| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Orbis Allan Gray Ltd | 302,252 | 3,428,929 | +3,126,677 | 0.05 | 0.63 | +0.58 | buy |
| Siren, L.L.C. | 9,250,005 | 10,825,013 | +1,575,008 | 13.48 | 14.22 | +0.75 | buy |
| Redmile Group, LLC | 3,904,456 | 5,220,846 | +1,316,390 | 14.15 | 16.94 | +2.79 | buy |
| Samsara BioCapital, LLC | 5,612,896 | 6,897,652 | +1,284,756 | 27.29 | 31.35 | +4.06 | buy |
| JENNISON ASSOCIATES LLC | 1,606,512 | 2,795,188 | +1,188,676 | 0.03 | 0.07 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 2,009,745 | 3,062,157 | +1,052,412 | 2.21 | 3.61 | +1.40 | buy |
| Bellevue Group AG | 3,244,537 | 4,056,592 | +812,055 | 2.51 | 3.39 | +0.88 | buy |
| Polar Capital Holdings Plc | 794,082 | 1,322,011 | +527,929 | 0.14 | 0.27 | +0.12 | buy |
| NAN FUNG TRINITY (HK) Ltd | 37,642 | 263,245 | +225,603 | 0.14 | 0.92 | +0.78 | buy |
| Integral Health Asset Management, LLC | 100,000 | 300,000 | +200,000 | 0.27 | 0.67 | +0.40 | buy |
| STEMPOINT CAPITAL LP | 726,204 | 886,893 | +160,689 | 5.45 | 6.70 | +1.25 | buy |
| ADAR1 Capital Management, LLC | 20,087 | 69,589 | +49,502 | 0.07 | 0.23 | +0.16 | buy |
| Granahan Investment Management, LLC | 129,914 | 153,769 | +23,855 | 0.20 | 0.29 | +0.09 | buy |
| DnB Asset Management AS | 21,515 | 35,059 | +13,544 | 0.00 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 2,014,393 | 2,026,758 | +12,365 | 0.89 | 0.98 | +0.09 | buy |
| StoneCrest Wealth Management, Inc. | 47,332 | 59,003 | +11,671 | 0.77 | 1.01 | +0.23 | buy |
| Mill Creek Capital Advisors, LLC | 7,500 | 12,500 | +5,000 | 0.01 | 0.01 | +0.01 | buy |
| Knott David M Jr | 9,000 | 13,913 | +4,913 | 0.14 | 0.28 | +0.14 | buy |
| China Universal Asset Management Co., Ltd. | 16,850 | 21,622 | +4,772 | 0.05 | 0.07 | +0.02 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 18,060 | 21,762 | +3,702 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 3,415 | 5,676 | +2,261 | 0.04 | 0.07 | +0.03 | buy |
| VERUS CAPITAL PARTNERS, LLC | 9,385 | 11,050 | +1,665 | 0.03 | 0.03 | +0.01 | buy |
| MN Wealth Advisors, LLC | 7,196 | 8,155 | +959 | 0.14 | 0.18 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 61,834 | 62,678 | +844 | 0.05 | 0.06 | +0.01 | buy |
| Longaeva Partners L.P. | 26,386 | 27,006 | +620 | 0.14 | 0.10 | -0.04 | buy |
| NEOS Investment Management LLC | 9,283 | 9,899 | +616 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 9,283 | 9,899 | +616 | 0.03 | 0.03 | +0.01 | buy |
| Three Seasons Wealth, LLC | 10,746 | 10,968 | +222 | 0.04 | 0.05 | +0.01 | buy |
| SYON CAPITAL LLC | 9,140 | 9,170 | +30 | 0.02 | 0.02 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 29,473 | 29,476 | +3 | 0.06 | 0.07 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,068 | 2,004 | -64 | 0.00 | 0.00 | +0.00 | sell |
| Accent Capital Management, LLC | 407 | 100 | -307 | 0.01 | 0.00 | -0.00 | sell |
| Values First Advisors, Inc. | 19,152 | 18,564 | -588 | 0.38 | 0.42 | +0.04 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 154,901 | 152,854 | -2,047 | 0.17 | 0.21 | +0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 101,742 | 85,293 | -16,449 | 0.72 | 0.70 | -0.02 | sell |
| Jasper Ridge Partners, L.P. | 64,169 | 42,455 | -21,714 | 0.05 | 0.04 | -0.01 | sell |
| LOOMIS SAYLES & CO L P | 724,238 | 691,913 | -32,325 | 0.03 | 0.04 | +0.00 | sell |
| Clearbridge Investments, LLC | 348,449 | 295,475 | -52,974 | 0.01 | 0.01 | +0.00 | sell |
| E. Ohman J:or Asset Management AB | 69,887 | 16,374 | -53,513 | 0.06 | 0.02 | -0.04 | sell |
| Lighthouse Investment Partners, LLC | 74,000 | 15,000 | -59,000 | 0.08 | 0.02 | -0.06 | sell |
| Rock Springs Capital Management LP | 794,133 | 733,477 | -60,656 | 1.73 | 1.66 | -0.07 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,023,959 | 1,952,877 | -71,082 | 0.54 | 0.58 | +0.04 | sell |
| Candriam S.C.A. | 229,900 | 145,633 | -84,267 | 0.04 | 0.03 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,799,456 | 2,431,333 | -368,123 | 1.71 | 1.67 | -0.04 | sell |
| Vestal Point Capital, LP | 1,500,000 | 700,000 | -800,000 | 2.53 | 1.13 | -1.40 | sell |
| Holocene Advisors, LP | 2,461,596 | 1,387,120 | -1,074,476 | 0.21 | 0.13 | -0.08 | sell |