| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 9,887,233 | 10,196,046 | +308,813 | 0.01 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,188,127 | 8,654,106 | +465,979 | 0.01 | 0.01 | -0.00 | buy |
| Samsara BioCapital, LLC | 6,788,609 | 6,788,609 | 0 | 11.84 | 10.45 | -1.38 | hold |
| Redmile Group, LLC | 5,453,083 | 5,238,837 | -214,246 | 2.75 | 2.47 | -0.27 | sell |
| VANGUARD GROUP INC | 3,836,560 | 4,034,665 | +198,105 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 2,940,672 | 2,940,672 | 0 | 0.14 | 0.11 | -0.03 | hold |
| STATE STREET CORP | 2,808,924 | 2,773,516 | -35,408 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,074,475 | 2,409,207 | -665,268 | 0.44 | 0.33 | -0.11 | sell |
| Hood River Capital Management LLC | 832,792 | 2,349,721 | +1,516,929 | 0.14 | 0.30 | +0.16 | buy |
| Bellevue Group AG | 2,165,203 | 2,161,203 | -4,000 | 0.29 | 0.28 | -0.01 | sell |
| NORGES BANK | 0 | 1,730,104 | +1,730,104 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,422,536 | 1,543,025 | +120,489 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,339,081 | 1,399,202 | +60,121 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 744,443 | 1,155,536 | +411,093 | 0.04 | 0.05 | +0.02 | buy |
| Clearbridge Investments, LLC | 747,105 | 924,395 | +177,290 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 112,996 | 783,474 | +670,478 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 583,774 | 748,489 | +164,715 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,074,382 | 742,300 | -332,082 | 0.18 | 0.11 | -0.07 | sell |
| Fisher Asset Management, LLC | 105,833 | 734,019 | +628,186 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 708,187 | 709,831 | +1,644 | 0.06 | 0.05 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 925,584 | 670,342 | -255,242 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 505,224 | 620,623 | +115,399 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 800,672 | 618,914 | -181,758 | 0.02 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 590,800 | 592,000 | +1,200 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 253,527 | 547,723 | +294,196 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 528,288 | 521,845 | -6,443 | 0.40 | 0.40 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 460,654 | 502,793 | +42,139 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 366,078 | 408,281 | +42,203 | 0.01 | 0.01 | +0.00 | buy |
| AXA S.A. | 372,250 | 372,355 | +105 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 439,557 | 313,467 | -126,090 | 0.06 | 0.04 | -0.03 | sell |
| CITIGROUP INC | 269,281 | 289,138 | +19,857 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 278,775 | +278,775 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 400,000 | 275,000 | -125,000 | 0.33 | 0.26 | -0.07 | sell |
| MORGAN STANLEY | 247,567 | 273,520 | +25,953 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 309,646 | 273,340 | -36,306 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 248,736 | 248,736 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 279,951 | 244,605 | -35,346 | 0.05 | 0.04 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 92,364 | 233,300 | +140,936 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 222,800 | 216,585 | -6,215 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 487,285 | 212,862 | -274,423 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 171,976 | 199,777 | +27,801 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 254,039 | 195,774 | -58,265 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 425,312 | 179,902 | -245,410 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 230,450 | 179,562 | -50,888 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 166,866 | +166,866 | 0.00 | 0.22 | +0.22 | buy |
| BARCLAYS PLC | 81,331 | 165,449 | +84,118 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 207,491 | 160,153 | -47,338 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 156,841 | +156,841 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 272,795 | 149,685 | -123,110 | 0.03 | 0.02 | -0.02 | sell |
| SG Americas Securities, LLC | 0 | 136,507 | +136,507 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 133,039 | +133,039 | 0.00 | 0.75 | +0.75 | buy |
| E. Ohman J:or Asset Management AB | 92,000 | 122,000 | +30,000 | 0.02 | 0.02 | +0.01 | buy |
| Rafferty Asset Management, LLC | 132,991 | 115,672 | -17,319 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 58,222 | 101,679 | +43,457 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 101,278 | 100,014 | -1,264 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 39,754 | 98,081 | +58,327 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 88,526 | 94,795 | +6,269 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 84,200 | 84,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 19,536 | 83,374 | +63,838 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 155,788 | 63,082 | -92,706 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 56,870 | 56,870 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RICE HALL JAMES & ASSOCIATES, LLC | 46,000 | 56,761 | +10,761 | 0.02 | 0.02 | +0.00 | buy |
| EntryPoint Capital, LLC | 48,826 | 50,522 | +1,696 | 0.19 | 0.23 | +0.04 | buy |
| Polar Asset Management Partners Inc. | 48,600 | 48,600 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 84,037 | 48,296 | -35,741 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 47,797 | 48,125 | +328 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 372,559 | 48,100 | -324,459 | 0.09 | 0.01 | -0.08 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 45,492 | 45,234 | -258 | 0.00 | 0.00 | +0.00 | sell |
| NOMURA HOLDINGS INC | 0 | 44,717 | +44,717 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,808 | 43,254 | -554 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 40,033 | 42,902 | +2,869 | 0.02 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,293 | 42,123 | +7,830 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 41,944 | +41,944 | 0.00 | 0.03 | +0.03 | buy |
| LPL Financial LLC | 37,667 | 40,368 | +2,701 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 39,966 | 39,966 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 29,881 | 39,792 | +9,911 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 38,974 | 38,974 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 0 | 38,726 | +38,726 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 38,000 | 38,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 36,851 | 36,624 | -227 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,631 | 36,331 | +32,700 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 61,029 | 35,331 | -25,698 | 0.07 | 0.03 | -0.04 | sell |
| Jasper Ridge Partners, L.P. | 31,568 | 31,568 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Point72 Asset Management, L.P. | 8,193 | 28,649 | +20,456 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 37,924 | 27,784 | -10,140 | 0.01 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 39,713 | 27,633 | -12,080 | 0.00 | 0.00 | -0.00 | sell |
| Values First Advisors, Inc. | 25,979 | 26,119 | +140 | 0.13 | 0.11 | -0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,330 | 26,028 | -302 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 25,191 | +25,191 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,526 | 24,316 | -210 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 30,096 | 24,096 | -6,000 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 24,980 | 23,312 | -1,668 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 22,010 | 22,413 | +403 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 19,812 | 20,779 | +967 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 171,094 | 20,350 | -150,744 | 0.05 | 0.01 | -0.05 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 56,850 | 18,757 | -38,093 | 0.08 | 0.03 | -0.06 | sell |
| ALTFEST L J & CO INC | 0 | 17,794 | +17,794 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 12,645 | 17,674 | +5,029 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 20,432 | 16,427 | -4,005 | 0.00 | 0.00 | +0.00 | sell |
| Dynamic Technology Lab Private Ltd | 28,444 | 15,690 | -12,754 | 0.03 | 0.01 | -0.01 | sell |