| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 15,380,675 | 17,243,152 | +1,862,477 | 0.03 | 0.04 | +0.01 | buy |
| Siren, L.L.C. | 10,825,013 | 10,825,013 | 0 | 14.22 | 14.75 | +0.53 | hold |
| Redmile Group, LLC | 5,220,846 | 9,066,621 | +3,845,775 | 16.94 | 29.51 | +12.58 | buy |
| BlackRock, Inc. | 7,217,034 | 7,469,293 | +252,259 | 0.01 | 0.01 | +0.00 | buy |
| Samsara BioCapital, LLC | 6,897,652 | 6,897,652 | 0 | 31.35 | 32.95 | +1.60 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 5,759,428 | 6,717,655 | +958,227 | 0.04 | 0.06 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,402,437 | 6,206,618 | -195,819 | 0.03 | 0.04 | +0.00 | sell |
| Orbis Allan Gray Ltd | 3,428,929 | 4,179,983 | +751,054 | 0.63 | 0.87 | +0.23 | buy |
| STATE STREET CORP | 4,034,434 | 4,031,317 | -3,117 | 0.01 | 0.01 | +0.00 | sell |
| Bellevue Group AG | 4,056,592 | 3,584,573 | -472,019 | 3.39 | 4.19 | +0.81 | sell |
| JENNISON ASSOCIATES LLC | 2,795,188 | 3,340,492 | +545,304 | 0.07 | 0.11 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 1,774,168 | 2,236,837 | +462,669 | 0.04 | 0.05 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,431,333 | 2,197,385 | -233,948 | 1.67 | 1.78 | +0.11 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,034,024 | 2,149,036 | +115,012 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 2,026,758 | 2,049,679 | +22,921 | 0.98 | 1.01 | +0.03 | buy |
| Polar Capital Holdings Plc | 1,322,011 | 1,983,628 | +661,617 | 0.27 | 0.43 | +0.16 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,952,877 | 1,920,233 | -32,644 | 0.58 | 0.69 | +0.11 | sell |
| Holocene Advisors, LP | 1,387,120 | 1,890,927 | +503,807 | 0.13 | 0.23 | +0.10 | buy |
| Woodline Partners LP | 1,211,088 | 1,500,470 | +289,382 | 0.21 | 0.28 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 1,324,213 | 1,398,983 | +74,770 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,050,506 | 1,336,632 | +286,126 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 700,000 | 1,324,422 | +624,422 | 1.13 | 1.82 | +0.69 | buy |
| Paradigm Biocapital Advisors LP | 3,062,157 | 1,226,080 | -1,836,077 | 3.61 | 1.23 | -2.38 | sell |
| Capital World Investors | 1,128,752 | 1,128,752 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MARSHALL WACE, LLP | 368,037 | 1,060,275 | +692,238 | 0.02 | 0.06 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 886,893 | 1,035,496 | +148,603 | 6.70 | 9.78 | +3.08 | buy |
| BNP Paribas Asset Management Holding S.A. | 829,422 | 981,915 | +152,493 | 0.04 | 0.06 | +0.01 | buy |
| CITADEL ADVISORS LLC | 495,946 | 900,799 | +404,853 | 0.01 | 0.03 | +0.02 | buy |
| Pictet Asset Management Holding SA | 1,195,967 | 875,084 | -320,883 | 0.05 | 0.05 | -0.01 | sell |
| FEDERATED HERMES, INC. | 797,913 | 797,913 | 0 | 0.06 | 0.06 | +0.01 | hold |
| NORTHERN TRUST CORP | 721,062 | 763,803 | +42,741 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 733,477 | 739,816 | +6,339 | 1.66 | 2.14 | +0.49 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 514,224 | 725,409 | +211,185 | 0.02 | 0.04 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 554,602 | 723,875 | +169,273 | 0.02 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 835,851 | 717,253 | -118,598 | 0.07 | 0.07 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 708,253 | 707,101 | -1,152 | 0.02 | 0.02 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 702,095 | 701,011 | -1,084 | 0.00 | 0.01 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 700,000 | +700,000 | 0.00 | 0.05 | +0.05 | buy |
| Clearbridge Investments, LLC | 295,475 | 691,418 | +395,943 | 0.01 | 0.03 | +0.02 | buy |
| UBS Group AG | 905,432 | 679,784 | -225,648 | 0.01 | 0.01 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 691,913 | 638,629 | -53,284 | 0.04 | 0.04 | +0.01 | sell |
| Nuveen, LLC | 604,417 | 581,654 | -22,763 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 88,530 | 560,084 | +471,554 | 0.00 | 0.03 | +0.02 | buy |
| Integral Health Asset Management, LLC | 300,000 | 500,000 | +200,000 | 0.67 | 1.30 | +0.63 | buy |
| Eagle Health Investments LP | 363,300 | 494,019 | +130,719 | 3.52 | 5.10 | +1.58 | buy |
| Fisher Asset Management, LLC | 531,439 | 458,017 | -73,422 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 459,727 | 446,390 | -13,337 | 2.31 | 2.45 | +0.14 | sell |
| ADAR1 Capital Management, LLC | 69,589 | 407,273 | +337,684 | 0.23 | 1.20 | +0.97 | buy |
