| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 1,513,280 | 3,074,475 | +1,561,195 | 0.42 | 0.44 | +0.02 | buy |
| Aberdeen Group plc | 168,997 | 583,774 | +414,777 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 325,000 | 400,000 | +75,000 | 0.54 | 0.32 | -0.22 | buy |
| J. Goldman & Co LP | 98,388 | 171,094 | +72,706 | 0.06 | 0.04 | -0.02 | buy |
| Atom Investors LP | 10,092 | 77,515 | +67,423 | 0.02 | 0.06 | +0.04 | buy |
| BIT Capital GmbH | 481,762 | 528,288 | +46,526 | 0.63 | 0.34 | -0.29 | buy |
| Hood River Capital Management LLC | 792,047 | 832,792 | +40,745 | 0.31 | 0.14 | -0.17 | buy |
| Dynamic Technology Lab Private Ltd | 13,628 | 28,444 | +14,816 | 0.03 | 0.03 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 23,605 | 31,568 | +7,963 | 0.01 | 0.01 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 42,300 | 48,600 | +6,300 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,671 | 9,600 | +4,929 | 0.04 | 0.04 | -0.00 | buy |
| DnB Asset Management AS | 15,422 | 19,812 | +4,390 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 275,894 | 279,951 | +4,057 | 0.10 | 0.05 | -0.05 | buy |
| JENNISON ASSOCIATES LLC | 138,458 | 140,776 | +2,318 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 44,406 | 46,000 | +1,594 | 0.05 | 0.02 | -0.02 | buy |
| Clarius Group, LLC | 13,037 | 13,680 | +643 | 0.02 | 0.01 | -0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 15,400 | 15,030 | -370 | 0.11 | 0.05 | -0.06 | sell |
| China Universal Asset Management Co., Ltd. | 13,868 | 9,370 | -4,498 | 0.03 | 0.01 | -0.02 | sell |
| Cinctive Capital Management LP | 48,335 | 40,033 | -8,302 | 0.04 | 0.02 | -0.02 | sell |
| Ikarian Capital, LLC | 291,701 | 183,701 | -108,000 | 0.57 | 0.27 | -0.30 | sell |
| Deep Track Capital, LP | 680,000 | 372,559 | -307,441 | 0.35 | 0.09 | -0.25 | sell |
| Laurion Capital Management LP | 525,056 | 214,972 | -310,084 | 0.08 | 0.02 | -0.06 | sell |
| Woodline Partners LP | 1,061,750 | 708,187 | -353,563 | 0.17 | 0.06 | -0.12 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 525,000 | 125,000 | -400,000 | 0.02 | 0.00 | -0.02 | sell |
| Redmile Group, LLC | 6,419,610 | 5,453,083 | -966,527 | 4.18 | 2.75 | -1.44 | sell |
| ORBIMED ADVISORS LLC | 3,574,632 | 1,074,382 | -2,500,250 | 1.17 | 0.18 | -0.99 | sell |