| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| 683 Capital Management, LLC | 3,250,000 | 5,750,000 | +2,500,000 | 0.28 | 0.39 | +0.11 | buy |
| NEA Management Company, LLC | 15,838,009 | 18,093,034 | +2,255,025 | 1.16 | 1.23 | +0.07 | buy |
| Monaco Asset Management SAM | 556,000 | 2,726,104 | +2,170,104 | 0.29 | 1.23 | +0.94 | buy |
| Opaleye Management Inc. | 2,440,109 | 3,910,000 | +1,469,891 | 0.63 | 0.80 | +0.18 | buy |
| Woodline Partners LP | 177,942 | 781,778 | +603,836 | 0.00 | 0.01 | +0.00 | buy |
| Laurion Capital Management LP | 2,300,851 | 2,463,647 | +162,796 | 0.02 | 0.03 | +0.00 | buy |
| SMITH, MOORE & CO. | 126,000 | 226,000 | +100,000 | 0.02 | 0.02 | +0.01 | buy |
| Financial Advocates Investment Management | 67,850 | 106,850 | +39,000 | 0.00 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 19,908 | 39,816 | +19,908 | 0.00 | 0.00 | 0.00 | buy |
| Sivia Capital Partners, LLC | 24,568 | 35,018 | +10,450 | 0.02 | 0.02 | +0.00 | buy |
| Palo Alto Investors LP | 6,391,775 | 6,277,093 | -114,682 | 0.85 | 0.66 | -0.20 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,634,084 | 1,444,617 | -189,467 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 732,628 | 532,628 | -200,000 | 0.24 | 0.10 | -0.14 | sell |
| Eversept Partners, LP | 5,994,472 | 5,484,148 | -510,324 | 0.47 | 0.34 | -0.13 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,130,268 | 5,500,000 | -630,268 | 2.03 | 1.22 | -0.81 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,027,134 | 222,134 | -805,000 | 0.17 | 0.03 | -0.14 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 4,694,065 | 3,524,908 | -1,169,157 | 0.22 | 0.13 | -0.09 | sell |
| Monashee Investment Management LLC | 3,459,854 | 859,854 | -2,600,000 | 0.48 | 0.10 | -0.38 | sell |