| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 577,874 | 2,916,109 | +2,338,235 | 0.00 | 0.01 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 5,104,760 | 6,358,113 | +1,253,353 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 114,556 | 939,603 | +825,047 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 803,815 | +803,815 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 701,975 | +701,975 | 0.00 | 0.09 | +0.09 | buy |
| Focus Partners Wealth | 0 | 700,000 | +700,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 683,423 | +683,423 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 389,452 | +389,452 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 891,279 | 1,275,412 | +384,133 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 351,600 | +351,600 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 289,265 | +289,265 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 100 | 245,100 | +245,000 | 0.00 | 0.00 | +0.00 | buy |
| Opti Capital Management, LP | 182,319 | 414,152 | +231,833 | 0.01 | 0.03 | +0.02 | buy |
| Jain Global LLC | 0 | 199,902 | +199,902 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 695,915 | 895,524 | +199,609 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 194,031 | +194,031 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 156,932 | +156,932 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,171,847 | 6,320,684 | +148,837 | 1.25 | 1.45 | +0.20 | buy |
| Squarepoint Ops LLC | 71,944 | 217,921 | +145,977 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 74,644 | 207,744 | +133,100 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 1,157,500 | 1,287,200 | +129,700 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 118,349 | +118,349 | 0.00 | 0.03 | +0.03 | buy |
| LMR Partners LLP | 0 | 115,649 | +115,649 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 768,476 | 882,676 | +114,200 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 105,056 | +105,056 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 83,130 | +83,130 | 0.00 | 0.02 | +0.02 | buy |
| Laurion Capital Management LP | 1,487,982 | 1,551,428 | +63,446 | 0.08 | 0.13 | +0.05 | buy |
| MACKENZIE FINANCIAL CORP | 299,815 | 352,473 | +52,658 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 52,039 | +52,039 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 217,987 | 269,589 | +51,602 | 0.22 | 0.24 | +0.01 | buy |
| VANGUARD GROUP INC | 10,034,149 | 10,083,881 | +49,732 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 154,700 | 201,715 | +47,015 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 43,697 | +43,697 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,029,209 | 3,072,773 | +43,564 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 36,900 | +36,900 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 34,971 | +34,971 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 23,672 | +23,672 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,250,461 | 2,272,448 | +21,987 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 541,000 | 560,900 | +19,900 | 0.01 | 0.02 | +0.00 | buy |
| DRIVE WEALTH MANAGEMENT, LLC | 0 | 16,677 | +16,677 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 16,600 | +16,600 | 0.00 | 0.02 | +0.02 | buy |
| Cerity Partners LLC | 0 | 13,761 | +13,761 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3 | 10,678 | +10,675 | 0.00 | 0.00 | +0.00 | buy |
| Traynor Capital Management, Inc. | 14,000 | 23,272 | +9,272 | 0.00 | 0.00 | +0.00 | buy |
| HB Wealth Management, LLC | 37,700 | 46,700 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 34,471 | 42,116 | +7,645 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 5,134 | +5,134 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 16,000 | 19,300 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Banque Transatlantique SA | 0 | 2,986 | +2,986 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 14,564 | 17,019 | +2,455 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 28,018 | 30,018 | +2,000 | 0.01 | 0.02 | +0.00 | buy |
| Moors & Cabot, Inc. | 10,000 | 11,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| AGF MANAGEMENT LTD | 0 | 0 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 47,050 | 47,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 26,158 | 26,158 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WHITEBOX ADVISORS LLC | 0 | 0 | 0 | 0.20 | 0.18 | -0.01 | hold |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 3.17 | 4.26 | +1.09 | hold |
| SILVERBACK ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 0.06 | +0.06 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.22 | 0.24 | +0.02 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.46 | 0.57 | +0.10 | hold |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 2,750,000 | 2,750,000 | 0 | 0.19 | 0.22 | +0.03 | hold |
| Texas Yale Capital Corp. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 683 Capital Management, LLC | 0 | 0 | 0 | 0.65 | 0.71 | +0.06 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 0 | 0 | 0.05 | 0.05 | -0.00 | hold |
| NEA Management Company, LLC | 18,093,034 | 18,093,034 | 0 | 0.92 | 1.53 | +0.61 | hold |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.11 | 0.21 | +0.09 | hold |
| Rock Springs Capital Management LP | 0 | 0 | 0 | 0.19 | 0.30 | +0.11 | hold |
| Opaleye Management Inc. | 0 | 0 | 0 | 1.07 | 1.41 | +0.34 | hold |
| Capital Advisors, Ltd. LLC | 17 | 17 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Sequoia Financial Advisors, LLC | 118,500 | 118,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.10 | 0.13 | +0.03 | hold |
| CHOREO, LLC | 48,111 | 48,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Financial Advocates Investment Management | 78,616 | 78,616 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 0.76 | 1.20 | +0.44 | hold |
| DeepCurrents Investment Group LLC | 0 | 0 | 0 | 0.50 | 0.54 | +0.05 | hold |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.16 | 0.15 | -0.00 | hold |
| Shaolin Capital Management LLC | 0 | 0 | 0 | 0.50 | 0.72 | +0.22 | hold |
| Woodline Partners LP | 728,459 | 728,459 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Octagon Capital Advisors LP | 18,350,000 | 18,350,000 | 0 | 2.82 | 2.76 | -0.07 | hold |
| Velan Capital Investment Management LP | 75,000 | 75,000 | 0 | 0.06 | 0.08 | +0.03 | hold |
| Morton Brown Family Wealth, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corient Private Wealth LLC | 3,391,483 | 3,391,483 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Allostery Investments LP | 613,028 | 613,028 | 0 | 1.09 | 0.97 | -0.12 | hold |
| Siren, L.L.C. | 5,208,968 | 5,208,968 | 0 | 0.21 | 0.32 | +0.12 | hold |
| SMITH, MOORE & CO. | 300,000 | 300,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Exome Asset Management LLC | 1,097,999 | 1,097,999 | 0 | 0.75 | 1.08 | +0.33 | hold |
| Federation des caisses Desjardins du Quebec | 750 | 750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rialto Wealth Management, LLC | 10,752 | 10,752 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 64,777 | 64,777 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 0 | 0 | 0 | 0.52 | 0.62 | +0.10 | hold |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 2,112,745 | 2,112,745 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 20,220 | 20,219 | -1 | 0.00 | 0.00 | +0.00 | sell |