| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,794,490 | 13,834,875 | +40,385 | 0.03 | 0.03 | -0.00 | buy |
| Siren, L.L.C. | 9,250,005 | 9,250,005 | 0 | 16.78 | 16.95 | +0.18 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,893,886 | 8,761,650 | -132,236 | 0.04 | 0.04 | -0.00 | sell |
| BlackRock, Inc. | 7,307,269 | 6,695,880 | -611,389 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 5,612,896 | 5,612,896 | 0 | 32.18 | 40.66 | +8.48 | hold |
| VANGUARD GROUP INC | 4,845,205 | 4,861,594 | +16,389 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 4,398,281 | 3,929,039 | -469,242 | 13.37 | 14.81 | +1.45 | sell |
| STATE STREET CORP | 3,134,140 | 3,074,296 | -59,844 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 2,506,890 | 2,947,295 | +440,405 | 1.81 | 2.30 | +0.49 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,661,608 | 2,913,246 | +251,638 | 1.70 | 1.81 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 1,670,187 | 2,450,286 | +780,099 | 0.03 | 0.04 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,844,997 | 2,024,865 | +179,868 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 1,944,158 | 1,974,964 | +30,806 | 1.07 | 0.98 | -0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,847,449 | 1,887,410 | +39,961 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 1,374,031 | 1,824,031 | +450,000 | 6.85 | 8.37 | +1.52 | buy |
| MARSHALL WACE, LLP | 1,635,300 | 1,640,437 | +5,137 | 0.07 | 0.07 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,600,554 | +1,600,554 | 0.00 | 2.42 | +2.42 | buy |
| Polar Capital Holdings Plc | 2,583,371 | 1,500,000 | -1,083,371 | 0.51 | 0.28 | -0.23 | sell |
| Vestal Point Capital, LP | 1,300,000 | 1,500,000 | +200,000 | 2.98 | 2.80 | -0.19 | buy |
| Commodore Capital LP | 1,745,000 | 1,450,000 | -295,000 | 4.13 | 3.63 | -0.51 | sell |
| GOLDMAN SACHS GROUP INC | 1,404,423 | 1,289,973 | -114,450 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,018,000 | 1,215,000 | -803,000 | 0.12 | 0.07 | -0.05 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 514,092 | 1,177,515 | +663,423 | 0.16 | 0.33 | +0.17 | buy |
| NORGES BANK | 1,633,422 | 1,175,278 | -458,144 | 0.01 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,136,453 | 1,136,453 | 0 | 0.61 | 0.68 | +0.07 | hold |
| Capital World Investors | 1,128,752 | 1,128,752 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Pictet Asset Management Holding SA | 89,027 | 987,464 | +898,437 | 0.00 | 0.04 | +0.03 | buy |
| CITADEL ADVISORS LLC | 967,549 | 976,625 | +9,076 | 0.03 | 0.03 | -0.00 | buy |
| Woodline Partners LP | 860,307 | 944,432 | +84,125 | 0.18 | 0.18 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 933,432 | +933,432 | 0.00 | 0.08 | +0.08 | buy |
| MORGAN STANLEY | 853,437 | 904,387 | +50,950 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 761,541 | 794,133 | +32,592 | 1.40 | 1.75 | +0.35 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 313,689 | 769,442 | +455,753 | 2.08 | 3.22 | +1.14 | buy |
| LOOMIS SAYLES & CO L P | 760,645 | 742,939 | -17,706 | 0.04 | 0.03 | -0.00 | sell |
| NORTHERN TRUST CORP | 765,280 | 736,786 | -28,494 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 663,927 | 692,676 | +28,749 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 326,385 | 644,232 | +317,847 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 617,107 | 635,891 | +18,784 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 987,710 | 601,153 | -386,557 | 0.09 | 0.05 | -0.05 | sell |
| Ensign Peak Advisors, Inc | 335,946 | 600,639 | +264,693 | 0.02 | 0.04 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 566,212 | 528,115 | -38,097 | 5.81 | 6.02 | +0.21 | sell |
| Nuveen, LLC | 397,342 | 496,553 | +99,211 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 877,374 | 474,144 | -403,230 | 0.10 | 0.05 | -0.05 | sell |
| Fisher Asset Management, LLC | 456,871 | 412,411 | -44,460 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 407,686 | +407,686 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 134,182 | 375,316 | +241,134 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 365,946 | +365,946 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 341,010 | +341,010 | 0.00 | 2.47 | +2.47 | buy |
| Candriam S.C.A. | 496,756 | 339,333 | -157,423 | 0.10 | 0.07 | -0.03 | sell |
