| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 1,600,554 | +1,600,554 | 0.00 | 2.42 | +2.42 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 933,432 | +933,432 | 0.00 | 0.08 | +0.08 | buy |
| Pictet Asset Management Holding SA | 89,027 | 987,464 | +898,437 | 0.00 | 0.04 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 1,670,187 | 2,450,286 | +780,099 | 0.03 | 0.04 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 514,092 | 1,177,515 | +663,423 | 0.16 | 0.33 | +0.17 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 313,689 | 769,442 | +455,753 | 2.08 | 3.22 | +1.14 | buy |
| Fairmount Funds Management LLC | 1,374,031 | 1,824,031 | +450,000 | 6.85 | 8.37 | +1.52 | buy |
| Bellevue Group AG | 2,506,890 | 2,947,295 | +440,405 | 1.81 | 2.30 | +0.49 | buy |
| ROYAL BANK OF CANADA | 0 | 407,686 | +407,686 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 365,946 | +365,946 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 341,010 | +341,010 | 0.00 | 2.47 | +2.47 | buy |
| BANK OF AMERICA CORP /DE/ | 326,385 | 644,232 | +317,847 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 269,400 | +269,400 | 0.00 | 2.36 | +2.36 | buy |
| Ensign Peak Advisors, Inc | 335,946 | 600,639 | +264,693 | 0.02 | 0.04 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,661,608 | 2,913,246 | +251,638 | 1.70 | 1.81 | +0.10 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 134,182 | 375,316 | +241,134 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 2,209 | 241,000 | +238,791 | 0.00 | 0.02 | +0.02 | buy |
| Vestal Point Capital, LP | 1,300,000 | 1,500,000 | +200,000 | 2.98 | 2.80 | -0.19 | buy |
| JPMORGAN CHASE & CO | 75,147 | 273,587 | +198,440 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,844,997 | 2,024,865 | +179,868 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 177,265 | 339,027 | +161,762 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 132,348 | +132,348 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 60,540 | 191,998 | +131,458 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 156,371 | 285,320 | +128,949 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 103,482 | +103,482 | 0.00 | 0.66 | +0.66 | buy |
| Nuveen, LLC | 397,342 | 496,553 | +99,211 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 860,307 | 944,432 | +84,125 | 0.18 | 0.18 | -0.00 | buy |
| Granahan Investment Management, LLC | 0 | 73,375 | +73,375 | 0.00 | 0.11 | +0.11 | buy |
| RAYMOND JAMES FINANCIAL INC | 61,379 | 125,477 | +64,098 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 61,607 | +61,607 | 0.00 | 1.42 | +1.42 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 15,942 | 76,738 | +60,796 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 0 | 51,478 | +51,478 | 0.00 | 0.26 | +0.26 | buy |
| MORGAN STANLEY | 853,437 | 904,387 | +50,950 | 0.00 | 0.00 | +0.00 | buy |
| MASTERS CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.34 | +0.34 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 7,834 | 54,556 | +46,722 | 0.01 | 0.05 | +0.04 | buy |
| Cinctive Capital Management LP | 0 | 45,422 | +45,422 | 0.00 | 0.09 | +0.09 | buy |
| FMR LLC | 13,794,490 | 13,834,875 | +40,385 | 0.03 | 0.03 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,847,449 | 1,887,410 | +39,961 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 27,366 | 66,261 | +38,895 | 0.18 | 0.45 | +0.27 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 36,103 | +36,103 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 169,825 | 205,085 | +35,260 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 10,000 | 43,000 | +33,000 | 0.01 | 0.03 | +0.02 | buy |
| Rock Springs Capital Management LP | 761,541 | 794,133 | +32,592 | 1.40 | 1.75 | +0.35 | buy |
| Hood River Capital Management LLC | 1,944,158 | 1,974,964 | +30,806 | 1.07 | 0.98 | -0.09 | buy |
| AMI ASSET MANAGEMENT CORP | 0 | 29,601 | +29,601 | 0.00 | 0.06 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 663,927 | 692,676 | +28,749 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 11,550 | 38,137 | +26,587 | 0.00 | 0.00 | +0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 26,000 | +26,000 | 0.00 | 0.65 | +0.65 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 52,628 | 73,902 | +21,274 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 21,100 | +21,100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 617,107 | 635,891 | +18,784 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 18,037 | +18,037 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,845,205 | 4,861,594 | +16,389 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 0 | 15,153 | +15,153 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 15,153 | +15,153 | 0.00 | 0.14 | +0.14 | buy |
| Verition Fund Management LLC | 15,702 | 30,104 | +14,402 | 0.00 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 8,174 | 21,400 | +13,226 | 0.01 | 0.02 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 10,380 | +10,380 | 0.00 | 0.24 | +0.24 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 10,280 | +10,280 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 967,549 | 976,625 | +9,076 | 0.03 | 0.03 | -0.00 | buy |
| SEI INVESTMENTS CO | 81,232 | 89,145 | +7,913 | 0.00 | 0.00 | +0.00 | buy |
| Mill Creek Capital Advisors, LLC | 0 | 7,500 | +7,500 | 0.00 | 0.01 | +0.01 | buy |
| E. Ohman J:or Asset Management AB | 57,185 | 64,568 | +7,383 | 0.05 | 0.06 | +0.01 | buy |
| Invesco Ltd. | 54,937 | 61,964 | +7,027 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,347 | 9,115 | +6,768 | 0.00 | 0.01 | +0.01 | buy |
| XPONANCE, INC. | 0 | 6,346 | +6,346 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 216,223 | 222,430 | +6,207 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 5,793 | +5,793 | 0.00 | 0.05 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,557 | 23,737 | +5,180 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,635,300 | 1,640,437 | +5,137 | 0.07 | 0.07 | -0.00 | buy |
| Legal & General Group Plc | 66,719 | 71,795 | +5,076 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 57,923 | 62,926 | +5,003 | 1.49 | 1.39 | -0.10 | buy |
| RHUMBLINE ADVISERS | 120,752 | 125,381 | +4,629 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 8,512 | 12,891 | +4,379 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 53,563 | 56,716 | +3,153 | 0.10 | 0.11 | +0.01 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 2,665 | +2,665 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 18,181 | 20,770 | +2,589 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 40,744 | 43,302 | +2,558 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 46,049 | 48,363 | +2,314 | 0.01 | 0.01 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 2,261 | +2,261 | 0.00 | 0.01 | +0.01 | buy |
| Values First Advisors, Inc. | 18,208 | 20,125 | +1,917 | 0.34 | 0.39 | +0.05 | buy |
| KLP KAPITALFORVALTNING AS | 12,400 | 14,100 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 2,400 | 3,900 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 17,726 | 19,211 | +1,485 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 13,103 | 14,314 | +1,211 | 0.37 | 0.44 | +0.07 | buy |
| Creative Planning | 19,722 | 20,767 | +1,045 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 13,293 | 14,286 | +993 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 17,172 | 18,150 | +978 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,436 | 11,146 | +710 | 0.02 | 0.02 | +0.00 | buy |
| US BANCORP \DE\ | 848 | 1,554 | +706 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 617 | +617 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 18,767 | 19,360 | +593 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,795 | 62,372 | +577 | 0.00 | 0.00 | -0.00 | buy |
| Compagnie Lombard Odier SCmA | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,168 | 3,668 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 67 | 424 | +357 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 6,839 | 7,128 | +289 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 6,678 | 6,966 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 227 | 510 | +283 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,574 | 17,849 | +275 | 0.00 | 0.00 | +0.00 | buy |