| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,196,046 | 13,635,261 | +3,439,215 | 0.00 | 0.04 | +0.03 | buy |
| MARSHALL WACE, LLP | 212,862 | 2,945,408 | +2,732,546 | 0.00 | 0.16 | +0.16 | buy |
| Fairmount Funds Management LLC | 0 | 1,962,953 | +1,962,953 | 0.00 | 8.43 | +8.43 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,594,869 | +1,594,869 | 0.00 | 0.12 | +0.12 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 199,777 | 1,725,622 | +1,525,845 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 6,155,464 | 7,172,370 | +1,016,906 | 0.00 | 0.01 | +0.01 | buy |
| Commodore Capital LP | 0 | 950,000 | +950,000 | 0.00 | 3.01 | +3.01 | buy |
| CITADEL ADVISORS LLC | 783,474 | 1,718,059 | +934,585 | 0.01 | 0.07 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 14,033 | 849,178 | +835,145 | 0.00 | 0.02 | +0.02 | buy |
| LOOMIS SAYLES & CO L P | 0 | 776,665 | +776,665 | 0.00 | 0.04 | +0.04 | buy |
| Capital World Investors | 0 | 721,957 | +721,957 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 716,782 | +716,782 | 0.00 | 1.18 | +1.18 | buy |
| VANGUARD GROUP INC | 4,034,665 | 4,743,482 | +708,817 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 656,967 | +656,967 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,654,106 | 9,283,421 | +629,315 | 0.01 | 0.05 | +0.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 516,005 | +516,005 | 0.00 | 0.18 | +0.18 | buy |
| Octagon Capital Advisors LP | 0 | 488,000 | +488,000 | 0.00 | 3.59 | +3.59 | buy |
| LORD, ABBETT & CO. LLC | 0 | 471,300 | +471,300 | 0.00 | 0.06 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 195,774 | 666,885 | +471,111 | 0.00 | 0.03 | +0.03 | buy |
| MPM BioImpact LLC | 0 | 416,144 | +416,144 | 0.00 | 2.55 | +2.55 | buy |
| Paradigm Biocapital Advisors LP | 0 | 400,000 | +400,000 | 0.00 | 0.60 | +0.60 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 385,925 | +385,925 | 0.00 | 2.02 | +2.02 | buy |
| Woodline Partners LP | 709,831 | 1,089,461 | +379,630 | 0.05 | 0.32 | +0.27 | buy |
| Ikarian Capital, LLC | 0 | 357,185 | +357,185 | 0.00 | 4.41 | +4.41 | buy |
| Bellevue Group AG | 2,161,203 | 2,510,690 | +349,487 | 0.28 | 2.09 | +1.81 | buy |
| GOLDMAN SACHS GROUP INC | 1,399,202 | 1,720,582 | +321,380 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 22,413 | 312,161 | +289,748 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 1,730,104 | 1,990,819 | +260,715 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,409,207 | 2,659,240 | +250,033 | 0.33 | 2.09 | +1.76 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,543,025 | 1,770,324 | +227,299 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 194,668 | +194,668 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 183,243 | +183,243 | 0.00 | 1.77 | +1.77 | buy |
| Soleus Capital Management, L.P. | 0 | 167,543 | +167,543 | 0.00 | 0.55 | +0.55 | buy |
| STEMPOINT CAPITAL LP | 0 | 166,307 | +166,307 | 0.00 | 1.80 | +1.80 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 48,296 | 201,576 | +153,280 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 38,974 | 187,974 | +149,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 39,792 | 185,003 | +145,211 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 273,520 | 413,385 | +139,865 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 137,861 | +137,861 | 0.00 | 0.84 | +0.84 | buy |
| NORTHERN TRUST CORP | 620,623 | 746,527 | +125,904 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 502,793 | 622,409 | +119,616 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 45,234 | 158,610 | +113,376 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 103,919 | +103,919 | 0.00 | 0.13 | +0.13 | buy |
| Integral Health Asset Management, LLC | 275,000 | 375,000 | +100,000 | 0.26 | 1.43 | +1.17 | buy |
| TD ASSET MANAGEMENT INC | 273,340 | 362,810 | +89,470 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,028 | 114,338 | +88,310 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 75,108 | +75,108 | 0.00 | 0.07 | +0.07 | buy |
| Proficio Capital Partners LLC | 0 | 54,717 | +54,717 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 45,020 | +45,020 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 45,000 | +45,000 | 0.00 | 0.27 | +0.27 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 40,984 | +40,984 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 94,795 | 135,231 | +40,436 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 38,172 | +38,172 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 34,676 | +34,676 | 0.00 | 0.06 | +0.06 | buy |
| TUDOR INVESTMENT CORP ET AL | 27,633 | 61,895 | +34,262 | 0.00 | 0.03 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 0 | 32,955 | +32,955 | 0.00 | 0.04 | +0.04 | buy |
| Jasper Ridge Partners, L.P. | 31,568 | 64,169 | +32,601 | 0.01 | 0.09 | +0.08 | buy |
| Patient Square Capital LP | 0 | 32,000 | +32,000 | 0.00 | 0.52 | +0.52 | buy |
| Baird Financial Group, Inc. | 0 | 31,904 | +31,904 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 84,200 | 115,400 | +31,200 | 0.00 | 0.00 | +0.00 | buy |
| HAMILTON LANE ADVISORS LLC | 0 | 29,478 | +29,478 | 0.00 | 1.23 | +1.23 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 28,599 | +28,599 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 38,726 | 67,271 | +28,545 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 179,562 | 207,492 | +27,930 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 27,786 | +27,786 | 0.00 | 0.22 | +0.22 | buy |
| Allianz Asset Management GmbH | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 24,019 | +24,019 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 22,900 | +22,900 | 0.00 | 0.12 | +0.12 | buy |
| ALLIANCEBERNSTEIN L.P. | 56,870 | 79,350 | +22,480 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 21,800 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 21,055 | +21,055 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,188 | +20,188 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 17,616 | +17,616 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 15,755 | +15,755 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 24,316 | 38,590 | +14,274 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 48,125 | 61,790 | +13,665 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 13,256 | +13,256 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 100,014 | 113,261 | +13,247 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 3,777 | 16,888 | +13,111 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,254 | 56,269 | +13,015 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,386 | 22,586 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 10,819 | +10,819 | 0.00 | 0.04 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,191 | 35,301 | +10,110 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 20,350 | 30,200 | +9,850 | 0.01 | 0.05 | +0.04 | buy |
| Scientech Research LLC | 0 | 9,716 | +9,716 | 0.00 | 0.12 | +0.12 | buy |
| Harvest Investment Services, LLC | 0 | 9,635 | +9,635 | 0.00 | 0.10 | +0.10 | buy |
| Corient Private Wealth LLC | 0 | 9,120 | +9,120 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 8,647 | +8,647 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,674 | 26,275 | +8,601 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 10,485 | 18,816 | +8,331 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 8,012 | +8,012 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 8,000 | +8,000 | 0.00 | 0.28 | +0.28 | buy |
| ADAR1 Capital Management, LLC | 12,000 | 19,505 | +7,505 | 0.02 | 0.17 | +0.16 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 7,440 | +7,440 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 7,359 | +7,359 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 7,254 | +7,254 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,765 | 16,506 | +6,741 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,966 | 46,667 | +6,701 | 0.00 | 0.01 | +0.01 | buy |