| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 17,243,152 | 17,995,241 | +752,089 | 0.04 | 0.04 | -0.00 | buy |
| Siren, L.L.C. | 10,825,013 | 9,575,013 | -1,250,000 | 14.75 | 10.69 | -4.06 | sell |
| BlackRock, Inc. | 7,469,293 | 9,494,084 | +2,024,791 | 0.01 | 0.01 | +0.00 | buy |
| Samsara BioCapital, LLC | 6,897,652 | 6,897,652 | 0 | 32.95 | 31.16 | -1.79 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,206,618 | 6,794,837 | +588,219 | 0.04 | 0.04 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,717,655 | 6,727,085 | +9,430 | 0.06 | 0.06 | +0.00 | buy |
| Orbis Allan Gray Ltd | 4,179,983 | 5,933,533 | +1,753,550 | 0.87 | 1.12 | +0.25 | buy |
| STATE STREET CORP | 4,031,317 | 4,728,681 | +697,364 | 0.01 | 0.01 | +0.00 | buy |
| Redmile Group, LLC | 9,066,621 | 4,311,092 | -4,755,529 | 29.51 | 15.92 | -13.60 | sell |
| NORGES BANK | 0 | 2,769,910 | +2,769,910 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,149,036 | 2,753,787 | +604,751 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 2,607,348 | +2,607,348 | 0.00 | 0.05 | +0.05 | buy |
| Bellevue Group AG | 3,584,573 | 2,449,547 | -1,135,026 | 4.19 | 2.83 | -1.36 | sell |
| JENNISON ASSOCIATES LLC | 3,340,492 | 2,358,587 | -981,905 | 0.11 | 0.08 | -0.04 | sell |
| Hood River Capital Management LLC | 2,049,679 | 2,224,788 | +175,109 | 1.01 | 0.89 | -0.12 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,920,233 | 2,205,618 | +285,385 | 0.69 | 0.70 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,197,385 | 2,111,410 | -85,975 | 1.78 | 1.55 | -0.23 | sell |
| Polar Capital Holdings Plc | 1,983,628 | 1,878,580 | -105,048 | 0.43 | 0.29 | -0.13 | sell |
| Holocene Advisors, LP | 1,890,927 | 1,755,978 | -134,949 | 0.23 | 0.22 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 1,731,402 | +1,031,402 | 0.05 | 0.13 | +0.08 | buy |
| MORGAN STANLEY | 219,027 | 1,538,776 | +1,319,749 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,500,470 | 1,500,470 | 0 | 0.28 | 0.26 | -0.02 | hold |
| GOLDMAN SACHS GROUP INC | 1,398,983 | 1,411,477 | +12,494 | 0.01 | 0.01 | -0.00 | buy |
| Capital World Investors | 1,128,752 | 1,160,409 | +31,657 | 0.01 | 0.01 | -0.00 | buy |
| Clearbridge Investments, LLC | 691,418 | 1,059,776 | +368,358 | 0.03 | 0.05 | +0.02 | buy |
| BNP Paribas Asset Management Holding S.A. | 981,915 | 979,845 | -2,070 | 0.06 | 0.05 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 707,101 | 975,197 | +268,096 | 0.02 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 763,803 | 974,576 | +210,773 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,336,632 | 972,257 | -364,375 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 875,084 | 911,075 | +35,991 | 0.05 | 0.05 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 725,409 | 890,607 | +165,198 | 0.04 | 0.04 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 26,882 | 878,726 | +851,844 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 864,286 | +864,286 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 701,011 | 864,286 | +163,275 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 500,000 | 750,000 | +250,000 | 1.30 | 1.69 | +0.39 | buy |
| FEDERATED HERMES, INC. | 797,913 | 734,513 | -63,400 | 0.06 | 0.06 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 723,875 | 717,512 | -6,363 | 0.02 | 0.02 | -0.00 | sell |
| Rock Springs Capital Management LP | 739,816 | 715,452 | -24,364 | 2.14 | 1.92 | -0.22 | sell |
| Casdin Capital, LLC | 350,000 | 665,000 | +315,000 | 1.30 | 1.83 | +0.53 | buy |
| Nuveen, LLC | 581,654 | 651,749 | +70,095 | 0.01 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 638,629 | 596,055 | -42,574 | 0.04 | 0.04 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 717,253 | 579,052 | -138,201 | 0.07 | 0.05 | -0.01 | sell |
| Eagle Health Investments LP | 494,019 | 555,272 | +61,253 | 5.10 | 5.06 | -0.04 | buy |
| UBS Group AG | 679,784 | 511,170 | -168,614 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 463,730 | +463,730 | 0.00 | 0.03 | +0.03 | buy |
| Fisher Asset Management, LLC | 458,017 | 439,447 | -18,570 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,060,275 | 430,500 | -629,775 | 0.06 | 0.02 | -0.04 | sell |
