| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 5,220,846 | 9,066,621 | +3,845,775 | 16.94 | 29.51 | +12.58 | buy |
| FMR LLC | 15,380,675 | 17,243,152 | +1,862,477 | 0.03 | 0.04 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,759,428 | 6,717,655 | +958,227 | 0.04 | 0.06 | +0.02 | buy |
| Orbis Allan Gray Ltd | 3,428,929 | 4,179,983 | +751,054 | 0.63 | 0.87 | +0.23 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 700,000 | +700,000 | 0.00 | 0.05 | +0.05 | buy |
| MARSHALL WACE, LLP | 368,037 | 1,060,275 | +692,238 | 0.02 | 0.06 | +0.04 | buy |
| Polar Capital Holdings Plc | 1,322,011 | 1,983,628 | +661,617 | 0.27 | 0.43 | +0.16 | buy |
| Vestal Point Capital, LP | 700,000 | 1,324,422 | +624,422 | 1.13 | 1.82 | +0.69 | buy |
| JENNISON ASSOCIATES LLC | 2,795,188 | 3,340,492 | +545,304 | 0.07 | 0.11 | +0.04 | buy |
| Holocene Advisors, LP | 1,387,120 | 1,890,927 | +503,807 | 0.13 | 0.23 | +0.10 | buy |
| JANE STREET GROUP, LLC | 88,530 | 560,084 | +471,554 | 0.00 | 0.03 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 1,774,168 | 2,236,837 | +462,669 | 0.04 | 0.05 | +0.02 | buy |
| CITADEL ADVISORS LLC | 495,946 | 900,799 | +404,853 | 0.01 | 0.03 | +0.02 | buy |
| Clearbridge Investments, LLC | 295,475 | 691,418 | +395,943 | 0.01 | 0.03 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 339,613 | +339,613 | 0.00 | 1.97 | +1.97 | buy |
| ADAR1 Capital Management, LLC | 69,589 | 407,273 | +337,684 | 0.23 | 1.20 | +0.97 | buy |
| Woodline Partners LP | 1,211,088 | 1,500,470 | +289,382 | 0.21 | 0.28 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 1,050,506 | 1,336,632 | +286,126 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 7,217,034 | 7,469,293 | +252,259 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 514,224 | 725,409 | +211,185 | 0.02 | 0.04 | +0.01 | buy |
| Integral Health Asset Management, LLC | 300,000 | 500,000 | +200,000 | 0.67 | 1.30 | +0.63 | buy |
| Cinctive Capital Management LP | 0 | 172,535 | +172,535 | 0.00 | 0.56 | +0.56 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 554,602 | 723,875 | +169,273 | 0.02 | 0.02 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 829,422 | 981,915 | +152,493 | 0.04 | 0.06 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 886,893 | 1,035,496 | +148,603 | 6.70 | 9.78 | +3.08 | buy |
| ARMISTICE CAPITAL, LLC | 200,000 | 336,959 | +136,959 | 0.22 | 0.55 | +0.33 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 16,647 | 149,714 | +133,067 | 0.00 | 0.01 | +0.01 | buy |
| Eagle Health Investments LP | 363,300 | 494,019 | +130,719 | 3.52 | 5.10 | +1.58 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,034,024 | 2,149,036 | +115,012 | 0.01 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 260,000 | 350,000 | +90,000 | 0.71 | 1.30 | +0.59 | buy |
| XTX Topco Ltd | 11,817 | 100,425 | +88,608 | 0.01 | 0.09 | +0.07 | buy |
| Nicholas Investment Partners, LP | 0 | 82,511 | +82,511 | 0.00 | 0.29 | +0.29 | buy |
| Candriam S.C.A. | 145,633 | 225,998 | +80,365 | 0.03 | 0.06 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,324,213 | 1,398,983 | +74,770 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 49,955 | +49,955 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 48,184 | +48,184 | 0.00 | 0.04 | +0.04 | buy |
| NORTHERN TRUST CORP | 721,062 | 763,803 | +42,741 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 82,462 | 119,597 | +37,135 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,951 | 48,236 | +35,285 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 21,762 | 51,951 | +30,189 | 0.00 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 48,927 | 76,748 | +27,821 | 0.02 | 0.03 | +0.01 | buy |
| Clearstead Advisors, LLC | 14 | 26,074 | +26,060 | 0.00 | 0.01 | +0.01 | buy |
| D.A. DAVIDSON & CO. | 0 | 24,832 | +24,832 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 2,026,758 | 2,049,679 | +22,921 | 0.98 | 1.01 | +0.03 | buy |
| SEI INVESTMENTS CO | 120,527 | 143,359 | +22,832 | 0.01 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 263,245 | 285,495 | +22,250 | 0.92 | 1.54 | +0.62 | buy |
| Scientech Research LLC | 5,014 | 26,288 | +21,274 | 0.14 | 1.08 | +0.94 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 20,465 | +20,465 | 0.00 | 0.06 | +0.06 | buy |
