| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Monaco Asset Management SAM | 2,726,104 | 3,850,920 | +1,124,816 | 1.23 | 1.59 | +0.36 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,494,794 | 6,434,046 | +939,252 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,444,617 | 1,887,512 | +442,895 | 0.01 | 0.01 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 3,592,765 | 3,948,249 | +355,484 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 309,979 | 630,961 | +320,982 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 287,259 | +287,259 | 0.00 | 0.14 | +0.14 | buy |
| Alyeska Investment Group, L.P. | 5,487,516 | 5,767,456 | +279,940 | 0.03 | 0.03 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 641,498 | 916,250 | +274,752 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 242,649 | +242,649 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 500,003 | 657,838 | +157,835 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 149,835 | +149,835 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 3,335,511 | 3,484,932 | +149,421 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 146,957 | +146,957 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,500,000 | 5,645,352 | +145,352 | 1.22 | 1.25 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 104,612 | +104,612 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 310,213 | 385,133 | +74,920 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 67,546 | +67,546 | 0.00 | 0.01 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 50,050 | +50,050 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 5,750,000 | 5,800,000 | +50,000 | 0.54 | 0.58 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 47,050 | +47,050 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 181,638 | 228,455 | +46,817 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 39,655 | +39,655 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 83,543 | 119,062 | +35,519 | 0.00 | 0.00 | +0.00 | buy |
| HB Wealth Management, LLC | 0 | 27,500 | +27,500 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 93,500 | 118,500 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| STEPH & CO | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 333,594 | 350,961 | +17,367 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 11,064 | +11,064 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 1,409,262 | 1,419,262 | +10,000 | 0.30 | 0.33 | +0.03 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 19,908 | 26,158 | +6,250 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 781,778 | 787,288 | +5,510 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 7,930,508 | 7,935,735 | +5,227 | 0.00 | 0.00 | +0.00 | buy |
| Traynor Capital Management, Inc. | 10,000 | 14,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 35,018 | 39,018 | +4,000 | 0.02 | 0.02 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 31,171 | 34,471 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 1,328 | +1,328 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 261 | +261 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 20,218 | 20,220 | +2 | 0.00 | 0.00 | +0.00 | buy |
| AGF MANAGEMENT LTD | 0 | 0 | 0 | 0.00 | 0.01 | +0.01 | hold |
| FEDERATED HERMES, INC. | 3,065,136 | 3,065,136 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 552,000 | 552,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 954 | 954 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 3,524,908 | 3,524,908 | 0 | 0.13 | 0.16 | +0.03 | hold |
| WHITEBOX ADVISORS LLC | 0 | 0 | 0 | 0.19 | 0.23 | +0.03 | hold |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 2.73 | 3.05 | +0.32 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.21 | 0.21 | +0.01 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.39 | 0.31 | -0.07 | hold |
| Palo Alto Investors LP | 6,277,093 | 6,277,093 | 0 | 0.66 | 0.80 | +0.15 | hold |
| 683 Capital Management, LLC | 0 | 0 | 0 | 0.73 | 0.64 | -0.09 | hold |
| Cambridge Investment Research Advisors, Inc. | 16,000 | 16,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 0 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Verition Fund Management LLC | 0 | 0 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Nantahala Capital Management, LLC | 672,856 | 672,856 | 0 | 0.06 | 0.06 | -0.01 | hold |
| NEA Management Company, LLC | 18,093,034 | 18,093,034 | 0 | 1.23 | 0.98 | -0.25 | hold |
| Rock Springs Capital Management LP | 0 | 0 | 0 | 0.14 | 0.16 | +0.02 | hold |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.09 | 0.10 | +0.02 | hold |
| Opaleye Management Inc. | 0 | 0 | 0 | 0.90 | 0.70 | -0.21 | hold |
| Moors & Cabot, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.12 | 0.12 | +0.00 | hold |
| Monashee Investment Management LLC | 859,854 | 859,854 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Cetera Investment Advisers | 12,536 | 12,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHOREO, LLC | 48,111 | 48,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MFA WEALTH ADVISORS, LLC | 1,872 | 1,872 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 1.16 | 1.16 | +0.01 | hold |
| DeepCurrents Investment Group LLC | 0 | 0 | 0 | 0.60 | 0.50 | -0.10 | hold |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.11 | 0.11 | -0.00 | hold |
| Shaolin Capital Management LLC | 0 | 0 | 0 | 0.45 | 0.68 | +0.23 | hold |
| Octagon Capital Advisors LP | 9,187,883 | 9,187,883 | 0 | 1.37 | 1.45 | +0.09 | hold |
| Morton Brown Family Wealth, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corient Private Wealth LLC | 3,391,483 | 3,391,483 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SMITH, MOORE & CO. | 226,000 | 226,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Clearstead Advisors, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 597,694 | 597,694 | 0 | 0.02 | 0.02 | +0.00 | hold |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 0 | 0 | 0 | 0.53 | 0.54 | +0.01 | hold |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 712,776 | 712,776 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFS Partners, LLC | 130 | 128 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 790 | 750 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 206 | 141 | -65 | 0.00 | 0.00 | 0.00 | sell |
| Global Retirement Partners, LLC | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 2,834 | 0 | -2,834 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 16,288 | 12,054 | -4,234 | 0.00 | 0.00 | -0.00 | sell |
| Trellis Wealth Advisors LLC | 15,000 | 10,000 | -5,000 | 0.01 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 11,760,251 | 11,754,397 | -5,854 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 280,975 | 274,529 | -6,446 | 0.00 | 0.00 | +0.00 | sell |
| Cape Investment Advisory, Inc. | 7,000 | 0 | -7,000 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 19,315 | 10,876 | -8,439 | 0.00 | 0.00 | -0.00 | sell |
| Texas Yale Capital Corp. | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 10,484 | 0 | -10,484 | 0.00 | 0.00 | -0.00 | sell |
| Financial Advocates Investment Management | 106,850 | 93,550 | -13,300 | 0.01 | 0.01 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 18,696 | 4,456 | -14,240 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 823,900 | 800,000 | -23,900 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 441,015 | 410,700 | -30,315 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,261,597 | 1,228,077 | -33,520 | 0.00 | 0.00 | +0.00 | sell |
| NOMURA HOLDINGS INC | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 58,445 | 0 | -58,445 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,283,618 | 2,212,377 | -71,241 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 532,628 | 416,958 | -115,670 | 0.10 | 0.07 | -0.03 | sell |