| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 1,513,280 | 3,074,475 | +1,561,195 | 0.42 | 0.44 | +0.02 | buy |
| MPM BioImpact LLC | 0 | 1,028,330 | +1,028,330 | 0.00 | 1.33 | +1.33 | buy |
| VANGUARD GROUP INC | 2,969,534 | 3,836,560 | +867,026 | 0.00 | 0.00 | -0.00 | buy |
| Clearbridge Investments, LLC | 0 | 747,105 | +747,105 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 744,443 | +744,443 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 357,072 | 925,584 | +568,512 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 28,800 | 590,800 | +562,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 320,819 | 800,672 | +479,853 | 0.01 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 42,324 | 487,285 | +444,961 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 168,997 | 583,774 | +414,777 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 174,976 | 439,557 | +264,581 | 0.04 | 0.06 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,191,256 | 1,422,536 | +231,280 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 33,357 | 225,145 | +191,788 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 111,866 | 254,039 | +142,173 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 138,072 | 272,795 | +134,723 | 0.05 | 0.03 | -0.01 | buy |
| Squarepoint Ops LLC | 10,439 | 145,060 | +134,621 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,232,146 | 1,339,081 | +106,935 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 92,364 | +92,364 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 0 | 92,000 | +92,000 | 0.00 | 0.02 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 0 | 76,347 | +76,347 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 325,000 | 400,000 | +75,000 | 0.57 | 0.33 | -0.23 | buy |
| Walleye Capital LLC | 0 | 74,292 | +74,292 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 98,388 | 171,094 | +72,706 | 0.08 | 0.05 | -0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 12,882 | 84,037 | +71,155 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 139,064 | 207,491 | +68,427 | 0.02 | 0.01 | -0.01 | buy |
| Atom Investors LP | 10,092 | 77,515 | +67,423 | 0.02 | 0.06 | +0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 58,870 | +58,870 | 0.00 | 0.03 | +0.03 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 58,222 | +58,222 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 402,481 | 460,654 | +58,173 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 56,850 | +56,850 | 0.00 | 0.08 | +0.08 | buy |
| AlphaQuest LLC | 8,369 | 61,029 | +52,660 | 0.03 | 0.07 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 170,471 | 222,800 | +52,329 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 46,635 | 95,590 | +48,955 | 0.02 | 0.02 | -0.01 | buy |
| EntryPoint Capital, LLC | 0 | 48,826 | +48,826 | 0.00 | 0.19 | +0.19 | buy |
| BIT Capital GmbH | 481,762 | 528,288 | +46,526 | 0.76 | 0.40 | -0.36 | buy |
| Hood River Capital Management LLC | 792,047 | 832,792 | +40,745 | 0.31 | 0.14 | -0.17 | buy |
| Bank of New York Mellon Corp | 196,982 | 230,450 | +33,468 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,267 | 39,754 | +29,487 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 60,619 | 88,526 | +27,907 | 0.00 | 0.00 | -0.00 | buy |
| Values First Advisors, Inc. | 0 | 25,979 | +25,979 | 0.00 | 0.13 | +0.13 | buy |
| Virtu Financial LLC | 0 | 23,960 | +23,960 | 0.00 | 0.01 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 21,011 | +21,011 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Trading LLC | 10,000 | 30,096 | +20,096 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 953 | 20,432 | +19,479 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 20,866 | 39,713 | +18,847 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 20,729 | 37,667 | +16,938 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 0 | 16,867 | +16,867 | 0.00 | 0.07 | +0.07 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 16,181 | +16,181 | 0.00 | 0.02 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 13,628 | 28,444 | +14,816 | 0.03 | 0.03 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 238,747 | 253,527 | +14,780 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 157,281 | 171,976 | +14,695 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 14,410 | +14,410 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 12,343 | +12,343 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 29,269 | 41,410 | +12,141 | 0.01 | 0.01 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 12,011 | +12,011 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.02 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 11,790 | +11,790 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,418 | 37,924 | +11,506 | 0.01 | 0.01 | -0.01 | buy |
| MetLife Investment Management, LLC | 29,324 | 39,966 | +10,642 | 0.00 | 0.00 | -0.00 | buy |
| M&T BANK CORP | 0 | 10,611 | +10,611 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 10,287 | +10,287 | 0.00 | 0.01 | +0.01 | buy |
| Utah Retirement Systems | 0 | 10,286 | +10,286 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 23,605 | 31,568 | +7,963 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 94,056 | 101,278 | +7,222 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 42,300 | 48,600 | +6,300 | 0.02 | 0.01 | -0.01 | buy |
| Swiss National Bank | 78,300 | 84,200 | +5,900 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,671 | 9,600 | +4,929 | 0.04 | 0.04 | -0.00 | buy |
| DnB Asset Management AS | 15,422 | 19,812 | +4,390 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 12,390 | 16,695 | +4,305 | 0.01 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,294 | 24,526 | +4,232 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 275,894 | 279,951 | +4,057 | 0.10 | 0.05 | -0.05 | buy |
| Russell Investments Group, Ltd. | 32 | 3,979 | +3,947 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 45,112 | 47,797 | +2,685 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,471 | 43,808 | +2,337 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 138,458 | 140,776 | +2,318 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 44,406 | 46,000 | +1,594 | 0.05 | 0.02 | -0.02 | buy |
| BARCLAYS PLC | 80,101 | 81,331 | +1,230 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 10,905 | 11,988 | +1,083 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 18,539 | 19,536 | +997 | 0.00 | 0.00 | -0.00 | buy |
| Clarius Group, LLC | 13,037 | 13,680 | +643 | 0.02 | 0.01 | -0.01 | buy |
| AdvisorNet Financial, Inc | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 372,043 | 372,250 | +207 | 0.02 | 0.01 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 29,716 | 29,881 | +165 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 138 | +138 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 131 | +131 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,893 | 2,023 | +130 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,361 | 1,416 | +55 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 105 | 160 | +55 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 242 | 279 | +37 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 45 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,553 | 22,586 | +33 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 3,777 | 3,777 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artal Group S.A. | 11,259,438 | 11,259,438 | 0 | 5.15 | 2.41 | -2.75 | hold |
| Ameritas Investment Partners, Inc. | 5,742 | 5,742 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 309,646 | 309,646 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 56,870 | 56,870 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 120,000 | 120,000 | 0 | 0.00 | 0.00 | -0.00 | hold |