| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Orbis Allan Gray Ltd | 302,252 | 3,428,929 | +3,126,677 | 0.05 | 0.63 | +0.58 | buy |
| NORGES BANK | 0 | 2,079,515 | +2,079,515 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 9,250,005 | 10,825,013 | +1,575,008 | 13.48 | 14.22 | +0.75 | buy |
| FMR LLC | 14,012,078 | 15,380,675 | +1,368,597 | 0.03 | 0.03 | +0.01 | buy |
| Redmile Group, LLC | 3,904,456 | 5,220,846 | +1,316,390 | 14.15 | 16.94 | +2.79 | buy |
| Samsara BioCapital, LLC | 5,612,896 | 6,897,652 | +1,284,756 | 27.29 | 31.35 | +4.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,545,887 | 5,759,428 | +1,213,541 | 0.03 | 0.04 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 1,606,512 | 2,795,188 | +1,188,676 | 0.03 | 0.07 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 2,009,745 | 3,062,157 | +1,052,412 | 2.21 | 3.61 | +1.40 | buy |
| BNP Paribas Asset Management Holding S.A. | 579 | 829,422 | +828,843 | 0.00 | 0.04 | +0.04 | buy |
| Bellevue Group AG | 3,244,537 | 4,056,592 | +812,055 | 2.51 | 3.39 | +0.88 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 20,324 | 554,602 | +534,278 | 0.00 | 0.02 | +0.01 | buy |
| Polar Capital Holdings Plc | 794,082 | 1,322,011 | +527,929 | 0.14 | 0.27 | +0.12 | buy |
| First Turn Management, LLC | 0 | 459,727 | +459,727 | 0.00 | 2.31 | +2.31 | buy |
| BlackRock, Inc. | 6,760,187 | 7,217,034 | +456,847 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 134,610 | 495,946 | +361,336 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 871,050 | 1,211,088 | +340,038 | 0.15 | 0.21 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 733,603 | 1,050,506 | +316,903 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,914,927 | 5,195,465 | +280,538 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,763,103 | 4,034,434 | +271,331 | 0.00 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.71 | +0.71 | buy |
| AQR CAPITAL MANAGEMENT LLC | 21,176 | 280,324 | +259,148 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 159,068 | 405,523 | +246,455 | 0.01 | 0.03 | +0.02 | buy |
| NAN FUNG TRINITY (HK) Ltd | 37,642 | 263,245 | +225,603 | 0.14 | 0.92 | +0.78 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.22 | +0.22 | buy |
| Integral Health Asset Management, LLC | 100,000 | 300,000 | +200,000 | 0.27 | 0.67 | +0.40 | buy |
| Ensign Peak Advisors, Inc | 652,236 | 835,851 | +183,615 | 0.04 | 0.07 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 726,204 | 886,893 | +160,689 | 5.45 | 6.70 | +1.25 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 158,265 | +158,265 | 0.00 | 1.46 | +1.46 | buy |
| Man Group plc | 34,182 | 182,024 | +147,842 | 0.00 | 0.02 | +0.01 | buy |
| iA Global Asset Management Inc. | 0 | 123,272 | +123,272 | 0.00 | 0.07 | +0.07 | buy |
| Nuveen, LLC | 494,163 | 604,417 | +110,254 | 0.00 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 106,228 | +106,228 | 0.00 | 0.05 | +0.05 | buy |
| Hudson Bay Capital Management LP | 10,000 | 100,000 | +90,000 | 0.00 | 0.03 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 88,530 | +88,530 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,954,810 | 2,034,024 | +79,214 | 0.00 | 0.01 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 78,046 | +78,046 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 12,008 | 84,349 | +72,341 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 443,155 | 514,224 | +71,069 | 0.02 | 0.02 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 64,534 | +64,534 | 0.00 | 0.13 | +0.13 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 55,117 | +55,117 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 50,418 | +50,418 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,087 | 69,589 | +49,502 | 0.07 | 0.23 | +0.16 | buy |
| Trexquant Investment LP | 0 | 48,927 | +48,927 | 0.00 | 0.02 | +0.02 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 40,283 | +40,283 | 0.00 | 0.08 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 51,288 | 90,553 | +39,265 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 29,300 | +29,300 | 0.00 | 0.21 | +0.21 | buy |