| Casdin Capital, LLC | 260,000 | 350,000 | +90,000 | 0.71 | 1.30 | +0.59 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 339,613 | +339,613 | 0.00 | 1.97 | +1.97 | buy |
| ARMISTICE CAPITAL, LLC | 200,000 | 336,959 | +136,959 | 0.22 | 0.55 | +0.33 | buy |
| NAN FUNG TRINITY (HK) Ltd | 263,245 | 285,495 | +22,250 | 0.92 | 1.54 | +0.62 | buy |
| RAYMOND JAMES FINANCIAL INC | 245,387 | 253,599 | +8,212 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 226,168 | 241,794 | +15,626 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 232,018 | 232,672 | +654 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 145,633 | 225,998 | +80,365 | 0.03 | 0.06 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 281,444 | 223,064 | -58,380 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 372,731 | 219,027 | -153,704 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 280,324 | 211,960 | -68,364 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 405,523 | 178,672 | -226,851 | 0.03 | 0.01 | -0.02 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 168,547 | 177,377 | +8,830 | 0.01 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 170,773 | 174,419 | +3,646 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 186,926 | 173,765 | -13,161 | 0.01 | 0.01 | +0.00 | sell |
| Cinctive Capital Management LP | 0 | 172,535 | +172,535 | 0.00 | 0.56 | +0.56 | buy |
| Granahan Investment Management, LLC | 153,769 | 156,314 | +2,545 | 0.29 | 0.37 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 16,647 | 149,714 | +133,067 | 0.00 | 0.01 | +0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 152,854 | 146,606 | -6,248 | 0.21 | 0.27 | +0.06 | sell |
| SEI INVESTMENTS CO | 120,527 | 143,359 | +22,832 | 0.01 | 0.01 | +0.00 | buy |
| iA Global Asset Management Inc. | 123,272 | 123,212 | -60 | 0.07 | 0.09 | +0.02 | sell |
| Swiss National Bank | 123,200 | 123,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 82,462 | 119,597 | +37,135 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 108,864 | 112,501 | +3,637 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 129,132 | 104,456 | -24,676 | 0.02 | 0.02 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 107,183 | 102,912 | -4,271 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 82,110 | 100,690 | +18,580 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,817 | 100,425 | +88,608 | 0.01 | 0.09 | +0.07 | buy |
| Artia Global Partners LP | 96,285 | 96,285 | 0 | 0.68 | 1.07 | +0.39 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 158,265 | 94,265 | -64,000 | 1.46 | 0.80 | -0.66 | sell |
| Hudson Bay Capital Management LP | 100,000 | 83,450 | -16,550 | 0.03 | 0.02 | -0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 82,511 | +82,511 | 0.00 | 0.29 | +0.29 | buy |
| Aisling Capital Management LP | 77,031 | 77,031 | 0 | 0.71 | 0.80 | +0.09 | hold |
| Trexquant Investment LP | 48,927 | 76,748 | +27,821 | 0.02 | 0.03 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,815 | 74,916 | +14,101 | 0.00 | 0.00 | +0.00 | buy |
| StoneCrest Wealth Management, Inc. | 59,003 | 70,914 | +11,911 | 1.01 | 1.47 | +0.47 | buy |
| ExodusPoint Capital Management, LP | 106,228 | 67,068 | -39,160 | 0.05 | 0.03 | -0.02 | sell |
| Man Group plc | 182,024 | 62,118 | -119,906 | 0.02 | 0.01 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,798 | 61,906 | +16,108 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 85,293 | 60,201 | -25,092 | 0.70 | 0.53 | -0.17 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 21,762 | 51,951 | +30,189 | 0.00 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 49,955 | +49,955 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 32,827 | 49,942 | +17,115 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 63,336 | 49,914 | -13,422 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,951 | 48,236 | +35,285 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 48,184 | +48,184 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 46,657 | 47,463 | +806 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 48,152 | 47,093 | -1,059 | 0.06 | 0.08 | +0.02 | sell |
| BARCLAYS PLC | 251,913 | 43,051 | -208,862 | 0.00 | 0.00 | -0.00 | sell |
| Jasper Ridge Partners, L.P. | 42,455 | 42,455 | 0 | 0.04 | 0.05 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 25,286 | 39,333 | +14,047 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 20,110 | 38,728 | +18,618 | 0.00 | 0.00 | +0.00 | buy |