| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Laurion Capital Management LP | 0 | 2,300,851 | +2,300,851 | 0.00 | 0.08 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,224,610 | 6,495,420 | +2,270,810 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,366,769 | +1,366,769 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 499,822 | 1,812,405 | +1,312,583 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 12,058,968 | 13,308,968 | +1,250,000 | 0.38 | 0.40 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,805,137 | 2,736,385 | +931,248 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 1,705,436 | 2,287,780 | +582,344 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 12,318 | 562,061 | +549,743 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 5,958,888 | 6,391,775 | +432,887 | 0.59 | 0.85 | +0.26 | buy |
| Qube Research & Technologies Ltd | 228,592 | 659,685 | +431,093 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 2,937,931 | 3,272,270 | +334,339 | 0.00 | 0.01 | +0.00 | buy |
| Monaco Asset Management SAM | 280,000 | 556,000 | +276,000 | 0.10 | 0.29 | +0.19 | buy |
| Squarepoint Ops LLC | 46,441 | 300,034 | +253,593 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,015,783 | 1,231,745 | +215,962 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 210,000 | +210,000 | 0.00 | 0.10 | +0.10 | buy |
| JPMORGAN CHASE & CO | 0 | 201,898 | +201,898 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 180,987 | +180,987 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 177,942 | +177,942 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 144,949 | +144,949 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 140,083 | +140,083 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 11,635,634 | 11,763,784 | +128,150 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 221,803 | 322,330 | +100,527 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 98,036 | +98,036 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 90,806 | +90,806 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 506,888 | 592,889 | +86,001 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 64,600 | +64,600 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,100,800 | 1,160,700 | +59,900 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 58,445 | +58,445 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 53,600 | +53,600 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 52,575 | +52,575 | 0.00 | 0.02 | +0.02 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 49,500 | +49,500 | 0.00 | 0.04 | +0.04 | buy |
| TWINBEECH CAPITAL LP | 0 | 42,536 | +42,536 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,219,829 | 1,252,764 | +32,935 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 28,520 | +28,520 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 0 | 24,568 | +24,568 | 0.00 | 0.02 | +0.02 | buy |
| Brevan Howard Capital Management LP | 0 | 21,377 | +21,377 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 713,028 | 732,628 | +19,600 | 0.29 | 0.24 | -0.05 | buy |
| WOLVERINE TRADING, LLC | 0 | 19,197 | +19,197 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 19,122 | +19,122 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,802 | 17,298 | +12,496 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 12,215 | +12,215 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,272,925 | 2,283,618 | +10,693 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 9,271 | +9,271 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 68,500 | 73,500 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 12,200 | 16,907 | +4,707 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 10,000 | 12,536 | +2,536 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 56 | +56 | 0.00 | 0.00 | 0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 3,404 | 3,404 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 19,908 | 19,908 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WHITEBOX ADVISORS LLC | 0 | 0 | 0 | 0.16 | 0.15 | -0.01 | hold |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 4.50 | 11.84 | +7.35 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.13 | 0.16 | +0.03 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.55 | 0.42 | -0.13 | hold |
| Texas Yale Capital Corp. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 683 Capital Management, LLC | 0 | 0 | 0 | 0.56 | 0.62 | +0.06 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 0 | 0 | 0.06 | 0.08 | +0.01 | hold |
| Verition Fund Management LLC | 0 | 0 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Nantahala Capital Management, LLC | 672,856 | 672,856 | 0 | 0.06 | 0.08 | +0.02 | hold |
| NEA Management Company, LLC | 15,838,009 | 15,838,009 | 0 | 0.96 | 1.16 | +0.20 | hold |
| EcoR1 Capital, LLC | 9,195,404 | 9,195,404 | 0 | 0.22 | 0.28 | +0.06 | hold |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.07 | 0.10 | +0.02 | hold |
| Rock Springs Capital Management LP | 0 | 0 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Opaleye Management Inc. | 0 | 0 | 0 | 0.78 | 0.70 | -0.07 | hold |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.10 | 0.13 | +0.03 | hold |
| Monashee Investment Management LLC | 3,459,854 | 3,459,854 | 0 | 0.56 | 0.48 | -0.07 | hold |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 0.87 | 1.12 | +0.25 | hold |
| DeepCurrents Investment Group LLC | 0 | 0 | 0 | 0.45 | 0.48 | +0.04 | hold |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.09 | 0.13 | +0.04 | hold |
| Shaolin Capital Management LLC | 0 | 0 | 0 | 0.41 | 0.44 | +0.03 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,130,268 | 6,130,268 | 0 | 1.73 | 2.03 | +0.30 | hold |
| Octagon Capital Advisors LP | 9,187,883 | 9,187,883 | 0 | 1.34 | 1.32 | -0.02 | hold |
| Morton Brown Family Wealth, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFS Partners, LLC | 130 | 130 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SMITH, MOORE & CO. | 126,000 | 126,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 790 | 790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 6,130,272 | 6,130,272 | 0 | 0.03 | 0.04 | +0.01 | hold |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 0 | 0 | 0 | 0.50 | 0.46 | -0.04 | hold |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 185,300 | 185,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 3,807,661 | 3,807,661 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Advisory Services Network, LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,035 | 954 | -81 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 47,908 | 46,903 | -1,005 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 34,543 | 29,935 | -4,608 | 0.00 | 0.00 | +0.00 | sell |
| Arcus Capital Partners, LLC | 10,042 | 0 | -10,042 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 10,505 | 0 | -10,505 | 0.00 | 0.00 | -0.00 | sell |
| waypoint wealth counsel | 11,758 | 0 | -11,758 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 32,897 | 14,433 | -18,464 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 20,700 | 0 | -20,700 | 0.00 | 0.00 | -0.00 | sell |
| HCR Wealth Advisors | 22,000 | 0 | -22,000 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 713,551 | 689,251 | -24,300 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 312,357 | 287,338 | -25,019 | 0.00 | 0.00 | +0.00 | sell |
| Financial Advocates Investment Management | 98,350 | 67,850 | -30,500 | 0.01 | 0.00 | -0.00 | sell |