| DEUTSCHE BANK AG\ | 197,186 | 226,168 | +28,982 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 27,140 | +27,140 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 677,035 | 702,095 | +25,060 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 129,914 | 153,769 | +23,855 | 0.20 | 0.29 | +0.09 | buy |
| GUGGENHEIM CAPITAL LLC | 6,288 | 28,886 | +22,598 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 685,964 | 708,253 | +22,289 | 0.01 | 0.02 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 21,327 | +21,327 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 30,651 | 48,152 | +17,501 | 0.04 | 0.06 | +0.03 | buy |
| RAYMOND JAMES FINANCIAL INC | 228,151 | 245,387 | +17,236 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 17,203 | +17,203 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 68,171 | 82,462 | +14,291 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 21,515 | 35,059 | +13,544 | 0.00 | 0.01 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 13,266 | +13,266 | 0.00 | 0.05 | +0.05 | buy |
| Hood River Capital Management LLC | 2,014,393 | 2,026,758 | +12,365 | 0.89 | 0.98 | +0.09 | buy |
| XTX Topco Ltd | 0 | 11,817 | +11,817 | 0.00 | 0.01 | +0.01 | buy |
| StoneCrest Wealth Management, Inc. | 47,332 | 59,003 | +11,671 | 0.77 | 1.01 | +0.23 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 11,400 | +11,400 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 10,527 | +10,527 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 10,468 | +10,468 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 10,009 | +10,009 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 10,000 | +10,000 | 0.00 | 0.06 | +0.06 | buy |
| WESBANCO BANK INC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Lido Advisors, LLC | 0 | 9,793 | +9,793 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 391 | 9,584 | +9,193 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 8,845 | +8,845 | 0.00 | 0.05 | +0.05 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 159,741 | 168,547 | +8,806 | 0.01 | 0.01 | +0.00 | buy |
| Cerity Partners LLC | 0 | 8,539 | +8,539 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 8,049 | +8,049 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,982 | +6,982 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 6,740 | +6,740 | 0.00 | 0.00 | +0.00 | buy |
| RWC Asset Management LLP | 0 | 6,718 | +6,718 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,571 | +6,571 | 0.00 | 0.04 | +0.04 | buy |
| Flaharty Asset Management, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.03 | +0.03 | buy |
| Mariner, LLC | 10,000 | 15,849 | +5,849 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 5,757 | +5,757 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 5,345 | +5,345 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 5,341 | +5,341 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 5,087 | +5,087 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 5,014 | +5,014 | 0.00 | 0.14 | +0.14 | buy |
| WELCH & FORBES LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| GABELLI FUNDS LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Mill Creek Capital Advisors, LLC | 7,500 | 12,500 | +5,000 | 0.01 | 0.01 | +0.01 | buy |
| Knott David M Jr | 9,000 | 13,913 | +4,913 | 0.14 | 0.28 | +0.14 | buy |
| Neuberger Berman Group LLC | 0 | 4,841 | +4,841 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,850 | 21,622 | +4,772 | 0.05 | 0.07 | +0.02 | buy |
| Orion Porfolio Solutions, LLC | 0 | 4,640 | +4,640 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,513 | 32,847 | +4,334 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 5,500 | 9,400 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 18,060 | 21,762 | +3,702 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 119,600 | 123,200 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 117,309 | 120,527 | +3,218 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 24,004 | 27,131 | +3,127 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 0 | 3,000 | +3,000 | 0.00 | 0.02 | +0.02 | buy |