| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 15,838,009 | 18,093,034 | +2,255,025 | 1.16 | 1.23 | +0.07 | buy |
| Artal Group S.A. | 13,308,968 | 13,308,968 | 0 | 0.40 | 0.31 | -0.10 | hold |
| VANGUARD GROUP INC | 11,763,784 | 11,760,251 | -3,533 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 9,187,883 | 9,187,883 | 0 | 1.32 | 1.37 | +0.05 | hold |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 11.84 | 2.73 | -9.11 | hold |
| FMR LLC | 8,189,147 | 7,930,508 | -258,639 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 6,391,775 | 6,277,093 | -114,682 | 0.85 | 0.66 | -0.20 | sell |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 1.12 | 1.16 | +0.04 | hold |
| 683 Capital Management, LLC | 3,250,000 | 5,750,000 | +2,500,000 | 0.39 | 0.54 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 6,495,420 | 5,597,378 | -898,042 | 0.01 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,130,268 | 5,500,000 | -630,268 | 2.03 | 1.22 | -0.81 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,891,005 | 5,494,794 | +2,603,789 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 5,487,516 | +5,487,516 | 0.00 | 0.03 | +0.03 | buy |
| Eversept Partners, LP | 5,994,472 | 5,484,148 | -510,324 | 0.53 | 0.38 | -0.15 | sell |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.13 | 0.11 | -0.02 | hold |
| CITADEL ADVISORS LLC | 3,874,726 | 4,093,836 | +219,110 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 2,440,109 | 3,910,000 | +1,469,891 | 0.63 | 0.80 | +0.18 | buy |
| DEUTSCHE BANK AG\ | 3,807,661 | 3,807,661 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 3,750,000 | 3,750,000 | 0 | 0.20 | 0.26 | +0.06 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 2,736,385 | 3,592,765 | +856,380 | 0.01 | 0.01 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 4,694,065 | 3,524,908 | -1,169,157 | 0.22 | 0.13 | -0.09 | sell |
| Corient Private Wealth LLC | 3,272,270 | 3,391,483 | +119,213 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,231,745 | 3,335,511 | +2,103,766 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.10 | 0.09 | -0.01 | hold |
| FEDERATED HERMES, INC. | 3,133,114 | 3,065,136 | -67,978 | 0.01 | 0.01 | -0.00 | sell |
| Monaco Asset Management SAM | 556,000 | 2,726,104 | +2,170,104 | 0.29 | 1.23 | +0.94 | buy |
| Laurion Capital Management LP | 2,300,851 | 2,463,647 | +162,796 | 0.08 | 0.07 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,283,618 | 2,283,618 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 2,693,965 | 2,117,714 | -576,251 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 671,600 | 2,046,600 | +1,375,000 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,634,084 | 1,444,617 | -189,467 | 0.01 | 0.01 | -0.00 | sell |
| DAFNA Capital Management LLC | 1,409,262 | 1,409,262 | 0 | 0.38 | 0.30 | -0.08 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,252,764 | 1,261,597 | +8,833 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 180,558 | 1,156,236 | +975,678 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 1,127,699 | +1,127,699 | 0.00 | 0.90 | +0.90 | buy |
| Monashee Investment Management LLC | 3,459,854 | 859,854 | -2,600,000 | 0.48 | 0.10 | -0.38 | sell |
| TWO SIGMA ADVISERS, LP | 1,160,700 | 823,900 | -336,800 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 177,942 | 781,778 | +603,836 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 100 | 769,628 | +769,528 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 689,251 | 712,776 | +23,525 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 672,856 | 672,856 | 0 | 0.08 | 0.06 | -0.02 | hold |
| TD ASSET MANAGEMENT INC | 422,260 | 641,498 | +219,238 | 0.00 | 0.00 | +0.00 | buy |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 597,694 | 597,694 | 0 | 0.03 | 0.02 | -0.01 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,000 | 552,000 | +535,000 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 732,628 | 532,628 | -200,000 | 0.24 | 0.10 | -0.14 | sell |
| CITIGROUP INC | 2,287,780 | 500,003 | -1,787,777 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 386,558 | 441,015 | +54,457 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,812,405 | 333,594 | -1,478,811 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 185,300 | 310,213 | +124,913 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 808,771 | 309,979 | -498,792 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 287,338 | 280,975 | -6,363 | 0.00 | 0.00 | -0.00 | sell |
| SMITH, MOORE & CO. | 126,000 | 226,000 | +100,000 | 0.02 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,027,134 | 222,134 | -805,000 | 0.20 | 0.03 | -0.16 | sell |
| Qube Research & Technologies Ltd | 659,685 | 181,638 | -478,047 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.13 | 0.12 | -0.02 | hold |
| Financial Advocates Investment Management | 67,850 | 106,850 | +39,000 | 0.00 | 0.01 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 73,500 | 93,500 | +20,000 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 83,543 | +83,543 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 58,445 | 58,445 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHOREO, LLC | 0 | 48,111 | +48,111 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA HOLDINGS INC | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 24,568 | 35,018 | +10,450 | 0.02 | 0.02 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 46,903 | 31,171 | -15,732 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 20,218 | 20,218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 19,908 | 19,908 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE TRADING, LLC | 19,197 | 19,315 | +118 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 17,298 | 18,696 | +1,398 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 12,215 | 16,288 | +4,073 | 0.00 | 0.00 | -0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 15,000 | 16,000 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| Trellis Wealth Advisors LLC | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| Cetera Investment Advisers | 12,536 | 12,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 19,122 | 10,484 | -8,638 | 0.00 | 0.00 | -0.00 | sell |
| Texas Yale Capital Corp. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Moors & Cabot, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Traynor Capital Management, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 3,404 | 2,834 | -570 | 0.00 | 0.00 | -0.00 | sell |
| MFA WEALTH ADVISORS, LLC | 0 | 1,872 | +1,872 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 954 | 954 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 790 | 790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 56 | 206 | +150 | 0.00 | 0.00 | 0.00 | buy |
| PFS Partners, LLC | 130 | 130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Morton Brown Family Wealth, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AGF MANAGEMENT LTD | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 592,889 | 0 | -592,889 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 64,600 | 0 | -64,600 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 29,935 | 0 | -29,935 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 98,036 | 0 | -98,036 | 0.00 | 0.00 | -0.00 | sell |
| WHITEBOX ADVISORS LLC | 0 | 0 | 0 | 0.15 | 0.19 | +0.04 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.16 | 0.21 | +0.04 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.42 | 0.39 | -0.03 | hold |
| SG Americas Securities, LLC | 28,520 | 0 | -28,520 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 0 | 0 | 0 | 0.62 | 0.73 | +0.11 | hold |
| MACQUARIE GROUP LTD | 9,271 | 0 | -9,271 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 0 | 0 | 0.08 | 0.10 | +0.02 | hold |