| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 709,831 | 1,089,461 | +379,630 | 0.05 | 0.32 | +0.27 | buy |
| Bellevue Group AG | 2,161,203 | 2,510,690 | +349,487 | 0.28 | 2.09 | +1.81 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,409,207 | 2,659,240 | +250,033 | 0.33 | 2.09 | +1.76 | buy |
| Integral Health Asset Management, LLC | 275,000 | 375,000 | +100,000 | 0.26 | 1.43 | +1.17 | buy |
| Jasper Ridge Partners, L.P. | 31,568 | 64,169 | +32,601 | 0.01 | 0.09 | +0.08 | buy |
| J. Goldman & Co LP | 20,350 | 30,200 | +9,850 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 12,000 | 19,505 | +7,505 | 0.02 | 0.17 | +0.16 | buy |
| China Universal Asset Management Co., Ltd. | 15,393 | 19,850 | +4,457 | 0.01 | 0.08 | +0.07 | buy |
| Clarius Group, LLC | 13,680 | 13,422 | -258 | 0.01 | 0.04 | +0.03 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 56,761 | 55,987 | -774 | 0.02 | 0.13 | +0.11 | sell |
| Values First Advisors, Inc. | 26,119 | 18,234 | -7,885 | 0.11 | 0.43 | +0.32 | sell |
| VIRTUS ADVISERS, LLC | 9,771 | 1,707 | -8,064 | 0.04 | 0.03 | -0.01 | sell |
| DnB Asset Management AS | 20,779 | 12,252 | -8,527 | 0.00 | 0.00 | +0.00 | sell |
| Corton Capital Inc. | 14,834 | 5,759 | -9,075 | 0.06 | 0.14 | +0.09 | sell |
| Polar Asset Management Partners Inc. | 48,600 | 20,600 | -28,000 | 0.01 | 0.01 | +0.00 | sell |
| Exome Asset Management LLC | 133,039 | 77,439 | -55,600 | 0.75 | 2.52 | +1.76 | sell |
| E. Ohman J:or Asset Management AB | 122,000 | 53,500 | -68,500 | 0.02 | 0.05 | +0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 166,866 | 90,193 | -76,673 | 0.21 | 0.70 | +0.49 | sell |
| Candriam S.C.A. | 744,443 | 582,354 | -162,089 | 0.04 | 0.14 | +0.11 | sell |
| Fisher Asset Management, LLC | 734,019 | 554,737 | -179,282 | 0.00 | 0.01 | +0.01 | sell |
| Polar Capital Holdings Plc | 2,940,672 | 2,708,371 | -232,301 | 0.11 | 0.66 | +0.54 | sell |
| Hood River Capital Management LLC | 2,349,721 | 1,898,641 | -451,080 | 0.30 | 1.21 | +0.91 | sell |
| BIT Capital GmbH | 521,845 | 65,315 | -456,530 | 0.39 | 0.22 | -0.16 | sell |
| Clearbridge Investments, LLC | 924,395 | 421,384 | -503,011 | 0.01 | 0.01 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 742,300 | 151,800 | -590,500 | 0.11 | 0.14 | +0.03 | sell |
| Aberdeen Group plc | 748,489 | 142,187 | -606,302 | 0.01 | 0.01 | +0.00 | sell |
| Redmile Group, LLC | 5,238,837 | 4,549,881 | -688,956 | 2.47 | 13.70 | +11.23 | sell |
| Samsara BioCapital, LLC | 6,788,609 | 5,612,896 | -1,175,713 | 10.45 | 33.30 | +22.84 | sell |
| Siren, L.L.C. | 11,259,438 | 9,250,005 | -2,009,433 | 4.51 | 17.66 | +13.15 | sell |