| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,834,875 | 14,012,078 | +177,203 | 0.03 | 0.03 | -0.00 | buy |
| Siren, L.L.C. | 9,250,005 | 9,250,005 | 0 | 16.95 | 13.48 | -3.48 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,761,650 | 6,883,058 | -1,878,592 | 0.04 | 0.03 | -0.01 | sell |
| BlackRock, Inc. | 6,695,880 | 6,760,187 | +64,307 | 0.00 | 0.00 | -0.00 | buy |
| Samsara BioCapital, LLC | 5,612,896 | 5,612,896 | 0 | 40.66 | 27.29 | -13.37 | hold |
| VANGUARD GROUP INC | 4,861,594 | 4,914,927 | +53,333 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,024,865 | 4,545,887 | +2,521,022 | 0.01 | 0.03 | +0.02 | buy |
| Redmile Group, LLC | 3,929,039 | 3,904,456 | -24,583 | 14.81 | 14.15 | -0.66 | sell |
| STATE STREET CORP | 3,074,296 | 3,763,103 | +688,807 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 2,947,295 | 3,244,537 | +297,242 | 2.30 | 2.51 | +0.21 | buy |
| JANUS HENDERSON GROUP PLC | 2,450,286 | 3,013,445 | +563,159 | 0.04 | 0.05 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,913,246 | 2,799,456 | -113,790 | 1.81 | 1.71 | -0.09 | sell |
| Holocene Advisors, LP | 0 | 2,461,596 | +2,461,596 | 0.00 | 0.21 | +0.21 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,177,515 | 2,023,959 | +846,444 | 0.33 | 0.54 | +0.21 | buy |
| Hood River Capital Management LLC | 1,974,964 | 2,014,393 | +39,429 | 0.98 | 0.89 | -0.09 | buy |
| Paradigm Biocapital Advisors LP | 1,600,554 | 2,009,745 | +409,191 | 2.42 | 2.21 | -0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,887,410 | 1,954,810 | +67,400 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,215,000 | 1,951,866 | +736,866 | 0.07 | 0.12 | +0.04 | buy |
| Fairmount Funds Management LLC | 1,824,031 | 1,824,031 | 0 | 8.37 | 6.11 | -2.26 | hold |
| JENNISON ASSOCIATES LLC | 365,946 | 1,606,512 | +1,240,566 | 0.01 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,289,973 | 1,563,089 | +273,116 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 1,500,000 | 1,500,000 | 0 | 2.80 | 2.53 | -0.26 | hold |
| Pictet Asset Management Holding SA | 987,464 | 1,322,931 | +335,467 | 0.04 | 0.05 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,136,453 | 1,166,788 | +30,335 | 0.68 | 0.54 | -0.14 | buy |
| UBS Group AG | 339,027 | 1,131,787 | +792,760 | 0.00 | 0.01 | +0.01 | buy |
| Capital World Investors | 1,128,752 | 1,128,752 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Point72 Asset Management, L.P. | 132,348 | 1,006,725 | +874,377 | 0.01 | 0.08 | +0.07 | buy |
| MARSHALL WACE, LLP | 1,640,437 | 973,914 | -666,523 | 0.07 | 0.04 | -0.03 | sell |
| Woodline Partners LP | 944,432 | 871,050 | -73,382 | 0.18 | 0.15 | -0.02 | sell |
| FEDERATED HERMES, INC. | 241,000 | 800,455 | +559,455 | 0.02 | 0.05 | +0.04 | buy |
| Rock Springs Capital Management LP | 794,133 | 794,133 | 0 | 1.75 | 1.73 | -0.02 | hold |
| Polar Capital Holdings Plc | 1,500,000 | 794,082 | -705,918 | 0.28 | 0.14 | -0.14 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 769,442 | 769,442 | 0 | 3.22 | 2.21 | -1.01 | hold |
| NORTHERN TRUST CORP | 736,786 | 738,695 | +1,909 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 644,232 | 733,603 | +89,371 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 528,115 | 726,204 | +198,089 | 6.02 | 5.45 | -0.57 | buy |
| LOOMIS SAYLES & CO L P | 742,939 | 724,238 | -18,701 | 0.03 | 0.03 | -0.00 | sell |
| ROYAL BANK OF CANADA | 407,686 | 724,044 | +316,358 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 273,587 | 713,988 | +440,401 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 692,676 | 685,964 | -6,712 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 635,891 | 677,035 | +41,144 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 600,639 | 652,236 | +51,597 | 0.04 | 0.04 | +0.00 | buy |
| MORGAN STANLEY | 904,387 | 604,002 | -300,385 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 933,432 | 558,703 | -374,729 | 0.08 | 0.04 | -0.03 | sell |
| Fisher Asset Management, LLC | 412,411 | 533,176 | +120,765 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 496,553 | 494,163 | -2,390 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 375,316 | 443,155 | +67,839 | 0.01 | 0.02 | +0.00 | buy |
| Eagle Health Investments LP | 269,400 | 363,300 | +93,900 | 2.36 | 3.55 | +1.20 | buy |