| UBS Group AG | 177,265 | 339,027 | +161,762 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 339,016 | 333,626 | -5,390 | 0.01 | 0.01 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 317,400 | 291,200 | -26,200 | 0.02 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 156,371 | 285,320 | +128,949 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 343,492 | 284,412 | -59,080 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 75,147 | 273,587 | +198,440 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 269,400 | +269,400 | 0.00 | 2.36 | +2.36 | buy |
| FEDERATED HERMES, INC. | 2,209 | 241,000 | +238,791 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 372,737 | 225,897 | -146,840 | 0.03 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 216,223 | 222,430 | +6,207 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 215,405 | 209,206 | -6,199 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 169,825 | 205,085 | +35,260 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 60,540 | 191,998 | +131,458 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 179,923 | 171,948 | -7,975 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 154,000 | 154,000 | 0 | 2.05 | 1.97 | -0.08 | hold |
| Russell Investments Group, Ltd. | 182,932 | 153,886 | -29,046 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 317,645 | 136,283 | -181,362 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 0 | 132,348 | +132,348 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 127,000 | 127,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artia Global Partners LP | 172,185 | 126,285 | -45,900 | 1.62 | 1.15 | -0.47 | sell |
| RAYMOND JAMES FINANCIAL INC | 61,379 | 125,477 | +64,098 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 120,752 | 125,381 | +4,629 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 285,000 | 125,000 | -160,000 | 0.72 | 0.31 | -0.41 | sell |
| TFG Asset Management GP Ltd | 0 | 103,482 | +103,482 | 0.00 | 0.66 | +0.66 | buy |
| Integral Health Asset Management, LLC | 125,000 | 100,000 | -25,000 | 0.45 | 0.33 | -0.11 | sell |
| Rafferty Asset Management, LLC | 111,671 | 99,855 | -11,816 | 0.02 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 160,774 | 97,334 | -63,440 | 0.01 | 0.01 | -0.00 | sell |
| AXA S.A. | 105,960 | 92,992 | -12,968 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 81,232 | 89,145 | +7,913 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 84,339 | 84,339 | 0 | 2.43 | 2.46 | +0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 82,110 | 82,110 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 15,942 | 76,738 | +60,796 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 52,628 | 73,902 | +21,274 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 0 | 73,375 | +73,375 | 0.00 | 0.11 | +0.11 | buy |
| Legal & General Group Plc | 66,719 | 71,795 | +5,076 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 27,366 | 66,261 | +38,895 | 0.18 | 0.45 | +0.27 | buy |
| E. Ohman J:or Asset Management AB | 57,185 | 64,568 | +7,383 | 0.05 | 0.06 | +0.01 | buy |
| Jasper Ridge Partners, L.P. | 64,169 | 64,169 | 0 | 0.07 | 0.06 | -0.01 | hold |
| DIADEMA PARTNERS LP | 57,923 | 62,926 | +5,003 | 1.49 | 1.39 | -0.10 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,795 | 62,372 | +577 | 0.00 | 0.00 | -0.00 | buy |
| Informed Momentum Co LLC | 92,038 | 62,347 | -29,691 | 0.51 | 0.33 | -0.18 | sell |
| Invesco Ltd. | 54,937 | 61,964 | +7,027 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 61,607 | +61,607 | 0.00 | 1.42 | +1.42 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 78,193 | 57,497 | -20,696 | 0.62 | 0.53 | -0.09 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 53,563 | 56,716 | +3,153 | 0.10 | 0.11 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 7,834 | 54,556 | +46,722 | 0.01 | 0.05 | +0.04 | buy |
| CITIGROUP INC | 148,684 | 51,668 | -97,016 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 0 | 51,478 | +51,478 | 0.00 | 0.26 | +0.26 | buy |
| MASTERS CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.34 | +0.34 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,891 | 49,964 | -24,927 | 0.01 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,046 | 49,375 | -3,671 | 0.00 | 0.00 | -0.00 | sell |