.10 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 166,307 | 566,212 | +399,905 | 1.80 | 5.81 | +4.01 | buy |
| ADAR1 Capital Management, LLC | 19,505 | 157,079 | +137,574 | 0.17 | 0.97 | +0.80 | buy |
| Patient Square Capital LP | 32,000 | 154,000 | +122,000 | 0.52 | 2.05 | +1.53 | buy |
| Soleus Capital Management, L.P. | 167,543 | 285,000 | +117,457 | 0.55 | 0.72 | +0.17 | buy |
| Hood River Capital Management LLC | 1,898,641 | 1,944,158 | +45,517 | 1.21 | 1.07 | -0.15 | buy |
| Rock Springs Capital Management LP | 716,782 | 761,541 | +44,759 | 1.18 | 1.40 | +0.22 | buy |
| J. Goldman & Co LP | 30,200 | 40,090 | +9,890 | 0.03 | 0.03 | -0.00 | buy |
| Birchview Capital, LP | 8,000 | 16,000 | +8,000 | 0.28 | 0.45 | +0.17 | buy |
| PROFUND ADVISORS LLC | 16,076 | 23,598 | +7,522 | 0.03 | 0.03 | +0.01 | buy |
| Exome Asset Management LLC | 77,439 | 84,339 | +6,900 | 2.52 | 2.43 | -0.09 | buy |
| DnB Asset Management AS | 12,252 | 17,726 | +5,474 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 5,524 | 10,436 | +4,912 | 0.01 | 0.02 | +0.00 | buy |
| DIADEMA PARTNERS LP | 53,160 | 57,923 | +4,763 | 2.59 | 1.49 | -1.10 | buy |
| E. Ohman J:or Asset Management AB | 53,500 | 57,185 | +3,685 | 0.05 | 0.05 | -0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,659,240 | 2,661,608 | +2,368 | 2.09 | 1.70 | -0.39 | buy |
| SIG BROKERAGE, LP | 6,016 | 6,978 | +962 | 0.01 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,966 | 2,396 | +430 | 0.00 | 0.00 | -0.00 | buy |
| Values First Advisors, Inc. | 18,234 | 18,208 | -26 | 0.43 | 0.34 | -0.09 | sell |
| MOODY ALDRICH PARTNERS LLC | 27,786 | 27,366 | -420 | 0.22 | 0.18 | -0.04 | sell |
| Scientech Research LLC | 9,716 | 9,176 | -540 | 0.12 | 0.08 | -0.04 | sell |
| China Universal Asset Management Co., Ltd. | 19,850 | 18,991 | -859 | 0.08 | 0.06 | -0.02 | sell |
| SYON CAPITAL LLC | 10,819 | 9,562 | -1,257 | 0.04 | 0.03 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 516,005 | 514,092 | -1,913 | 0.18 | 0.16 | -0.02 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 55,987 | 53,563 | -2,424 | 0.13 | 0.10 | -0.03 | sell |
| Bellevue Group AG | 2,510,690 | 2,506,890 | -3,800 | 2.09 | 1.81 | -0.28 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 90,193 | 78,193 | -12,000 | 0.70 | 0.58 | -0.13 | sell |
| Polar Asset Management Partners Inc. | 20,600 | 8,174 | -12,426 | 0.01 | 0.01 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 776,665 | 760,645 | -16,020 | 0.04 | 0.04 | -0.01 | sell |
| BIT Capital GmbH | 65,315 | 42,694 | -22,621 | 0.22 | 0.12 | -0.11 | sell |
| Informed Momentum Co LLC | 137,861 | 92,038 | -45,823 | 0.84 | 0.51 | -0.33 | sell |
| Aberdeen Group plc | 142,187 | 91,482 | -50,705 | 0.01 | 0.01 | -0.01 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 385,925 | 313,689 | -72,236 | 2.02 | 2.08 | +0.06 | sell |
| Clearbridge Investments, LLC | 421,384 | 343,492 | -77,892 | 0.01 | 0.01 | -0.01 | sell |
| Candriam S.C.A. | 582,354 | 496,756 | -85,598 | 0.14 | 0.10 | -0.04 | sell |
| Fisher Asset Management, LLC | 554,737 | 456,871 | -97,866 | 0.01 | 0.01 | -0.00 | sell |
| Ikarian Capital, LLC | 357,185 | 244,179 | -113,006 | 4.41 | 2.56 | -1.85 | sell |
| Polar Capital Holdings Plc | 2,708,371 | 2,583,371 | -125,000 | 0.66 | 0.51 | -0.15 | sell |
| Redmile Group, LLC | 4,549,881 | 4,398,281 | -151,600 | 13.70 | 13.37 | -0.34 | sell |
| Octagon Capital Advisors LP | 488,000 | 329,000 | -159,000 | 3.59 | 2.08 | -1.51 | sell |
| Woodline Partners LP | 1,089,461 | 860,307 | -229,154 | 0.32 | 0.18 | -0.14 | sell |
| Integral Health Asset Management, LLC | 375,000 | 125,000 | -250,000 | 1.43 | 0.45 | -0.99 | sell |
| Fairmount Funds Management LLC | 1,962,953 | 1,374,031 | -588,922 | 8.43 | 6.85 | -1.58 | sell |