| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 514,092 | 1,177,515 | +663,423 | 0.16 | 0.33 | +0.17 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 313,689 | 769,442 | +455,753 | 2.08 | 3.22 | +1.14 | buy |
| Fairmount Funds Management LLC | 1,374,031 | 1,824,031 | +450,000 | 6.85 | 8.37 | +1.52 | buy |
| Bellevue Group AG | 2,506,890 | 2,947,295 | +440,405 | 1.81 | 2.30 | +0.49 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,661,608 | 2,913,246 | +251,638 | 1.70 | 1.81 | +0.10 | buy |
| Vestal Point Capital, LP | 1,300,000 | 1,500,000 | +200,000 | 2.98 | 2.80 | -0.19 | buy |
| Woodline Partners LP | 860,307 | 944,432 | +84,125 | 0.18 | 0.18 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 7,834 | 54,556 | +46,722 | 0.01 | 0.05 | +0.04 | buy |
| MOODY ALDRICH PARTNERS LLC | 27,366 | 66,261 | +38,895 | 0.18 | 0.45 | +0.27 | buy |
| Rock Springs Capital Management LP | 761,541 | 794,133 | +32,592 | 1.40 | 1.75 | +0.35 | buy |
| Hood River Capital Management LLC | 1,944,158 | 1,974,964 | +30,806 | 1.07 | 0.98 | -0.09 | buy |
| Polar Asset Management Partners Inc. | 8,174 | 21,400 | +13,226 | 0.01 | 0.01 | +0.01 | buy |
| E. Ohman J:or Asset Management AB | 57,185 | 64,568 | +7,383 | 0.05 | 0.06 | +0.01 | buy |
| DIADEMA PARTNERS LP | 57,923 | 62,926 | +5,003 | 1.49 | 1.39 | -0.10 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 53,563 | 56,716 | +3,153 | 0.10 | 0.11 | +0.01 | buy |
| Values First Advisors, Inc. | 18,208 | 20,125 | +1,917 | 0.34 | 0.39 | +0.05 | buy |
| DnB Asset Management AS | 17,726 | 19,211 | +1,485 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 13,103 | 14,314 | +1,211 | 0.37 | 0.44 | +0.07 | buy |
| E Fund Management Co., Ltd. | 10,436 | 11,146 | +710 | 0.02 | 0.02 | +0.00 | buy |
| Accent Capital Management, LLC | 400 | 607 | +207 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,991 | 19,069 | +78 | 0.06 | 0.06 | +0.01 | buy |
| SYON CAPITAL LLC | 9,562 | 9,524 | -38 | 0.03 | 0.02 | -0.00 | sell |
| SIG BROKERAGE, LP | 6,978 | 6,392 | -586 | 0.01 | 0.01 | -0.01 | sell |
| Virtus Investment Advisers, LLC | 3,939 | 2,822 | -1,117 | 0.03 | 0.03 | -0.00 | sell |
| PROFUND ADVISORS LLC | 23,598 | 21,346 | -2,252 | 0.03 | 0.03 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,844 | 23,944 | -4,900 | 0.07 | 0.08 | +0.01 | sell |
| LOOMIS SAYLES & CO L P | 760,645 | 742,939 | -17,706 | 0.04 | 0.03 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 78,193 | 57,497 | -20,696 | 0.58 | 0.48 | -0.10 | sell |
| Integral Health Asset Management, LLC | 125,000 | 100,000 | -25,000 | 0.45 | 0.33 | -0.11 | sell |
| Informed Momentum Co LLC | 92,038 | 62,347 | -29,691 | 0.51 | 0.33 | -0.18 | sell |
| J. Goldman & Co LP | 40,090 | 8,688 | -31,402 | 0.03 | 0.01 | -0.02 | sell |
| STEMPOINT CAPITAL LP | 566,212 | 528,115 | -38,097 | 5.81 | 6.02 | +0.21 | sell |
| BIT Capital GmbH | 42,694 | 4,278 | -38,416 | 0.12 | 0.01 | -0.11 | sell |
| Fisher Asset Management, LLC | 456,871 | 412,411 | -44,460 | 0.01 | 0.01 | -0.00 | sell |
| Artia Global Partners LP | 172,185 | 126,285 | -45,900 | 1.62 | 1.15 | -0.47 | sell |
| Clearbridge Investments, LLC | 343,492 | 284,412 | -59,080 | 0.01 | 0.01 | -0.00 | sell |
| Sofinnova Investments, Inc. | 116,117 | 26,440 | -89,677 | 0.24 | 0.06 | -0.19 | sell |
| ADAR1 Capital Management, LLC | 157,079 | 39,677 | -117,402 | 0.97 | 0.23 | -0.74 | sell |
| Candriam S.C.A. | 496,756 | 339,333 | -157,423 | 0.10 | 0.07 | -0.03 | sell |
| Soleus Capital Management, L.P. | 285,000 | 125,000 | -160,000 | 0.72 | 0.31 | -0.41 | sell |
| Ikarian Capital, LLC | 244,179 | 49,179 | -195,000 | 2.56 | 0.58 | -1.98 | sell |
| Commodore Capital LP | 1,745,000 | 1,450,000 | -295,000 | 4.13 | 3.63 | -0.51 | sell |
| LORD, ABBETT & CO. LLC | 877,374 | 474,144 | -403,230 | 0.10 | 0.05 | -0.05 | sell |
| Redmile Group, LLC | 4,398,281 | 3,929,039 | -469,242 | 13.37 | 14.81 | +1.45 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,018,000 | 1,215,000 | -803,000 | 0.12 | 0.07 | -0.05 | sell |
| Polar Capital Holdings Plc | 2,583,371 | 1,500,000 | -1,083,371 | 0.51 | 0.28 | -0.23 | sell |