| CITIGROUP INC | 20,110 | 38,728 | +18,618 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 82,110 | 100,690 | +18,580 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 10,468 | 28,706 | +18,238 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 14 | 18,173 | +18,159 | 0.00 | 0.17 | +0.16 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 32,827 | 49,942 | +17,115 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 16,541 | +16,541 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,798 | 61,906 | +16,108 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 226,168 | 241,794 | +15,626 | 0.00 | 0.00 | +0.00 | buy |
| Fieldview Capital Management, LLC | 0 | 14,648 | +14,648 | 0.00 | 0.21 | +0.21 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,815 | 74,916 | +14,101 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 14,092 | +14,092 | 0.00 | 0.06 | +0.06 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 25,286 | 39,333 | +14,047 | 0.00 | 0.00 | +0.00 | buy |
| StoneCrest Wealth Management, Inc. | 59,003 | 70,914 | +11,911 | 1.01 | 1.47 | +0.47 | buy |
| Tidal Investments LLC | 0 | 9,791 | +9,791 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 168,547 | 177,377 | +8,830 | 0.01 | 0.02 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 5,030 | 13,615 | +8,585 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 245,387 | 253,599 | +8,212 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 7,735 | +7,735 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 7,688 | +7,688 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 28,886 | 36,476 | +7,590 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 12,480 | 19,481 | +7,001 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 7,000 | +7,000 | 0.00 | 0.07 | +0.07 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 6,706 | +6,706 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 733,477 | 739,816 | +6,339 | 1.66 | 2.14 | +0.49 | buy |
| Russell Investments Group, Ltd. | 7,760 | 13,740 | +5,980 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,210 | 13,995 | +5,785 | 0.01 | 0.02 | +0.01 | buy |
| E. Ohman J:or Asset Management AB | 16,374 | 22,136 | +5,762 | 0.02 | 0.03 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 5,409 | +5,409 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 5,324 | +5,324 | 0.00 | 0.00 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 5,182 | +5,182 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 5,016 | +5,016 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 4,779 | +4,779 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 4,739 | +4,739 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,210 | 19,747 | +4,537 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 6,740 | 11,272 | +4,532 | 0.00 | 0.00 | +0.00 | buy |
| Chung Wu Investment Group, LLC | 0 | 4,200 | +4,200 | 0.00 | 0.18 | +0.18 | buy |
| JPMORGAN CHASE & CO | 170,773 | 174,419 | +3,646 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 108,864 | 112,501 | +3,637 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,623 | 29,178 | +3,555 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 5,341 | 8,617 | +3,276 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 630 | 3,350 | +2,720 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 153,769 | 156,314 | +2,545 | 0.29 | 0.37 | +0.08 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 8,049 | 10,364 | +2,315 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 11,146 | 13,449 | +2,303 | 0.02 | 0.02 | +0.00 | buy |
| Creative Planning | 27,131 | 29,192 | +2,061 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 6,493 | 8,091 | +1,598 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 36,424 | 37,887 | +1,463 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 4,841 | 6,224 | +1,383 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 4,736 | 6,113 | +1,377 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 22,362 | 23,616 | +1,254 | 0.01 | 0.01 | +0.00 | buy |
| STRS OHIO | 2,700 | 3,700 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 3,499 | 4,492 | +993 | 0.01 | 0.02 | +0.01 | buy |