| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,012,078 | 15,380,675 | +1,368,597 | 0.03 | 0.03 | +0.01 | buy |
| Siren, L.L.C. | 9,250,005 | 10,825,013 | +1,575,008 | 13.48 | 14.22 | +0.75 | buy |
| BlackRock, Inc. | 6,760,187 | 7,217,034 | +456,847 | 0.00 | 0.01 | +0.00 | buy |
| Samsara BioCapital, LLC | 5,612,896 | 6,897,652 | +1,284,756 | 27.29 | 31.35 | +4.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,883,058 | 6,402,437 | -480,621 | 0.03 | 0.03 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,545,887 | 5,759,428 | +1,213,541 | 0.03 | 0.04 | +0.01 | buy |
| Redmile Group, LLC | 3,904,456 | 5,220,846 | +1,316,390 | 14.15 | 16.94 | +2.79 | buy |
| VANGUARD GROUP INC | 4,914,927 | 5,195,465 | +280,538 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 3,244,537 | 4,056,592 | +812,055 | 2.51 | 3.39 | +0.88 | buy |
| STATE STREET CORP | 3,763,103 | 4,034,434 | +271,331 | 0.00 | 0.01 | +0.00 | buy |
| Orbis Allan Gray Ltd | 302,252 | 3,428,929 | +3,126,677 | 0.05 | 0.63 | +0.58 | buy |
| Paradigm Biocapital Advisors LP | 2,009,745 | 3,062,157 | +1,052,412 | 2.21 | 3.61 | +1.40 | buy |
| JENNISON ASSOCIATES LLC | 1,606,512 | 2,795,188 | +1,188,676 | 0.03 | 0.07 | +0.04 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,799,456 | 2,431,333 | -368,123 | 1.71 | 1.67 | -0.04 | sell |
| NORGES BANK | 0 | 2,079,515 | +2,079,515 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,954,810 | 2,034,024 | +79,214 | 0.00 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 2,014,393 | 2,026,758 | +12,365 | 0.89 | 0.98 | +0.09 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,023,959 | 1,952,877 | -71,082 | 0.54 | 0.58 | +0.04 | sell |
| JANUS HENDERSON GROUP PLC | 3,013,445 | 1,774,168 | -1,239,277 | 0.05 | 0.04 | -0.02 | sell |
| Holocene Advisors, LP | 2,461,596 | 1,387,120 | -1,074,476 | 0.21 | 0.13 | -0.08 | sell |
| GOLDMAN SACHS GROUP INC | 1,563,089 | 1,324,213 | -238,876 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 794,082 | 1,322,011 | +527,929 | 0.14 | 0.27 | +0.12 | buy |
| Woodline Partners LP | 871,050 | 1,211,088 | +340,038 | 0.15 | 0.21 | +0.05 | buy |
| Pictet Asset Management Holding SA | 1,322,931 | 1,195,967 | -126,964 | 0.05 | 0.05 | +0.00 | sell |
| Capital World Investors | 1,128,752 | 1,128,752 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 733,603 | 1,050,506 | +316,903 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,131,787 | 905,432 | -226,355 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 726,204 | 886,893 | +160,689 | 5.45 | 6.70 | +1.25 | buy |
| Ensign Peak Advisors, Inc | 652,236 | 835,851 | +183,615 | 0.04 | 0.07 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 579 | 829,422 | +828,843 | 0.00 | 0.04 | +0.04 | buy |
| FEDERATED HERMES, INC. | 800,455 | 797,913 | -2,542 | 0.05 | 0.06 | +0.01 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 769,442 | 769,442 | 0 | 2.21 | 3.01 | +0.79 | hold |
| Rock Springs Capital Management LP | 794,133 | 733,477 | -60,656 | 1.73 | 1.66 | -0.07 | sell |
| NORTHERN TRUST CORP | 738,695 | 721,062 | -17,633 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 685,964 | 708,253 | +22,289 | 0.01 | 0.02 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 677,035 | 702,095 | +25,060 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 1,500,000 | 700,000 | -800,000 | 2.53 | 1.13 | -1.40 | sell |
| LOOMIS SAYLES & CO L P | 724,238 | 691,913 | -32,325 | 0.03 | 0.04 | +0.00 | sell |
| Nuveen, LLC | 494,163 | 604,417 | +110,254 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 20,324 | 554,602 | +534,278 | 0.00 | 0.02 | +0.01 | buy |
| Fisher Asset Management, LLC | 533,176 | 531,439 | -1,737 | 0.01 | 0.01 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 443,155 | 514,224 | +71,069 | 0.02 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 134,610 | 495,946 | +361,336 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 0 | 459,727 | +459,727 | 0.00 | 2.31 | +2.31 | buy |
| TWO SIGMA INVESTMENTS, LP | 159,068 | 405,523 | +246,455 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 604,002 | 372,731 | -231,271 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 973,914 | 368,037 | -605,877 | 0.04 | 0.02 | -0.02 | sell |
| Eagle Health Investments LP | 363,300 | 363,300 | 0 | 3.55 | 3.52 | -0.03 | hold |