| Clearbridge Investments, LLC | 284,412 | 348,449 | +64,037 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 285,320 | 344,684 | +59,364 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 333,626 | 312,398 | -21,228 | 0.01 | 0.01 | -0.00 | sell |
| Orbis Allan Gray Ltd | 0 | 302,252 | +302,252 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 191,998 | 259,790 | +67,792 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 222,430 | 241,627 | +19,197 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 341,010 | 233,920 | -107,090 | 2.47 | 1.26 | -1.21 | sell |
| Candriam S.C.A. | 339,333 | 229,900 | -109,433 | 0.07 | 0.04 | -0.02 | sell |
| RAYMOND JAMES FINANCIAL INC | 125,477 | 228,151 | +102,674 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209,206 | 197,317 | -11,889 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 171,948 | 197,186 | +25,238 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 175,000 | +175,000 | 0.00 | 0.64 | +0.64 | buy |
| Russell Investments Group, Ltd. | 153,886 | 172,423 | +18,537 | 0.01 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 76,738 | 159,741 | +83,003 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 225,897 | 159,068 | -66,829 | 0.01 | 0.01 | -0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 154,901 | +154,901 | 0.00 | 0.17 | +0.17 | buy |
| Caption Management, LLC | 3,000 | 153,702 | +150,702 | 0.01 | 0.33 | +0.32 | buy |
| LORD, ABBETT & CO. LLC | 474,144 | 147,671 | -326,473 | 0.05 | 0.02 | -0.04 | sell |
| Rafferty Asset Management, LLC | 99,855 | 141,409 | +41,554 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 976,625 | 134,610 | -842,015 | 0.03 | 0.00 | -0.03 | sell |
| Granahan Investment Management, LLC | 73,375 | 129,914 | +56,539 | 0.11 | 0.20 | +0.09 | buy |
| RHUMBLINE ADVISERS | 125,381 | 123,763 | -1,618 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 73,902 | 119,933 | +46,031 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 127,000 | 119,600 | -7,400 | 0.00 | 0.00 | -0.00 | sell |
| TFG Asset Management GP Ltd | 103,482 | 117,882 | +14,400 | 0.66 | 0.64 | -0.02 | buy |
| SEI INVESTMENTS CO | 89,145 | 117,309 | +28,164 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 205,085 | 109,904 | -95,181 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 66,261 | 101,742 | +35,481 | 0.45 | 0.72 | +0.26 | buy |
| Integral Health Asset Management, LLC | 100,000 | 100,000 | 0 | 0.33 | 0.27 | -0.06 | hold |
| Artia Global Partners LP | 126,285 | 96,285 | -30,000 | 1.15 | 0.63 | -0.52 | sell |
| EFG Asset Management (North America) Corp. | 51,478 | 88,106 | +36,628 | 0.26 | 0.42 | +0.17 | buy |
| ALLIANCEBERNSTEIN L.P. | 82,110 | 82,142 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 0 | 77,031 | +77,031 | 0.00 | 0.63 | +0.63 | buy |
| Lighthouse Investment Partners, LLC | 0 | 74,000 | +74,000 | 0.00 | 0.10 | +0.10 | buy |
| E. Ohman J:or Asset Management AB | 64,568 | 69,887 | +5,319 | 0.06 | 0.06 | +0.00 | buy |
| Invesco Ltd. | 61,964 | 68,171 | +6,207 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,964 | 66,353 | +16,389 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 71,795 | 64,726 | -7,069 | 0.00 | 0.00 | -0.00 | sell |
| Jasper Ridge Partners, L.P. | 64,169 | 64,169 | 0 | 0.06 | 0.05 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,372 | 62,375 | +3 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 54,556 | 61,834 | +7,278 | 0.05 | 0.05 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,334 | 60,988 | -36,346 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 31,230 | 59,573 | +28,343 | 0.41 | 0.54 | +0.14 | buy |
| AMERIPRISE FINANCIAL INC | 35,300 | 54,145 | +18,845 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 43,302 | 51,288 | +7,986 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 56,716 | 50,944 | -5,772 | 0.11 | 0.10 | -0.00 | sell |
| MetLife Investment Management, LLC | 48,363 | 48,363 | 0 | 0.01 | 0.01 | -0.00 | hold |
| StoneCrest Wealth Management, Inc. | 0 | 47,332 | +47,332 | 0.00 | 0.77 | +0.77 | buy |
| Cubist Systematic Strategies, LLC | 0 | 45,061 | +45,061 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 49,375 | 44,805 | -4,570 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 0 | 43,571 | +43,571 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 39,521 | +39,521 | 0.00 | 1.45 | +1.45 | buy |