| Bank of New York Mellon Corp | 232,672 | 365,218 | +132,546 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 900,799 | 331,851 | -568,948 | 0.03 | 0.01 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 241,794 | 303,268 | +61,474 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 49,955 | 291,996 | +242,041 | 0.01 | 0.03 | +0.03 | buy |
| NAN FUNG TRINITY (HK) Ltd | 285,495 | 285,495 | 0 | 1.54 | 1.55 | +0.01 | hold |
| ARMISTICE CAPITAL, LLC | 336,959 | 278,000 | -58,959 | 0.55 | 0.42 | -0.12 | sell |
| Trexquant Investment LP | 76,748 | 275,712 | +198,964 | 0.03 | 0.09 | +0.07 | buy |
| First Turn Management, LLC | 446,390 | 271,227 | -175,163 | 2.45 | 1.60 | -0.86 | sell |
| AQR CAPITAL MANAGEMENT LLC | 211,960 | 247,521 | +35,561 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 14,644 | 245,027 | +230,383 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 253,599 | 240,665 | -12,934 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 1,035,496 | 239,146 | -796,350 | 9.78 | 2.28 | -7.51 | sell |
| Candriam S.C.A. | 225,998 | 216,146 | -9,852 | 0.06 | 0.05 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 177,377 | 209,991 | +32,614 | 0.02 | 0.02 | +0.00 | buy |
| Senator Investment Group LP | 0 | 205,000 | +205,000 | 0.00 | 0.41 | +0.41 | buy |
| Logos Global Management LP | 0 | 200,000 | +200,000 | 0.00 | 0.47 | +0.47 | buy |
| Susquehanna Portfolio Strategies, LLC | 48,184 | 199,052 | +150,868 | 0.04 | 0.17 | +0.14 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 188,588 | +188,588 | 0.00 | 0.12 | +0.12 | buy |
| JPMORGAN CHASE & CO | 174,419 | 177,692 | +3,273 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 143,359 | 173,623 | +30,264 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 156,314 | 163,759 | +7,445 | 0.37 | 0.32 | -0.05 | buy |
| Swiss National Bank | 123,200 | 149,800 | +26,600 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 112,501 | 145,460 | +32,959 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,690 | 139,820 | +39,130 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 146,606 | 139,534 | -7,072 | 0.27 | 0.25 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 37,887 | 133,482 | +95,595 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 13,740 | 130,287 | +116,547 | 0.00 | 0.01 | +0.01 | buy |
| MGO ONE SEVEN LLC | 0 | 125,077 | +125,077 | 0.00 | 0.11 | +0.11 | buy |
| iA Global Asset Management Inc. | 123,212 | 122,812 | -400 | 0.09 | 0.08 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 173,765 | 122,223 | -51,542 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 223,064 | 120,364 | -102,700 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 32,690 | 115,011 | +82,321 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 38,728 | 113,031 | +74,303 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 102,912 | 111,186 | +8,274 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 62,118 | 104,346 | +42,228 | 0.01 | 0.01 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.11 | +0.11 | buy |
| Artia Global Partners LP | 96,285 | 96,285 | 0 | 1.07 | 1.01 | -0.06 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 94,265 | 94,265 | 0 | 0.80 | 0.74 | -0.06 | hold |
| Invesco Ltd. | 119,597 | 94,156 | -25,441 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 91,500 | +91,500 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 82,511 | 90,334 | +7,823 | 0.29 | 0.28 | -0.01 | buy |
| BEACONLIGHT CAPITAL, LLC | 0 | 87,893 | +87,893 | 0.00 | 2.13 | +2.13 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,916 | 85,644 | +10,728 | 0.00 | 0.00 | +0.00 | buy |
| StoneCrest Wealth Management, Inc. | 70,914 | 78,780 | +7,866 | 1.47 | 1.38 | -0.09 | buy |
| Aisling Capital Management LP | 77,031 | 77,031 | 0 | 0.80 | 0.90 | +0.10 | hold |
| Hudson Bay Capital Management LP | 83,450 | 75,000 | -8,450 | 0.02 | 0.02 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 61,906 | 72,527 | +10,621 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 172,535 | 71,909 | -100,626 | 0.56 | 0.16 | -0.40 | sell |
| MetLife Investment Management, LLC | 47,463 | 65,038 | +17,575 | 0.01 | 0.02 | +0.00 | buy |
| Rafferty Asset Management, LLC | 104,456 | 62,608 | -41,848 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 49,914 | 61,144 | +11,230 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 12,130 | 58,350 | +46,220 | 0.01 | 0.04 | +0.03 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 51,951 | 52,132 | +181 | 0.02 | 0.02 | +0.01 | buy |