| Integral Health Asset Management, LLC | 100,000 | 300,000 | +200,000 | 0.27 | 0.67 | +0.40 | buy |
| Clearbridge Investments, LLC | 348,449 | 295,475 | -52,974 | 0.01 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 312,398 | 281,444 | -30,954 | 0.01 | 0.01 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 21,176 | 280,324 | +259,148 | 0.00 | 0.01 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 37,642 | 263,245 | +225,603 | 0.14 | 0.92 | +0.78 | buy |
| Casdin Capital, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.71 | +0.71 | buy |
| BARCLAYS PLC | 344,684 | 251,913 | -92,771 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 228,151 | 245,387 | +17,236 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 241,627 | 232,018 | -9,609 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 197,186 | 226,168 | +28,982 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.22 | +0.22 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 197,317 | 186,926 | -10,391 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 34,182 | 182,024 | +147,842 | 0.00 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 713,988 | 170,773 | -543,215 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 159,741 | 168,547 | +8,806 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 158,265 | +158,265 | 0.00 | 1.46 | +1.46 | buy |
| Granahan Investment Management, LLC | 129,914 | 153,769 | +23,855 | 0.20 | 0.29 | +0.09 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 154,901 | 152,854 | -2,047 | 0.17 | 0.21 | +0.03 | sell |
| Candriam S.C.A. | 229,900 | 145,633 | -84,267 | 0.04 | 0.03 | -0.01 | sell |
| Rafferty Asset Management, LLC | 141,409 | 129,132 | -12,277 | 0.02 | 0.02 | +0.00 | sell |
| iA Global Asset Management Inc. | 0 | 123,272 | +123,272 | 0.00 | 0.07 | +0.07 | buy |
| Swiss National Bank | 119,600 | 123,200 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 117,309 | 120,527 | +3,218 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 123,763 | 108,864 | -14,899 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 109,904 | 107,183 | -2,721 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 106,228 | +106,228 | 0.00 | 0.05 | +0.05 | buy |
| Hudson Bay Capital Management LP | 10,000 | 100,000 | +90,000 | 0.00 | 0.03 | +0.02 | buy |
| Artia Global Partners LP | 96,285 | 96,285 | 0 | 0.63 | 0.68 | +0.05 | hold |
| WELLS FARGO & COMPANY/MN | 51,288 | 90,553 | +39,265 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 88,530 | +88,530 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 101,742 | 85,293 | -16,449 | 0.72 | 0.70 | -0.02 | sell |
| SG Americas Securities, LLC | 12,008 | 84,349 | +72,341 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 68,171 | 82,462 | +14,291 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 82,142 | 82,110 | -32 | 0.00 | 0.00 | +0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 78,046 | +78,046 | 0.00 | 0.04 | +0.04 | buy |
| Aisling Capital Management LP | 77,031 | 77,031 | 0 | 0.63 | 0.71 | +0.08 | hold |
| ADAR1 Capital Management, LLC | 20,087 | 69,589 | +49,502 | 0.07 | 0.23 | +0.16 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 64,534 | +64,534 | 0.00 | 0.13 | +0.13 | buy |
| Legal & General Group Plc | 64,726 | 63,336 | -1,390 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 61,834 | 62,678 | +844 | 0.05 | 0.06 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,375 | 60,815 | -1,560 | 0.00 | 0.00 | +0.00 | sell |
| StoneCrest Wealth Management, Inc. | 47,332 | 59,003 | +11,671 | 0.77 | 1.01 | +0.23 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 55,117 | +55,117 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 50,418 | +50,418 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 48,927 | +48,927 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 30,651 | 48,152 | +17,501 | 0.04 | 0.06 | +0.03 | buy |
| MetLife Investment Management, LLC | 48,363 | 46,657 | -1,706 | 0.01 | 0.01 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,805 | 45,798 | +993 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 64,169 | 42,455 | -21,714 | 0.05 | 0.04 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 39,469 | 41,772 | +2,303 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 40,283 | +40,283 | 0.00 | 0.08 | +0.08 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 66,353 | 38,200 | -28,153 | 0.01 | 0.00 | -0.00 | sell |