| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 12,058,968 | 13,308,968 | +1,250,000 | 0.37 | 0.40 | +0.03 | buy |
| Palo Alto Investors LP | 5,958,888 | 6,391,775 | +432,887 | 0.59 | 0.85 | +0.26 | buy |
| Monaco Asset Management SAM | 280,000 | 556,000 | +276,000 | 0.10 | 0.29 | +0.19 | buy |
| ADAR1 Capital Management, LLC | 713,028 | 732,628 | +19,600 | 0.29 | 0.24 | -0.05 | buy |
| Financial Advocates Investment Management | 98,350 | 67,850 | -30,500 | 0.01 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 3,314,700 | 3,250,000 | -64,700 | 0.25 | 0.28 | +0.03 | sell |
| DAFNA Capital Management LLC | 1,476,052 | 1,409,262 | -66,790 | 0.32 | 0.38 | +0.06 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,338,090 | 1,027,134 | -310,956 | 0.20 | 0.17 | -0.03 | sell |
| Eversept Partners, LP | 6,432,715 | 5,994,472 | -438,243 | 0.52 | 0.47 | -0.04 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,103,048 | 1,634,084 | -468,964 | 0.01 | 0.01 | -0.00 | sell |
| Opaleye Management Inc. | 2,982,200 | 2,440,109 | -542,091 | 0.72 | 0.63 | -0.10 | sell |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 1,310,477 | 597,694 | -712,783 | 0.06 | 0.03 | -0.03 | sell |
| Madison Avenue Partners, LP | 5,054,472 | 4,140,773 | -913,699 | 0.65 | 0.79 | +0.14 | sell |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 5,000,000 | 3,750,000 | -1,250,000 | 0.27 | 0.20 | -0.07 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 6,954,110 | 4,694,065 | -2,260,045 | 0.26 | 0.22 | -0.03 | sell |