| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,005,654 | 10,414,535 | +2,408,881 | 0.00 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 2,033,789 | 4,245,000 | +2,211,211 | 0.31 | 1.60 | +1.29 | buy |
| Artal Group S.A. | 9,059,507 | 11,259,438 | +2,199,931 | 2.80 | 7.22 | +4.41 | buy |
| Samsara BioCapital, LLC | 4,598,828 | 6,788,609 | +2,189,781 | 9.99 | 19.85 | +9.86 | buy |
| Redmile Group, LLC | 4,733,248 | 6,402,505 | +1,669,257 | 1.60 | 4.31 | +2.71 | buy |
| Polar Capital Holdings Plc | 1,501,926 | 2,940,672 | +1,438,746 | 0.08 | 0.34 | +0.26 | buy |
| STATE STREET CORP | 813,984 | 2,159,337 | +1,345,353 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.05 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,171,952 | 8,321,471 | +1,149,519 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 1,131,668 | +1,131,668 | 0.00 | 0.06 | +0.06 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 972,733 | +972,733 | 0.00 | 0.30 | +0.30 | buy |
| VANGUARD GROUP INC | 2,052,718 | 2,854,984 | +802,266 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 353,855 | 1,011,829 | +657,974 | 0.10 | 0.67 | +0.57 | buy |
| Hood River Capital Management LLC | 0 | 499,144 | +499,144 | 0.00 | 0.26 | +0.26 | buy |
| CITADEL ADVISORS LLC | 45,720 | 538,850 | +493,130 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 515,616 | 924,883 | +409,267 | 0.04 | 0.19 | +0.15 | buy |
| BIT Capital GmbH | 28,367 | 392,399 | +364,032 | 0.03 | 0.80 | +0.77 | buy |
| MORGAN STANLEY | 220,556 | 584,163 | +363,607 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,088,074 | 1,430,764 | +342,690 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 14,563 | 307,037 | +292,474 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 853,072 | 1,141,547 | +288,475 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 280,847 | +280,847 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 9,711 | 270,000 | +260,289 | 0.03 | 1.57 | +1.54 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 245,459 | +245,459 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 242,132 | +242,132 | 0.00 | 0.02 | +0.02 | buy |
| Tri Locum Partners LP | 0 | 207,147 | +207,147 | 0.00 | 1.91 | +1.91 | buy |
| Aberdeen Group plc | 0 | 168,997 | +168,997 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 161,884 | +161,884 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 142,793 | +142,793 | 0.00 | 0.48 | +0.48 | buy |
| JENNISON ASSOCIATES LLC | 0 | 137,049 | +137,049 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 135,000 | +135,000 | 0.00 | 0.18 | +0.18 | buy |
| JANE STREET GROUP, LLC | 0 | 124,955 | +124,955 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 120,000 | +120,000 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 107,709 | +107,709 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 409,433 | 514,504 | +105,071 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 32,318 | 136,049 | +103,731 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.27 | +0.27 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 302,384 | 394,138 | +91,754 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 72,285 | +72,285 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 71,640 | +71,640 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,568 | 89,143 | +68,575 | 0.00 | 0.00 | +0.00 | buy |
| PATHWAY CAPITAL MANAGEMENT, LP | 0 | 64,873 | +64,873 | 0.00 | 1.36 | +1.36 | buy |
| Bank of New York Mellon Corp | 123,183 | 182,385 | +59,202 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 23,200 | 79,957 | +56,757 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 832 | 49,710 | +48,878 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,748 | 48,372 | +41,624 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 40,680 | +40,680 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 291,842 | 330,336 | +38,494 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 38,000 | +38,000 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 37,842 | +37,842 | 0.00 | 0.06 | +0.06 | buy |
| Virtue Capital Management, LLC | 0 | 35,909 | +35,909 | 0.00 | 0.11 | +0.11 | buy |
| SEI INVESTMENTS CO | 0 | 32,214 | +32,214 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 27,570 | 59,281 | +31,711 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 2,137,925 | 2,168,925 | +31,000 | 0.24 | 0.62 | +0.38 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 0 | 28,423 | +28,423 | 0.00 | 0.15 | +0.15 | buy |
| D. E. Shaw & Co., Inc. | 68,822 | 95,291 | +26,469 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 63,588 | 89,750 | +26,162 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 25,292 | +25,292 | 0.00 | 0.01 | +0.01 | buy |
| Jasper Ridge Partners, L.P. | 0 | 23,605 | +23,605 | 0.00 | 0.02 | +0.02 | buy |
| Blackstone Inc. | 0 | 18,343 | +18,343 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 18,342 | +18,342 | 0.00 | 0.01 | +0.01 | buy |
| Quantbot Technologies LP | 0 | 17,700 | +17,700 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 0 | 17,306 | +17,306 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 148,898 | 165,567 | +16,669 | 0.00 | 0.00 | +0.00 | buy |
| ADVISORY RESEARCH INC | 0 | 16,582 | +16,582 | 0.00 | 0.05 | +0.05 | buy |
| Clarius Group, LLC | 0 | 14,966 | +14,966 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 83,600 | 98,100 | +14,500 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 32,825 | 47,002 | +14,177 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 13,792 | +13,792 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 12,390 | 24,940 | +12,550 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 12,352 | +12,352 | 0.00 | 0.05 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,040 | 14,967 | +10,927 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 40,316 | 50,515 | +10,199 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,175 | 53,055 | +9,880 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 0 | 9,455 | +9,455 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 16,321 | 24,983 | +8,662 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 21,502 | 28,930 | +7,428 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,441 | 8,346 | +6,905 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 10,681 | 17,046 | +6,365 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,351 | 29,324 | +5,973 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,416 | 7,366 | +5,950 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 21,648 | 27,573 | +5,925 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 5,828 | +5,828 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 21,495 | 27,198 | +5,703 | 0.00 | 0.01 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 5,557 | +5,557 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 51,402 | 56,778 | +5,376 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 4,988 | +4,988 | 0.00 | 0.06 | +0.06 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,270 | 22,497 | +4,227 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,987 | 22,178 | +4,191 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 336,294 | 339,894 | +3,600 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 10,820 | 13,796 | +2,976 | 0.00 | 0.00 | +0.00 | buy |
| Tao Capital Management LP | 0 | 2,842 | +2,842 | 0.00 | 0.05 | +0.05 | buy |
| CANADA LIFE ASSURANCE Co | 1,142 | 3,777 | +2,635 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,132 | +2,132 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,380 | 14,410 | +2,030 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,348 | 5,742 | +1,394 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 4,217 | 4,869 | +652 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,577 | 3,181 | +604 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 536 | +536 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,087 | 1,377 | +290 | 0.00 | 0.00 | +0.00 | buy |