| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 1,425,000 | 18,350,000 | +16,925,000 | 2.80 | 4.95 | +2.15 | buy |
| NEA Management Company, LLC | 18,093,034 | 18,093,034 | 0 | 1.53 | 1.68 | +0.14 | hold |
| BlackRock, Inc. | 3,072,773 | 12,142,596 | +9,069,823 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 10,083,881 | 11,410,792 | +1,326,911 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 4.26 | 3.31 | -0.95 | hold |
| FMR LLC | 7,592,980 | 7,315,325 | -277,655 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 6,358,113 | 7,146,022 | +787,909 | 0.02 | 0.02 | -0.00 | buy |
| 683 Capital Management, LLC | 6,100,000 | 6,340,000 | +240,000 | 0.68 | 0.79 | +0.11 | buy |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 1.20 | 1.54 | +0.34 | hold |
| Palo Alto Investors LP | 6,276,893 | 5,739,013 | -537,880 | 1.31 | 1.50 | +0.19 | sell |
| Siren, L.L.C. | 5,208,968 | 5,208,968 | 0 | 0.32 | 0.33 | +0.01 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,320,684 | 5,146,782 | -1,173,902 | 1.45 | 1.30 | -0.16 | sell |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.15 | 0.20 | +0.04 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,272,448 | 4,555,080 | +2,282,632 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 4,163,734 | 4,459,087 | +295,353 | 0.02 | 0.02 | +0.00 | buy |
| Corient Private Wealth LLC | 3,391,483 | 3,693,683 | +302,200 | 0.01 | 0.01 | -0.00 | buy |
| Monaco Asset Management SAM | 4,849,134 | 3,550,000 | -1,299,134 | 2.70 | 1.65 | -1.05 | sell |
| Opaleye Management Inc. | 4,287,415 | 3,545,000 | -742,415 | 1.05 | 0.88 | -0.17 | sell |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.21 | 0.25 | +0.04 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,569,155 | 2,732,294 | +1,163,139 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 882,676 | 2,481,406 | +1,598,730 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 2,112,745 | 2,261,455 | +148,710 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,275,412 | 1,745,127 | +469,715 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 3,896,841 | 1,695,762 | -2,201,079 | 0.49 | 0.21 | -0.27 | sell |
| TWO SIGMA ADVISERS, LP | 1,287,200 | 1,672,200 | +385,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,138,947 | 1,621,419 | +482,472 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 410,116 | 1,520,126 | +1,110,010 | 0.00 | 0.00 | +0.00 | buy |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 2,750,000 | 1,500,000 | -1,250,000 | 0.22 | 0.10 | -0.13 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,731,355 | 1,383,863 | -347,492 | 0.11 | 0.11 | +0.00 | sell |
| Laurion Capital Management LP | 1,551,428 | 1,343,772 | -207,656 | 0.13 | 0.19 | +0.06 | sell |
| Focus Partners Wealth | 700,000 | 1,150,000 | +450,000 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 803,815 | 1,117,972 | +314,157 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 1,097,999 | 1,097,999 | 0 | 1.08 | 1.11 | +0.03 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 282,264 | 1,091,564 | +809,300 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 201,715 | 897,388 | +695,673 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 907,854 | 849,921 | -57,933 | 0.28 | 0.29 | +0.01 | sell |
| CITADEL ADVISORS LLC | 156,932 | 767,561 | +610,629 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 695,553 | 760,448 | +64,895 | 0.07 | 0.07 | -0.00 | buy |
| Atom Investors LP | 701,975 | 730,357 | +28,382 | 0.09 | 0.08 | -0.02 | buy |
| MACKENZIE FINANCIAL CORP | 352,473 | 553,064 | +200,591 | 0.00 | 0.00 | +0.00 | buy |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 497,694 | 497,694 | 0 | 0.02 | 0.03 | +0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 2,678,036 | 496,248 | -2,181,788 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 728,459 | 495,153 | -233,306 | 0.01 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 560,900 | 485,900 | -75,000 | 0.02 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 434,049 | +434,049 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 20,219 | 386,708 | +366,489 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,916,109 | 382,677 | -2,533,432 | 0.01 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 376,802 | 374,169 | -2,633 | 0.04 | 0.04 | +0.00 | sell |
| SILVERBACK ASSET MANAGEMENT LLC | 0 | 350,000 | +350,000 | 0.06 | 0.07 | +0.00 | buy |
| BARCLAYS PLC | 245,100 | 338,792 | +93,692 | 0.00 | 0.00 | +0.00 | buy |
| SMITH, MOORE & CO. | 300,000 | 300,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Qube Research & Technologies Ltd | 895,524 | 249,784 | -645,740 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 0 | 246,864 | +246,864 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 43,697 | 239,245 | +195,548 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 207,744 | 233,170 | +25,426 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 231,049 | +231,049 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 227,228 | 227,228 | 0 | 0.05 | 0.05 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 939,603 | 160,695 | -778,908 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.13 | 0.17 | +0.04 | hold |
| ALPS ADVISORS INC | 0 | 122,644 | +122,644 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 118,500 | 118,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 0 | 115,813 | +115,813 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 264,085 | 105,961 | -158,124 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 0 | 105,175 | +105,175 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 103,947 | +103,947 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 98,976 | +98,976 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 98,303 | +98,303 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 98,157 | +98,157 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 95,796 | +95,796 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 64,777 | 95,291 | +30,514 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 90,447 | +90,447 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 96,113 | 89,382 | -6,731 | 0.13 | 0.06 | -0.07 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 77,000 | +77,000 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 48,111 | 76,111 | +28,000 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 75,000 | 75,000 | 0 | 0.08 | 0.09 | +0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 72,061 | +72,061 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 10,678 | 67,434 | +56,756 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 43,761 | 67,362 | +23,601 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 56,808 | +56,808 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 54,428 | +54,428 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 47,050 | 50,415 | +3,365 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 28,977 | 46,894 | +17,917 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 0 | 42,915 | +42,915 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 38,946 | +38,946 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 42,116 | 35,271 | -6,845 | 0.00 | 0.00 | -0.00 | sell |
| Sivia Capital Partners, LLC | 30,018 | 30,018 | 0 | 0.02 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 0 | 26,420 | +26,420 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 26,158 | 26,158 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caption Management, LLC | 0 | 25,480 | +25,480 | 0.00 | 0.00 | +0.00 | buy |
| DRIVE WEALTH MANAGEMENT, LLC | 16,677 | 25,474 | +8,797 | 0.00 | 0.01 | +0.00 | buy |
| US BANCORP \DE\ | 33,487 | 24,100 | -9,387 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 22,000 | 23,550 | +1,550 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 23,401 | +23,401 | 0.00 | 0.00 | +0.00 | buy |
| Banco BTG Pactual S.A. | 0 | 22,009 | +22,009 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 0 | 21,159 | +21,159 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 19,391 | +19,391 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 19,300 | 19,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 0 | 18,066 | +18,066 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 919 | 17,117 | +16,198 | 0.00 | 0.00 | +0.00 | buy |